Journal of International Oncology 2013;40(10):726-729

doi:10.3760/cma.j.issn.1673-422X.2013.10.002

Roles of miR-494 in tumors

Mingchun LI ; Aibing WU ; Zhixiong YANG

Keywords

MicroRNAs; Neoplasms; Target gene

Country

China

Language

Chinese

Abstract

MiR-494 involves in cell cycle regulation,differentiation and apoptosis processes of normal ceils.Recent study shows that abnormal expression of miR-494 is associated with oncogenesis closely,and it participates in the invasion and metastasis of tumor cells and so on.MiR-494 is not only a tumor suppressor gene,but also can be considered as a cancer-promoting gene.MiR-494 can regulate the oncogenesis and development of the tumor through a variety of target genes and signaling pathways.