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Researeh on resveratrol's effect in suppressing growth and inducing apoptosis of lens epithelial cells

Qin FENG ; Qiang WU ; Bin LU ; Qinjin CHEN

Chinese Journal of Primary Medicine and Pharmacy.2008;15(2):264-266,后插3.

Objective To explore the contribution of resveratrol(Res)to the proliferation and apoptosis of lens epithelial cells in vitro.Methods Methyl thiazolyl tetrazolium(MTT)assay was used to measure its effects on the proliferation of lens epithelial cells cultured with different concentrations of Res for 24h,48h and 72 h.HE staining,transmission electron microscope(TEM),TUNEL fluorescence staining and the Annexin V assay by flow cytometer(FCM)were applied to observe the ceumorphological change detect the apoptosis induced by Res quantitatively.Results Res obviously suppressed the proliferation(P＜0.01)and induced the apoptosis of lens epithelial cells in concentration-dependent manner.The rate of apoptosis in control was 4.67%,and 17.31%,32.77%after having been treated with 100μmol/L and 200μmol/L Res for 24h,respectively.Conclusion The results of this study confirm the ability of Res to suppress the growth and the proliferation of lens epithelial cells with a typical apoptotm feature in vitro.Therefore,Res might be considered as a possible treatment strategy for after-cataract.

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Diagnosis of leiomyomatous tumor of gastrointestinal tract by CT

Jingchang LIU ; Hongtao LIU ; Xuehua GONG

Chinese Journal of Primary Medicine and Pharmacy.2011;18(11):1482-1483,后插1. doi:10.3760/cma.j.issn.1008-6706.2011.11.021

Objective To explore the CT manifestation and the diagnostic value of leiomyomatous tmnor of gastrointestinal tract in 8 patients.Methods 8 patients with gastrointestinnal tract leiomyoma tumor were scaned with GE HISPEED CT/I.proceeding to scan with contrast agent when detected and ascertained the nidus.Results There were 4 eases gastric smooth muscle tumors in 8 patients,and 1 case was leiomyosarcoma of stomach,1 case was duodenal muscle tumors,1 case as jejuna muscle tumors and another is leiomyosarcoma of jejunum.Conclusion The location,contour and characteristic of imaging is important standard of leiomyomatous tumor of gastrointestinal tract.

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CT features and differential diagnosis of focal nodular hyperplasia of the liver

Dong CHEN ; Heng PAN ; Changnong XIE

Chinese Journal of Primary Medicine and Pharmacy.2009;16(1):6-7,后插4. doi:10.3760/cma.j.issn.1008-6706.2009.01.003

Objective To discuss the appearances of focal nodular hyperplasia(FNH) of the liver on the muhiphase helical CT scanning, and to improve its diagnostic accuracy with CT. Methods Helical CT scanning of pre- and post- contrast arterial phase,portal venous phase and delayed phase was performed in 10 cases with surgically and pathologically proved FNH. Results On pre- contrast scans,9 of 11 FNH lesions were hypodense(either homo-geneous or non-homogeneous), the other two lesions were isodense. On the arterial phase scans, all lesions were markedly and homogeneously enhanced,except for the central scar area. Tortuous and dilated arteries were seen at the center or peripheral area in 3 out of 11 lesions. On the portal phase and delayed phase scans ,4 of 11 lesions turned to isedanse of slightly hypodense,7 lesions remained slightly hyperdense. Central scar was found in 8 FNH lesions ,2 of them showed no enhancement while the other six demonstrated late enhancement. Conclusion Mulfiphase helical CT scanning can fully reflect the blood supplying and pathologic features of FNH, and it is of great value in diagnosing and differentiating FNH.

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The function of kinney damage in patient with kidney stone by extracorporeal shock wave lithotripsy method

Jie LI

Chinese Journal of Primary Medicine and Pharmacy.2006;0(04):-.

Objective To discuss the change and the regulation of tumornecrosis factor(TNF-?) and epidermal growth factor(EGF) before and after extracorporeal shock wave lithotripsy.Method Radioimmunoassay was used to measure TNF-? in 50 cases urine sample before and after ESWL.Results TNF-? level in urine after ESWL were increased significantly at 1～4d(t=2.82,P

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Total mesorectal excision and single stapling technique in low positioned rectal cancer

Zhiqiang ZHANG

Chinese Journal of Primary Medicine and Pharmacy.2006;0(04):-.

Objective To evaluate the effect of total mesorectal excision with single stapling technique for low positioned rectal cancer.Methods Based on total mesorectal excision,56 cases of low positioned rectal cancer underwent anal preserving operation with single stapling technique and purse-string forceps.The 2 years follow-up result was retrospectively analyzed on radical resection effect,defecating function,complication rate and recurrent rate.Results All the resection margins were clear and had no intraoperative death,anastomotic leakage or occurrence of incontinence.Anastomotic stricture rate was 4%(2/56) and local recurrent rate was 5%(3/56).The patients were satisfied with anal function.Conclusion Based on total mesorectal excision,anal preserving operation for low positioned rectal cancers using single stapling technique and purse-string forceps can improve the postoperative quality of life,that is safe,feasible,practical and economical.

