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Expression of bFGF in chronic interstitial nephritis

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To study the expression of basic fibroblast growth factor(bFGF)in the kidney tissues of chronic interstitial nephritis(CIN).Methods Expression of bFGF was assayed in 30 patients with CIN and 5 normal persons by SP method of immunohistochemical technique.The average gray value and average optical density of the bFGF positive parts and its ratio with the whole visual field had been measured with video analysis system.Results The expression of bFGF in the kidney tissues of CIN was significantly stronger than that in normal tissues.The average gray value,average optical density and the positive areas were significantly high compared with that of normal cases.Conclusion The bFGF can promote the proliferation of fibroblasts and monocytes in renal interstitial patients and lead to renal interstitial fibrosis in the end.

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Analysis of the relationship between type 2 diabetic peripheral neuropathy and urinary albumin execretory rate

Xiaoling LI ; Lyun ZHU ; Licheng MA

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To analyse the risk factors relating to diabetic peripheral neuropathy(DPN).Methods 214 type 2 DM cases were investigated and the factors relating to DPN were analysed including age 、diabetic duration 、fasting blood glucose(FBG) 、post blood glucose(PBG)、 HbA_1c、blood pressure(BP)、 urinary albumin excretory rate(UAER)and lipid.Results Logistic regresstion analysis showed that UAER and FBG were relatively independent risk factors.Conclusion In many risk factors UAER and FBG are the most important factors of all in developling DPN.

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A clinical analysis of 53 cases of hypereosinophilia

Jie LIN ; Yongji WU

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To comprehend the etiology and the clinical characteristics of hypereosinophilia.Methods The clinical data of 53 patients with hypereosinophilia admitted to Peking Union Medical College Hospital from November 1992 to February 2005 were analyzed.Results The causes of reactive hypereosinophilia included allergic diseases,infections,connective tissue diseases,malignant diseases,lung diseases,eosinophilic gastroenteritis.idiopathic hypereosinophilic syndrome had longer course of disease;more organ involved than reactive causes.The incidence of lymph node enlargement,spleen enlargement and thrombus was higher than the reactive.IHES had higher level of white blood cell count,absolute eosinophilic count,IgG and CRP.Conclusion The etiology and clinical characteristics of hypereosinophilia are various,so the differential diagnosis of hypereosinophilia is very important.

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Effects of uremic serum on TGF-?_1 of human renal tubular epithelial cells

Haiyan LIU ; Xiaowen CHEN ; Huafeng LIU

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

10 000 u,5 000~10 000u and 10 000 u group,and the gene expression was slightly increased in molecular weight 5 000～10 000 u group,but no significant difference of gene expression and protein secretion in 10 000 u uremic toxin,through promoting the gene expression and protein excretion of TGF-?_1 of renal tubular epithelial cells in patients with chronic renal failure.

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Relationship between hyperleptinemia and atherosclerosis in maintenance hemodialysis patients

Jun MA ; Hualin QI ; Chen XU

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To determine whether plasma Leptin level is associated with atherosclerosis in maintenance hemodialysis(MHD)patients.Methods During 1997-01~2003-06,plasma Leptin levels in MHD patients and healthy volunteers were measured and intima-media thickness(IMT)and prevalence of atherosclerotic plaques of the extracranial common carotid artery were also measured.Results Plasma Leptin levels in the MHD patients were higher than those in the healthy volunteers(P

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Implications of concentration of mFas and serum sFas in acute leukemia

Xuexia WANG ; Jiarong CHEN ; Zhaodong HAN

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To explore the role of expression of membrane Fas(mFas)antigen and serum soluble Fas(sFas)in acute leukemia.Methods Strept avidin-biotin complex method of immunohistochemical staining assay and sandwich enzyme-linked immunosorbent assay(ELISA)were used to detect the expression of mFas antigen in bone marrow cells and serum sFas in 30 patients with acute leukemia in Binzhou Medical College Affiliatd Hospital from November 2001 to September 2002,which was compared with normal control group.The relation between expression of serum sFas and chemotherapy outcome were evaluated too.Results The expression of mFas antigen in ALL(5.62?2.27)% and ANLL(8.80?4.15)% were respectively and significantly lower than that in normal control group(28.75?11.20)%(P

