Journal Detail Information

1

Cite

Share

Response of fetal rat calvarial cells on mineral trioxide aggregate after IL-1beta stimulation.

Sool Heon LEE ; Ji Il PARK ; Young Joon KIM

The Journal of the Korean Academy of Periodontology.2009;39(3):359-365. doi:10.5051/jkape.2009.39.3.359

PURPOSE: The purpose of this study was to investigate the ability of Mineral trioxide aggregate(MTA) to support osteoclastic differentiation from fetal rat calvarial cell. METHODS: In this study, response of IL-6, RANKL, and OPG in fetal rat calvarial cells stimulated with IL-1beta on MTA was evaluated by ELISA and RT-PCR. RESULTS: The results were as follows; there was no significant difference between glass and MTA at 5days. In ELISA analysis, Glass group and MTA group showed similar IL-6 expression, Glass+IL-1beta group and MTA+IL-1beta group showed similar IL-6 expression. In RT-PCR analysis, Glass group and MTA group showed similar IL-6, RANKL, OPG mRNA expression, MTA+IL-1beta group and Glass+IL-1beta group showed 3 fold increase of IL-6 and RNAKL mRNA expression when compared with MTA group. All groups showed similar OPG mRNA expression. CONCLUSIONS: MTA does not suppress cell proliferation and increase the proinflammatory cytokine that induce osteoclastogenesis. Thus, MTA is biocompatible material that could be used in various clinical conditions.
Aluminum Compounds ; Animals ; Biocompatible Materials ; Calcium Compounds ; Cell Proliferation ; Cytokines ; Drug Combinations ; Enzyme-Linked Immunosorbent Assay ; Glass ; Glutamates ; Guanine ; Interleukin-6 ; Osteoclasts ; Oxides ; Rats ; RNA, Messenger ; Silicates ; Pemetrexed

2

Cite

Share

The effect of the freeze dried bone allograft and gel/putty type demineralized bone matrix on osseous regeneration in the rat calvarial defects.

Deug Han KIM ; Ji Youn HONG ; Eun Kyoung PANG

The Journal of the Korean Academy of Periodontology.2009;39(3):349-358. doi:10.5051/jkape.2009.39.3.349

PURPOSE: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix on osseous regeneration in the rat calvarial defects. METHODS: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft(SureOss(TM)), Demineralized Bone Matrix(ExFuse(TM)Gel, ExFuse(TM)Putty), or were left untreated for sham-surgery control and were evaluated by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was done between each groups and time intervals with ANOVA and paired t-test. RESULTS: Defect closure, New bone area, Augmented area in the SureOss(TM), ExFuse(TM) Gel, ExFuse(TM) Putty groups were significantly greater than in the sham-surgery control group at each healing interval(P<0.05). In the New bone area and Defect closure, there were no significant difference between experimental groups. Augmented area in the ExFuse(TM) Gel, ExFuse(TM) Putty groups were significantly greater than SureOss(TM) group at 2weeks(P<0.05), however there was no significant difference at 8 weeks. CONCLUSIONS: All of SureOss(TM), ExFuse(TM) Gel, ExFuse(TM) Putty groups showed significant new bone formation and augmentation in the calvarial defect model.
Alveolar Bone Loss ; Animals ; Bone Matrix ; Bone Regeneration ; Bone Transplantation ; Humans ; Male ; Osteogenesis ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Transplantation, Homologous

3

Cite

Share

Non-submerged type implant stability analysis during initial healing period by resonance frequency analysis.

Deug Han KIM ; Eun Kyoung PANG ; Chang Sung KIM ; Seong Ho CHOI ; Kyoo Sung CHO

The Journal of the Korean Academy of Periodontology.2009;39(3):339-348. doi:10.5051/jkape.2009.39.3.339

