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Chinese Journal of Vaccines and Immunization.2008;0(01):-.

Varicella is an acute,highly contagious respiratory and caused by Varicella-zoster virus(VZV),After the primary infection,VZV induce Varicella,then the virus remains dormant in sensory nerve roots in life.Upon the reactivation,shingles can occur.Most of patients can recovery very soon,but kinds of potentially sever complication can induce death.Nowadays the VZV vaccination isn’t included in the expanded immunization program in our country. Varicella outbreaks take place at times in the middle of children of our country.The paper offers concise description about pathogen characteristics,diagnosis methods,clinical character,epidemiology knowledge and strategy of prevention.

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Study Progress on Hepatitis E

Ting WU ; Lang JIANG

Chinese Journal of Vaccines and Immunization.2008;0(04):-.

10%～20% of acute clinical sporatic hepatitis is hepatitis E (HE). HE has a severe diaease low mortality in general population of about 0.5～1.5%. It has been reported as severe disease and the mortality increased to 20% in pregnant women and old people. China is high-epidemic for hepatitis E virus (HEV). HEV is mainly transmitted through faecaloral route,data also showed that HEV could be transferred through blood donation. The epidemiology,diagnostics and vaccine development of HE is reviewed in this paper.

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The Immunogenicity and Impact Factors of Hepatitis A Attenuated Live Vaccine and Inactivated Vaccine

Hui ZHENG ; Fuqiang CUI

Chinese Journal of Vaccines and Immunization.2008;0(04):-.

Hepatitis A is one of the global public health problems,and China has high prevalence. In order to decrease the incidence of hepatitis A,China has integrated Hepatitis A vaccine into Expanded Program on Immunization (EPI) in 2007. The paper will provide some ideas on the immunogenicity and impact factors of the different types of hepatitis A vaccines that are used in China.

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Analysis and Evaluation on Quality of Live Attenuated Measles Vaccine from Market Surveillance Sampling

Hanhua FANG ; Xiaoxin WANG ; Min YI

Chinese Journal of Vaccines and Immunization.2008;0(06):-.

Objective To ensure the quality of live attenuated measles vaccine on the market,viral titers were determined as the market surveillance test.Methods The measles vaccine was sampled from sites located in 24 provinces (cities,autonomous regions) of China,including provincial CDC,municipal CDC,county CDC,and primary users.The virus titer of samples was tested to evaluate the quality status of measles vaccine on the market.Results For all the 54 lots of measles vaccine sampled in this study,the virus titers were in compliance with the requirements of the China Pharmacopeia Vol.III (2005 edition).In comparison with the original test results provided by the manufacturers,the mean virus titer was decreased 0.2 lg?0.3.Conclusion Viral titers of measles vaccine batches sampled from the market were all in compliance with the requirements of the China Pharmacopeia Vol.III (2005 edition).It showed that the measles vaccine in China market has good stability,and the cold chain system for measles vaccine conveyance and storage could ensure the vaccine efficacy.

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Epidemiological Characteristics of Japanese Encephalitis in Shanghai

Yanting LI ; Yiyi ZHU ; Bihong JIN

Chinese Journal of Vaccines and Immunization.2008;0(06):-.

Objectives To understand the epidemiological characteristics of Japanese Encephalitis in Shanghai and to provide evidence for preventing JE.Methods Epidemic characteristics,JEV antibody in healthy population and swine infection rate in Shanghai were analyzed by methods of field survey,serology and molecular biology.Results JE incident rate in Shanghai was 0.077/100,000 in 2006;and 0.129/100,000 in 2007.Antibody positive rate before JE epidemic fastigium was 60.39%;postive rate after epidemic was 85.44%.JE IgG positive rate was 26.92% in 3-month swine and 14.86% in swine for sale;JE Gene in mosquito was analyzed for type 1.Conclusion The JE prevalence rate is relatively low in Shanghai.JE antibody positive rate is high in Shanghai population.Swine as a media is infected by JE virus.The JE virus in mosquitoes belongs to genotype 1.

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Analysis on Influenza Antibodies Detection Rate and Infected Recently among Infants

Fengjiao HU ; Hongxia NI ; Suli JIAO

Chinese Journal of Vaccines and Immunization.2008;0(06):-.

