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Serum Bisphenol A Concentration in Postmenopausal Women with Osteoporosis.

Dong Hyun KIM ; Chi Hyuk OH ; Yoo Chul HWANG ; In Kyung JEONG ; Kyu Jeong AHN ; Ho Yeon CHUNG ; Jae Suk CHANG

Journal of Bone Metabolism.2012;19(2):87-93. doi:10.11005/jbm.2012.19.2.87

OBJECTIVES: Bishphenol A (BPA) is a representative endocrine disruptor and is also known as a xenoestrogen. The objective of the present study is to investigate how many patients are exposed to BPA and to analyze the relationships between serum BPA concentration, bone mineral density (BMD) and biochemical bone markers in postmenopausal women with osteoporosis. METHODS: Total 51 patients were enrolled for measuring BPA and clinical variables including BMD and bone markers. The relationship between BPA and clinical variables were analyzed by the Pearson's correlation test and the Kruskal-Wallis test. Serum BPA concentration was measured by enzyme linked immunosorbent assay (ELISA). RESULTS: BPA was detected in all samples. The mean BPA concentration was 1.44 +/- 0.52 ng/mL. There was no statistically significant correlation between BPA and clinical variables. CONCLUSION: There was no statistical significance between serum BPA concentration and clinical variables related to bone metabolism. To clarify the effect of BPA on bone metabolism, further large scaled and high risk group investigation may be needed.
Benzhydryl Compounds ; Bone Density ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Osteoporosis ; Phenols

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Mortality after Hip Fractures in Nonagenarians.

Bun Jung KANG ; Young Kyun LEE ; Ki Woong LEE ; Sung Hun WON ; Yong Chan HA ; Kyung Hoi KOO

Journal of Bone Metabolism.2012;19(2):83-86. doi:10.11005/jbm.2012.19.2.83

OBJECTIVES: Nonagenarians with hip fractures represent a special group of people because of their advanced age and co-morbidities. We evaluated mortality after hip fractures in nonagenarians. METHODS: Fifty-one patients were studied over a 2-year period. There were 39 female and 12 male patients. Twenty seven patients sustained an intertrochanteric fracture of the femur, 24 suffered from femoral neck fracture. The American Society of Anaesthetists (ASA) score of II was the most frequent among 51. Forty-one of them had one or more co-morbidities. Patient review was done 2 years after the fracture. RESULTS: The mortality rate at one year was 53.4% in men, and 15.7% in women. After multivariate analysis, the type of fracture (intertrochanteric fracture) was identified as a risk factor for one-year mortality (P = 0.025). CONCLUSION: The outcome in nonagenarians with hip fractures is poor due to the high rates of mortality, especially in men, and this could be informed to patients and their families before hip fracture surgery.
Aged, 80 and over ; Female ; Femoral Neck Fractures ; Femur ; Hip ; Hip Fractures ; Humans ; Male ; Multivariate Analysis ; Risk Factors

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A Case of CATCH22 Syndrome Diagnosed in Postmenopausal Woman.

Seung Kyung LEE ; Min Jeong LEE ; Hyo Jin LEE ; Bu Kyung KIM ; Young Bae SOHN ; Yoon Sok CHUNG

Journal of Bone Metabolism.2013;20(1):57-60. doi:10.11005/jbm.2013.20.1.57

CATCH 22 Syndrome is caused by chromosome 22q11.2 microdeletion, characterized by developmental abnormalities of the third and fourth pharyngeal pouches. It has a prevalence estimated at 1:3,000-1:9,000. Most deletions occurs sporadic, but autosomal dominant inheritance observed in 6-10% of cases. CATCH22 often diagnosed due to hypocalcemia during neonatal period or decreased immunity or facial defect, so it is very rare being diagnosed CATCH22 in adulthood. We report a 57 year old female who referred to mental change due to hypocalcemia and is diagnosed CATCH22. She was presented with hypoparathyroidism, single kidney due to renal agenesis, and mild facial defect. Our patient responded well to calcium and vitamin D treatment and she is on follow-up in outpatient clinic.
Ambulatory Care Facilities ; Calcium ; Congenital Abnormalities ; DiGeorge Syndrome ; Female ; Follow-Up Studies ; Humans ; Hypocalcemia ; Hypoparathyroidism ; Kidney ; Kidney Diseases ; Prevalence ; Vitamin D ; Wills

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A Case of Nutritional Osteomalacia in Young Adult Male.

