Nuclear Medicine and Molecular Imaging  2009;43(4):352-356

Diffuse Bone Marrow Uptake of 99mTc-MIBI in A Case of Intravascular Large B-cell Lymphoma.

Seung Hwan MOON 1 ; So Won OH ; Jin Chul PAENG ; Jin Ho PAIK ; Dong Soo LEE

Affiliations

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Keywords

Intravascular large B-cell lymphoma; 99mTc-MIBI; 18F-FDG PET

Country

Republic of Korea

Language

English

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large cell lymphoma, characterized by proliferation of lymphoid cells in the intravascular space of various organs without causing a mass effect. Although 18F-FDG PET is a powerful imaging tool in lymphoma, the usefulness of 18F-FDG PET in the assessment of IVLBCL is still controversial. 99mTc-MIBI, a tumor imaging radiopharmaceutical with a different mechanism from that of 18F-FDG, has been reported to be also effective in lymphoma. However, there is nearly no report on the efficacy of 99mTc-MIBI in the assessment of IVLBCL. We present one case of IVLBCL that showed 99mTc-MIBI accumulation in the involved bone marrow as an incidental finding, which was discrepant from that of 18F-FDG PET.