0.05).Conclusion The group of 13 months age of infants were rarely infected influenza virus in the first time exposure at the age of ≤4 months due to maternal antibodies protection.Whenas,the group of 8 months age who were exposed at the age of ≥5 months,were more easier infected the influenza virus than the group of 13 months age in the first time exposure at the age of ≤4 months.

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Analysis on Coverage of Hepatitis A Vaccine among Pre-school Children in Shandong Province

Bingyu YAN ; Li ZHANG ; Lizhi SONG

Chinese Journal of Vaccines and Immunization.2008;0(06):-.

Objective To reveal the hepatitis A vaccine (HepA) coverage among pre-school children in Shandong province before Hepatitis A vaccine was introduced to the EPI and to provide evidence for improving the strategy for hepatitis A control.Methods A cross-section survey was conducted among children aged between 2 and 6 years old in Shandong province in March 2008.The study population was selected by random sampling method and HepA immunization history was obtained by immunization record or recall.Results 78.90% had received one dose of HepA at least.The coverage rate decreased with age and the differences in three age groups were statistically significant (x 2 =11.54,P=0.02).The coverage rates among the boys and girls were 77.67% and 80.30% respectively,the difference was not significantly(x 2 =1.17,P=0.28).The HepA coverage rates among the children living in the eastern areas and in the richer areas were higher than the centrale and western areas and poverty areas,the difference has statistic significance (x 2 =27.25,58.17,P

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Analysis of Prevalence Season and Trend of Meningococcal Disease by Circular Distribution in China

Guijun NING ; Junhong LI ; Zundong YIN

Chinese Journal of Vaccines and Immunization.2008;0(06):-.

Objective To analyze the prevalence season and trend of meningococcal disease in China by epidemic years from 2004 to 2008 in order to provide scientific basis for making strategies of meningococcal disease prevention and control.Methods The incidence numbers of meningococcal disease were calculated by weeks,epidemic years and areas.The seasonality and prevalence trends of meningococcal disease were analyzed by circular distribution.Results The incidence trend of meningococcal disease had obvious seasonality in China (P

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Analysis on CIinical Characteristics of Adult Measles Inpatients in Urumqi Municipal

Maimaiti MIJITI ; He SUN ; Yan ZHANG

Chinese Journal of Vaccines and Immunization.2008;0(06):-.

Objectives To analyze the clinical and laboratory characteristics,and characteristics of population distribution as well,and to provide the scientific data for the adult measles control.Methods Using descriptive epidemiology and statistical approach to analyze the clinical information for the adult measles patients hospitalized in People's Hospital of Xinjiang Uygur Autonomous Region of Urumqi city in Xinjiang province of China between Oct.2007 and Mar.2008.Results The average age of all the patients was 25.5 years old.63 patients had fever and most of them were at 39.1～40.0℃.61(96.8%) patients had rash,and 54 (85.7%) patients had koplik spots at the moment of hospitalization.26 (41.3%) patients had the complications of acute tracheobronchitis.And the chest radiograph of 28 (44.4%) patients showed the inflammatory shadow.The proportion of the neutrophils of 11 (17.5%) patients was high level in the blood testing.The alanine aminotransferase of 18 (28.6%) patients were elevated.All the patients were recovery.Conclusion More and more adult measles patients occurred in China in recent years.The clinical characteristics among the patients was variable.It is necessary to discuss and make a decision about the issue of supplementary immunization for adult population in China.

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Application of a Simple Method for Detection of Rubella Virus Genome by Loop-mediated Isothermal Amplification (LAMP)

Shuang WANG ; Jianhui ZHOU ; Xiang HOU

Chinese Journal of Vaccines and Immunization.2008;0(06):-.

Objective To use a new simple Reverse Transcription Loop-mediated isothermal amplification(RTLAMP) method was applied to detect rubella virus nucleic acid and compared with Reverse TranscriptionPolymerase Chain Reaction (RT-PCR).Method Comparing the detection rate of the RT-LAMP method with that of RT-PCR for detecting rubella virus nucleic acid from rubella virus.Results The nucleic acid positive rates of all 11 strains of rubella virus were 100% by the two methods,the positive rate was 55%.Conclusion RT-LAMP is more simple and convenient than RT-PCR.

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