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Hyun Mi KIM ; Jin Young BAE ; Yoo Jin CHO ; Mi Ju KIM ; Hyun Hwa CHA ; Won Joon SEONG

Obstetrics & Gynecology Science.2014;57(2):180-180. doi:10.5468/ogs.2014.57.2.180

The Editorial Office of Obstet Gynecol Sci would like to correct the author's name. The Editorial Office apologizes for any inconvenience that it may have caused.

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A case of cystic adenomyoma of the uterus after complete abortion without transcervical curettage.

Mi Ju KIM

Obstetrics & Gynecology Science.2014;57(2):176-179. doi:10.5468/ogs.2014.57.2.176

We diagnosed a 2-cm, large cystic adenomyoma after complete abortion without transcervical curettage, based on symptoms of dysmenorrhea, time of onset, and sonographic findings. The cystic adenomyoma was treated successfully with laparoscopic mass excision.
Adenomyoma* ; Curettage* ; Dysmenorrhea ; Female ; Laparoscopy ; Ultrasonography ; Uterus*

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Inguinal endometriosis in a patient without a previous history of gynecologic surgery.

Da Hee KIM ; Min Jung KIM ; Mi La KIM ; Jong Taek PARK ; Ji Hyun LEE

Obstetrics & Gynecology Science.2014;57(2):172-175. doi:10.5468/ogs.2014.57.2.172

Endometriosis, defined as growth of endometrial stroma and glands outside the uterine cavity, is a chronic and recurrent disease that affects patients' quality of life. Ectopic endometrial tissue can proliferate at any location in the body, but the pelvic organs and peritoneum are the most frequent implantation sites. Among extrapelvic endometriosis, inguinal endometriosis is a very rare gynecologic condition usually associated with previous pelvic surgery. Endometriosis should be preoperatively distinguished from other inguinal masses using computed tomography, magnetic resonance imaging, or ultrasonography. Here, we report a case of right inguinal endometriosis in a patient with no previous history of gynecologic surgery; in addition, we have provided a brief review of relevant literature.
Endometriosis* ; Female ; Gynecologic Surgical Procedures* ; Humans ; Magnetic Resonance Imaging ; Peritoneum ; Quality of Life ; Round Ligament of Uterus ; Ultrasonography

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A case of vulvar hematoma with rupture of pseudoaneurysm of pudendal artery.

Hye Ri HONG ; Kyu Ri HWANG ; Sung Ae KIM ; Jeong Eun KWON ; Hye Won JEON ; Ji Eun CHOI ; Young Ho SO

Obstetrics & Gynecology Science.2014;57(2):168-171. doi:10.5468/ogs.2014.57.2.168

Vulvar hematomas are uncommon outside of the obstetric population and may be the result of trauma to the perineum. Vulvar hematomas most often present with low abdominal pain and urologic and neurologic symptoms. The vulva has rich vascularization that is supplied by the pudendal artery, a branch of the anterior division of the internal iliac artery. We describe a rare case of a 15-cm-sized vulvar hematoma with the suggested rupture of a pseudoaneurysm of the left pudendal artery without trauma injury. A 14-year-old girl presented with sudden pain and swelling in her left labium and was successfully treated with selective arterial embolization and surgical evacuation. We provide a literature review and discuss patient treatment and management strategies.
Abdominal Pain ; Adolescent ; Aneurysm, False* ; Arteries* ; Female ; Hematoma* ; Humans ; Iliac Artery ; Neurologic Manifestations ; Perineum ; Rupture* ; Vulva

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Comparison of the efficacy of three once-weekly bisphosphonates on bone mineral density gains in Korean women.

Ji Hyun LEE ; Byung Chul JEE ; Chang Suk SUH ; Seok Hyun KIM ; Young Min CHOI ; Jung Gu KIM ; Shin Yong MOON

Obstetrics & Gynecology Science.2013;56(3):176-181. doi:10.5468/ogs.2013.56.3.176

