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MMP-9 expression in breast cancer metastasis and its clinical significance

International Journal of Biomedical Engineering.2010;33(6):381-384. doi:10.3760/cma.j.issn.1673-4181.2010.06.015

Matrix metallopmteinase 9(MMP-9) is one kind of matrix metalloproteinases and plays a role in the process of breast cancer metastasis. It can not only degrade the basement membrane and the extracellular matrix around tumor tissue but also promote angiogenesis, even create conditions for the growth of tumors, local invasion and distant metastasis. Current study shows that the over-expression of MMP-9 can significantly speed up the breast lymph node metastasis and the relevant research will provide guidance for clinical treatment and prognosis of breast cancer.

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Study on cellular deformation of in vitro osteoblasts' shear stress loading experiment and their mechanotransduction region

Weizhong TENG ; Xizheng ZHANG

International Journal of Biomedical Engineering.2010;33(6):340-342. doi:10.3760/cma.j.issn.1673-4181.2010.06.005

Objective To study the main mechanotransduction area and to estimate the overall shear deformation of rat osteoblasts in shear stress loading experiment based on data acquired from the in vitro rat osteoblast experimental, and to study the effects of four-point bending medium flow generated shear stress on cells. Methods Viscoelastic mechanics theory was used in the calculation process, the standard viscoelastic model was adopted for cells, and shear force on the cellular surface was simplified to be uniform. Results The cellular deformation caused by shear force was about one-tenth of that from tensile loading experiment which induced equivalent biological response. Conclusion In terms of mechanical stimulus induced biological responds, the mechanical transduction caused by cellular deformation in shear stress loading experiment is negligible, and the main transduction area is in the cellular membranes experiencing shear stress.

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Induced pluripotent stem cell inductive system: status quo and future

Jingtao YANG ; Qiang SHE

International Journal of Biomedical Engineering.2010;33(6):372-375. doi:10.3760/cma.j.issn.1673-4181.2010.06.013

Induced pluripotent stem(iPS)-cell technology is a great breakthrough in stem cell research field in recent years, it is not only injecting new vitality for the research of reprogramming of somatic cell, but also bringing a new dawn to the study of mechanism of disease and development of regenerative medicine. As key issues of iPS-cell technology, the study of iPS cell induction system has progressed in the composition of transcription factor, gene delivery, as well as induction efficiency. In this article, research advance of iPS cell induction system in recent years is reviewed and the prospect is discussed as well.

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Research progress of effects of neurotrophic factors in the repair of spinal cord injury

Haizhen ZHOU ; Qixin ZHENG

International Journal of Biomedical Engineering.2010;33(5):309-312. doi:10.3760/cma.j.issn.1673-4181.2010.05.013

Spinal cord injury(SCI) is a serious nervous system trauma,which may consequently lead to various degrees of paralysis and toilet obstacles,and its disability and the high cost heavily burdened the families and community.Therefore,the research on spinal cord tissue regeneration and the repair after injury has important practical significance.A large number of experimental studies have shown that neurotrophic factor plays an important role in the nerve tissue repair process.This article reviews new research progress about the effects of neurotrophic factor in this field.

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Progress in stem cell therapy for Alzheimer's disease

Yudong LIU ; Shenggang SUN

International Journal of Biomedical Engineering.2009;32(5):291-294. doi:10.3760/cma.j.issn.1673-4181.2009.05.009

Stem ceils transplantation is one of the potential therapeutic strategies for Alzheimer's disease (AD). Many animal models following stem cell transplantation showed improvement in memory and cognitive function. However, the pathological changes in AD, such as arnyloid beta deposits, negatively affect the survival and differentiaition of stem cells. Stem cells transfectcd with neprilysin or administration of phenserine could at-tenuate these adverse effects. Genetic modification of stem cell by over expression of neurotrophic factors could attenuate the adverse effects not only on stem cells but also on degenerative neurons. Further investigation on how to overcome the adverse effects of phathological factors in AD on stem cells and maximize the therapeutic effects of stem cells would support the hope for introduction of stem cells transplation into clinical application.

