Journal Detail Information

1

Cite

Share

A pilot-study to assess the effectiveness and feasibility of internet-based structured group cognitive behavior therapy in patients with mild depressive disorder

Linya CHANG ; Fei DING ; Weihong LU ; Chenyu YE ; Lili XUE ; Yu WANG ; Rui SONG ; Yan WANG ; Yi ZHU ; Hua TAO ; Huiming ZHOU ; Yiru FANG ; Chengmei YUAN

Chinese Journal of Psychiatry.2020;53(1):35-41. doi:10.3760/cma.j.issn.1006-7884.2020.01.007

Objective To explore the effectiveness and feasibility of internet-based structured group cognitive behavior therapy (I-GCBT) in patients with mild depressive disorder.Methods In this randomized controlled trial,based on a random number table which was generated from spss20.0,96 patients with mild depressive disorder were randomized to I-GCBT(n=64) and face-to-face group cognitive behavior therapy(GCBT,n=32).I-GCBT and GCBT patients were assessed by HAMD17,HAMA,Global Assessment of Functioning Scale,GAF and 16 Items Quick Inventory of Depressive Symptomatology-Self Report,QIDS-SR16 at baseline,4th week,8th week and 12th week.The differences between I-GCBT and GCBT were analyzed by repetitive measure analysis of variance and chi-square test.Results (1)There was no significant difference between I-GCBT and GCBT on demographics,duration of past depression history,baseline of HAMD17,GAF and QIDS-SR16,but a significantly higher HAMA seen in GCBT (t=-2.08,P=0.04).(2) The interaction of times and groups was significant in GAF (F=4.09,P＜0.01) but not in HAMD17,HAMA and QIDS-SR16 (F=0.69,P＞0.05;F=0.95,P＞0.05;F=0.64,P＞0.05).In all measurement scales,Time main effects were significant (HAMD17∶ F=32.81,P＜0.01;HAMA∶ F=20.86,P＜0.01;GAF∶ F=105.98,P＜0.01;QIDS-SR16∶ F=25.27,P＜0.01).The symptoms remission rate of the overall patients was 62％ (43/69) after 12 weeks treatment,lower in I-GCBT (57％,25/44) and higher in GCBT (72％,18/25).There was no significant difference between two groups (x2=1.57,P=0.21).(3) The overall dropout rate was 26％ during the 12-weeks treatment specifically 29％(15/51) in I-GCBT and 20％(6/30) in GCBT without significant difference in-between (x2=0.87,P=0.35).97％(58/60) patients rated the treatment as acceptable (I-GCBT∶ 97％(35/36),GCBT∶ 96％ (23/24)),and the difference of acceptability between two groups was not significant (x2=0.09,P=0.78).Conclusion The effectiveness and feasibility of I-GCBT are comparable to GCBT for mild depressive disorder.And the treatment adherence of I-GCBT seems good.

2

Cite

Share

Association of dynamic functional connectivity with bilateral precuneus at resting-state with obsessive-compulsive disorder

Zhenning DING ; Ping LI ; Dan LYU ; Yunhui CHEN ; Tinghuizi SHANG ; Xiaoyu BAI ; Zhenghai SUN ; Jian XIAO ; Guangfeng ZHANG ; Wanqiang LIU ; Yu GUO

Chinese Journal of Psychiatry.2022;55(2):106-114. doi:10.3760/cma.j.cn113661-20210917-00283

Objective:To investigate the dynamic functional connectivity (dFC) of bilateral precuneus at resting-state in obsessive-compulsive disorder (OCD).Methods:Fifty patients with OCD who matched the criteria of ICD-10 and 50 healthy controls (HCs) were examined by the resting-state functional magnetic resonance imaging scanning. Voxel-based whole-brain dFC method was used to analyze the dFC of bilateral precuneus at resting-state in OCD; Pearson correlation analyses was used to analyze the relationship between the abnormal dFC values and clinical symptoms in OCD; support vector machine analyses was used to explore whether abnormal dFC could be used to identify OCD.Results:Compared with HCs, patients with OCD showed decreased dFC values between left precuneus and left medial prefrontal cortex (MPFC) (0.23±0.02 vs. 0.26±0.03, t=-6.23, P<0.05, GRF corrected), left cuneus (0.24±0.03 vs. 0.28±0.04, t=-5.30, P<0.05, GRF corrected), and left paracentral lobule (0.23±0.03 vs. 0.27±0.04, t=-5.36, P<0.05, GRF corrected); and decreased dFC values between right precuneus and left postcentral gyrus (0.23±0.04 vs. 0.27±0.04, t=-5.12, P<0.05, GRF corrected). The decreased dFC values between left precuneus and left MPFC was positively correlated with the total score of Yale-Brown obsessive compulsive scale (Y-BOCS)( r=0.289, P<0.05, uncorrected); the decreased dFC values between right precuneus and left posterior central gyrus was positively correlated with Y-BOCS total scores ( r=0.292, P<0.05, uncorrected) and obsessive subscale scores ( r=0.304, P<0.05, uncorrected). The area under the curve value of the decreased dFC values between right precuneus and left posterior central gyrus was 0.856; the Youden Index was 0.52; the sensitivity was 100%, and the specificity was 52%. Conclusions:The dFC of bilateral precuneus decreases at resting-state in patients with OCD. The abnormal dFC value between the right precuneus and the left posterior central gyrus may have implications to identify OCD.

