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Helicobacter pylori Infection Associated with Pulmonary Disease.

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2013;13(4):207-211. doi:10.7704/kjhugr.2013.13.4.207

The topic of the extragastric manifestations of Helicobacter pylori infection continues to capture the attention of many researchers all over the world. Some extragastric diseases, possibly linked to H. pylori infection, have been largely investigated. Although evidence is emerging that the prevalence of H. pylori is declining in all age groups, the understanding of its disease spectrum continues to evolve. There are, in fact, several studies concerning cardiovascular diseases, pulmonary diseases, hematologic disease, eye and skin diseases, hepatobiliary disease, diabetes mellitus, and neurological disorders. Among them, this article reviews the literature published pertaining to H. pylori eradication and pulmonary disease such as bronchial asthma, chronic bronchitis, chronic obstructive pulmonary disease, and lung cancer.
Asthma ; Bronchitis, Chronic ; Cardiovascular Diseases ; Diabetes Mellitus ; Helicobacter pylori* ; Helicobacter* ; Hematologic Diseases ; Humans ; Lung Diseases* ; Lung Neoplasms ; Nervous System Diseases ; Prevalence ; Pulmonary Disease, Chronic Obstructive ; Skin Diseases

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Is Endoscopic Resection Really Safe for Mucosal Gastric Cancers?.

Si Hyung LEE

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(1):56-57. doi:10.7704/kjhugr.2017.17.1.56

No abstract available.
Stomach Neoplasms*

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An Usual Cause of Intermittent Dysphagia.

Moon Won LEE ; Gwang Ha KIM

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(1):54-55. doi:10.7704/kjhugr.2017.17.1.54

No abstract available.
Deglutition Disorders*

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A Case of a Rapidly Progressive Small Bowel Lymphoma with High Ki-67 Expression.

Jiyeon YOO ; Hee Jun KANG ; Hyungkeun KIM ; Sujeong HAN ; Seung Hyun OH ; Sung Hoon JUNG ; Jung Hwan OH ; Eun Jung JEON

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(1):49-53. doi:10.7704/kjhugr.2017.17.1.49

Primary intestinal lymphoma is a rare disease. It accounts for approximately 1~4% of gastrointestinal malignancy. Extranodal lymphoma of the intestine mainly arises from B cells. Diffuse large B-cell lymphoma is the most common type of the disease. Approximately 40% of intestinal lymphoma can be cured, while 60% have varied disease progression. Ki-67 proliferation has been recently used as an index of cell growth to predict the progression of the disease. Reported herein is a case of a rapidly progressive small bowel diffuse large B-cell lymphoma in a 51-year-old man with a high Ki-67 expression level. He visited the emergency department because of hematochezia. Abdominal computed tomography revealed distal small bowel segmental wall thickening. He underwent operation due to spontaneous small bowel perforation. The result of the pathological examination of the resected specimen was compatible with diffuse large B-cell lymphoma. The Ki-67 index within 5 months was 90%.
B-Lymphocytes ; Disease Progression ; Emergency Service, Hospital ; Gastrointestinal Hemorrhage ; Humans ; Intestine, Small ; Intestines ; Lymphoma* ; Lymphoma, B-Cell ; Lymphoma, Large B-Cell, Diffuse ; Middle Aged ; Rare Diseases

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Gastrointestinal Stromal Tumor of the Stomach Presenting as a Perigastric Abscess.

Dong Ryul KIM ; Jee Young AN ; Soo Jeong HAN ; Hyungkeun KIM ; Seoree KIM ; Jiyeon YOO ; Seung Hyun OH ; Chung Min HAN ; Jung Hwan OH

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(1):45-48. doi:10.7704/kjhugr.2017.17.1.45

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. A 77-year-old man was referred for the evaluation of general weakness and leukocytosis. Computed tomography showed a 9.5×6.5-cm cavitary lesion with an air-fluid level near the stomach, which was thought to be a perigastric abscess. Upper endoscopy revealed a fistula on the greater curvature at the mid body of the stomach. The margin of the fistula opening was clearly demarcated, and yellow turbid fluid oozing from the fistula was seen. Laparoscopic wedge resection was performed at the perforated area of the stomach. Immunohistochemistry revealed CD117 expression. A diagnosis of intermediate-risk GIST was made. No recurrence was identified within 18 months after the operation. The final diagnosis was perforated gastric GIST communicating with the gastric lumen and presenting as an intra-abdominal abscess.
Abdominal Abscess ; Abscess* ; Aged ; Diagnosis ; Endoscopy ; Fistula ; Gastrointestinal Stromal Tumors* ; Gastrointestinal Tract ; Humans ; Immunohistochemistry ; Laparoscopy ; Leukocytosis ; Recurrence ; Stomach*

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Esophageal Cancer with Solitary Renal Metastasis Treated with Multidisciplinary Therapy: A Case Report and Mini Review of the Literature.

