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Relationship between the expression of B7-1 in liver tissue and the effect of interferon-alpha treatment in patients with chronic hepatitis B

Xingfeng REN ; Kangxian LUO ; Lian ZHANG

Chinese Journal of Practical Internal Medicine.2001;21(2):83-84.

Objectives To evaluate the relationship between the expression of B7-1 in liver tissue and the effect of interferon- alpha(α- IFN) treatment in patients with chronic hepatitis B(CHB).Methods The expression of B7 -1in liver biopsy specimens from 68 CHB patients was studied with immunohistochemistry before α-IFN treatment.Results B7-1 was expressed in 45(66.2%) liver tissues among 68 patients with CHB,but none in 5 normal controls.The total response ratio of α- IFN in patients with B7-1 positive was 66.7%(30/45),which was significantly higherthan 39.1%(9/23)in the patients with B7-1 negative(x2 =7.20,P <0.01).B7-1 expression was closely corelat-ed with the histological activity grade(HAI) and serum alanine transaminase(ALT) level.Conclusions The level of B7-1 expression in liver tissue may be regarded as an effective parameter for predicting α-IFN response in patients with CHB.

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Relationship between apolipoprotein E polymorphism and coronary heart disease

Shaomin ZHANG ; Yan CUI

Chinese Journal of Practical Internal Medicine.2001;21(1):18-20.

Objective To study the effect of apolipoprotein E (ApoE) polymorphism on serum lipids and the relationship between apolipoprotein E polymorphism and coronary heart disease (CHD).Methods Polymerize chain reaction (PCR) and HhaI digestion were used for the detection of apolipoprotein E genotype on 71 patients with CHD and 69 control subjects.Results The frequencies of apolipoprotein E4 allele and E3/4 genotype were obviously increased in CHD group than in control group (P<0.01,P<0.05). Conclusion The apolipoprotein E polymorphism is related to the occurrence of coronary heart disease; apolipoprotein E4 allele is one of the most important hereditary factor for the occurrence of CHD.

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Analysis of the reason for misdiagnosis of sarcoidosis.

Chunlei WANG ; Jian KANG ; Zhenhua LI

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To explore the common reason for misdiagnosis of sarcoidosis to increase the diagnosis rate of sarcoidosis and reduce misdiagnosis rate.Methods Analyze clinical manifestation and misdiagnosis reason retrospectively of 98 patients confirmed sarcoidosis according to pathological proof,in which 39 patients are misdiagnosed.Results The major reasons for misdiagnosis were delitescent sarcoidosis progress,clinical manifestation lacking specificity and lack of research.The most common diseases misdiagnosed were pulmonary tuberculosis,lung cancer and lymphoma.Conclusion The major methods to reduce misdiagnosis are to know well about clinical characteristics,imageology manifestation and laboratory exam about sarcoidosis.

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Clinical analysis of acute arsenic poisoning treated by early plasma exchange in 11 patients.

Chunhua ZHANG ; Fengtong HAO

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To investigate the effect of plasma exchange early on treatment for acute arsenic poisoning and prevention for acute renal failure.Methods Eleven patients of acute arsenic poisoning were treated by plasma exchange early.Their clinical features and biochemistry indexes were observed before and after treatment.Results After plasma exchange,the clinical features of all patients improved.Nine patients had normal renal function and 2 patients had impaired renal function.Conclusion Early plasma exchange is an effective measure for prevention for acute renal failure caused by acute arsenic poisoning.

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Retrospective analysis of disease spectrum of fever patients.

Xiaolin GUO ; Yan GAO ; Xia YANG

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To describe the disease's spectrum of fever patients,especially to analyze the epidemic characterization of infectious diseases,to offer the proof for fever department in screening of infectious diseases.Methods A total of 15081 patients were analyed for patients presenting to the Infectious Diseases Department,People's Hospital,Peking University,between June 2005 to May 2006.A retrospective study was used to analyze the disease's spectrum and epidemic characterization.Results Among the disease's spectrum of fever patients,the first leading cause was respiratory diseases(78.22%),followed by infection with the special patients(10.50%)、acute gastroenteritis(3.57%)、the infection at other site with etiological factor determined(2.82%)、infectious diseases(2.30%)、urinary system infection(2.06%) and fever of unknown origin(0.53%),respectively;Among the spectrum of infectious diseases,the first leading cause was infectious diarrheal disease(29.97%),followed by measles(24.78%)、lung tuberculosis(11.24%).Conclusion The spectrum of fever is complex.To obtain the epidemic characterization of infectious diseases,it's helpful to the fever department to screen and prevent the infectious diseases.

