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Holistic Integrative Medicine Declaration

Journal of Nanjing University of Traditional Chinese Medicine.2024;40(9):前插1-前插2.

Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM from the perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modern medicine.

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Holistic Integrative Medicine Declaration

Journal of Nanjing University of Traditional Chinese Medicine.2024;40(9):前插1-前插2.

Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM from the perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modern medicine.

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Holistic Integrative Medicine Declaration

Journal of Nanjing University of Traditional Chinese Medicine.2024;40(9):前插1-前插2.

Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM from the perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modern medicine.

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Investigation of TCM Syndromes on Maternal Separation in C5 7/BL6 Mice

Yao-Yao BIAN ; Li-Li YANG ; Zong-Li WANG ; Zhen MEI ; Bei-Lei WANG ; Gui-Hua XU

Journal of Nanjing University of Traditional Chinese Medicine.2015;(2):138-142. doi:10.14148/j.issn.1672-0482.2015.0138

OBJECTIVE To investigate TCM syndromes on maternal separation in C5 7/BL6 mice.METHODS Neonatal mice were intervened through maternal separation.The effects of maternal separation on spontaneous activities of mice were e-valuated by field test and the effects on immobility times of mice were evaluated by forced swimming test and tail suspension test.Four diagnostic quantitative indicators measurement and quantitative dialectical method were employed to explore the state of Qi,Blood,Yin and Yang in mice.Hypothalamus-pituitary-adrenal(HPA) cortical axis function was observed through adre-nocorticotropic hormone(ACTH)and corticosterone(CORT)determination.The level of energy metabolism was investigated through the measurement of cyclic adenosine monophosphate/cyclic guanosine monophosphate (cAMP/cGMP),ATPase and superoxide dismutase(SOD).RESULTS No statistical significance(P>0.05)was observed in the total path of animal activi-ties between each group in field test.Compared with the control group and MS1 5 group,in the forced swimming test and tail suspension test,the immobility time of mice of MS18 group was significantly increased(P<0.01).The levels of Yang heat, cAMP/cGMP,Na+-K+-ATPase and SOD significantly decreased(P<0.01),while ACTH and CORT significantly increased (P<0.01)of MS18 group,compared to the control group and MS15 group.CONCLUSION Maternal separation shows sig-nificant effects on behavior in mice.The mice exhibit depression-like behavior,upset HPA axis balance and reduce body energy metabolism,which characterized as Yang deficiency symptoms in TCM.

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Study the Effects of Qianyang Yuyin Granules on Renal Blood Flow and Blood Pressures in Anesthetized Normal Dogs

Heng-Wen SONG ; Le SHI ; Zhu-Yuan FANG ; Xuan-Xuan ZHU ; Fang-Fang ZHU ; Yang SHEN ; Tai-Lin ZENG ; Li XU

Journal of Nanjing University of Traditional Chinese Medicine.2015;(2):143-146. doi:10.14148/j.issn.1672-0482.2015.0143

OBJECTIVE To study the effects of Qianyang Yuyin Granules(QYG)on blood pressure and renal blood flow in anesthetized normal dogs and the mechanism of hypertensive renal injury treatment.METHODS The renal blood flow,cardiac output(CO)and blood pressures were determined by PowerLab system at 15,30,60,90,120,180 min after QYG(3.08,6. 15,12.30 g/kg)administration,respectively.RESULTS Compared with the control group,QYG(12.30 g/kg)reduced sys-tolic blood pressure(SBP) significantly(P<0.05) at 120 min and 180 min,and increased the renal blood flow(P<0.05~0.01)at 90,180 min;QYG(6.15 g/kg)reduced SBP(P<0.05)at 120 min,and increased the renal blood flow(P<0.05) at 90,120 min.The effects of QYG(3.08 g/kg) were not obvious;The three QYG groups hardly affected CO (P>0.05). CONCLUSION QYG can increase the renal blood flow,improve the renal function and then reduce blood pressure.

