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Study on the drug during coronary stent in animal

International Journal of Biomedical Engineering.2010;33(3):172-175,后插2. doi:10.3760/cma.j.issn.1673-4181.2010.03.010

Objective To explore the feasibility of clinical application of biodegradable polymer-coated drug-eluting stent. Methods Thirty each of the drug-eluting stent or bare-metal stents were implanted randomly into the anterior descending arteries, circumflex and right canine coronary arteries of thirty healthy pigs. The pathological examination was taken at 2 weeks to 6 months after coronary angiography to investigate the inflammation, thrombosis and endothelialization. Results Macroscopic observation of the stented arteries demonstrated complete incorporation of stent wires into the arterial wall and smooth vessel lumens. There were no significant differences existing between two kinds of the stents in terms of thrombosis, inflammation and endothelialization. The lumen loss in the biodegradable polymer-coated drug-eluting stent group is less than that in the bare-metal stent group. Conclusion The biodegradable polymer-coated drug-eluting stent is promising with good biocom-patibility, blood compatibility and phyaicochemical stability after being implanted into pig coronary arteries. The blood vessel transplanted with the drug-eluting stents maintains a high patency rate due to rapid endothelialization.

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A Study of Transmit-side Frequency Compounding for Elastography by Simulation

Shaoguo CUI ; Caibi PENG ; Juan BAO

International Journal of Biomedical Engineering.2010;33(5):266-269,288. doi:10.3760/cma.j.issn.1673-4181.2010.05.003

Objective No reports has been found to date on whether frequency compounding can improve elastographic image signal to noise ratio (SNRe) and how it affects elastogram performance.In this paper simulations investigation was carried out on transmit-side frequency compounding (TSFC)for elastography.Methods 50 mm×50 mm tissue model was simulated with two round hard inclusions of 10mm diameter uniformly distributed along the tissue central axial line,and their elasticity modulus were 10 times of the background.Then simulation of 3.5 MHz、5 MHz and 7.5 MHz probes were introduced to form compression elastography of the double-lesion model by quasi-static compression method (applied strain 1%).Then,sub-elastograms obtained by the combination of 3.5 MHz and 5 MHz,3.5 MHz and 5 MHz,3.5 MHz and 7.5 MHz were compounded,respectively.Results Before compounding,signal to noise ratio (SNRe) of the various sub-elastograms were 8.42,9.62,10.73,respectively,contrast to noise ratio (CNRe) were 11.35,14.82,18.37,respectively and axial resolutions were 9.83,9.82,9.81.After compounding elastograms,the SNRe were 11.82,13.05,19.45,CNRe were 22.31,27.63,56.12,while axial resolutions were 9.83,9.83,9.83.Conclusion Frequency compounding elastograms have higher SNRe and CNRe than any sub-elastogram before compounding and have no axial resolution loss.The TSFC can improve elastogram performance efficiently and frequency compounding for elastography enhancement is feasible.

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Study on coding working memory event via independent components energies of multichannel local field potentials

Xufei DUAN ; Wenwen BAI ; Xin TIAN

International Journal of Biomedical Engineering.2010;33(2):76-78,82,前插1. doi:10.3760/cma.j.issn.1673-4181.2010.02.003

Objective To investigate how the independent components(ICs)energies of multichannel local field potentials(LFPs) code event base on the analysis of ICA of the cortical LFPs of rats. Methods Taking the event point as the zero point, 15-channel LFPs between the span of ±500ms recorded from the prefrontal cortex of rats were decomposed into 15 ICs. The energies of the ICs were computed in a 50-ms window. By sliding the window with step of 25 ms, a dynamic distribution mapping of the 15 ICs' energies was established. ICs with distinctly increased energies during the span of ±200 ms, which indicating that these ICs energies coded event,were selected as the targets. The corresponding channels of these ICs were determined consequently via the inverse transformation of ICA. Results Considering each trail of the repetitious analysis for the same segment of data, the spatial localization of the dominate function region(s) turned out to be relatively stable in spite of the uncertainty of the number and sequence of the target IC(s) due to the ambiguities of the decomposition of ICA.Meanwhile, the analysis results of a series of data segments showed satisfactory correspondence between data segments and dominate function regions. Conclusion The ICs' energies of multichannel LFPs are able to code events in working memories; It is valid for ICA to identify the coding patterns of multichannel LFPs to events; ICA is capable to localize the dominate function regions of event coding with satisfactory robustness.

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Progress in the study of coronary artery in-stent stenosis

Fengxiang LI

International Journal of Biomedical Engineering.2006;0(04):-.

Coronary stenting played an increasingly important role in the interventional treatment of coronary artery disease. However, in-stent restenosis is one of the major causes that limited the development of the technology. As the mechanism of in-stent restenosis became more and more clear, studies on the prevention of in-stent restenosis became increasingly active, and had gained remarkable achievements. The latest research indicates that drug-eluting stents had more unique application value in the prevention of restenosis, as compared with uncoated coronary stents. Drug-eluting stents significantly reduced the incidence of restenosis, and had broad prospects for application, but long-term treatment outcome required further observation.

