Journal of International Oncology 2013;40(9):655-658

doi:10.3760/cma.j.issn.1673-422X.2013.09.005

Effects of anti-tumor drugs on myeloid-derived suppressor cells

Tian WANG ; Xiaohua LIANG

Keywords

Myeloid cells; Antineoplastic agents; Immunosuppressive agents; Myeloied derived suppressor cells

Country

China

Language

Chinese

Abstract

Myeloid-derived suppressor cells (MDSCs) play an important immunosuppressive role during the tumor development process.And the progression of many tumors are always accompanied with abnormal accumulation of MDSCs.Moreover,both the accumulation and functions of MDSCs could be affected by complicated factors.Therefore,how to effectively reduce the immunosuppressive effects of MDSCs in oncotherapy has become the focus of scholars.Recent studies show that anti-tumor drugs can affect many biological behaviors of MDSCs.