3

Cite

Share

Progress in research and application of the hierarchical taxonomy of psychopathology

Yinqing FAN ; Zhen WANG

Chinese Journal of Psychiatry.2023;56(1):3-10. doi:10.3760/cma.j.cn113661-20220919-00264

The existing diagnostic systems of psychiatry are mainly based on phenomenology, and their application in scientific research and clinical practice has certain limitations. The hierarchical taxonomy of psychopathology (HiTOP) model was proposed based on the structural evidence in the past nearly 100 years. HiTOP hews closely to existing data and construct the psychopathology classification system by empirical method. Here, we review the background, content, research progress and clinical application about HiTOP model and prospect its application in psychiatry in the future.

4

Cite

Share

The significance and assessment of psychosocial functioning as a long-term indicator of depression

Hao YANG ; Ning ZHANG

Chinese Journal of Psychiatry.2023;56(1):11-16. doi:10.3760/cma.j.cn113661-20220408-00093

The aim of treating depression has gone from symptom control to functional recovery. The concept of functioning has also shifted from social functioning to psychosocial functioning. For a long time, the use of assessment tools for psychosocial functioning has been confused in depressed patients. In this paper, we sort out the tools regarding the assessment of depression functioning. In addition, we recommend corresponding evaluation strategies and emphasize the significance of psychosocial functioning as a long-term indicator of depression.

5

Cite

Share

A case of severe sinus bradycardia in a schizophrenic patient after abrupt clozapine withdrawal

Ruilin ZHANG ; Yutao ZHANG ; Xiu WU ; Erfang WANG

Chinese Journal of Psychiatry.2023;56(1):71-72. doi:10.3760/cma.j.cn113661-20220531-00138

This paper reports a case of severe sinus bradycardia (39 beats/min) in a schizophrenic patient after abrupt clozapine withdrawal. And his heart rate returned to normal after taking theophylline extended-release tablets combined with the Xinbao pill.

6

Cite

Share

Major depressive disorder and problematic internet use co-morbidity in adult Asperger′s syndrome: a case report

Jiexian YANG ; Wei HAO ; Xiaojie ZHANG

Chinese Journal of Psychiatry.2023;56(1):73-76. doi:10.3760/cma.j.cn113661-20220929-00275

Asperger′s syndrome (AS) is a neurodevelopmental disorder characterised by difficulty in social interaction, restricted interests and stereotyped behavior, usually with clumsy movements. AS generally starts in childhood, but because of its normal intellectual development and linguistic competence, some patients may be delayed or even diagnosed in adulthood. The core clinical symptoms between adults AS and children AS are similar, including deficiency in social interaction and non-verbal communication impairment, narrow interest range and stereotyped behavior, commonly with psychiatric comorbidities. Many cases of adult AS have reported psychiatric comorbidities, among which mood disorders are the most common comorbidity of adult AS. This article is written on a case of adult AS comorbidity with major depressive disorder and problematic internet use in the outpatient of our hospital.

7

Cite

Share

Deutetrabenazine in the treatment of tardive dyskinesia induced by antipsychotics: a case report

Li SUN ; Lili CAI ; Guangbiao HUANG

Chinese Journal of Psychiatry.2022;55(2):142-144. doi:10.3760/cma.j.cn113661-20210520-00167

Tardive dyskinesia (TD) is a common adverse reaction during the treatment of antipsychotic drugs and there is no satisfactory treatment for it. Deutetrabenazine has been approved by FDA in 2017 to treat TD. This drug has just been launched in China and there are few reports on its clinical application in China. This article reports a 19-year-old female diagnosed with "schizophrenia". She has taken antipsychotics for a long time. Recently, she had symptoms such as the opening mouth and sticking tongue out, head and neck receding, difficulty chewing, slurred speech, drooling, etc. and was diagnosed with "TD". She was adjusted for drugs and was prescribed vitamin E and clonazepam. The therapeutic effect of this symptomatic treatment was poor. After being treated with Deutetrabenazine, her symptoms gradually alleviated and the therapeutic effect was definite. This case report will provide references and experience for clinical work.