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Effects of Flos Puerariae-Semen Hoveniae Compatibility on Liver Function and Pathologic Morphology in Rats with Alcoholic Liv-er Disease

Ming LIU ; Shao-Hong CHEN ; Gan-Sheng ZHONG ; Hai-Yan LIU ; Tong ZHAO

Journal of Nanjing University of Traditional Chinese Medicine.2015;(2):147-151. doi:10.14148/j.issn.1672-0482.2015.0147

OBJECTIVE To explore the de-alcoholic and hepatoprotective function of Flos puerariae-Semen hoveniae (2∶1) compatibility and determine the optimal dosage regimen.METHODS Chronic alcoholic liver injury animal models were es-tablished by gavages of 56°Red Star Erguotou in rats.Experimental animals were given different doses(3,6,12 g/kg)of Flos puerariae-Semen hoveniae (2∶1) extracts within different medication courses (4,8,12 weeks).The liver index,ALT, AST,TP,ALB and ALP in serum were detected.The liver pathological morphologies were also observed.RESULTS Chron-ic alcoholic liver injury models were successfully replicated.Flos puerariae-Semenhoveniae(2∶1)compatibility group of each dose displayed no therapeutic effect within four weeks.The level of ALT in Flos puerariae-Semen hoveniae (2∶1) compatibil-ity group of each dose significantly decreased(P<0.05~0.01)after eight weeks administration.After 12 weeks,Flos puer-ariae-Semenhoveniae(2∶1)compatibility groups showed significantly decreased AST and increased ALB(P<0.05).Low and high dose groups displayed reduced ALT (P<0.05) while the low dose group showed increased TP (P<0.01).The changes in liver pathological morphology were fairly consistent with relevant indicators of liver function.CONCLUSION Flos puerariae-Semen hoveniae (2∶1) compatibility group of each dose shows promising de-alcoholic and hepatoprotective effects after eight weeks of administration.The relevant indicators of liver function improve to varying degrees as the therapy time prolongs.Among them,low dose group performs better than medium and high dose groups.

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Antipyretic Effects and Immune Regulation Function of Tongfu Xiere Therapy in Fever Rats with Meningitis

Ya-Juan LIU ; Si-Chao ZHANG ; Xiao-Jun WANG ; Xiao-Yun QIN

Journal of Nanjing University of Traditional Chinese Medicine.2015;(2):152-155. doi:10.14148/j.issn.1672-0482.2015.0152

OBJECTIVE Based on the brain-gut axis theory,to investigate the antipyretic effect and immune regulation function of Tongfu Xiere therapy in fever rats with meningitis.METHODS The rat fever model induced bacterial Meninggitis was established with inj ecting the Escherichia coli into cerebellomedullary cistern.The experimental animals were divided into six groups:the normal group,the model group,Dachengqi decoction group,Xingnaoj ing inj ection group,Dachengqi decoction+Xingnaojing injection group and paracetamol group.Antipyretic effect of each drug was observed by measuring body temper-ature after treatment.The levels of IFN-γ,IL-4 and SP in plasma were detected by enzyme-linked immunosorbent assay.RE-SULTS Compared to the model group,Dachengqi decoction group,Xingnaojing injection group and Dachengqi decoction+Xingnaojing injection group significantly reduced the temperature of the fever rats(P<0.05),the levels of IFN-γ(P<0.01), IL-4(P<0.05)and SP(P<0.05),and the ratio of IFN-γ/IL-4(P<0.05).CONCLUSION Tongfu Xiere therapy shows anti-pyretic effect on fever rats with Meningitis,which is related to immune regulation biologically mediated by brain-gut axis com-ponents.

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The Neuroprotective Effects of Yueju Pills on Parkinson's Disease Model in vitro

Chang CHEN ; Juan-Juan TANG ; Bao-Mei XIA ; Qing CHEN ; Qi-Sheng WANG ; Wei-Wei TAO ; Yang ZHAO ; Gang CHEN

Journal of Nanjing University of Traditional Chinese Medicine.2015;(2):156-159. doi:10.14148/j.issn.1672-0482.2015.0156

