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Effects of rosiglitazone on the mRNA expressions of MMP-1、TIMP-1 and Collagen Ⅲ in rat kidney fibroblasts cultured in high glucose.

Zhaohui ZHENG ; Haijian LI ; Zhangsuo LIU

Chinese Journal of Practical Internal Medicine.2000;0(12):-.

Objective To investigate into the protective effects of rosiglitazone on rat kidney fibroblasts(NRK)damaged by high glucose.Methods From Jan.2005 to Sep.2005,the NRK cells were cultured in vitro,and were divided into five groups:normal glucose group(NG,1 000 mg/L D-glucose),high glucose group(HG,4 500 mg/L D-glucose),HG+RGZ(5 ?mol/L),HG+RGZ(10 ?mol/L)and HG+RGZ(15 ?mol/L).The mRNA expressions of T MMP-1、TIMP-1 and Collagen Ⅲ were measured with RT-PCR.Results Compared with NG group,the mRNA expression of MMP-1 decreased markedly in HG group(P

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Investigation into G6PD deficiency gene frequency in Tujia nationality in Jiangkou,Guizhou.

Changxue WU ; Keren SHAN ; Yan HE

Chinese Journal of Practical Internal Medicine.2000;0(12):-.

Objective The frequency of G6PD deficiency in the Tujia nationality in Jiangkou,Guizhou was investigated.Methods In Oct.2002,227 male subjects were selected randomly from the local people,and NBT qualitative and G6PD/6PGD quantitative methods were used to detect G6PD deficiency in them.Results Among the 227 subjects,17 cases of G6PD deficiency were found.The gene frequency of G6PD deficiency was 0.0749.Conclusion There is a high incidence of G6PD deficiency in Tujia nationality in Jiangkou,Guizhou.The investigation will illustrate the distribution of G6PD deficiency in Guizhou,and provide some useful data for the preventing G6PD deficiency,directing clinical management,improving minority population diathesis and studying the origin of Tujia nationality.

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A study of combination therapy for hyperphosphatemia with calcium-containing phosphate binders and low-calcium dialysate in hemodialysis patients.

Yaowen XU ; Guanyu WANG ; Ying QIAN

Chinese Journal of Practical Internal Medicine.2000;0(12):-.

1.78 mmol/L,intact parothyroid(iPTH)2.37 mmol/L,calcium dose was 1 000 mg/d;if serum Ca~ 2+ was0.05].After low-calcium dialysis(1.25 mmol/L Ca~ 2+ dialysate)for 6 months:the serum Ca~ 2+ level had no change[(2.37?0.26)mmol/L to (2.41?0.24)mmol/L];the serum P level had decreased significantly from[(2.60?0.47)mmol/L to (2.29?0.58)mmol/L];the iPTH had increased significantly from[(130.7?84.6)pg?mL~ -1 to (169.2?105.8)pg?mL~ -1 ,P

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Analysis 96 Patient with Hemorrhage in Cerebral Ganglion.

Ying MA

Chinese Journal of Practical Internal Medicine.2006;0(S1):-.

Objective To study clinical characteristics of the thalamic hemorrhage,probe into the correlation factor of judged prognosis in early days and case-fatality rate.Methods To 2003—2005 96 thalamic hemorrhage sufferer's clin- ical data were analysed.Results The advanced age and high blood pressure is main cause of disease of the thalamic hemorrhage.Conclusion To observe the thalamic hemorrhage sufferer's vital signs have the certain reference value to judged prognosis,case-fatality rate and serious complications were related to bloods closely in early days,whether break into the brain room,hypothalamus and the brain stem whether implicate.

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Clinical analsis of drug induced liver disease.

Yan LIU

Chinese Journal of Practical Internal Medicine.2006;0(S1):-.

Objective To analyze clinical process and therapy means of drug induced liver disease(DILD).Methods The retrospectively study on the clinical data 40 patients of DILD was used.Results(1)18 patients with DILD are more 60 year(45.0%); 17 patients have chronic dease(42.5%); 3 patients are sensitive to drug.10 patients have unite using drug(25%); 4 patients have bibulosity; 20 patients had not cease drug when DILD happened with al- imentary tract symptom(50%);(2)72.7% DILD with antibiotics happened in 2 weeks,most cases are acute bile de- posit type.95.2%DILD with Chinese traditional medicine happened after 2 weeks,is are chronic hepatotoxicity,it is obvious that liver cell damage type and bile deposit type.and commix-type.Very few Chinese traditional medicine also lead to acute hepatotoxicity.By protect liver of therapy:6 patients cure,32 patients mend,2 have patients no change. Conclusion DILD is very normal in clinical,must be in advance know and guard for DILD,the key is to cease drug when DILD happened.

