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A Study for Incidence of Childhood Leukemia in Kyongnam Province, Korea.

Soon Yong LEE ; Kwang Yong PARK ; Geun Ha CHI ; Myung Jin KO ; Tae Jin YANG ; Sang Kyu PARK ; Byeung Kyu PARK ; Sang Duk KIM ; Ki Hong PARK ; Young Tak LIM ; Young Ho LEE ; Jae Sun PARK ; Hee Young SIN ; Chul Joo LYU ; Hacki Ki KIM ; Kun Soo LEE ; Jeong Ok HAH ; Heung Sik KIM ; Tai Ju WHANG ; Jin Ho CHUN

Korean Journal of Pediatric Hematology-Oncology.2001;8(1):27-34.

PURPOSE: Of the cancers in childhood, leukemia is the most frequent one. For the desirable control of childhood leukemia, the basic data for the incidence has a great importance. The authors made a report about the incidence of leukemia in childhood, which analyzed the data from 126 cases in Kyongnam province, Korea, during 1991~1995. METHODS: The data were obtained from 126 new cases of childhood leukemia who had been living in the Kyongnam province and were diagnosed at the 26 university hospitals or general hospitals in the Kyongnam area and other cities from 1991 to 1995. RESULTS: The age-and-sex adjusted annual incidence rate per 100,000 population during 1991~1995 varied from 1.82 to 2.86, and cumulative annual incidence rate was 2.41 (male 2.26 and female 2.57 respectively). Male to female sex ratio was 1:1 in total cases. By the major types of childhood leukemia, the cases were composed of acute lymphocytic leukemia 70.6%, acute myelocytic leukemia 26.9% and chronic myelocytic leukemia 2.5%. The cumulative annual incidence rate per 100,000 population (crude rate) during 1991~1995 were 2.77 in Ulsan city, 2.62 in Chinju city and 2.34 in the whole area of Kyongnam province. CONCLUSION: It was concluded that the age-and-sex adjusted annual incidence rate per 100,000 of childhood in Kyongnam province was 2.41, which was lower than that in Pusan city in the same period. And, there was no significant difference of the cumulative annual incidence rate between Ulsan area and Chinju area in the same period.
Busan ; Female ; Gyeongsangnam-do* ; Hospitals, General ; Hospitals, University ; Humans ; Incidence* ; Korea* ; Leukemia* ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Leukemia, Myeloid, Acute ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Sex Ratio ; Ulsan

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Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Children with Acute Myelogenous Leukemia in Korea.

e Young SHIN

Korean Journal of Pediatric Hematology-Oncology.2001;8(1):9-16.

PURPOSE: Autografts with peripheral blood stem cells (PBSCT) have become an accepted alternative to bone marrow transplantation for restoring hematopoiesis after marrow ablative therapy. METHODS: Questionnaires are given to all the transplantation centers in Korea. Eleven centers reported 63 cases and retrospective analysis of these cases were done. RESULTS: Sixty-three children with acute myelogenous leukemia (AML) underwent PBSCT following cytoreductive chemotherapy at 11 transplant centers of the Korean Society of Pediatric Hematology-Oncology from January, 1996 through June, 2000. The patients consisted of 40 males and 23 females with a median age at PBSCT of 10 year (range 1~16). Peripheral blood stem cell (PBSC) were collected by a median of 5 apheresis per patient. Various kinds of multi-drug therapy as cytoreductive regimen were used, and the 'BCVAC' regimen consisting of BCNU, cyclophosphamide, VP-16 and cytarabine was used in 35 patients. The median number of infused mononuclear cell (MNC) and CD34 cells was 8.14 (0.3~26.6) 108/kg and 4.90 (0.12~46.9) 106/kg, respectively. Hematological recovery was evaluated in all patients. The median number of days required to achieve an absolute neutrophil count (ANC) of > 500/mm3, > 1,000/mm3 and platelet count of > 50 103/mm3 was 12 (8~48), 12 (9~84) and 35 (10~370), respectively. Sixteen patients relapsed 1 month to 18 months (median 2 months) after PBSCT, 1 patient progressed to secondary MDS 15 months after PBSCT and 1 patient died at d+39 due to CMV infection. So currently 45 patients are surviving disease free at 2 to 50 months (median 23 months). CONCLUSION: Even though the follow-up period was short and the number of patient was small the autologous PBSCT might be an alternative therapy in childhood AML.
Autografts ; Blood Component Removal ; Bone Marrow ; Bone Marrow Transplantation ; Carmustine ; Child ; Cyclophosphamide ; Cytarabine ; Drug Therapy ; Etoposide ; Female ; Follow-Up Studies ; Hematopoiesis ; Hematopoietic Stem Cell Transplantation* ; Hematopoietic Stem Cells* ; Humans ; Korea* ; Leukemia, Myeloid, Acute* ; Male ; Neutrophils ; Platelet Count ; Surveys and Questionnaires ; Retrospective Studies ; Stem Cells

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Pediatric Allogeneic Hematopoietic Stem Cell Transplantation in Korea: April 2000: The Korean Society of Pediatric Hematology-Oncology.