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Clinical study of insulin Lispro in the treatment of diabetes mellitus

Weiling CUI ; Zhihong LIAO ; Yanbing LI

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To assess the efficacy and safety of insulin Lispro in type 1 or type 2 diabetic patients.Methods Forty diabetic patients were assigned to receive premeal insulin Lispro plus bedtime Neutral Protamine Hagedorn(NPH)insulin for 12 weeks.The following characters were compared between before and after treatment,including fasting plasma glucose(FPG),1 h and 2 h postprandial glucose(after a standardized meal),glycosylated hemoglobin(GHbA_1c)levels,total daily insulin dose and the number of hypoglycemic episodes.Results Thirty-nine subjects fulfilled the study.After 12 weeks of Lispro treatment,the levels of FPG and 1 h and 2 h postprandial glucose were decreased significantly,being 1.12 mmol/L,2.37 mmol/L and 1.92 mmol/L respectively;GHbA_1c was decreased by 1.45%(from 8.9% to 7.5%).The dose of insulin Lispro was not changed,compared with the dose of regular human insulin at baseline.The incidence of hypoglycemia was decreased from 19.5 every week at baseline to 9.8 every week with Lispro.Conclusion Insulin Lispro is an effective agent for good glucose control with fewer hypoglycemic episodes in diabetic patients.

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Analysis of platelet-associated immunoglobulin subsets in idiopathic thrombocytopenia purpuras resistant to immuno therapy

Fang XU ; Huaxin WU ; Peng XU

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To analyse platelete associated immunoglobulin(PAIg)subsets in idiopathic thrombocytopenia purpuras resistant to prednisone and cyclosporine.Methods Evaluate PAIg subsets in seventeen ITP patients resistant to prednisone,four cases resistant to both prednisone and cyclosporine,thirty in-patients responding to prednisone as the control.All patients were admitted from 1999 to 2004.Results The levels of PAIgA,PAIgG and PAIgM were significantly higher in the seventeen ITP patients resistant to prednisone than that in the thirty cases responsive to prednisone(P

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Study of association between serum resistin,TNF-? and insulin resistance in type 2 diabetes mellitus.

Jingxiong ZHOU ; Xisheng LI ; Guorui CHEN

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To assess the association of serum resistin,TNF-? and insulin resistance in type 2 diabetes mellitus.Methods 42 cases of T2DM and 40 cases of control were involved in the study.Their waist circumference(WC),the levels of fasting serum resistin,TNF-?,fasting blood glucose(FBG) and fasting insulin(FINS)were measured.Results The levels of serum resistin,TNF-? and Homa-IR in T2DM group were significantly higher than those in control group,while serum FINS level was significantly lower than that in control group[(11.76?2.72)vs(8.65?3.00)?g/L,P

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Retrospective study of 33 deaths of in-patients with percutaneous coronary intervention

Hongbin ZHU ; Lijun JIN ; Taiming DONG

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To discuss the reasons of death in the in-patients with percutaneous coronary intervention(PCI).Methods Retrospective analysis was done in 33 cases who died in or after the procedures among 3 252 in-patients with PCI.Results 4 patients died in procedures and the others died after procedures.The major reasons of death in order were:cardiogenic shock,ventricular fibrillation,acute left heart failure,multiple organ failure,heart rupture and acute renal failure.The in-hospital mortality rate was 1.01%.Conclusion The major reasons of death of patients with PCI are cardiogenic shock,ventricular fibrillation and acute left heart failure.Taking some measures will reduce the in-hospital mortality rate.

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