OBJECTIVE: To assess the efficacies of once-weekly bisphosphonates on bone mineral density (BMD) gains in Korean women aged 50 years or more. METHODS: We selected 166 patients who received: alendronate 70 mg (n=48), alendronate 70 mg + cholecalciferol 2,800 IU (n=31) or risedronate 35 mg (n=87) for one year. The baseline BMD and the % changes of BMD at one-year were compared among the three medication groups. RESULTS: The menopausal status and number of women with osteoporosis was not different among the three groups, but mean age of women was significantly lower in alendronate group. Baseline BMD at L1-4 and femur neck (FN) was similar, but baseline BMD at femur total (FT) was significantly lower in alendronate group. After one-year use, the median % changes of BMD at three sites were similar among the three groups; however, the median values were highest in alendronate + cholecalciferol group (L1-4: 4.48%, 6.74%, and 4.50%; FT: 2.09%, 3.70%, and 2.31%; FN: 3.05%, 3.79%, and 2.03%). CONCLUSION: Among three once-weekly bisphosphonates, BMD gains were highest after one-year use of alendronate+cholecalciferol, although statistically not significant.
Aged ; Alendronate ; Bone Density ; Cholecalciferol ; Diphosphonates ; Etidronic Acid ; Female ; Femur ; Femur Neck ; Humans ; Osteoporosis ; Risedronate Sodium

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The frequency and clinical significance of intra-amniotic inflammation defined as an elevated amniotic fluid matrix metalloproteinase-8 in patients with preterm labor and low amniotic fluid white blood cell counts.

Chan Wook PARK ; Bo Hyun YOON ; Sun Min KIM ; Joong Shin PARK ; Jong Kwan JUN

Obstetrics & Gynecology Science.2013;56(3):167-175. doi:10.5468/ogs.2013.56.3.167

OBJECTIVE: To determine the frequency and clinical significance of intra-amniotic inflammation (IAI) defined as an elevated amniotic fluid (AF) matrix metalloproteinase-8 (MMP-8) concentration in patients with preterm labor and intact membranes (PTL) and low AF white blood cell (WBC) counts. METHODS: Adverse pregnancy outcomes were compared according to the presence or absence of IAI in 220 singleton gestations who underwent amniocentesis due to PTL (gestational age<35.7 weeks) and had low AF WBC counts (<19 cells/mm3). Adverse pregnancy outcomes included preterm birth within 5 days of amniocentesis, acute histologic chorioamnionitis (acute-HCA) and positive AF culture. IAI was defined as an elevated AF MMP-8 concentration (> or =23 ng/mL). RESULTS: IAI was present in 19% of study population. Adverse pregnancy outcomes were significantly more frequent in patients with IAI than in those without IAI (preterm birth within 5 days of amniocentesis, 88% vs. 41%; acute-HCA, 47% vs. 11%; positive AF culture, 10% vs. 2%; each for P<0.05). Patients with IAI had a significantly shorter median amniocentesis-to-delivery interval than those without IAI (7.8 hours [0.01-3,307.3 hours] vs. 310.3 hours [0.01-2,973.8 hours]; P<0.001 from survival analysis). Multiple logistic regression analysis demonstrated that only an IAI (odds ratio, 3.3; 95% confidence interval, 1.5-7.3; P<0.005) retained a statistical significance in the prediction of acute-HCA after other confounding variables were adjusted. CONCLUSION: Approximately one-fifth of patients with PTL and low AF WBC counts have an evidence of IAI and are at risk for impending preterm delivery and acute-HCA when AF MMP-8 concentration is used.
Amniocentesis ; Amniotic Fluid ; Chorioamnionitis ; Confounding Factors (Epidemiology) ; Female ; Humans ; Inflammation ; Leukocyte Count ; Leukocytes ; Logistic Models ; Matrix Metalloproteinase 8 ; Membranes ; Obstetric Labor, Premature ; Parturition ; Pregnancy ; Pregnancy Outcome ; Premature Birth

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Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age.

Young Joo KIM ; Jee Eun LEE ; Soo Hyun KIM ; Sung Shin SHIM ; Dong Hyun CHA

Obstetrics & Gynecology Science.2013;56(3):160-166. doi:10.5468/ogs.2013.56.3.160