PURPOSE: The purpose of the present study was to analyze the implant stability quotient(ISQ) values for Korean non-submerged type implant and determine the factors that affect implant stability. METHODS: A total of 49 Korean non-submerged type implants were installed in 24 patients, and their stability was measured by resonance frequency analysis(RFA) at the time of surgery, and 1, 2, 3, 4, 8, 12 weeks postoperatively. The data for implant site, age, sex, implant length and diameter, graft performing, bone type, and insertion torque were analyzed. RESULTS: The lowest mean stability measurement was at 3 weeks. There was significant difference between implant placement and 12 weeks. There was significant difference between implant placement and 12 weeks in diameters of 4.1 mm and 4.8 mm. Also, there were significant differences between diameters of 4.1 mm and 4.8 mm at implant placement and 12 weeks after surgery. This result suggests that the factor related to implant diameter may affect the level of implant stability. No statistically significant relationship was found between the resonance frequency analysis and the variables of maxilla/mandible, sex, anterior/posterior, implant length, age of patient, graft performing, bone type, insertion torque during initial healing period. CONCLUSIONS: These findings suggest that the factor related to implant diameter may affect the variance of implant stability, and ISQ value of implant was stable enough for proved stability level during initial healing period.
Bone Regeneration ; Dental Implants ; Humans ; Osseointegration ; Torque ; Transplants

4

Cite

Share

Induction of IL-8 and reactive oxygen species in periodontal ligament cells by Aggregatibacter actinomycetemcomitans.

Yang Sin LEE ; Hong Gyu PARK ; Sung Whan KIM ; Jeong Heon CHA ; Yun Jung YOO

The Journal of the Korean Academy of Periodontology.2009;39(3):331-337. doi:10.5051/jkape.2009.39.3.331

PURPOSE: Interleukin (IL)-8 is one of pro-inflammatory cytokines. Reactive oxygen species (ROS) are reduced metabolites of O2. Aggregatibacter actinomycetemcomitans is one of representative periodontopathogens. To investigate the role of A. actinomycetemcomitans in IL-8 expression of periodontal ligament (PDL) cells, we estimated the production of IL-8 and ROS in A. actinomycetemcomitans treated PDL cells. METHODS: The IL-8 production was determined by enzyme-linked immunosorbent assay. The ROS production was estimated using H2DCFDA and FACS. RESULTS: A. actinomycetemcomitans increased the production of IL-8 and ROS at 10, 100, and 500 multiplicity of infection. N-cetylcysteine, an antioxidant of ROS, down-regulated the production of IL-8 induced by A. actinomycetemcomitans. CONCLUSION: These results suggest that A. actinomycetemcomitans induces IL-8 production and ROS may act as a mediator in this process.
Cytokines ; Enzyme-Linked Immunosorbent Assay ; Fluoresceins ; Interleukin-8 ; Interleukins ; Periodontal Ligament ; Reactive Oxygen Species

5

Cite

Share

The effects of bone regeneration in rabbit calvarial defect with particulated and block type of hydroxyapatite.

Sun Ja GU ; Joo Yeon SOHN ; Hyun Chang LIM ; Yoo Jung UM ; Ui Won JUNG ; Chang Sung KIM ; Yong Keun LEE ; Seong Ho CHOI

The Journal of the Korean Academy of Periodontology.2009;39(3):321-329. doi:10.5051/jkape.2009.39.3.321

PURPOSE: The purpose of this study was to evaluate the bone regeneration of particulated hydroxyapatite(HA) and block type of hydroxyapatite graft in rabbit calvarial defects. METHODS: An 8 mm calvarial circular defects were created in sixteen young adult New Zealand white male rabbits (weight 3.0~3.5 kg). Each defects were filled with Bio-Oss, particulated HA and block type HA. Sham surgery control defects were filled with blood clots. The pecimens were harvested at 4 weeks and 8 weeks for histologic and histomorphometric evaluation. RESULTS: Histomorphometric analysis demonstrated statistical differences in defect closure, new bone formation, and bone density of the four groups. Block type of HA group showed increased bone formation and bone density at 4 weeks and 8 weeks compared with Bio-Oss group or sham surgery control group(p<0.05). CONCLUSIONS: Block type of HA is an effective material for osteoconduction in rabbit calvarial defects, which may acts as a guide in use of these products in human application.
Bone Density ; Bone Regeneration ; Bone Substitutes ; Durapatite ; Humans ; Hydroxyapatites ; Male ; Minerals ; New Zealand ; Osteogenesis ; Rabbits ; Salicylamides ; Transplants ; Young Adult

6

Cite

Share

A retrospective study of the dental implants placed in the controlled diabetes mellitus patients.

