Journal of Bone Metabolism  2014;21(3):163-167

doi:10.11005/jbm.2014.21.3.163

Factors and Mechanisms Involved in the Coupling from Bone Resorption to Formation: How Osteoclasts Talk to Osteoblasts.

Kyoji IKEDA 1 ; Sunao TAKESHITA

Affiliations

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Keywords

Bone remodeling; Bone resorption; Osteoblasts; Osteoclasts

Country

Republic of Korea

Language

English

Abstract

Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone disease such as osteoporosis ensues. Among multiple phases of the complex remodeling process, we focus in this review on factors and mechanisms that are involved in the coupling of bone formation to preceding resorption.