Journal Detail Information

1

Cite

Share

Ga-67 Citrate and Tc-99m MDP Uptake in the Lung and Stomach Associated with Hypercalcemia.

Myung Hee SOHN ; Seok Tae LIM ; Young Jin JEONG ; Dong Wook KIM ; Hwan Jeong JEONG ; Chang Yeol YIM

Nuclear Medicine and Molecular Imaging.2009;43(4):366-367.

Ga-67 scintigraphy demonstrated increased uptake in the lungs and stomach in a 26-year-old man with hypercalcemia. A primitive neuroectodermal tumor was confirmed by bone marrow examination. Tc-99m MDP uptake in the same locations as Ga-67 revealed by bone scintigraphy was consistent with metastatic calcification. Although the mechanism of Ga-67 uptake in metastatic calcification is not understood, the presence of an inflammatory process is suggested.
Adult ; Bone Marrow Examination ; Citrates ; Citric Acid ; Gallium ; Humans ; Hypercalcemia ; Lung ; Neuroectodermal Tumors, Primitive ; Stomach ; Technetium Tc 99m Medronate

2

Cite

Share

Intra-abdominal Kikuchi's Disease Mimicking Malignant Lymphoma on FDG PET-CT.

Hye Suk HAN ; Gi Hyun KIM ; Young Shim CHO ; Hye Jin JOO ; Ok Jun LEE ; Dong Hee RYU ; Ki Hyeong LEE ; Seung Taik KIM

Nuclear Medicine and Molecular Imaging.2009;43(4):363-365.

Kikuchi's disease is a self-limiting benign disease characterized by cervical lymphadenopathy, but it can be mistaken for malignant disease, and when involved lymph nodes are unusually located, diagnosis can be more difficult. The authors report the case of a 19-year-old man with Kikuchi's disease, who had isolated intraabdominal lymphadenopathy and increased 18-fluoro-deoxyglucose (FDG) uptake in positron emission tomographycomputed tomography (PET-CT). Although its incidence is extremely rare, intra-abdominal Kikuchi's disease with increased FDG uptake in PET-CT image should be considered in the differential diagnosis when constitutional symptoms mimic those of malignant lymphoma.
Abdomen ; Diagnosis, Differential ; Electrons ; Histiocytic Necrotizing Lymphadenitis ; Humans ; Hydrazines ; Incidence ; Lymph Nodes ; Lymphatic Diseases ; Lymphoma ; Positron-Emission Tomography ; Young Adult

3

Cite

Share

A Neurofibroma Confused with Sarcomatous Transformation on F-18 FDG PET/CT in Neurofibromatosis-1.

Soon Ah PARK ; Jeong Hoon SONG ; Chung Yong YANG ; Hun Soo KIM ; Seung Chol PARK

Nuclear Medicine and Molecular Imaging.2009;43(4):361-362.

We present a patient with high 18F-fluorodeoxyglucose (FDG) uptake detected in a neurofibroma that was confused with sarcomatous transformation on a positron emission tomography/computed tomography (PET/CT) scan. A 39-year-old male patient with a 20-year history of neurofibromatosis-1 (NF-1) performed FDG PET/CT scan for the evaluation of lesions with sarcomatous transformation. The FDG PET/CT images demonstrated varying degrees of increased FDG uptake in the multiple nodules throughout whole body. The left pelvic mass with the highest FDG uptake had a maximum standardized uptake values (maxSUV) 5.0 and surgical resection was performed. Histological analysis confirmed the presence of a benign neurofibroma infiltrated with inflammatory cells.
Adult ; Electrons ; Humans ; Male ; Neurofibroma ; Neurofibromatoses

4

Cite

Share

Primary Malignant Peritoneal Mesothelioma Mimicking Peritoneal Carcinomatosis on F-18 FDG PET/CT.

Jin Suk KIM ; Seok Tae LIM ; Young Jin JEONG ; Dong Wook KIM ; Hwan Jeong JEONG ; Myung Hee SOHN

Nuclear Medicine and Molecular Imaging.2009;43(4):357-360.

Malignant mesothelioma of the peritoneum is a rare neoplasm with a rapidly fatal course. The tumour arises from the mesothelial cells lining the pleura and peritoneum or, rarely, in the pericardium or tunica vaginalis. This neoplasm is characterized by being difficult to diagnose, having a rapid evolution and a poor response to therapy. Mesothelioma is very glucose avid, and malignant pleural mesothelioma has been reported concerning the utility of F-18 FDG PET or PET/CT. But little has been known about the imaging finding of malignant peritoneal mesothelioma on F-18 FDG PET/CT. We report a case of malignant peritoneal mesothelioma mimicking peritoneal carcinomatosis of F-18 FDG PET/CT.
Carcinoma ; Glucose ; Mesothelioma ; Pericardium ; Peritoneum ; Pleura

5

Cite

Share

Diffuse Bone Marrow Uptake of 99mTc-MIBI in A Case of Intravascular Large B-cell Lymphoma.

Seung Hwan MOON ; So Won OH ; Jin Chul PAENG ; Jin Ho PAIK ; Dong Soo LEE

Nuclear Medicine and Molecular Imaging.2009;43(4):352-356.

Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large cell lymphoma, characterized by proliferation of lymphoid cells in the intravascular space of various organs without causing a mass effect. Although 18F-FDG PET is a powerful imaging tool in lymphoma, the usefulness of 18F-FDG PET in the assessment of IVLBCL is still controversial. 99mTc-MIBI, a tumor imaging radiopharmaceutical with a different mechanism from that of 18F-FDG, has been reported to be also effective in lymphoma. However, there is nearly no report on the efficacy of 99mTc-MIBI in the assessment of IVLBCL. We present one case of IVLBCL that showed 99mTc-MIBI accumulation in the involved bone marrow as an incidental finding, which was discrepant from that of 18F-FDG PET.
B-Lymphocytes ; Bone Marrow ; Fluorodeoxyglucose F18 ; Incidental Findings ; Lymphocytes ; Lymphoma ; Lymphoma, B-Cell ; Lymphoma, Large B-Cell, Diffuse

6

Cite

Share

Development of Optical Molecular Imaging System for the Acquisition of Bioluminescence Signals from Small Animals.

Byeong Il LEE ; Hyeon Sik KIM ; Hye Jin JEONG ; Hyung Jae LEE ; Seung Min MOON ; Seung Young KWON ; Eun Seo CHOI ; Shin Young JEONG ; Hee Seung BOM ; Jung Joon MIN

Nuclear Medicine and Molecular Imaging.2009;43(4):344-351.

PURPOSE: Optical imaging is providing great advance and improvement in genetic and molecular imaging of animals and humans. Optical imaging system consists of optical imaging devices, which carry out major function for monitoring, tracing, and imaging in most of molecular in-vivo researches. In bio-luminescent imaging, small animals containing luciferase gene locally irradiate light, and emitted photons transmitted through skin of the small animals are imaged by using a high sensitive charged coupled device (CCD) camera. In this paper, we introduced optical imaging system for the image acquisition of bio-luminescent signals emitted from small animals. MATERIALS AND METHODS: In the system, Nikon lens and four LED light sources were mounted at the inside of a dark box. A cooled CCD camera equipped with a control module was used. RESULTS: We tested the performance of the optical imaging system using effendorf tube and light emitting bacteria which injected intravenously into CT26 tumor bearing nude mouse. The performance of implemented optical imaging system for bio-luminescence imaging was demonstrated and the feasibility of the system in small animal imaging application was proved. CONCLUSION: We anticipate this system could be a useful tool for the molecular imaging of small animals adaptable for various experimental conditions in future.
Animals ; Bacteria ; Enzyme Multiplied Immunoassay Technique ; Humans ; Light ; Luciferases ; Mice ; Mice, Nude ; Molecular Imaging ; Optical Imaging ; Photons ; Skin ; Ursidae

7

Cite

Share

A Convenient Radiolabeling of 11C(R)-PK11195 Using Loop Method in Automatic Synthesis Module.

Hak Jeong LEE ; Jae Min JEONG ; Yun Sang LEE ; Hyung Woo KIM ; Jae Yeon CHOI ; Dong Soo LEE ; June Key CHUNG ; Myung Chul LEE

Nuclear Medicine and Molecular Imaging.2009;43(4):337-343.

PURPOSE: ((R)-1-(2-chlorophenyl)-N-1-[11C]methyl-N-(1-propyl)-3-isoquinoline carboxamide ((R)-PK11195) is a specific ligand for the peripheral type benzodiazepine receptor and a marker of activated microglia, used to measure inflammation in neurologic disorders. We report here that a direct and simple radiosynthesis of [11C](R)-PK11195 inmild condition using NaH suspension in DMF and one-step loop method. MATERIALS AND METHODS: (R)-NDesmethyl- PK11195 (1 mg) in DMSO (0.1 mL) and NaH suspension in DMF (0.1 mL) were injected into a semi-prep HPLC loop. [11C]methyl iodide was passed through HPLC loop at room temperature. Purification was performed using semi-preparative HPLC. Aliquots eluted at 11.3 min were collected and analyzed by analytical HPLC and mass spectrometer. RESULTS: The labeling efficiency of [11C](R)-PK11195 was 71.8+/-8.5%. The specific activity was 11.8 +/-6.4 GBq/micromol and radiochemical purity was higher than 99.2%. The mass spectrum of the product eluted at 11.3 min showed m/z peaks at 353.1 (M+1), indicating the mass and structure of (R)-PK11195. CONCLUSION: By the one-step loop method with the [11C]CH3I automated synthesis module, [11C](R)-PK11195 could be easily prepared in high radiochemical yield using NaH suspension in DMF.
Chromatography, High Pressure Liquid ; Dimethyl Sulfoxide ; Inflammation ; Isoquinolines ; Microglia ; Nervous System Diseases ; Receptors, GABA-A

8

Cite

Share

Radiolabeling of NOTA and DOTA with Positron Emitting 68Ga and Investigation of In Vitro Properties.

Jae Min JEONG ; Young Ju KIM ; Yun Sang LEE ; Dong Soo LEE ; June Key CHUNG ; Myung Chul LEE

Nuclear Medicine and Molecular Imaging.2009;43(4):330-336.