Bin CHO

Korean Journal of Pediatric Hematology-Oncology.2001;8(1):1-8.

The Korean Society of Pediatric Hematology-Oncology surveyed pediatric allogeneic hematopoietic stem cell transplantation in Korea. From 1983 to April 2000, 267 children underwent allogeneic hematopoietic stem cell transplantation. Seventy-nine children were transplanted for acute myelogenous leukemia (AML), 76 for severe aplastic anemia (SAA), 62 for acute lymphoblastic leukemia (ALL), 44 for chronic myelogenous leukemia/myelodysplastic syndrome (CML/MDS) and 11 for nonmalignant rare disease. There were 152 males and 115 females with a median age of 9 years and median follow-up of 25 months. One hundred and eighty-nine of 267 cases were HLA-matched sibling transplants. The estimated event-free survival (EFS) of patients with SAA who underwent HLA-matched sibling transplants is 89%. The estimated EFS of ALL in CR1 and CR2 are 77% and 67%, respectively. The estimated EFS of AML in CR1 and CR2 are 73% and 60%, respectively. The estimated EFS of AML in CR1 prepared with Bu/Cy is 82%. The estimated EFS of CML/MDS is 71%. Eight out of 10 children with nonmalignant rare disease who underwent HLA-matched transplants are alive with disease free. Thirty-three children underwent unrelated bone marrow transplantation and 17 cord blood transplantation. Outcomes of patients with alternative stem cell sources are not estimated due to short median follow-up. These data shows that allogeneic hematopoietic stem cell transplantation is a curative method for children with hematopoietic stem cell disorders and we wish to share these results.
Anemia, Aplastic ; Bone Marrow Transplantation ; Child ; Disease-Free Survival ; Female ; Fetal Blood ; Follow-Up Studies ; Hematopoietic Stem Cell Transplantation* ; Hematopoietic Stem Cells* ; Humans ; Korea ; Leukemia, Myeloid, Acute ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Rare Diseases ; Siblings ; Stem Cell Transplantation ; Stem Cells

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A Case of Malignant Gastric Stromal Tumor.

Shin Heh KANG ; Sun Ye KIM ; Kyu Hyung LEE ; Kwang Eun CHA ; Sung Pyo HONG ; Kyung Po LEE ; Myung Seo KANG ; Yong Hee LEE

Korean Journal of Pediatric Hematology-Oncology.1999;6(1):162-167.

As leiomyosarcomas of smooth muscle origin are rare tumors found in adults, they are even more uncommon among children. Therefore, most of the existing literatures concerning pediatric leiomyosarcomas has been limited to case reports. More recently, ultrastructural and immunohistochemical studies revealed that some tumors may have properties more suggestive of nerve cells or vascular endothelial cells, rendering the gastrointestinal stromal tumor a more popular term. We experienced a 13 year old boy who was diagnosed and treated as iron deficiency anemia. Even after iron therapy, he had persistent anemia and endoscopic examination revealed a huge mass in the gastric cardia. Proximal gastrectomy was performed with margins free of tumor. The tumor cells showed high mitotic activity suggesting malignant nature. The immunohistochemical staining was positive for smooth muscle actin while negative for S-100 protein. Brief review of the literatures are presented.
Actins ; Adolescent ; Adult ; Anemia ; Anemia, Iron-Deficiency ; Cardia ; Child ; Endothelial Cells ; Gastrectomy ; Gastrointestinal Stromal Tumors ; Humans ; Iron ; Leiomyosarcoma ; Male ; Muscle, Smooth ; Neurons ; S100 Proteins

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A Case of Hepatoblatoma with Intraatrial Extension.

Jeong Ah CHOI ; Ju Suk LEE ; Young Tak LIM ; Hee Ju PARK

Korean Journal of Pediatric Hematology-Oncology.1999;6(1):156-161.

Hepatoblastoma is an uncommon malignant tumor of the liver in children, moreover its intracaval extension to the right atrium is extremely rare. Current data indicate that combined hepatectomy and resection of intraatrial extension is necessary for cure. However 40% of the patients present with tumor that would make primary complete resection impossible or extremely hazardous. In these case preoperative chemotherapy is recommanded. We recently experienced a rare case of hepatoblastoma which metastasized to lung and to right atrium via inferior vena cava. We report this case with brief review of literature.
Child ; Drug Therapy ; Heart Atria ; Hepatectomy ; Hepatoblastoma ; Humans ; Liver ; Lung ; Vena Cava, Inferior

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A Case of Mesenteric Castleman's Disease with Systemic Involvement.

Myung Seok SHIN ; Sun Young KIM ; Ji Young SUL ; Jin Man KIM ; Nak Gyun CHUNG ; Bin CHO ; Dae Chul JEONG ; Kyung Deok PARK ; Hack Ki KIM

Korean Journal of Pediatric Hematology-Oncology.2004;11(2):280-285.