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Characteristic pattern of neuron firings at hippocampus CA1 for fast-aging mouse

Xiaobo ZHENG ; Tiaotiao LIU ; Xin TIAN

International Journal of Biomedical Engineering.2010;33(1):24-26,30. doi:10.3760/cma.j.issn.1673-4181.2010.01.006

Objective To investigate the effect of fast-aging on the excitability of hippocampus CA1 neurons in mouse and the possible interaction between fast-aging and hippocampus. Methods Using brain slice and extracellular recording technique to record the firing of hippocampus CA1 neurons in fast-aging(SA M-P/8) and normal control mice, after preprocessing, neural firing train were obtained. Using neural firing rate and inter-spike-inter to investigate interaction between fast-aging and hippocampal neural firing. Results The neural firing rate of hippocampus CA1 neurons in fast-aging mice is (1.052±0.364) Hz(n=14), while the neural firing ratein normal control mice is (4.416±1.306) Hz(n=22). In fast-aging mice, 80.5% inter spike intervel(ISI) is longerthan 1sec, but in normal control mice, 95.6% ISI is shorter than 0.5sec. Conclusion The decreased firing rate of hippocampus CA1 and longer ISI observed in the fast-aging mice indicates that fast-aging significantly inhibit hippocampal CA1 neurons excitability.

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Progress in megnetic nanobead preparation and application in bio-mediacal engineering

Zikai ZHAO ; Guohua HUI ; Yuquan CHEN

International Journal of Biomedical Engineering.2009;32(3):183-185,189. doi:10.3760/cma.j.issn.1673-4181.2009.03.013

As a novel functional material with great application values, magnetic nanobead has been in fast development in recent years. Magnetic nanobead is provided with characteristics of beth polymeric and mag-netic particles, so it can be detected easily fi'om the medium and can be easily located since they can move di-rectionally when motivated by external electric field. The magnetic nanobead is widely used in biomedical engi-neering research due to its unique physical and chemical properties which simplify the complex experiments op-erations and shorten the testing period.

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Research progress of application of human hair keratin materials in regenerative medicine

Shaobo XU ; Jin ZHANG

International Journal of Biomedical Engineering.2013;36(3):189-192,后插1. doi:10.3760/cma.j.issn.1673-4181.2013.03.014

As many naturally-derived proteins,keratins have intrinsic biological activity,good biocompatibility and are biodegradable.Human hair keratins,as one type of the autogenous proteins,also have low immune rejection.Compared to other autogenous materials,human hair keratins come from a variety of sources and show attraction in field of regenerative medicine.The human hair keratins applied in neural implant materials,wound dressing,cell culture substrates,drug delivery system and soft tissue reconstructions,which are based on hydrogels,scaffolds coating,films and composite materials present huge development potential in regenerative medicine.

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Differentiation of mesenchymal stem cells to chondrocytes and its applications in cartilage repair

Lihua WANG ; Yongjun LIU

International Journal of Biomedical Engineering.2010;33(6):363-366,371. doi:10.3760/cma.j.issn.1673-4181.2010.06.011

Articular cartilage as a load-bearing connective tissues may often be caused defects by trauma,sports, degenerative or age-related diseases. As articular cartilage has a limited inherent repair capacity, a large variety of treatment approaches including autologous chondrocyte transplantation, microfracture and mosaicplasty methods have been developed. However, there are limitations in these strategies especially when using autologous chondrcytes. Mesenchymal stem cells are considered the most promising seed cells in the study of tissue engineered cartilage. This review focuses on the induction of mesenchymal stem cells into chondrocytes in vitro and their application in cartilage repair.

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Study of photosensitizers absorbed process by cells based on image processing technology

Zhan SHU ; Yingxin LI ; Jichun YANG ; Hongli CHEN ; Xiaoxi DONG

International Journal of Biomedical Engineering.2012;35(2):-. doi:10.3760/cma.j.issn.1673-4181.2012.02.007

ObjectiveTo study the feasibility of analyzing photosensitizers absorbing process by cells based on image processing technology.MethodsFluorescence images of Laryngeal cells were taken by inverted fluorescence microscope after adding photosensitizers for a certain time.Parameter L that reflects the fluorescence intensity of cells in different times was obtained and the calculation results were compared.ResultsThe fluorescence intensity of cells increased over time.Sobel operater and Otsu algorithm can both reflect the fluorescence intensity of images.ConclusionImage processing technology can effectively analyzes the process of photosensitizers absorbed by cells.

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Time-frequency analysis based on matching pursuit and its application in epilepsy EEG

Wuyang XIAO ; Xuyuan ZHENG

International Journal of Biomedical Engineering.2012;35(1):8-13,17. doi:10.3760/cma.j.issn.1673-4181.2012.01.003

ObjectiveMatching pursuit algorithm(MAP),for its good parametric characterization,was applied in epileptic electroencephalography(EEG) to study time-frequency distribution.MethodsSimulation experiment of time-frequency analysis was carried out to verify the matching pursuit algorithm s superiority on frequency resolution and parametric characterization.Fourier transform,Wigner-Ville distribution and matching pursuit algorithm were applied to the time-frequency analysis on normal EEG and epileptic EEG to study epileptic discharge in the time-frequency plane and the results were compared.ResultsSimulation results showed that the matching pursuit algorithm obtained a better time-frequency distribution.Distributions of epileptic EEG and normal EEG had significant difference in time-frequency plane.ConclusionTime-frequency analysis based on matching pursuit can better reveal the EEG characteristics.

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