PURPOSE: We established radiolabeling conditions of NOTA and DOTA with a generator-produced PET radionuclide 68Ga and studied in vitro characteristics such as stability, serum protein binding, octanol/water distribution, and interference with other metal ions. MATERIALS AND METHODS: Various concentrations of NOTA.3HCl and DOTA.4HCl were labeled with 1 mL 68GaCl3 (0.18~5.75 mCi in 0.1 M HCl) in various pH. NOTA.3HCl (0.373 mM) was labeled with 68GaCl3 (0.183~0.232 mCi/0.1 M HCl 1.0 mL) in the presense of CuCl2, FeCl2, InCl3, FeCl3, GaCl3, MgCl2 or CaCl2 (0~6.07 mM) at room temperature. The labeling efficiencies of 68Ga-NOTA and 68Ga-DOTA were checked by ITLC-SG using acetone or saline as mobile phase. Stabilities, protein bindings, and octanol distribution coefficients of the labeled compounds also were investigated. RESULTS: 68Ga-NOTA and 68Ga-DOTA were labeled optimally at pH 6.5 and pH 3.5, respectively, and the chelates were stable for 4 hr either in the reaction mixture at room temperature or in the human serum at 37 degreesC. NOTA was labeled at room temperature while DOTA required heating for labeling. 68Ga-NOTA labeling efficiency was reduced by CuCl2, FeCl2, InCl2, FeCl3 or GaCl3, however, was not influenced by MgCl2 or CaCl2. The protein binding was low (2.04~3.32%). Log P value of 68Ga-NOTA was -3.07 indicating high hydrophilicity. CONCLUSION: We found that NOTA is a better bifunctional chelating agent than DOTA for 68Ga labeling. Although, 68Ga-NOTA labeling is interfered by various metal ions, it shows high stability and low serum protein binding.
Acetone ; Copper ; Electrons ; Enzyme Multiplied Immunoassay Technique ; Gallium ; Heating ; Heterocyclic Compounds ; Hot Temperature ; Humans ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Ions ; Magnesium Chloride ; Protein Binding ; Protein Stability

9

Cite

Share

Discrepancy of Bone Metastases between F-18 FDG PET/CT and Bone Scan in a Patient with Prostate Cancer.

Seung Jin CHOI ; Chul Soo KIM ; Sung Su BYUN ; In Young HYUN

Nuclear Medicine and Molecular Imaging.2006;40(5):275-278.

We report the case of a 73-year-old man who had prostate cancer with bone metastases. Tc-99m HDP Whole body bone scan revealed multiple areas of increased bony uptake consistent with widespread bone metastases. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) demonstrated mild F-18 FDG uptake in the lymph nodes of neck, abdomen, and pelvis. However, abnormal F-18 FDG uptake was not seen in the skeletal system. Biopsy and immunohistochemical stains of left supraclavicular mass showed metastatic prostate adenocarcinoma. Currently, there are a few reported cases of F-18 FDG PET/CT evaluation of bone metastases in prostate cancer. We discuss the discrepancy between F-18 FDG PET/CT and bone scan in the detection of osseous metastases of prostate cancer.
Abdomen ; Adenocarcinoma ; Aged ; Biopsy ; Coloring Agents ; Electrons ; Humans ; Lymph Nodes ; Neck ; Neoplasm Metastasis* ; Pelvis ; Positron-Emission Tomography and Computed Tomography* ; Prostate* ; Prostatic Neoplasms*

10

Cite

Share

Detection of Superior Vena Cava Tumor Thrombus by F-18 FDG PET/CT in Recurrent Hepatocellular Carcinoma.

Seung Jin CHOI ; Chul Soo KIM ; Sung Su BYUN ; Kyung Hee LEE ; In Young HYUN

Nuclear Medicine and Molecular Imaging.2006;40(5):271-274.

We report the case of a 64-year-old man with superior vena cava (SVC) syndrome due to tumor thrombus from recurrent hepatocellular carcinoma (HCC). He presented with new onset of facial swelling for 10 days. HCC was detected ten years ago. He has undergone repeated transcatheter arterial embolization (TAE) and chemotherapy. Chest computed tomography (CT) demonstrated tumor thrombus in the SVC extending to right atrium. He underwent whole body F-18 fluorodeoxyglucose(FDG) positron emission tomography/computed tomography (PET/CT) scanning for assessing the effect of TAE in HCC. F-18 FDG PET/CT showed increased uptake in the residual liver mass indicating viable tumor. There was another intense F-18 FDG accumulation in SVC extending to right atrium to suggest tumor thrombus. This case illustrates that F-18 FDG PET/CT is useful to identification of distant metastases as well as assessment of response to therapy in long-term survival HCC patients.
Carcinoma, Hepatocellular* ; Drug Therapy ; Electrons ; Heart Atria ; Humans ; Liver ; Middle Aged ; Neoplasm Metastasis ; Positron-Emission Tomography and Computed Tomography* ; Superior Vena Cava Syndrome ; Thorax ; Thrombosis* ; Vena Cava, Superior*

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share