Coronary stenting played an increasingly important role in the interventional treatment of coronary artery disease. However, in-stent restenosis is one of the major causes that limited the development of the technology. As the mechanism of in-stent restenosis became more and more clear, studies on the prevention of in-stent restenosis became increasingly active, and had gained remarkable achievements. The latest research indicates that drug-eluting stents had more unique application value in the prevention of restenosis, as compared with uncoated coronary stents. Drug-eluting stents significantly reduced the incidence of restenosis, and had broad prospects for application, but long-term treatment outcome required further observation.