Journal of Bone Metabolism  2014;21(2):155-159

doi:10.11005/jbm.2014.21.2.155

Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate.

Yougun WON 1 ; Joon Ryul LIM ; Young Hwan KIM ; Hyung Keun SONG ; Kyu Hyun YANG

Affiliations

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Keywords

Atypical femoral fracture; Bisphosphonate

Country

Republic of Korea

Language

English

Abstract

Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective, well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture (AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing morbidities in patients treated with long term bisphosphonate. Pathogenic mechanisms of AFF and BRONJ are not fully identified and not identical. We report a case of BRONJ followed by AFF and its nonunion in a 67-year-old woman patient receiving an oral bisphosphonate during 7 years for the treatment of osteoporosis.