Young Hee KIM ; Yoo Jung UM ; Ui Won JUNG ; Chang Sung KIM ; Kyu Sung CHO ; Seong Ho CHOI

The Journal of the Korean Academy of Periodontology.2009;39(3):311-320. doi:10.5051/jkape.2009.39.3.311

PURPOSE: The aim of the present study was to analyze 7-year cumulative survival rate (CSR, %) of dental implants in the controlled diabetic patients and to evaluate the influence of the position, diameter and length of fixture, bone quality, age, gender and the method of maxillary sinus elevation on the survival rate. METHODS: The data of 342 placed implants in the 104 diabetic patients collected between 1995 and 2007 at the Department of Periodontology in Yonsei University Hospital were analyzed. RESULTS: Seven-year CSR of the 342 dental implants in the 104 controlled diabetic patients was 96.5%. The survival rates of the placed implants according the position have no statistically significant difference. The survival rates according to the length or diameter of the fixtures have no statistically significant difference. The survival rates according to the bone quality were 100% (Type I), 97.1% (Type II), 97.7% (Type III) and 85.7%(Type IV). The difference between the survival rate of Type I, II and III and that of Type IV was statistically significant. The survival rates according to patient gender were 96.8% (male), 95.5% (female). The survival rates according to patient age were 100% (< or = 59), 93.8% (> or = 60). The survival rates according to the method of sinus elevation in the maxillary posterior area were 96.8% (without sinus elevation), 92.9% (lateral approach) and 89.8% (crestal approach). CONCLUSIONS: Dental implants can be used successfully in the controlled diabetic patients. In case of upper posterior region which has poor bone density and older patients, the implant treatment should be more properly planed, executed, and followed-up.
Bone Density ; Dental Implants ; Diabetes Mellitus ; Humans ; Maxillary Sinus ; Retrospective Studies ; Survival Rate

7

Cite

Share

The effect of chlorhexidine on reduction of viable organisms in aerosol produced by ultrasonic scaler.

Woo Kyung SON ; Seung Yun SHIN ; Seung Beom KYE ; Seung Min YANG

The Journal of the Korean Academy of Periodontology.2009;39(3):303-310. doi:10.5051/jkape.2009.39.3.303

PURPOSE: The aerosol generated by ultrasonic scaler can contain bacteria or virus which can penetrate into body through respiratory systems of dentists, dental hygienist or patients. The aim of this study is to evaluate the effect of chlorhexidine digluconate as preoperative mouthrinse or lavage for ultrasonic scaler on the reduction of viable organisms in aerosol produced during periodontal treatment using ultrasonic scaler. METHODS: 30 patients with moderate chronic periodontitis were included and divided into 3 groups: Control (no preoperative mouthrinse and tap water as lavage), CHG (preoperative mouthrinse with 0.1% chlorhexidine digluconate and tap water as lavage), CHL (no reoperative mouthrinse and 0.1% chlorhexidine digluconate as lavage). Each patient received scaling or subgingival curettage for 30 min. In CHG group, mouthrinse with chlorhexidine digluconate was performed for 1 min. before treatment. Before, during and after scaling or subgingival curettage, air sampling was performed for 7 min. each (1000 L/7 min.) with trypticase-soy agar plate. Agar plates were incubated in 37degrees C aerobically. The numbers of colony-forming units (CFU) were counted and compared. RESULTS: The numbers of CFUs of the samples obtained during treatment were 97+/-14.0 in control, 73.1+/-14.9 in CHG group and 44.5+/-9.0 in CHL group. The difference among the 3 groups was determined to be statistically significant (one-way ANOVA with Bonferroni's correction, p-value: 0.0003). In contrast, the numbers of CFU of samples obtained before and after treatment were not significantly different among the groups. CONCLUSIONS: Chlorhexidine digluconate used as preoperative mouthrinse or lavage for ultrasonic scaler can reduce the microorganisms in aerosol produced during periodontal treatment using ultrasonic scaler. Less number of microorganisms were detected when chlorhexidine was used as lavage for ultrasonic scaler.
Aerosols ; Agar ; Bacteria ; Chlorhexidine ; Chronic Periodontitis ; Dental Hygienists ; Dentists ; Humans ; Respiratory System ; Stem Cells ; Subgingival Curettage ; Therapeutic Irrigation ; Ultrasonic Therapy ; Ultrasonics ; Viruses ; Water

8

Cite

Share

The retrospective study of survival rate of implants with maxillary sinus floor elevation.

