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A study of osteoporosis in patients with type-2 diabetes

Baoling HAN ; Yang ZHANG ; Fengping HANG

Chinese Journal of Practical Internal Medicine.2001;21(4):214-215.

Objective To investigate osteoporosis and its main associated factors in patients with type 2 diabetes (DM). Methods Bone mineral density(BMD)of lumbar vertebrae 2～4 and proximal femur in 40 type 2 diabetic patients were measured with dual energy X-ray absorptiometry and compared with control group(30～35 years old). Serum Ca, P, ALP and connective peptide in type 2 diabetes mellitus patients were measured. Results The area under the connective peptide releasing curre in osteoporosis group was lower than that of non-osteoporosis in type 2 diabetes. Conclu.sion BMD is correlated with the pancreatic islet function. The patients with pancreatic islet failure develop osteoporosis easily.

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Relationship between the expression of B7-1 in liver tissue and the effect of interferon-alpha treatment in patients with chronic hepatitis B

Xingfeng REN ; Kangxian LUO ; Lian ZHANG

Chinese Journal of Practical Internal Medicine.2001;21(2):83-84.

Objectives To evaluate the relationship between the expression of B7-1 in liver tissue and the effect of interferon- alpha(α- IFN) treatment in patients with chronic hepatitis B(CHB).Methods The expression of B7 -1in liver biopsy specimens from 68 CHB patients was studied with immunohistochemistry before α-IFN treatment.Results B7-1 was expressed in 45(66.2%) liver tissues among 68 patients with CHB,but none in 5 normal controls.The total response ratio of α- IFN in patients with B7-1 positive was 66.7%(30/45),which was significantly higherthan 39.1%(9/23)in the patients with B7-1 negative(x2 =7.20,P <0.01).B7-1 expression was closely corelat-ed with the histological activity grade(HAI) and serum alanine transaminase(ALT) level.Conclusions The level of B7-1 expression in liver tissue may be regarded as an effective parameter for predicting α-IFN response in patients with CHB.

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Relationship between apolipoprotein E polymorphism and coronary heart disease

Shaomin ZHANG ; Yan CUI

Chinese Journal of Practical Internal Medicine.2001;21(1):18-20.

Objective To study the effect of apolipoprotein E (ApoE) polymorphism on serum lipids and the relationship between apolipoprotein E polymorphism and coronary heart disease (CHD).Methods Polymerize chain reaction (PCR) and HhaI digestion were used for the detection of apolipoprotein E genotype on 71 patients with CHD and 69 control subjects.Results The frequencies of apolipoprotein E4 allele and E3/4 genotype were obviously increased in CHD group than in control group (P<0.01,P<0.05). Conclusion The apolipoprotein E polymorphism is related to the occurrence of coronary heart disease; apolipoprotein E4 allele is one of the most important hereditary factor for the occurrence of CHD.

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Clinical and laboratory study of moderate hypothermia on treating acute cerebrovascular disease.

Guoping TIAN ; Lihua WU ; Jing'E WANG ; Al ET ;

Chinese Journal of Practical Internal Medicine.2001;0(10):-.

Objective To demonstrate the moderate hypothermia's effect to acute cerebrovascular disease.Methods 82 prospective patients with acute cerebrovascular disease treated by moderate hypothermia were evaluated.According to the standard of clinical neurologic deficiency ,we contrasted the clinical and laboratory effect of control before moderate hypothermia and after moderate hypothermia. Results The neurologic function and SOD improved obviously; NO,ICAM-1,IL-1 and temperature decreased after moderate hypothermic therapy;patients'survival rate and recovery rate improved obviously too.The best therapy time was within 2h after acute cerebrevascular disease happened. Conclusions Moderate hypothermia can improve heal rate of brain damage and decrease mortality and disable rate.

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The expression of platelet activity in hypertensive patients complicated with ischemic cardiovascular and cerebrovascular disease

Xu LIANG ; Lin-Jie LUO ; Xin-Gen WANG ; Al ET ;

Chinese Journal of Practical Internal Medicine.2001;0(04):-.

Objective To observe the change of platelet activity marker in hypertensive patients complicated with ischemic cardiovascular and cerebrovascular disease ,and assess it s value in the happening of thrombotic disease. Method The platelet activity marker (CD62p,CD63) were measured by flow cytometry in 40 hypertensive patients complicated with ischemic cardiovascular and cerebrovascular disease (group C ),46 hypertensive patients not complicated with ischemic cardiovascular and cerebrovascular disease (group B),and 30 cases of healthy control (group A). Comparison between three groups were made. The serum fibrinogen were measured at the same time. Result serum level of CD62p, and CD63 in group B,C are higher than group A.(P

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Non-ST-segment elevation myocardial infarction:clinical feature and characteristics of its coronary artery lesion.

Jun XING ; Yaling HAN ; Xiaozeng WANG ;

Chinese Journal of Practical Internal Medicine.2000;0(11):-.

Objective To explore clinical feature and coronary artery lesion characteristics of non-ST-segment elevation myocardial infarction (NSTEMI).Methods Seventy-three patients of NSTEMI were studied,their clinical data and results of coronary angiography being analyzed.Results Risk factors of coronary artery disease among all the patients were 50(68%) with hypertension,26(35%) with diabetes,34(46%) with hyperlipidemia and 28(38%) with smoking history.There were 52(71%)with angina pectoris before this hospitalization,22(30.6%) with inhospatial angina pectoris,15(20.4%) with severe arrythmias,7(10.2%) with cardiac shock,3(4%) died.52(71%) were with ST-T depression and 21(29%) with normal ECG.Coronary angiography revealed 54(74%) with lesions in more than one vessel and 19(26%) in one vessel (P

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Effects of mycophenolate mofetil on patients with pauci-immune crescentic glomerulonephritis.