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Compaprision of hepatocellular carcinoma with tomor thromin in portal vein by different treatment method

Benqiang HUANG

Chinese Journal of Primary Medicine and Pharmacy.2006;0(01):-.

Objective To study the effective methods of treatment and life quality for hepatocellular carcinoma(HCC) with tomor thromin in portavein(TTPV).Methods 30 cases with HCC,according to different treatment methods were divided into 3 groups,to evaluate the life quality by gastrointestinal life quality index(GLQI).Results A group survival rates of one year,two years and three years were 100%,40% and 20%,respect-tively;B group survival rates of one year and two years were 40%,and 0%,respectively;C group survival rates of one year and two years were 20%,and 0%,respectively;The mean preoperative GLQI score was (106?13).It significantly decreased from the 2nd to 10th week after operations(P

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Ganglioneuroblastoma:three cases report and review of the literature

Xiaohong SUN

Chinese Journal of Primary Medicine and Pharmacy.2005;0(11):-.

Objective To explore the clinicopathologic features,histological classification,prognosis and diag- nosis of ganglioneuroblasroma (GNB).Methods Histopathologic appearance,immunohistiehemical stainings were observed and analyzed in three cases of GNB.The associated literature were reviewed.Results The characteristics of GNB was detected that there was gangliocytes in component of differentiated neuroblastic tumour ceils.Immunohisti- chemical staining showed the tumor cells were positive for NF,NSE and CgA,and negative for S-100 protein,LCA, CD99 and Syn.Conclusions GNB is an uncommon tumour with poor outcome which composed of gangliocytes and neuroblastoma.To make a histological classification according to age,the ratio of neuroblastic tumour component and the differation of GNB will be very useful in clinical therapy and prognostic evaluation.

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Diagnosis value of vascular ultrasound examination in detection of carotid artery disease

Hongchun ZHANG ; Tao PENG ; Lei GUO

Chinese Journal of Primary Medicine and Pharmacy.2010;17(17):2324-2325,后插一. doi:10.3760/cma.j.issn.1008-6706.2010.17.010

Objective To study the clinical value of vascular ultrasound examination in detection of carotid artery disease. Methods 53 cases of ischemic cerebrovascular disease who served as experimental group,tested 387 vessels; and used the same period 55 cases of healthy persons as control group, tested 394 blood vessels. Comparison of two blood flow parameters between groups with differences in plaque detection. Results The results of vascular ultrasound examination could detect the visual display and quantitative carotid artery lesions in the experimental group a significant thickening of carotid artery IMT,carotid artery plaque prevalence was significantly higher than control group (P ＜0.01). Conclusion Vascular ultrasound examination was an effective screening method to detect ischemic cerebrovascular disease.

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Study on the risk factors of premature rupture of membranes

Zhiquan LI ; Chenhong WANG

Chinese Journal of Primary Medicine and Pharmacy.2010;17(12):1633-1635,后插二. doi:10.3760/cma.j.issn.1008-6706.2010.12.024

Objective To investigate the risk factors of incidence of premature rupture of membranes and provide reference for prevention of premature rupture of membranes.Methods 890 cases of infants and maternal were studied,analyzing and screening the risk factors of premature rupture of membranes by Logistic.Results The single-factor analysis showed that the pregnant women with diabetes,pregnancy-induced hypertension,multiple preg-nancy and vaginifis had certain degree of contact with incidence of premature rupture of membranes.Multivariate Lo-gistic regression analysis showed that the multiple pregnancy and vaginitis were risk factors of incidence of premature rupture of membranes.Conclusion The multiple pregnancy and vaginitis were risk factors of incidence of premature rapture of membranes,assessment and control these risk factors could prevent and reduce the incidence of premature rupture of membranes.

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Effect of Shen-fu injection on pulmonary contusion rabbits

Hongjun ZHU ; Shudong YU ; Jingkang HE ; Shiqi LU

Chinese Journal of Primary Medicine and Pharmacy.2009;16(9):1542-1543,插1. doi:10.3760/cma.j.issn.1008-6706.2009.09.003

Objective To investigate the effects of Shen-fu injection on pulmonary contusion rabbits. Meth-ods Sixteen rabbits were randomly divided into 2 groups: the treatment group (Shen-fu group) and the control group. The animals were induced the pulmonary contusion models. After 60min, the animals in Shen-fu group re-ceived Shen-fu injection received 5 ml/kg, and those in control group 5 ml/kg LRS. The animals were killed six hours later, the right lung tissue wet-to-dry (W/D) ratio and myeloperoxidase (MPO) activity were obtained,the pro-tein expression of nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) were also detec-ted. Results The lung tissue W/D, MPO, and the protein expression of NF-κB and ICAM-1 were decreased evi-dently in Shen-fu group (P<0. 01). The morphologic and ultrastructural damages in Shen-fu group were milder than in control group. Conclusion Shen-fu injection is effective on pulmonary contusion rabbits.

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