Jeoung A YU ; Sang Min LEE ; Mi Kyung YOO ; Ui Won JUNG ; Chang Sung KIM ; Seong Ho CHOI ; Pil Kyoo PARK ; Kyoo Sung CHO

The Journal of the Korean Academy of Periodontology.2009;39(3):293-301. doi:10.5051/jkape.2009.39.3.293

PURPOSE: The purpose of this study is to show the total survival rate of implants with maxillary sinus floor elevation and the effects that reach the survival rate by classifying types of graft materials, implant surface, operation method, bone height. METHODS: In a total of 131 patients, 251 implants with sinus floor elevation were installed simultaneously or after regular healing. Various bone grafts (autograft, xonograft, allograft, alloplast) and implant surface (MTX-HA implant, chemical etching implant, Titanium oxide surface implant, resorbable blasting media implant, resorbable blast texturing implant, HA-coated implant) were used. All implants were investigated clinically and radiographically, being with 1 to 5 years follow-up period after installation. RESULTS: The survival rate of 251 implants with maxillary sinus floor elevation was 94%. The types of implant, surface, graft material, bone height have no statistically signi-ficant differencies. CONCLUSIONS: It can be suggested that maxillary sinus floor elevation may have predictable result with various bone graft materials and implant surface.
Dental Implants ; Floors and Floorcoverings ; Follow-Up Studies ; Humans ; Maxillary Sinus ; Retrospective Studies ; Survival Rate ; Titanium ; Transplantation, Homologous ; Transplants

9

Cite

Share

The effects of noncrystalline calcium phosphate glass on the healing of 1-wall intrabony defects in beagle dogs.

Dong Hoon BAIK ; Sung Joon HWANG ; Chang Sung KIM ; Yong Keun LEE ; Kyoo Sung CHO ; Jung Kiu CHAI ; Chong Kwan KIM ; Seong Ho CHOI

The Journal of the Korean Academy of Periodontology.2004;34(1):113-126. doi:10.5051/jkape.2004.34.1.113

No abstract available.
Animals ; Calcium* ; Dogs* ; Glass*

10

Cite

Share

The Comparison between the success rates of single implants replacing the mandibular first and second molar.

Hang Bin LEE ; Jung Won PAIK ; Chang Sung KIM ; Seong Ho CHOI ; Keun Woo LEE ; Kyoo Sung CHO

The Journal of the Korean Academy of Periodontology.2004;34(1):101-112. doi:10.5051/jkape.2004.34.1.101

Osseointegrated implnats have proven to be successful in both full and partial edentulous patients since the 1960s and recently have shown successful results when used to restore single tooth missing. However, in most studies reporting the success of single implants, single implants replacing anterior teeth are more frequently mentioned than posterior single implants. Moreover, in studies regarding posterior single implants, the replaced region seemed to be variable; the maxilla, mandible and areas from the first premolar to the second molar were mentioned. However, considering the difference in bone quality in the mandible and maxilla, and the increased occlusal force in the posterior region, the success rates in each region may be different. In this study, the cumulative success rates and amount of bone loss of single implants replacing the mandibular first and second molar, respectively, were compared and analyzed to come to the following conclusion. 1. The 20 (20 persons) single implants that were placed in the mandibular first molar region were all successful and showed a 100% 5 year cumulative success rate. Among the 27 (24 persons) single implants replacing the mandibular second molar, 8 failed (27.63%) showing a 5 year cumulative success rate of 70.37%. 2. Among the 8 failed implants, one showed symptoms of postoperative infection and one complained of parenthesia. 6 implants failed after functional loading; 5 showed mobility and one resulted in fixture fracture. 3. After the attachment of the prosthesis, there was no significant statistical difference regarding the marginal bone loss in group 1 and group 2 during the checkup period (P>0.05). In conclusion, restoration of the mandibular first molar using single implants was found to be an excellent treatment modality, and when replacing mandibular second molars with single implants, poor bone quality and risk of overloading must be considered.
Bicuspid ; Bite Force ; Humans ; Mandible ; Maxilla ; Molar* ; Prostheses and Implants ; Tooth

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share