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The effects of Ozagrel sodium on plasma levels of brain natriuretic peptide and IL-18 in patients with unstable angina pectoris

Juntang ZHANG

Chinese Journal of Primary Medicine and Pharmacy.2010;17(17):2371-2372. doi:10.3760/cma.j.issn.1008-6706.2010.17.033

Objective To study the treatment effect of Ozagrel sodiumin on plasma levels of BNP and IL-18in patients with unstable angina pectoris. Methods 106 patients with unstable angina pectoris were treated randomly with routine therapy(n =40) and with routine therapy plus Ozagrel sodium(n = 66) for 2 weeks. Before and after 2weeks of the therapy,the changes of BNP and IL-18 were measured. Results After 2 weeks,the levels of BNP and IL-18 in routine therapy group and Ozagrel sodium treatment group were decreased than those before treatment,but after 2 weeks of the therapy,BNP and IL-18 were significantly decreased in candesartan treatment group compared with those in the control group(P ＜0. 05). Conclusion On the basic of general treatment,using the Ozagrel sodium could lower the serum levels of BNP and IL-18 in UAP,and improve stability of atherosclerosis plaque.

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Experimental study on Lamivudine combined with Saikosaponins in anti-hepatitis B virus

Shaopeng LI ; Jiajia YAN

Chinese Journal of Primary Medicine and Pharmacy.2010;17(17):2346-2347. doi:10.3760/cma.j.issn.1008-6706.2010.17.021

Objective To study the effect of anti-hepatitis B virus of Lamivudine combined with Saikosaponins in vivo. Methods Chongqing duck hepatitis B model was selected and given to Lamivudine combined with Saikosaponins(combined group) oral treatment 28d, then the ducks were observed 7d after drug withdrawal. The levels of serum HBV DNA, HBsAg and transaminase(ALT, AST) were detected before and after treatment, and compared with that in Lamivudine group and Saikosaponins group as control. Results In combined group,the levels of serum HBV DNA and HbsAg were significantly decreased(P ＜ 0.05), and 7d after drug withdrawal the levels of serum HBV DNA and HBsAg showed no" anti-jump" compared with that at drug treatment 28d(P ＞ 0.05). In Lamivudine group and Saikosaponins group the levels of those increased again 7d after drug withdrawal (P ＜ 0. 05). In each group the levels of serum ALT and AST did not change within the same phase during drug treatment 28d and 7d after drug withdrawal(P ＞ 0. 05). Conclusion Lamivudine combined with Saikosaponins in vivo had the effect of anti-hepatitis Bvirus, and the effect was stable and lasting.

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Analysis of the surgery of 96 patients with hedge brain injury at frontotemporal bottom

Lei WEI ; Heng WANG ; Keqiang WANG ; Jiansong GUO

Chinese Journal of Primary Medicine and Pharmacy.2010;17(17):2342-2343. doi:10.3760/cma.j.issn.1008-6706.2010.17.019

Objective To explore the method and the clinical effects of surgical treatment for severe hedge brain injury at frontotemporal bottom. Methods 96 patients with severe hedge brain injury at frontotemporal bottom were scored by GOS before surgery. Then unilateral or bilateral craniotomy was carried out,via a large flap incision in the site of frontotemporal and parietal hair,and the blood clots within the surgical fieldand the inactivation brain tissue having been fell off were removed, and the contusion lesions of brain bottom were exposed, and the inactivation brain tissue was cleared. If the brain injury was serious ,the removal of frontal pole and temporal pole should be proper. Discretion to The removing or replacing the bone flap should be based on consideration of the circumstances. Six nonths or one year after injury,96 patients were scored by GOS again. Results There were 17 cases of grade Ⅰ(17.71%) ,11 cases of gradeⅡ (11.46%),13 cases of gradeⅢ (13.54%),21 cases of grade Ⅳ(21.86%),34 cases of grade Ⅴ (35.42%) in 96 patients. Conclusion Early surgical treatment of severe hedge brain injury at frontotemporal bottom could improve the cure rate and reduce the rate of disability.