8

Cite

Share

Effects of emotional cues on event-based prospective memory in patients with obsessive-compulsive disorder

Qian LIU ; Jie FAN ; Jie XIA ; Xiang WANG ; Mingtian ZHONG ; Xiongzhao ZHU

Chinese Journal of Psychiatry.2021;54(6):434-439. doi:10.3760/cma.j.cn113661-20210201-00071

Objective:To investigate the effect of emotional cues on prospective memory (PM) in obsessive-compulsive disorder (OCD) patients.Methods:From December 2014 to November 2019, 157 patients with obsessive-compulsive disorder (OCD) and 119 healthy controls (HC) matched for age, gender and intelligence participated in the study. A laboratory event-based PM paradigm was used to assess the PM function. The PM Accuracy (PM acc) of prospective memory pictures with different emotional cues in the two groups was investigated by a mixed design of 2 (group: OCD group, HC group)×3 (emotional cue attributes: positive, neutral, and negative). Correlation analysis was used to explore the relationship between PM acc and clinical variables in patients with OCD.Results:Repeated measures ANOVA showed that the main effect of emotional cues was not significant ( F=0.377, P>0.05), the difference between the two groups was significant ( F=8.863, P<0.01, η 2=0.030), and the PM acc of the OCD group was lower than HC. The interaction was significant ( F=3.261, P<0.05, η 2=0.012). Further simple effect analysis showed that in the HC group, PM acc with positive emotional cues and negative emotional cues were significantly greater than PM acc with neutral emotional cues (Cohen′s d values are 2.29 and 2.94). There was no significant difference between PM acc with positive emotional cues and PM acc with negative emotional cues. In the OCD group, PM acc with negative emotional cues was significantly greater than PM acc with positive and neutral emotional cues (Cohen′s d values are 1.57 and 1.14). There was no significant difference between PM acc with positive emotional cues and PM acc with neutral emotional cues. Correlation analysis showed that PM acc with positive and negative emotional cues of OCD patients were significantly positively correlated with state anxiety level ( r>0.200, P<0.01). There was no significant correlation between PM acc with neutral emotional cues and anxiety level. Conclusion:OCD patients had impaired prospective memory, mainly manifested as impaired prospective memory emotional enhancement effect, only negative emotion enhancement effect showed. In contrast, positive emotion has no enhancement effect on the prospective memory of OCD patients.

9

Cite

Share

Progression on subthreshold depression in the elderly with mild cognitive impairment

Zhenyong GAO ; Zhijiang WANG ; Ping YANG ; Caixia JIANG ; Huali WANG ; Xin YU

Chinese Journal of Psychiatry.2021;54(4):296-299. doi:10.3760/cma.j.cn113661-20201130-00487

Subthreshold depression is common in the elderly. It is also one of the neuropsychiatric symptoms that frequently affect patients with mild cognitive impairment (MCI). MCI patients with subthreshold depression may suffer from more severe cognitive impairment and an increased risk of dementia. In recent years, more attention has been paid to the relationship between subthreshold depression and cognitive impairment. This article reviews the research progress on the epidemiology and neuroimaging of subthreshold depression in the elderly with MCI.

10

Cite

Share

Exploring and establishing a whole course and accurate intervention model based on repeatedly measurement-based assessments for methamphetamine dependence

Ruihua LI ; Tianzhen CHEN ; Haifeng JIANG ; Hang SU ; Jiang DU ; Min ZHAO

Chinese Journal of Psychiatry.2022;55(2):83-89. doi:10.3760/cma.j.cn113661-20210617-00189

Methamphetamine (MA) has the characteristics of neurotoxicity and strong psychological dependence. At present, there is a lack of effective intervention for MA dependence. Aiming at the brain pathological damage and clinical characteristics of MA dependence, new multi-dimensional evaluation instruments were developed including virtual reality craving evaluation system, cognitive and impulsive damage assessment, and SWOT (strengths, weaknesses, opportunities and threats) analysis. Rehabilitation interventions were also investigated and developed including computerized cognitive addiction therapy, precise neuroregulatory intervention aimed at reducing craving, music therapy, and community-based addiction rehabilitation electronic system. On this basis, On this basis, we propose to establish a whole course and accurate intervention model based on repeatedly measurement-based assesments for MA dependence, or WARM model. The WARM model focuses on the difficulties of MA dependence at different stages and is committed to multi-dimensional rehabilitation of MA patients. The WARM model will further be explored with the assistance of artificial intelligence.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share