Objective To observe clinical efficacy of the combination of Chinese and Western medicine in treatment of neonatal jaundice.Methods 86 cases of jaundice in children with jaundice were randomly divided into study group and control group.Two groups of children were treated with TCM and Western medicine treatment of children in this study group was added based on the decoction of Chinese medicine treatment,two courses,the effects and relevant indicators were compared.Results Compared with the control group,the study group had the markedly effective rate and total effective rate was significantly improved,but not markedly lower,there were statistically significant differences(χ2 = 4.67,5.06,all P＜0.05);At the same time,the study group the average daily value of bilirubin decreased markedly,while the time spent doing back jaundice was significantly lower,there were statistically significant difference(t = 2.91,3.91,all P＜0.05).Conclusion Combination of Chinese and Western medicine in treatment of neonatal jaundice disease,could improve clinical syndrome quickly,and had good effect.