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Clinical observation of postoperative chemotherapy combined with tianzhicao capsule in breast cancer

Shuxin WEI ; Jun LIU ; Ming LU

Chinese Journal of Primary Medicine and Pharmacy.2010;17(17):2340-2341. doi:10.3760/cma.j.issn.1008-6706.2010.17.018

Objective To observe attenuation and synergy of postoperative chemotherapy combined with Tianzhicao capsule in patients who suffered from breast cancer. Methods 66 cases after radical mastectomy were randomly divided into treatment group 31 cases and 35 cases of control group. The patients of control group were treated with chemotherapies of CAF and TA. Treatment group patients were given Tianzhical capsule orally at the same time. Nausea and vomitting,the arrest of bone marrow before and after treatment were observed. The grade of life quality about every patient was evaluated. Results Myelosuppression and the occurrence of nausea and vomitting in treatment group was obviously lower than control group (P ＜ 0.05). The proportion of improvement and stabilization for the quality of life in treatment group was markedly higher than control group (P ＜ 0.05). Conclusion Traditional Chinese drug Tianzhicao capsule had attenuation and synergy to postoperative chemotherapy in breast cancer.

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Clinical analysis of laryngeal mask airway anesthesia and endotracheal intubation anesthesia

Siguang HU ; Wenling LIU ; Sheyang HUANG

Chinese Journal of Primary Medicine and Pharmacy.2010;17(17):2334-2335. doi:10.3760/cma.j.issn.1008-6706.2010.17.015

Objective To study the safety and efficacy of laryngeal mask airway(LMA) used in breast cancer general anesthesia. Methods Forty ASA Ⅰ or Ⅱ patients with breast cancer scheduled for selective radical mastectomy under general anesthesia were allocated randomly to either laryngeal mask airway group(group A,n =20) or tracheal tube group(group B, n = 20). SBP, DBP, HR, SpO2 of patients before anesthesia(To)/after intubation immediately (T1) and 5 minutes(T2) after intubation tracheal tube or laryngeal mask intubation/after extubation immediately (T3) and 5 minutes(T4) of after extubation tracheal tube or laryngeal mask were recorded. The different incidence of anesthetic complications and side effect were observed in both groups because intubation and extubation. Results In group B, SBP, DBP and HR were significantly higher than those in group A at T1 and T3 (P ＜ 0.05). Agitation, bucking and pharyngodynia incidence rate in group B were significantly higher than group A(P ＜ 0.05). Conclusion Ventilation with LMA in patients underwent breast cancer radical correction was better than endotracheal intubation general anesthesia in keeping stable hemodynamics and producing less anesthetic complications.

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Therapeutic Effect of Trimetazidine on Patients with Alcohol Cardiomyopathy

Jingli YUAN

Chinese Journal of Primary Medicine and Pharmacy.2010;17(17):2322-2323. doi:10.3760/cma.j.issn.1008-6706.2010.17.009

Objective To observe the therapeutic effect of Trimetazidine on patients with alcohol cardiomyopathy based on conventional medicine. Methods 46 cases with alcoholic cardiomyopathy were randomly divided into congroup (22 cases) and observation group(24 cases), they were given conventional therapy and additional Trimetazidine for 4 weeks respectively, we estimated therapeutic effect based on 6 min walking experiments, left entricular ejection fraction, and the content of C-reactive protein. Results The results of 6 min walking experiments (543.5 ±69.3) vs (492.7 ± 72.7),left ventricular ejection fraction (44.3 ± 8.6) vs (49.8 ± 9.5) and C-reactive protein content (5.2 ± 0.7) vs (8.9 ± 1.1) in observation group were better than control group. Conclusion Additional Trimetazidine could improve cardiac function by improving cardiacenergy metabolism and anti-inflammatory effect on alcohol cardiomyopathy patients ,Trimetazidine was of great value to generalization.

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Analysis of the related factors of local recurrence in patients with rectal cancer after Dixon operation

Haibin WANG ; Qi YU ; Chaoying GAO

Chinese Journal of Primary Medicine and Pharmacy.2010;17(18):2476-2478. doi:10.3760/cma.j.issn.1008-6706.2010.18.014

Objective To analyze the related factors of local recurrence in patients with rectal cancer after Dixon operation. Methods A retrospective analysis of clinical data of 100 patients from September 2005 to September 2007 in our hospital by TME standard surgicai treatment of low rectal cancer was carried out. Results Of 100 patients, the pre-sacral recurrence rate was 10. 0%, with gender, age, tumor size, tunor invasion lumen circumference,depth of invasion,lymph node metastasis and Duke's stage has nothing to do with the gross type,histological type and lumen,peritoneal tumor cell shedding,and as an independent prognostic factor. Of 90 patients without local recurrence,the 5-year survival rate was 76. 0% ,haff of the survival of 62 months;10 cases of local recurrence,5-year survival rate was 5. 0%, half of the survival of 24 months, suggested that local recurrence in patients influenced the prognosis. Conclusion The low local recurrence of rectal cancer related factors were gross type,histological type and the intestine, peritoneal tumor cells shed, seriously affect the prognosis of patients with local recurrence.

