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Effects of some herbal drugs on gingival fibroblast and periodontal ligament cellular activity.

Jin Soo DOO ; Jung Ku KANG ; Hyung Keun YOU ; Hyung Shik SHIN

The Journal of the Korean Academy of Periodontology.1997;27(3):459-468. doi:10.5051/jkape.1997.27.3.459

Healing of periodontal tissues require the migration and proliferation of gingival fibroblasts and periodontal ligament cells. There is many evidences that the some agents like cytokines and polypeptide growth factors are mediate these cellular events in wound healing. Recently someone is interested in herbal drugs on periodontal tissue healing processes. The purpose of this study was to examine the effects of 4 herbal drugs, Carthami Flis, Moutan Radicis Cortex, Scirpi Rhisoma, Seed of Carthamus tinctorius L. on human gingival fibroblasts and periodontal ligament cells. Periodontal ligament cells and gingival fibroblasts were primarily cultured from extracted premolar with non-periodontal diseases. The powder from extracted herbal drugs were prepared with distilled water. Cells were cultured with DMEM at 37degrees C, 5% CO2, 100% humidity incubator, and treated with each herbal drugs with proper concentration for 1, 2, and 3 days. The cell activity was determined by ELISA reader using MTT assay. There was the most significant elevation in 10(-3)g/ml of almost herbal drugs on cellular activities. The result of this study demonstrated that Carthami Flis, Moutan Radicis Cortex, Scirpi Rhisoma, Seed of Carthamus tinctorius L. appears to have beneficial effect on healing process after periodontal treatment.
Bicuspid ; Carthamus tinctorius ; Cytokines ; Enzyme-Linked Immunosorbent Assay ; Fibroblasts* ; Humans ; Humidity ; Incubators ; Intercellular Signaling Peptides and Proteins ; Periodontal Ligament* ; Water ; Wound Healing

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Effects of Ethanolic Extracts of Scutellaria Radix on the alveolar bone formation in the extract socket of rat.

Joon Bong PARK ; Yeek HERR ; Young Hyuk KWON ; Ki Hwan BAE ; Chong Pyung CHUNG

The Journal of the Korean Academy of Periodontology.1997;27(3):443-457. doi:10.5051/jkape.1997.27.3.443

The purpose of this study was to evaluate the effects of ethanolic extracts of Scutellaria Radix on the alveolar bone formation in the extract socket of rat. Thirty-six Sprague-dawley rats were used in this study. Mean body weight of rat was 130+/-5g. Experimental animal were administered 0.4% beta-aminopropionitril(Sigma, USA) with the solid commercial food for 5 days. All the maxillary 1st molar of the rats were extracted by using of the tissue forcep under the general anesthesia with Pentobarbital sodium(Tokyo Chemical Co., Japan) injection into intraperitoneal space. All the extracted rats were divided into two group, experimental group which were feeded the solid food mixed ethanolic extracts of Scutellaria Radix, and control group which were feeded same food without reagent. At 1, 3, 5, 7, 9 and 14th days after tooth extraction, rats in both groups were serially sacrificed respectively. All the specimen were treated as usual method and prepared Hematoxylin-eosin stain for the light microscopic observation. The results were as follows : 1. Bone formation of extracted socket starts from the area on remained periodontal ligament than other area. 2. In the case of administration of the extracted Scutellaria Radix showed rapid healing process of connective tissue than non-administrated group. 3. In the case of administration of the extracted Scutellaria Radixshowed rapid osteogenesis than non-administrated With above results, it was concluded that ethanolic extracts of Scutellaria Radix may play a favorable role on the healing process of exatraction socket after extraction in rats. It was suggested that further study to evaluate the different concentration and administration method of ethanolic extracts of the Scutellaria Radix into same experimental model.
Anesthesia, General ; Animals ; Body Weight ; Connective Tissue ; Ethanol* ; Models, Theoretical ; Molar ; Osteogenesis* ; Pentobarbital ; Periodontal Ligament ; Rats* ; Rats, Sprague-Dawley ; Scutellaria* ; Surgical Instruments ; Tooth Extraction

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The Distribution of Implant Patients and the Type of Implant Site.