OBJECTIVE To investigate the neuroprotective effect and the mechanism of Yueju alcohol extract (YJ-E) on chromaffin cells(PC12)injury in rats induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ion(MPP+).METHODS PC12 cells were given 1 mmol MPP+ to establish Parkinson's disease(PD) model in vitro.The protective effects of YJ-E on PC12 cells were measured by MTT assay and Hoechst staining.The expression of pituitary adenylate cyclase activating poly-peptide(PACAP)and the phosphorylation of extracellular regulated kinase(ERK)and cAMP response element binding pro-tein(CREB)were determined by Western blotting.RESULTS YJ-E(1.0,2.0,4.0 mg/mL)improved the survival of MPP+-injured PC12 cells significantly(P<0.01),and displayed no significant effect on normal PC12 cells(P>0.05).Meanwhile, YJ-E up-regulated the expression of PACAP and the phosphorylation of ERK and CREB significantly(P<0.01)of MPP+-in-jured PC12 cells.CONCLUSION YJ-E shows promising neuroprotective effects on PC12 cells in MPP+-induced Parkinson's disease model,and the mechanism may be associated with the up-regulation of the expression of PACAP and the phosphoryla-tion of downstream ERK and CREB.

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Immune Cell Proliferation Function and in vitro Antioxidant Activity of n-butanol Extract of Radix Isatidis

Jing-Yan YANG ; Li-Wei HE ; Wei DONG

Journal of Nanjing University of Traditional Chinese Medicine.2015;(2):160-164. doi:10.14148/j.issn.1672-0482.2015.0160

OBJECTIVE To investigate proliferative activities for peritoneal macrophages and splenic lymphocytes in mice and anti-oxidative potencyinvitro ofn-butanol extract ofRadixisatidis.METHODS 12 components were extracted and sep-arated from Radix isatidis by n-butanol.Each component of total n-butanol extracts was detected and analyzed by HPLC. The proliferative activities of each component for peritoneal macrophages and splenic lymphocytes were detected by MTT as-say.Anti-oxidative activities were evaluated by DPPH and ABTS radical scavenging and FRAP method.RESULTS No.2,6, 7 and 11 components showed the most potent proliferation on immune cells,with the highest proliferation index>3.No.2 and 6 components displayed the strongest antioxidant activities,with IC50 values on DPPH of 0.391,0.164 mg/mL,ABTS of 0. 164,0.338 mg/mL and Fe3+ reducibility values of 1.441,0.812 mmol/g equivalent weight of FeSO4 ,respectively.CONCLU-SION The n-butanol extract of Radix isatidis exhibit promoting proliferation for peritoneal macrophages and splenic lympho-cytes and pontent antioxidant activities.Further investigation of the chemical structure will help to clarify the material basis for Radix isatidis antiviral effects.

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Protective Effects of Total Flavonoids from Bamboo Leaves on UVB-irradiated Oxidative Damage in HaCaT Cells

Yang GAO ; Ruo-Kun YI ; Jia-Le SONG

Journal of Nanjing University of Traditional Chinese Medicine.2015;(2):165-169. doi:10.14148/j.issn.1672-0482.2015.0165

OBJECTIVE To investigate the protective effects of total flavonoids from bamboo (Phyllostachys pubescens) leaves (BLE) on UVB-irradiated oxidative damage in HaCaT keratinocytes.METHODS The HaCaT cells were pretreated with BLE for 24 h and then exposed to UVB(20 mJ/cm2) for 2 h.Cell viability was determined by MTT assay.The levels of reactive oxygen species (ROS),lipid peroxidation and antioxidant enzymes including catalase (CAT),superoxide dismutase (SOD) and glutathione peroxidase(GSH-Px) were measured.mRNA transcription levels of these antioxidant enzymes were determined by RT-PCR assay.In addition,the production of TNF-αand IL-6 were detected by ELISA assay.RESULTS BLE significantly reduced the UVB-induced HaCaT cell damage and improved the cell survival rates (P<0.05).Compared to the control group,BLE decreased the levels of ROS and lipid peroxidation,and increased the activities and mRNA transcription levels of endogenous antioxidant enzymes(SOD,CAT and GSH-Px)in UVB-irradiated HaCaT cells.In addition,BLE also in-hibited the secretion of TNF-αand IL-6 in UVB-irradiated HaCaT cells.CONCLUSION BLE can exhibit cytoprotective activi-ties against UVB-induced oxidative damage in HaCaT cells through the reduction of ROS,inhibition of lipid peroxidation and regulation of antioxidant enzymes activities.In addition,BLE can also decrease the levels of TNF-αand IL-6 in UVB-irradiated HaCaT cells.

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