OBJECTIVE: To evaluate the association of maternal age with occurrence of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age (AMA). METHODS: A retrospective review of the amniocentesis or chorionic villous sampling (CVS) database at Gangnam and Bundang CHA Medical Centers, between January 2001 and February 2012, was conducted. This study analyzed the incidence of fetal chromosomal abnormalities according to maternal age and the correlation between maternal age and fetal chromosomal abnormalities in Korean pregnant women > or =35 years of age. In addition, we compared the prevalence of fetal chromosomal abnormalities between women of AMA only and the others as the indication for amniocentesis or CVS. RESULTS: A total of 15,381 pregnant women were selected for this study. The incidence of aneuploidies increased exponentially with maternal age (P<0.0001). In particular, the risk of trisomy 21 (standard error [SE], 0.0378; odds ratio, 1.177; P<0.001) and trisomy 18 (SE, 0.0583; odds ratio, 1.182; P=0.0040) showed significant correlation with maternal age. Comparison between women of AMA only and the others as the indication for amniocentesis or CVS showed a significantly lower rate of fetal chromosomal abnormalities only in the AMA group, compared with the others (P<0.0001). CONCLUSION: This study demonstrates that AMA is no longer used as a threshold for determination of who is offered prenatal diagnosis, but is a common risk factor for fetal chromosomal abnormalities.
Amniocentesis ; Aneuploidy ; Chorion ; Chromosome Aberrations ; Down Syndrome ; Female ; Humans ; Incidence ; Maternal Age ; Odds Ratio ; Pregnant Women ; Prenatal Diagnosis ; Prevalence ; Retrospective Studies ; Risk Factors ; Trisomy

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Breast diseases during pregnancy and lactation.

Ji Hoon YU ; Min Jeong KIM ; Hyonil CHO ; Hyun Ju LIU ; Sei Jun HAN ; Tae Gyu AHN

Obstetrics & Gynecology Science.2013;56(3):143-159. doi:10.5468/ogs.2013.56.3.143

Breast is a typical female sexual physiologic organ that is influenced by steroid hormone from menarche until menopause. Therefore various diseases can be developed by continuous action of estrogen and progesterone. Breast diseases are mainly categorized as benign and malignant. It is very important to distinguish the malignancy from breast diseases. However, it is very difficult to diagnose malignancy in pregnant and lactating women even though the same breast diseases took place. Therefore, we will review breast diseases such as breast carcinoma during pregnancy and lactation.
Breast ; Breast Diseases ; Estrogens ; Female ; Humans ; Hypogonadism ; Lactation ; Menarche ; Menopause ; Mitochondrial Diseases ; Ophthalmoplegia ; Pregnancy ; Progesterone

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Dyslipidemia in women with polycystic ovary syndrome.

Jin Ju KIM ; Young Min CHOI

Obstetrics & Gynecology Science.2013;56(3):137-142. doi:10.5468/ogs.2013.56.3.137

Dyslipidemia is a very common metabolic abnormality in women with polycystic ovary syndrome (PCOS). Insulin resistance is a key pathophysiology of PCOS, thus dyslipidemia in women with PCOS may be consistent with those found in an insulin resistant state. In recent meta-analysis, triglycerides and low-density lipoprotein (LDL) cholesterol levels were 26 mg/dL and 12 mg/dL higher, and high-density lipoprotein cholesterol concentration was 6 mg/dL lower in women with PCOS than those of controls. Alterations in LDL quality also have been reported in women with PCOS: women with PCOS have an increased proportion of atherogenic small dense LDL or decreased mean LDL particle size. However, in a recent Korean study, non-obese Korean women with PCOS had no significant quantitative or qualitative changes in LDL cholesterol profile. Lipoprotein (a) has been identified as an independent risk factor for coronary heart disease, and its elevation in PCOS patients has been consistently reported in diverse studies including non-obese Korean population. Some studies have investigated apolipoprotein (Apo) A-I and ApoC-I levels in women with PCOS and levels of ApoA-I, which has cardio-protective effects, were significantly lower in women with PCOS than those of controls. ApoC-I is known to increase the postprandial serum lipid level that is common in coronary artery disease patients, and one study reported that such an elevation may be the earliest variation of lipid abnormality in women with PCOS. In conclusion, women with PCOS should receive a complete lipid test, and lifestyle modification, including diet and exercise, is the first line therapy for all women with PCOS and is particularly important for those with dyslipidemia.
Apolipoprotein A-I ; Apolipoproteins ; Cholesterol ; Cholesterol, LDL ; Coronary Artery Disease ; Coronary Disease ; Diet ; Dyslipidemias ; Female ; Humans ; Insulin ; Insulin Resistance ; Life Style ; Lipoprotein(a) ; Lipoproteins ; Particle Size ; Polycystic Ovary Syndrome ; Risk Factors ; Triglycerides

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Should advanced maternal age be a reasonable indication for invasive diagnostic testing?.

Hyun Mee RYU

Obstetrics & Gynecology Science.2013;56(3):135-136. doi:10.5468/ogs.2013.56.3.135

No abstract available.
Maternal Age

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