Choong Kyun NOH ; Min Jeong LEE ; Bu Kyung KIM ; Yoon Sok CHUNG

Journal of Bone Metabolism.2013;20(1):51-55. doi:10.11005/jbm.2013.20.1.51

Vitamin D is an important hormone that can be a role of bone and calcium metabolism in the human organ. Thus, vitamin D deficiency could contribute to the severity of metabolic bone disease. The osteomalacia, one of the metabolic bone diseases, is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available phosphorus and calcium. We experienced a case of osteomalacia presented with walking disturbance, 30 year-old young aged man, caused by vitamin D deficiency due to strict vegetarian diet and lack of sunlight exposures.
Aged ; Bone Diseases, Metabolic ; Calcification, Physiologic ; Calcium ; Diet, Vegetarian ; Humans ; Male ; Osteomalacia ; Phosphorus ; Sunlight ; Vitamin D ; Vitamin D Deficiency ; Walking ; Young Adult

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Compression Fracture in Postpartum Osteoporosis.

Judith L GUTOWSKI

Journal of Bone Metabolism.2014;21(2):161-161. doi:10.11005/jbm.2014.21.2.161

No abstract available.
Fractures, Compression* ; Osteoporosis* ; Postpartum Period*

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Atypical Femoral Fracture: 2015 Position Statement of the Korean Society for Bone and Mineral Research.

Kyu Hyun YANG ; Byung Woo MIN ; Yong Chan HA

Journal of Bone Metabolism.2015;22(3):87-91. doi:10.11005/jbm.2015.22.3.87

Bisphosphonate (BP) is a useful anti-resorptive agent which decreases the risk of osteoporotic fracture by about 50%. However, recent evidences have shown its strong correlation with the occurrence of atypical femoral fracture (AFF). The longer the patient takes BP, the higher the risk of AFF. Also, the higher the drug adherence, the higher the risk of AFF. It is necessary to ask the patients who are taking BP for more than 3 years about the prodromal symptoms such as dull thigh pain. Simple radiography, bone scan, and magnetic resonance imaging (MRI) are good tools for the diagnosis of AFF. The pre-fracture lesion depicted on the hip dual energy X-ray absorptiometry (DXA) images should not be missed. BP should be stopped immediately after AFF is diagnosed and calcium and vitamin D (1,000 to 2,000 IU) should be administered. The patient should be advised not to put full weight on the injured limb. Daily subcutaneous injection of recombinant human parathyroid hormone (PTH; 1-34) is recommended if the patient can afford it. Prophylactic femoral nailing is indicated when the dreaded black line is visible in the lateral femoral cortex, especially in the subtrochanteric area.
Absorptiometry, Photon ; Calcium ; Diagnosis ; Extremities ; Femoral Fractures* ; Hip ; Humans ; Injections, Subcutaneous ; Magnetic Resonance Imaging ; Osteoporotic Fractures ; Parathyroid Hormone ; Prodromal Symptoms ; Radiography ; Thigh ; Vitamin D

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A Case of Cavernous Sinus Thrombophlebitis and Meningitis as a Complication in Osteopetrosis.

Hyun Chul CHUNG ; So Hyun PARK ; Eun Sook KIM ; Young Il KIM ; Sun Ho LEE ; Il Seong NAM-GOONG

Journal of Bone Metabolism.2014;21(3):227-232. doi:10.11005/jbm.2014.21.3.227

Osteopetrosis is a rare genetic bone disease characterized by increased bone density but prone to breakage due to defective osteoclastic function. Among two primary types of autosomal dominant osteopetrosis (ADO), osteopetrosis type II is characterized by sclerosis of bones, predominantly involving the spine, the pelvis, and the skull base. Fragility of bones and dental abscess are leading complications. This report presents a case of osteopetrosis in a 52-years-old female, which was complicated by the development of cavernous sinus thrombophlebitis and meningitis. She was suffered from multiple fractures since one year ago. Laboratory data revealed elevated serum levels of tartrate resistant acid phosphatase (TRAP) without carbonic anhydrase II DNA mutation. A thoracolumbar spine X-ray showed, typical findings of ADO type II (ADO II; Albers-Schonberg disease), prominent vertebral endplates so called the 'rugger jersey spine'. Her older sister also showed same typical spine appearance. We report a case of ADO II with cavernous sinus thrombophlebitis and meningitis that was successfully treated with long-term antibiotics with right sphenoidotomy.
Abscess ; Acid Phosphatase ; Anti-Bacterial Agents ; Bone Density ; Bone Diseases ; Carbonic Anhydrase II ; Cavernous Sinus Thrombosis* ; DNA ; Female ; Humans ; Meningitis* ; Osteoclasts ; Osteopetrosis* ; Pelvis ; Sclerosis ; Siblings ; Skull Base ; Spine

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Intravenous Zoledronate for a Patient with Paget's Disease.

