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Progress in stem cell therapy for Alzheimer's disease

International Journal of Biomedical Engineering.2009;32(5):291-294. doi:10.3760/cma.j.issn.1673-4181.2009.05.009

Stem ceils transplantation is one of the potential therapeutic strategies for Alzheimer's disease (AD). Many animal models following stem cell transplantation showed improvement in memory and cognitive function. However, the pathological changes in AD, such as arnyloid beta deposits, negatively affect the survival and differentiaition of stem cells. Stem cells transfectcd with neprilysin or administration of phenserine could at-tenuate these adverse effects. Genetic modification of stem cell by over expression of neurotrophic factors could attenuate the adverse effects not only on stem cells but also on degenerative neurons. Further investigation on how to overcome the adverse effects of phathological factors in AD on stem cells and maximize the therapeutic effects of stem cells would support the hope for introduction of stem cells transplation into clinical application.

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DSP-based design of family health monitor

Shuqin MENG ; Lei WANG

International Journal of Biomedical Engineering.2009;32(5):280-282. doi:10.3760/cma.j.issn.1673-4181.2009.05.006

Objective To design a new portable vital signs monitor for family use. Methods TMS320F2812, a kind of digital signal processor, was applied as the main processor to control the functional mod-ules including A/D convertor, LCD display. Bluetooth communication module was introduced to achieve real-time fast transfer of data between the system and the PC. Results Not only can the system monitor electrocardiogram (ECG), breath rate, pulse rate, body temperature and other vital signs accurately, but also it runs stably. Conclusion The features of DSP and Bluetooth were well combined in the design of the family-oriented, easy to use, multi-functional monitor with small size, low power consumption and convenience. A broad application and market prospects can be predicted.

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Current development and application of laser therapy equipment

Yingxin LI

International Journal of Biomedical Engineering.2009;32(5):257-261. doi:10.3760/cma.j.issn.1673-4181.2009.05.001

The principal and technique of laser therapy are discoursed upon in chief, current development and application of laser therapy equipment are described by introducing some lasers applied in surgery and medicine such as ophthalmology and photodynamic therapy. Finally, individual view to evolution trend of laser therapy equipment is presented.

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Research progress in minimally invasive treatment of spinal metastatic carcinoma

Xijiang ZHAO ; Xinsheng QI

International Journal of Biomedical Engineering.2009;32(5):317-320. doi:10.3760/cma.j.issn.1673-4181.2009.05.016

With the development of modem tumor diagnostic techniques and therapies, the survival rate of malignant tumor has been remarkably increased. With the increase in survival rate of cancer-beating patients, the chance of tumor metastasis is elevated. Minimally invasive treatment provides a new strategy to the therapy of spinal metastatic carcinoma. Its benefits include smaller surgical wound,, higher efficacy and fewer complications, and thus have a broad application prospects in the field of spinal metastatic tumors. In this article, a general re-view is given on minimally invasive treatments of spinal metastatic carcinoma, as well as the latest progress in the field. It was proposed that the united application of the treatment might be a promising hot spot of tumor therapy.

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Progress in strength, strength testing methods of all-ceramic dental materials

Jingyuan PENG ; Xiaoping LUO

International Journal of Biomedical Engineering.2009;32(5):306-309. doi:10.3760/cma.j.issn.1673-4181.2009.05.013

All-ceramic dental materials could meet the requirements for extraordinary aesthetics and ex-cellent biocompatibility in vivo, thus are widely utilized in prosthetic dentistry. Since the all-ceramic materials have low strength reliability and the disadvantage is recently concerned, the relevant research has been the focus in the area. The purpose of this artical is to review the relevant studies and with focus on the factors that influence the strength including material component, microstructures and manufacture process, as well as strength improv-ing approaches such as ingredient alteration, fabrication optimization and surface treatment. As for various strength testing methods, all the existing test methods are compared and evaluated.