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DSP-based design of family health monitor

Shuqin MENG ; Lei WANG

International Journal of Biomedical Engineering.2009;32(5):280-282. doi:10.3760/cma.j.issn.1673-4181.2009.05.006

Objective To design a new portable vital signs monitor for family use. Methods TMS320F2812, a kind of digital signal processor, was applied as the main processor to control the functional mod-ules including A/D convertor, LCD display. Bluetooth communication module was introduced to achieve real-time fast transfer of data between the system and the PC. Results Not only can the system monitor electrocardiogram (ECG), breath rate, pulse rate, body temperature and other vital signs accurately, but also it runs stably. Conclusion The features of DSP and Bluetooth were well combined in the design of the family-oriented, easy to use, multi-functional monitor with small size, low power consumption and convenience. A broad application and market prospects can be predicted.

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Current development and application of laser therapy equipment

Yingxin LI

International Journal of Biomedical Engineering.2009;32(5):257-261. doi:10.3760/cma.j.issn.1673-4181.2009.05.001

The principal and technique of laser therapy are discoursed upon in chief, current development and application of laser therapy equipment are described by introducing some lasers applied in surgery and medicine such as ophthalmology and photodynamic therapy. Finally, individual view to evolution trend of laser therapy equipment is presented.

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Research progress in minimally invasive treatment of spinal metastatic carcinoma

Xijiang ZHAO ; Xinsheng QI

International Journal of Biomedical Engineering.2009;32(5):317-320. doi:10.3760/cma.j.issn.1673-4181.2009.05.016

With the development of modem tumor diagnostic techniques and therapies, the survival rate of malignant tumor has been remarkably increased. With the increase in survival rate of cancer-beating patients, the chance of tumor metastasis is elevated. Minimally invasive treatment provides a new strategy to the therapy of spinal metastatic carcinoma. Its benefits include smaller surgical wound,, higher efficacy and fewer complications, and thus have a broad application prospects in the field of spinal metastatic tumors. In this article, a general re-view is given on minimally invasive treatments of spinal metastatic carcinoma, as well as the latest progress in the field. It was proposed that the united application of the treatment might be a promising hot spot of tumor therapy.

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Progress in strength, strength testing methods of all-ceramic dental materials

Jingyuan PENG ; Xiaoping LUO

International Journal of Biomedical Engineering.2009;32(5):306-309. doi:10.3760/cma.j.issn.1673-4181.2009.05.013

All-ceramic dental materials could meet the requirements for extraordinary aesthetics and ex-cellent biocompatibility in vivo, thus are widely utilized in prosthetic dentistry. Since the all-ceramic materials have low strength reliability and the disadvantage is recently concerned, the relevant research has been the focus in the area. The purpose of this artical is to review the relevant studies and with focus on the factors that influence the strength including material component, microstructures and manufacture process, as well as strength improv-ing approaches such as ingredient alteration, fabrication optimization and surface treatment. As for various strength testing methods, all the existing test methods are compared and evaluated.

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Progress in genetic models associated with Parkinson's disease

Weixiong ZHANG ; Yuefei SHEN

International Journal of Biomedical Engineering.2009;32(5):313-316. doi:10.3760/cma.j.issn.1673-4181.2009.05.015

Parkinson's disease(PD) is a kind of degenerative disease caused by both genetic and environ-mental factors. Concerning these two factors, various animal models for parkinson's disease were made for the study. Transgenic animal models were made by the method of microinjection, electronic perforation, particle bom-bardment, virus vector transfection and so on, which can express exogenous target gene. These models imitated the process of Parkinson's desease induced by virulence gene and provided a powerful tool for investigation on e-tiopathogenesis, gene therapy and medical intervention. In this article, we reviewed the progress of genetic models associated with PD and theirs contribution to PD research.

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