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Comparative study on the clinical efficacy of triple needling and conventional acupuncture in the treatment of cervical spondylosis of vertebral artery type

Shangzhen GAO ; Yanling LI ; Xiaoning ZHANG ; Xuyun ZHOU

Chinese Journal of Primary Medicine and Pharmacy.2010;17(18):2464-2465. doi:10.3760/cma.j.issn.1008-6706.2010.18.008

Objective To compare the clinical efficacy of triple needling and conventional acupuncture in the treatment of cervical spondylosis of vertebral artery type. Methods 49 cases with cervical spondylosis of vertebral artery type were randomly divided into two groups ,24 patients of control group treated with conventional acupuncture,25 patients of observation group treated with triple needling,the clinical results of two groups were compared. Results The obvious effective rate of the observation group was significantly higher than the control group, there were significant differences between two groups( x2 =4. 69 ,P < 0. 05). The improvement of average flow velocity(Vm) of the observation group was better than the control group, there was significant difference between two groups ( P < 0. 05 ).Conclusion Triple needling in the treatment of cervical spondylosis of vertebral artery type had better clinical results, and it was worthy of concern.

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Clinical significance of interleukin-1 、interleukin-8 and tumor necrosis factor-α levels in herniated intervertebral disc

Jingchao LI

Chinese Journal of Primary Medicine and Pharmacy.2010;17(18):2456-2457. doi:10.3760/cma.j.issn.1008-6706.2010.18.004

Objective To detect the levels of interleukin-1 (IL-1) ,interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α) in herniated intervertebral disc,and discuss the role of IL-1 、IL-8 and TNF-α in the course of the intervertebral disc degeneration and to clarify the mechanism of the lumbar intervertebral disc degeneration and herniation. Methods The medium was analyzed subsequently for the production of IL-1 、IL-8 and TNF-α in the control group and herniation group ( experiment group). Results The levels of IL-1 、 IL-8 and TNF-α in the experiment group were ( 71.35 ± 11.23 ) μg/L, (7.33 ± 2.45 ) μg/L, ( 6.54 ± 2.67 ) μg/L; The levels of IL-1 、 IL-8 and TNF-αin the control group were(28.58 ± 12.25) μg/L, (2.35 ± 1.15 ) μg/L, ( 3.33 ± 1.45 ) μg/L. The levels of IL-1 、IL-8 and TNF-α in the experiment group were obviously higher than that in the control group. There was statistical significance (P < 0. 01 ). Conclusion There was obvious relationship between the levels of IL-1 、IL-8 and TNF-α in herniated intervertebral disc and disc degeneration. The increase of the levels of IL-1 、IL-8 and TNF-α could be the cause of intervertebral disc herniation and disc degeneration.

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Psychological changes after receiving comprehensive interventional therapy and the effect of psychological intervention on carcinoma patients

Yingxue HUA ; Hua JIANG ; Lichang ZHU ; Huijuan LI ; Dinghua CHEN

Chinese Journal of Primary Medicine and Pharmacy.2010;17(18):2454-2456. doi:10.3760/cma.j.issn.1008-6706.2010.18.003

Objective To study the psychological changes and the effect of psychological intervention and to discuss the influence of psychological rehabilitation on carcinoma patients after comprehensive interventional therapy.Methods 100 carcinoma patients were divided into two groups randomly:the psychological intervention group(50 casea) received both psychological intervention therapy and comprehensive intervention therapy;the control group (50 cases) received only comprehensive interventional therapy;Curative effects were assessed with the Symptom Checklist90(SCL-90) ,the Self Rating Depression Scale(SDS) and the Self Rating Anxiety Scale(SAS) for each patient. Results For the psychological intervention group, SCL-90 scores after therapy was significantly lower than that before therapy ( P < 0. 05 ), and were also significantly lower than that ( without anxiety agent) of the control group. The scores of SDS and SAS in post-therapy patients were significantly lower than that of pre-therapy patients in the psychological intervention group. The scores of SDS had no statistical difference between post-therapy patients and pre-therapy patients in the control group. The scores of SAS in post-therapy patients was significantly lower than that of pre-therapy patients in the control group. Both scores of SDS and SAS in the control group were significantly higher than that of the psychological intervention group after therapy. Conclusion Psychological intervention for carcinoma patients after comprehensive interventional therapy played an promotional role in psychological rehabilitation in the community.

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