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Progress in genetic models associated with Parkinson's disease

Weixiong ZHANG ; Yuefei SHEN

International Journal of Biomedical Engineering.2009;32(5):313-316. doi:10.3760/cma.j.issn.1673-4181.2009.05.015

Parkinson's disease(PD) is a kind of degenerative disease caused by both genetic and environ-mental factors. Concerning these two factors, various animal models for parkinson's disease were made for the study. Transgenic animal models were made by the method of microinjection, electronic perforation, particle bom-bardment, virus vector transfection and so on, which can express exogenous target gene. These models imitated the process of Parkinson's desease induced by virulence gene and provided a powerful tool for investigation on e-tiopathogenesis, gene therapy and medical intervention. In this article, we reviewed the progress of genetic models associated with PD and theirs contribution to PD research.

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A quadrature demodulation method based on DSP Builder and the circuit design used in EIT

You WU ; Hong SHA ; Chaoshi REN

International Journal of Biomedical Engineering.2009;32(5):276-279. doi:10.3760/cma.j.issn.1673-4181.2009.05.005

Objective To design and develop a quadrature demodulation circuit for detection of ampli-tude and phase information in EIT measurement. Methods A model structure file was built in matlab/simulink using the elements in Ahera DSP Builder and verified by simulated stimulation. Then the model file was convert-ed to VHDL file via Signal Compiler, and the synthesis, adaptation, simulation and hardware implementation were accomplished. Results The simulation and testing results show that the circuit can extract the real and imagi-nary information of the measured signal and it also meets the EIT measuring requirement, with acceptable mea-sure error. Conclusion The demodulation circuit based on DSP Builder can precisely give real and imaginary information of EIT and provides technological support for full-information complex impedance measurement.

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Research status on the effect of surface treatment of titanium & titanium alloy on bonding strength

Xiao LIU ; Xiaoping LUO

International Journal of Biomedical Engineering.2009;32(4):244-246. doi:10.3760/cma.j.issn.1673-4181.2009.04.013

Titanium & titanium alloy are popular in dentistry as dental material because of their good mechanical properties and extremely good biocompatibility. The bonding strength between the titanium and the resin agent is the decisive factor in evaluating the success of resin-bonded restoration. Appropriate surface treatment on the titanium is an effective way to reinforce the bending strength. The purpose of this review is to summarise the relevant studies and introduce some latest findings.

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Evaluation of the sterilizing efficiency on absorbable poly-L-lactide screws with two sterilants

Yuexiong YANG ; Weihong YANG ; Jing LI

International Journal of Biomedical Engineering.2009;32(4):201-205. doi:10.3760/cma.j.issn.1673-4181.2009.04.003

Objective To evaluate the sterilizing efficiency ofabscrbable poly-L-lactide (PLLA) screws sterilized with ethylene oxide and 60Co-γ radial. Methods One group of PLLA screws was sterilized in the ethylene oxide sterilization ease. In order to eliminate the rudimental ethylene oxide, the sterilized screws was put in the air for five days. The other group of PLLA screws was sterilized with 60Co-γ radial with absorbable dose of 15 kGy. Then all sterilized screws were characterized. Results Compared with the primal bend intensity of the PLLA screws, the bend intensity of sterilized screws did not descend remarkably (P＞0.05). Compared with the primal molecular weight of the PLLA screws, the molecular weight of screws with 60Co-γ radiation sterilization re-markably decreased 11%. It indicated that the material had degraded. The molecular weight of screws with ethylene oxide sterilization ordy decreased 3%. It indicated that the material didn't degrade obviously. Conclusion Ethylene oxide sterilization is a better way for sterilizing absorbable PLLA screws.

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Roles of basic fibroblast growth factor in the seft-renewal of human embryonic stem cells

Yanwei WANG ; Jianyuan LI

International Journal of Biomedical Engineering.2009;32(4):251-255. doi:10.3760/cma.j.issn.1673-4181.2009.04.015

The self-renewal and multi-lineage developmental potential are the unique properties of human embryonic stem(ES) cells. The growth factors that maintain human or mouse embryonic stem cells are different. Leuckemia inhibitory factor(LIF) does not maintain self-renewal of human ES cells(hESCs). Recently, a few growth factors have been found to be biologically relevant for hESCs functions in vitro, among them the basic fibroblast growth factor(bFGF) is one of the most significant regulators of hESCs self-renewal. The purpose of this review is to introduce the recent progress in the research on the expressions of bFGF and its receptors and their functions in hESCs.

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