Ming CHENG ; Zheng TANG ; Weixin HU ; Jinquan WANG ; Huiping CHEN ; Caihong ZENG ; Zhihong LIU ; Leishi LI

Chinese Journal of Practical Internal Medicine.2001;0(10):-.

Objective To compare the effect,relapse rate and outcomes between mycophenolate mofetil(MMF)and pulse intravenous cyclophosphamide(CTX)in the induction therapy of pauci-immune crescentic glomerulonephritis(PICGN)in Chinese.Methods A total of 44 patients who had PICGN[16 male,28 female,age(46.8?13.7)y],of whom 25 patients were ANCA positive,were enrolled in this study.All patients had renal involvement with ≥50% crescent formation prior to the study and received either MMF treatment(MMF group,n=22)or intermittent CTX pulse therapy(CTX group,n=22).The patients in both groups also received methylprednisolone(MP)pulse therapy followed by oral prednisone.General conditions,clinicopathological findings,remission rate,relapse rate,and outcomes were compared.All the patients were followed up until June 2005,with an average follow-up of 8～60(Med 27)months in the MMF group,and 6～72(Med 29)months in the CTX group.Results No significant difference was found between MMF group and CTX group in general conditions,base parameters of clinical and pathological findings.The remission rate at the 12th month in MMF and CTX group was 90.9% and 72.7% respectively.The complete remission rate in MMF group(59.1%)was significantly higher than that of the CTX group(27.3%)(P

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Non-traumatic rhabdomyolysis:clinical analysis of thirty-nine cases.

Jianfang CAI ; Xuan QU ; Hang LI ; Zhengyin LIU ; Xuewang LI

Chinese Journal of Practical Internal Medicine.2001;0(10):-.

Objective To evaluate clinical features,predisposing factors,therapeutic regimen and prognosis of non-traumatic rhabdomyolysis.Methods Clinical picture,therapeutic regimen and prognosis were investigated in 39 cases with non-traumatic rhabdomyolysis by retrospective analysis.Results Non-traumatic rhabdomyolysis mostly presented fever,asthenia,myalgia and/or muscular tenderness,swelling of involved muscles,red urine and oliguria or anuria.The complications and comorbidity of rhabdomyolysis included acute renal failure(ARF),disorders of metabolites and electrolytes,compartmental syndrome,infection,and multiple organ dysfunction.Infection(33.3%)was the most common etiology of non-traumatic rhabdomyolysis,followed by drugs(25.6%),metabolite or electrolyte derangements(10.3%)and alcohol intoxication(7.7%)etc.Therapeutic regimen covered treatment of the underlying diseases,volume repletion,alkalization and dealing with the complications.For the patients with established renal failure,renal replacement therapy was essential.Overall mortality was 15.4%,while the mortality in the patients with ARF was 20.7%.If surviving ARF,the patients' renal function promised to be normalized consequently.Conclusion Non-traumatic rhabdomyolysis is a syndrome with a variety of causes,different clinical presentations and versatile combination of complications,which confounds the diagnosis.However,if treated properly and in time,the survivors in all probability will recover from ARF.

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Detection of apolipoprotein B-100 gene mutation in patients of primary hypercholesterolemia families.

Ruimin YU ; Yubing ZHOU ; Jiansheng FENG ; Qilu CAI ; Chunlan LIN

Chinese Journal of Practical Internal Medicine.2001;0(10):-.

Objective To detect genetic mutation of apolipoprotein B-100(apoB-100)in patients with primary hypercholesterolemia.Methods One special segment of apoB-100 gene from nucleotide 10549 to 10895 was amplified by polymerase chain reaction(PCR).The PCR products were denatured and hybridized with specific aligonucleotide labeled with digoxigenin,and were analyzed by single strand conformation polymorphism(SSCP)to detect the apoB-100 gene mutation 3531CGC→CGT or other mutations.Results Overall 41 members of 11 primary hypercholesterolemia families were detected,but the above genetic mutation was not detected.Conclusion This genetic mutation is unlikely to exist or of significantly low incidence in Chinese population,and might not be the main cause of primary hypercholesterolemia in the 11 primary hypercholesterolemia families.

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Clinical characteristics of 31 patients with ANCA-associated vasculitis.

Weihua WU ; Xinmiao DU ; Qiurong ZHANG ; Ye TAO ; Ping FU ; Zhangxue HU

Chinese Journal of Practical Internal Medicine.2001;0(10):-.

Objective To investigate the clinical characteristics of 31 patients suffering from ANCA associated vasculitis(AAV).Methods The clinical data of 31 patients with ANCA positive profiles diagnosed as AAV were analyzed,including ANCA spectrum,renal and other organs' clinical features.Results There were 16 males and 15 females,average admission age(54.19?20.00)years(18 to 84 years).Totally 27 MPA and 4 WG were diagnosed;onset symptoms of renal involvement were in 15 cases and others in 16 cases;18 patients had respiratory system involvements including 8 cases with pulmonary hemorrhage.In admission 27 MPA patients with average SCr(460.42?354.55)?mol/L,and WG group with(659.62?535.1)?mol/L.ANCA spectrum showed 24 P-ANCA cases and 7 C-ANCA cases,while ELISA method showed 25 anti-MPO cases and 6 anti-PR3 cases.Conclusion AAV has many kinds of manifestations and progresses in many variable ways.Kidney and respiratory system are most vulnerable in AAV.The treatment is very limited in advanced stage of AAV.The key to improving the outcome of AAV is early detection of ANCA and early diagnosis.

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