Ki Choul KIM

Journal of Bone Metabolism.2014;21(3):223-226. doi:10.11005/jbm.2014.21.3.223

Paget's disease (PD) of bone is characterized by increase of bone resorption by atypical osteoclasts, followed by rapid new bone formation resulting in a disorganized mosaic bone. Although the pathophysiology is not fully understood, bisphosphonate, which is a potent anti-resorptive agent for treatment of osteoporosis, have been the most effective agents available for the treatment of PD. We report a case of PD of bone in a 49-year-old woman patient, who was treated with intravenous zoledronate.
Bone Density Conservation Agents ; Bone Resorption ; Diphosphonates ; Female ; Humans ; Middle Aged ; Osteitis Deformans ; Osteoclasts ; Osteogenesis ; Osteoporosis

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Increase in the Serum Parathyroid Hormone Level During a Bisphosphonate Drug Holiday.

Yoon Kyung SONG ; Jeong Min KIM ; Sun Jin PARK ; Seong Kyu LEE

Journal of Bone Metabolism.2014;21(3):217-222. doi:10.11005/jbm.2014.21.3.217

After discontinuation of bisphosphonate therapy, an antiresorptive effect and antifracture protection persist for an undefined period. Patients are encouraged to continue calcium and vitamin D supplementation, during a bisphosphonate drug holiday. However, assessment of adequate calcium intake during the bisphosphonate drug holiday is difficult. Therefore, we measured the serum intact parathyroid hormone (PTH) level as a surrogate marker. A premenopausal woman discontinued bisphosphonate therapy, after 7.5 years of treatment. Two months later, blood calcium and phosphorus levels were normal, serum 25-hydroxyvitamin D level was 31.3 ng/mL, but serum PTH level had increased to 94.9 pg/mL. The elemental calcium supplement dose was increased to 600 mg/day, with no change in the cholecalciferol dose (400 IU). Her serum PTH levels decreased to 49.1 after 4 months and 32.9 pg/mL after 5 months. The serum PTH level may be helpful in assessing adequate calcium intake during a bisphosphonate drug holiday.
Biomarkers ; Calcium ; Cholecalciferol ; Female ; Holidays* ; Humans ; Parathyroid Hormone* ; Phosphorus ; Vitamin D

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Bone Health and Clinical Results after Hip Fracture Surgery in Patients with Subclinical Hypothyroidism.

Ki Choul KIM ; Young Kyun LEE ; You Jin LEE ; Yong Chan HA ; Kyung Hoi KOO

Journal of Bone Metabolism.2014;21(3):213-216. doi:10.11005/jbm.2014.21.3.213

BACKGROUND: Subclinical thyroid dysfunction might influence a bone health. We evaluated whether subclinical hypothyroidism adversely affects bone health including bone mineral density (BMD), level of vitamin D, and bone turnover status in patients with hip fracture. METHODS: We evaluated 471 patients aged 50 years or older, who underwent hip fracture surgeries. BMD, level of vitamin D, bone turnover status, and one-year mortality were compared between subclinical hypothyroidism group and control group. RESULTS: BMD of femur and the level of 25-hydroxy-vitamin D (25-[OH]D) were similar in the two groups. There were no significant differences in bone turnover markers according to thyroid function. No significant differences were observed between the groups in utilization of intensive care unit (ICU), length of hospital stay, mobility, and one-year mortality. CONCLUSIONS: Subclinical hypothyroidism was not associated with reduced bone health, including BMD, the level of 25-(OH)D, and bone turnover marker.
Bone Density ; Femur ; Hip Fractures ; Hip* ; Humans ; Hypothyroidism* ; Intensive Care Units ; Length of Stay ; Mortality ; Thyroid Gland ; Vitamin D

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