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Molecular epidemiology profile of methicillin-resistant Staphylococcus aureus in ICU ward.

Wei XIONG ; Hongbo WANG ; Min TU

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To investigate molecular epidemiology profile of methicillin-resistant Staphylococcus aureus (MRSA) in ICU ward.Methods Twenty-five MRSA strains were typed by arbitrarily primed PCR (AP-PCR).Results Ten different AP-PCR patterns (A-G) were found among 25 MRSA strains.Most of MRSA in ICU ward were A and B pulsotype.Conclusion Hospital acquired MRSA is multi-resistant to antibiotics.A and B pulsotype MRSA outbreak occures in ICU ward.

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The therapeutic effect of plasma exchange and plasma perfusion on acute fatty liver of pregnancy.

Lianyi GUO ; Ying WEN ; Pei LIU

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To study the therapeutic effect of plasma exchange and plasma perfusion(PE+PP)on acute fatty liver of pregnancy.Methods Twenty-one patients with acute fatty liver of pregnancy were divided into two groups.In the treated group,the patients were treated with (PE+PP) on the basis of the conventional therapy,and the control group received the conventional therapy only?Liver function,kidney function and prothrombin activity(PTA) before treatment and 4 weeks,6 weeks after treatment were observed.Results After treatment with (PE+PA),the liver function,kidney function and PTA were ameliorated at 4 weeks and 6 weeks(P

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Relationship between plasma concentrations of adiponectin and high sensitive C reactive protein in diabetes with lower extremities vascular disease.

Juan WANG ; Caiping LI ; Chuanjiang ZHANG

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To observe plasma concentration of adiponectin and high sensitive C reactive protein (HsCRP) in Type 2 diabetes mellitus(T2DM) with/without lower extremities vascular disease,and explore the influences of adiponectin and HsCRP in the genesis and development of them.Methods We selected 115 subjects in our hospital and divided them into 2 groups:normal control group and T2DM group,including simple T2DM and T2DM with diabetic lower extremities vascular disease;in addition,we measured plasma adiponectin and HsCRP with ELISA and scattered radiation turbidimetry for them.Results Plasma adiponectin concentration in the comparing group was higher than T2DM,and the level in simple T2DM patients was higher than the one with lower extremities vascular disease,showing an obviously decreased tendency,and significant differences were detected in plasma adiponectin concentration between groups (P

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Detection of three kinds of cytokines in patients with viral myocarditis.

Bo HU ; Jue XU ; Guoqiang HONG

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To investigate the changes of TNF-?,IL-2 and IL-1? level in serum of patients with viral myocarditis and its clinical meaning.Methods The level of serum TNF-?,IL-2 and IL-1? in 45 cases of viral myocarditis was detected by ELISA,and the data were compared with control group.Results Serum TNF-?,IL-2 and IL-1? levels in viral myocarditis patients were significantly higher than control group and related to severity of the disease.Conclusion It suggests that immune dysfunction exists in patients with viral myocarditis.Higher level of TNF-?,IL-2 and IL-1? may be associated with development of the viral myocarditis,and it can be a new indicator for viral myocarditis.

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The prevalence and significance of autoantibodies in patients with nonalcoholic steatohepatitis.

Ming JIN

Chinese Journal of Practical Internal Medicine.2001;0(05):-.

Objective To study the relationship between the prevalence and the clinics,histology of autoantibodies in patients with nonalcoholic steatohepatitis.Methods This study was based on data related to 117 patients with NASH who were treated at the Departments of Youan Hospital between 2000 and 2005.The prevalence of autoantibodies in all patients were examined and the relationships were analyzed with sex,age,liver function,lipid index and liver biopsy.Results The prevalence of autoantibodies in 117 patients with NASH was 35%,29.1% of whom were ANA and/or SMA positive,higher than in the general population(6%~15%);ANA and/or SMA positive patients with NASH were older and mostly females as compared to ANA and/or SMA negative patients,but there were no significant differences in liver function,lipid index and liver biopsy between positive and negative patients.Conclusion ANA and/or SMA are common in NASH patients and often represent a nonspecific antibody response that is not associated with the severity of liver injury.

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