The Korean Journal of Helicobacter and Upper Gastrointestinal Research  2014;14(1):13-17

doi:10.7704/kjhugr.2014.14.1.13

Pharmacological Therapy of Peptic Ulcer.

Jung Hwan OH 1

Affiliations

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Keywords

Peptic ulcer; Peptic ulcer hemorrhage; Proton pump inhibitors; Therapy

Country

Republic of Korea

Language

Korean

Abstract

Peptic ulcer disease is one of the most commonly encountered diseases. Despite the decrease of Helicobacter pylori infection, the use of aspirin and non-steroidal anti-inflammatory drugs has increased in recent years. Peptic ulcer bleeding is a common emergency associated with high mortality. As an adjunct to endoscopic treatment, acid suppression with proton pump inhibitors (PPIs) is important in the management of peptic ulcer bleeding. A high dose intravenous PPI is effective in reducing rebleeding and the need for surgery. However, data about non-high dose intravenous PPIs are limited. In addition, novel PPIs are focused in this review, since progress has been made regarding new PPIs.