Journal of International Oncology 2013;40(9):668-670

doi:10.3760/cma.j.issn.1673-422X.2013.09.009

Wnt/β-catenin signaling pathway and glioma

Mengna CHEN ; Ting LIU ; Geng GUO

Keywords

Glioma; Cell proliferation; Neoplasm invasiveness; Apoptosis; Wnt/β-catenin signaling pathway

Country

China

Language

Chinese

Abstract

Wnt/β-catenin signaling pathway is highly conserved in evolution,which involves in the regulation of a variety of biological processes such as embryonic growth,development,energy metabolism and stem cells maintenance.Aberrant activation of Wnt/β-catenin signaling pathway has a closely relationship with tumorigenesis.Investigating the role of Wnt/β-catenin signaling in glioma cell proliferation,invasion,apoptosis and tumor angiogenesis will provide novel therapeutic targets and intervening measures for glioma treatment.