Castleman's disease (CD) is a lymphoproliferative disorder of unknown origin and rarely occurs in children. It has been further classified into two major subgroups: solitary or localized and multicentric CD. Furthermore, there are two main histological variants: hyaline-vascular, plasma cell types. Clinically, hyaline-vascular type is rarely associated with systemic symptoms, but the plasma cell type is frequently associated with the constitutional symptoms of fever, malaise, night sweat and the abnormal laboratory markers. Surgical excision of the affected lymph node plays an important role in the treatment of this disease. We encountered a case of the hyaline-vascular type CD located in the mesentery with systemic involvement. The clinical and biochemical abnormal findings improved after surgical resection of the involved lymph node.
Biomarkers ; Child ; Fever ; Giant Lymph Node Hyperplasia* ; Humans ; Lymph Nodes ; Lymphoproliferative Disorders ; Mesentery ; Plasma Cells ; Sweat

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A Case of Successful Treatment of Childhood Intractable Gastrointestinal Hemorrhage with Low Dose Recombinant Activated Factor VII (NovoSeven (R)).

Ji Yoon KIM ; Byung Ho CHOE ; Soonhak KWON ; Kun Soo LEE

Korean Journal of Pediatric Hematology-Oncology.2004;11(2):276-279.

Recombinant activated factor VII (rFVIIa, NovoSeven (R)) was initially developed for the treatment of bleeding in patients with hemophilia having antibodies against factor VIII or IX, and factor VII deficiency. Although the precise mode of action is still elusive and there are just several hypotheses, recently case reports have suggested a role of rFVIIa in the management of intractable or life-threatening bleeding in some non-hemophilic patients who do not respond to conventional treatments. We report the successful use of rFVIIa in a pediatric patient with intractable gastrointestinal bleeding.
Antibodies ; Factor VII Deficiency ; Factor VIIa* ; Factor VIII ; Gastrointestinal Hemorrhage* ; Hemophilia A ; Hemorrhage ; Humans

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Disconnection and Migration of Totally Implanted Vascular Access Devices in Three Pediatric Oncology Patients.

Ji Yoon KIM ; Myung Chul HYUN ; Sang Bum LEE ; Kun Soo LEE

Korean Journal of Pediatric Hematology-Oncology.2004;11(2):271-275.

Totally implanted vascular access devices are excellent for delivering chemotherapeutic agents and prolonged intravenous infusions in patients with cancer. Catheter disconnection and migration are rare but potentially serious complications of these widely used devices. Retrieval of the migrated fragment is generally indicated but may not be possible. We hereby report three cases of catheter disconnection and migration of totally implanted vascular access devices into the heart along with the review of literatures.
Catheters ; Heart ; Humans ; Infusions, Intravenous ; Vascular Access Devices*

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A Case of Ganciclovir-resistant CMV Antigenemia by UL97 Phosphotransferase Mutant Strain after Cord Blood Transplantation.

Young Shil PARK ; Yun Suk JEON ; Bin CHO ; Nak Gyun CHUNG ; Dong Gun LEE ; Su Mi CHOI ; Wan Shik SHIN ; Hack Ki KIM

Korean Journal of Pediatric Hematology-Oncology.2004;11(2):265-270.

Despite the availability of effective antiviral drugs, human cytomegalovirus (CMV) infection is still a serious life-threatening complication in recipients of allogeneic hematopoietic stem cell transplantation. Ganciclovir (GCV) preemptive therapy is currently the usual treatment for CMV disease and antigenemia. However, prolonged GCV therapy results in the emergence of drug-resistant virus. Most GCV-resistant clinical CMV isolates contain a mutation in the UL97 phosphotransferase gene. We report a case that GCV-resistant CMV antigenemia by UL97 phosphotransferase mutant strain at codon 460 and 605 which was improved by reduction of immunosuppressants for posttransplant lymphoproliferative disease after unrelated cord blood transplantation.
Antiviral Agents ; Codon ; Cytomegalovirus ; Fetal Blood* ; Ganciclovir ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppressive Agents

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A Case of Alveolar Soft Part Sarcoma in a Child.

Jee Yong KIM ; Geun Young LEE ; Ok Ran SHIN ; Ju Mee KANG ; Pil Sang JANG ; Dong Un KIM ; Young Hoon KIM ; Jin Tack KIM

Korean Journal of Pediatric Hematology-Oncology.2004;11(2):260-264.

Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor that accounts for 5% of pediatric non-rhabdomyosarcoma soft tissue sarcomas. The disease presents as a indolent asymptomatic mass and affects primarily younger patients. The clinical course is often indolent and late metastases can develop even after prolonged disease-free intervals. Radiotherapy and chemotherapy play a very limited role in the treatment. We report a pediatric case of ASPS with a brief review of the literature.
Child* ; Drug Therapy ; Humans ; Neoplasm Metastasis ; Radiotherapy ; Sarcoma ; Sarcoma, Alveolar Soft Part* ; Viperidae

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