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Correlation between P-glycoprotein and CD44 in cancer

Journal of International Oncology.2008;35(7):489-490,493.

P-glycoprotein(P-gp)and CD44 have been characterized and are known to be determinants of multidrug resistance(MDR)and cancer metastases.Recent researches suggest that there is a correlation between P-glycoprotein(MDR)and CD44(invasion and metastases).A better understanding of any relationship between drug resistance and tumor metastasis may lead to more effective tumor treatment.

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Advancement of molecular targeted therapies in squamous cell carcinoma of head and neck

Zhengcai LI

Journal of International Oncology.2010;37(1):40-42,75. doi:10.3760/cma.j.issn.1673-422X.2010.01.013

Current reseach of molecular targeted therapies in squamous cell carcinoma of head and neck(SCCHN) is particularly active.As epidermal growth factor receptor(EGFR) signaling pathway and angiogenesis play a key role in the growth of SCCHN,EGFR with its downstream effectors and molecular factors implicated in the angiogenesis process,such as vascular endothelial growth factor and its receptors,represent the main targets of new therapeutic agents now.

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Pirh2 and tumor

Xiaorong WU ; Dongming LIU

Journal of International Oncology.2012;(11):824-826,880. doi:10.3760/cma.j.issn.1673-422X.2012.011.008

Pirh2 (p53-induced protein with a Ring-H2 domain),one of the ubiquitin-protein E3 ligases,can promote p53 degradation via ubiquitin-proteasome pathway,and repress the biological functions of p53.Researchers have found that the Pirh2 is overexpressed in many cancers,which suggests Pirh2 is probably correlated with tumorigenesis and cancer development,and it may become a promising cancer therapeutic target.

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DNA double-strand break repair and ovarian cancer

Weizhi YOU ; Shiqian ZHANG ; Ling ZHANG

Journal of International Oncology.2011;38(1):60-63. doi:10.3760/cma.j.issn.1673-422X.2011.01.020

DNA double-strand break repair (DSBR) pathways are important repair pathways in human. DSBR pathways repair damaged DNA, maintain the integrity of the genetic information and therefore suppress cancer. More and more researches have indicated important roles of DSBR pathway genes in the development and treatment of ovarian cancer.

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CXCR4/CXCL12 axis and relapsed leukemia

Hongzhang YAO ; Ruilan GAO

Journal of International Oncology.2011;38(4):303-306. doi:10.3760/cma.j.issn.1673-422X.2011.04.019

The binding complex of chemokine receptor CXCR4 and its specific ligand CXCL12 triggers the downstream signaling pathway to form biological axis of CXCR4/CXCL12. The axis plays an important role in homing, repopulation of hematopoietic stem cells, as well as maintenance of normal hematopoiesis and homeostasis of hematopoietic microenvironment. Meanwhile, CXCR4/CXCL12 axis is also closely related with relapsed leukemia, since it may promote survival, proliferation, metastasis and drug resistance in leukemic cells.The expression level of CXCR4 could be treated as an important marker for predicting prognosis in patients wizh leukemia, therefore, the combination of CXCR4 inhibitors with routine chemotherapy may represent a powerful approach for the treatment of leukemia.

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Current research status of TOP2A gene with response to anthracycline-based chemotherapeutic agents in breast cancer

Xuyuan LI ; Weibing LI ; Yingcheng LIN

Journal of International Oncology.2011;38(2):127-129. doi:10.3760/cma.j.issn.1673-422X.2011.02.015

Anthracycline-based chemotherapeutic agents were extensively applied to the treatment of breast cancer. The relation of its response to TOP2A gene was proved by a number of clinical studies demonstrating that patients with both HER2 gene amplification and TOP2A gene aberration have a favored outcome,but a consensus was not yet achieved.

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Radiotherapy and cardiac injury

Yongli LI ; Xiangying XU ; Jianyu XU

Journal of International Oncology.2011;38(2):111-113. doi:10.3760/cma.j.issn.1673-422X.2011.02.010

During radiotherapy, ionizing radiation can damage some structures of the heart, including pericardium, myocardium, cardiac valve, conducting system, and coronary artery. Radiation-induced cardiac injury can manifest as abnormalities in many aspects including myocardium enzymes, perfusion imaging, electrocardiogram, strain rate imaging.

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CCL21/CCR7 axis and mechanisms of tumor invasion and metastasis

Kai CUI ; Bo ZHANG ; Sheng LI

Journal of International Oncology.2011;38(2):96-99. doi:10.3760/cma.j.issn.1673-422X.2011.02.005

Secondary lymphoid tissue chemokine (CCL21) is a double-edged sword, which exerts antitumor, anti-infection immune response by binding to the receptor CCR7 on the surface of the multiple immune cells. However, a variety of tumor cells also express the receptor CCR7, the combination of CCL21 with CCR7promotes the invasion and metastasis of tumor cells, leading to the facilitation of tumor development. Therefore,exploring the mechanism(s) of tumor invasion and metastasis might be helpful for use of CCL21 as tumor gene therapy through blocking of CCL21's promotion of tumor invasion and metastasis.

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Roles of periostin in cancer

Rong YANG ; Fusheng WU

Journal of International Oncology.2011;38(2):92-96. doi:10.3760/cma.j.issn.1673-422X.2011.02.004

Periostin, a extracellular matrix protein structurally similar to fasciclin proteins, is expressed specifically in various tumor tissues and correlates with tumor progression and prognosis. Periostin prevents the apoptosis of tumor cells, promotes tumor growth and can induce angiogenic signaling cascades through αvβ3-FAK and Flk-1/KDR. It also contributes to epithelial-mesenchymal-transformation promoting tumor invasion and metastasis. Periostin maybe a potential therapeutic target of cancer treatment.

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Advances in research of let-7 in cancer

Xiuming ZHU ; Lingjiao WU ; Fusheng WU

Journal of International Oncology.2011;38(2):89-92. doi:10.3760/cma.j.issn.1673-422X.2011.02.003

Let-7 is one of the most widely studied in miRNAs at present. let-7 can inhibit cell proliferation, promote cell differentiation and apoptosis, etc. Reduced expression of let-7 in different human tumor tissues or cells is accompanied by the changes of its target genes expression, which suggests that let-7 is closely linked to cancer.

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