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The short time clinical study of the combination therapy with pulse methylprednisolone plus pulse cyclophospha- mide in patients with lupus nephritis Abstract Objective

Determine TO

Chinese Journal of Practical Internal Medicine.2006;0(S1):-.

Methylprednisolone;;Cyclophosphamide;;lupus nephritis

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The analysis of 132 elder bronchial asthma patients.

Zhaoyin WU

Chinese Journal of Practical Internal Medicine.2006;0(S1):-.

Objective To discuss the clinical character and the result of treatment about elder bronchus.Methods to analyze the inducement of the disease,clinical representation,syndrome and result of treatment on 132 elder patients who are bronchial asthma.Results 39 patients were relaxed completely,81 patients were relaxed partly and 12 pa- tients were dead.Conclusion the state of elder bronchial asthma is very dangerous,and it has more syndrome and high dead rate.

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Analysis on the dangerous fact that influences hypertensive disease jiang xiaohong yan huizhong.

Xiaohong JIANG ; Huizhang YAN

Chinese Journal of Practical Internal Medicine.2006;0(S1):-.

Objective By checking on the government employees and teachers.measuring the blood pressure according to WHO,and sending the inquires papers on dangerous fact.Methods The civil servants and teachers in Dangling dis- trict were examined in October 2004.Results The result was made according to the statisitics analysis.It shows that occupation,sex,age,BMI,the history of smoking,the history of family.All these can cause the independent dan- gerous fact to the hypertensive disease.Conclusion Fat,high salt diet,smoking and drinking were all risk factors of high blood pressure.

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Evaluation of nasal continuous positive airway pressure on prethrombotic state in obstructive sleep apnea syndrome

Lei PAN ; Yong WANG ; Yue SUN

Chinese Journal of Practical Internal Medicine.2006;0(13):-.

Objective To estimate the effects of nasal continuous positive airway pressure(nCPAP)therapy on patients with OSAS in prethrombotic state.Methods One group of 30 patients with OSAS who were diagnosed from Sep.2003 to Sep.2005,one healthy control group of 30 cases.Blood samples were taken from people in the supine position in the morning immediately after overnight polysomnography and nCPAP theraphy(only in OSAS group).Results Compared with the normal controls,the level of the molecular marker GMP-140 increased in the blood of patients with OSAS,the levels of APTT,AT-Ⅲ decreased,and the level of t-PA decreased as well.The level of PAI increased.Compared with the healthy controls,datum indicated statistical differences between the two groups.Datum of the patients with OSAS were improved after nCPAP therapy:AHI decreased from 63.21?23.23 to 0.56?0.84;the nocturnal lowest of SaO_2 increased from 0.68?0.07 to 0.90?0.02;GMP-140 and PAI decreased to (17.07?7.97)% and (95.83?5.91)% respectively;AT-Ⅲ and t-PA increased to(95.20?6.67)% and (5.45?1.61)?g respectively.Conclusion Prethrombotic state is present in patients with OSAS.nCPAP therapy can decrease OSAS-related thrombotic complications.

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The Value of measuring plasma B-natriure peptide Levels in elderly patients with Left ventricular dysfunction

Liping ZHANG ; Zhigang ZHENG ; Peihua HOU

Chinese Journal of Practical Internal Medicine.2006;0(13):-.

Objective To evaluate the serum Level of B-natriure peptide(BNP)in elderly patients with Left Ventricular dysfunction and to determine the correlation between the BNPand hemodynamic Variable.Methods According to New York Heart Association(NYHA)class.51 patients with Left Ventricular dysfunction and 28 without Left Ventricular dysfunction(control group)were measured.BNP Levels were obtained,Left ventricular ejection fraction(LVEF)was assessed by echocardiography,center vein pressure(CVP)was determined in NYHA Class Ⅲ-Ⅳ groups.Results BNP were (39.32?5.51)ng/L in control group,respectively(265.94?63.13)ng/L in NYHA ClassⅡgroup(n=18),(569.93?109.17)ng/L 、CVP was(9.67?1.23)cmH_2O in NYHA class Ⅲ group,(2 764.33?1 020.53)、CVP was(19.61?4.57)cmH_2O in NYHA class Ⅳ.The difference of BNP and CVP in groups were scegnificant(all P

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