Kyoung Sik NAM ; Kyoungwon JUNG ; Moo In PARK ; Seun Ja PARK ; Won MOON ; Sung Eun KIM ; Jae Hyun KIM

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(1):39-44. doi:10.7704/kjhugr.2017.17.1.39

Solitary renal metastasis of esophageal cancer is rarely encountered. Herein, we report the case of a 47-year-old man who developed a solitary renal metastasis after concurrent chemoradiotherapy followed by esophagectomy with esophagogastrostomy for esophageal squamous cell carcinoma, and treatment with nephrectomy and subsequent chemotherapy. Histopathological evaluation after operation revealed that the kidney mass was a metastatic lesion from esophageal cancer. He completed 15 cycles of palliative chemotherapy after nephrectomy and remained cancer-free for 36 months. Although lymph node metastasis occurred during regular follow-up, no evidence of lymph node metastasis was found on the imaging study after 9 cycles of chemotherapy with radiotherapy.
Carcinoma, Squamous Cell ; Chemoradiotherapy ; Drug Therapy ; Esophageal Neoplasms* ; Esophagectomy ; Follow-Up Studies ; Humans ; Male ; Lymph Nodes ; Middle Aged ; Neoplasm Metastasis* ; Nephrectomy ; Radiotherapy

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Helicobacter pylori Eradication Restores the Diversity of Gastric Microbiota.

Yong Sung KIM

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(4):230-231. doi:10.7704/kjhugr.2017.17.4.230

No abstract available.
Helicobacter pylori* ; Helicobacter* ; Microbiota*

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Giant Esophageal Ulcers in a Patient with Human Immunodeficiency Virus.

Sung Eun KIM ; Seun Ja PARK

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(4):228-229. doi:10.7704/kjhugr.2017.17.4.228

No abstract available.
HIV* ; Humans ; Humans* ; Ulcer*

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A Rapidly Growing Gastric Squamous Cell Carcinoma Presenting as a Subepithelial Tumor.

Tae Un KIM ; Su Jin KIM ; Si Hak LEE

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(4):224-227. doi:10.7704/kjhugr.2017.17.4.224

Squamous cell carcinoma (SCC) of the stomach is a very rare disease, comprising less than 1% of all stomach cancers. Primary SCC of the stomach was first reported in 1895, and about 100 cases have been reported worldwide since then. Although there are several theories regarding its pathogenesis in the stomach, the process of development of SCC remains unclear. The prognosis of SCC of the stomach is poor compared to adenocarcinoma because it is often diagnosed at late stages and is more prone to lymphovascular invasion. We report a case of rapidly growing SCC of the stomach presenting as a subepithelial tumor on the cardia during screening endoscopy.
Adenocarcinoma ; Carcinoma, Squamous Cell* ; Cardia ; Endoscopy ; Epithelial Cells* ; Mass Screening ; Prognosis ; Rare Diseases ; Stomach ; Stomach Neoplasms

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Genetic Profile Analysis of a Patient with Metachronous Gastric Cancer with a Family History of Gastrointestinal Cancers.

Chung Min HAN ; Yuri HWANG ; Chan Kyung KIM ; Jung Hwan OH

The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2017;17(4):218-223. doi:10.7704/kjhugr.2017.17.4.218

A 67-year-old man underwent two endoscopic submucosal dissection procedures, one for gastric adenoma and one for early gastric cancer. The follow-up endoscopy showed metachronous recurrence at the anterior wall of the lower body, for which he underwent a subtotal gastrectomy. Four first- or second-degree relatives in his family have been diagnosed with gastric or colon cancers. The patient underwent counseling and genetic testing to identify single nucleotide polymorphisms and indel variants for 31 genes by next generation sequencing. Five missense mutations were identified, one each in ATM, BRIP1, and EPCAM and two in BRCA2. These genetic alterations may be candidates for genetic causes of this familial cluster of gastric cancer. This study identified genes that, for the first time, can be potentially associated with an increased risk of familial gastric cancer among the Korean population. These results may be helpful in evaluating other genetic factors related to the etiology of gastric cancer.
Adenoma ; Aged ; Colonic Neoplasms ; Counseling ; Endoscopy ; Follow-Up Studies ; Gastrectomy ; Gastrointestinal Neoplasms* ; Genetic Testing ; Humans ; Mutation, Missense ; Polymorphism, Single Nucleotide ; Recurrence ; Stomach Neoplasms*

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