Ji Eun PARK ; Jeong Ho YUN ; Ui Won JUNG ; Kyoo Sung CHO ; Jung Kiu CHAI ; Chong Kwan KIM ; Seong Ho CHOI

The Journal of the Korean Academy of Periodontology.2004;34(4):819-836. doi:10.5051/jkape.2004.34.4.819

Nowdays, the awareness of implant treatment has grown rapidly among dentists and patients alike in Korea, as it becomes a widely accepted treatment. The reason is that unlike crown and bridge or denture treatment, implant treatment helps preserve existing bone and improve masticatory functions. So, It is needed understanding about the type, distribution of implant patient. The following results on patient type and implant distribution were compiled from 4433 implant cases of 1596 patients treated at the periodontal dept. of Y University Hospital during 1992 to 2004. 1. There are no dissimilarities between men and women, with patients in their 40, 50s accounting for 52.5% of patients and 57.5% of implant treatments; the largest share of patients and implant treatments. 2. Mn. posterior area accounted for 54.9% of implant treatments followed by Mx. posterior area(27.6%), Mx anterior area(11.9%) and Mn anterior area(5.6%). 3. Partial edentulous patients treated by single crown and bridge-type prosthesis accounted for 97.5% and fully edentulous patient accounted for the remaining 2.5%. 4. The major cause of tooth loss is periodontal disease, followed by dental caries, trauma and congenital missing. Also, older people are more likely to suffer from tooth loss due to periodontal disease rather than dental caries. 5. In the distribution of bone quality for maxillae, type III was most, followed by type II, r type IV and r type I. As for mandible, type II was most, followed by type III, type IV and for type I. 6. In the distribution of bone quantity for maxillae, type C was most, followed by type B, type D, type A, and for type E. As for mandible, type B was 52% most, followed by type C, type D, type A and type E. 7. The majority of implants were those of 10-14mm in length (85.2%) and regular diameter in width (64%). The results provided us with basic data on patient type, implant distribution, bone condition, etc. We wish that our results coupled with other research data helps assist in the further study for better implant success/survival rates, etc.
Crowns ; Dental Caries ; Dentists ; Dentures ; Female ; Humans ; Korea ; Male ; Mandible ; Maxilla ; Periodontal Diseases ; Prostheses and Implants ; Tooth Loss

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A study on the mechanism of NO-induced apoptosis in human gingival fibroblast.

Kang Moon KIM ; Hyun Ju CHUNG ; Won Jae KIM

The Journal of the Korean Academy of Periodontology.2004;34(4):807-818. doi:10.5051/jkape.2004.34.4.807

No abstract available.
Apoptosis* ; Fibroblasts* ; Humans*

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The Effects of Dichloromethane fraction of Phlomodis Radix(DFPR) on differentiation of Mouse Calvarial Cell.

Dong Jin KIM ; Jeong Ho YUN ; Ui Won JUNG ; Yun Jung YOO ; Yun Chul KIM ; Hyung Keun YOU ; Chong Kwan KIM ; Sung Ho CHOI

The Journal of the Korean Academy of Periodontology.2004;34(4):791-805. doi:10.5051/jkape.2004.34.4.791

The purpose of this study was to evaluate the effects of DFPR on differentiation of mouse calvarial cell in vitro, to examine the possibility for periodontal regeneration. 10microgram/ml of DFPR was used as experimental concentration. osteogenic medium only was assigned as control, Experimental 1 was supplemented with 10nM dexamethasone, Experimental 2 with 10microgram/ml DFPR and Experimental 3 with 10nM dexamethasone + 10microgram/ml DFPR. cellular activity was evaluated by MTT method at 8, 12, 16 days, expression of mRNA of ALP, osteopontin, osteocalcin, collagen type-1 was detected by RT-PCR method at 4, 8, 12, 16 days of culture . extent of mineralization was observed by Von Kossa staining at 16 day of culture. The results are as follows 1)Any acceleration of differentiation was not observed at expression of differentiation marker, 2) Decrease in expression of extracelluar matrix and in bone nodule formation was observed The results suggested that DFPR have negative effect on the rate of differentiation on rat calvarial cell, decrease extracelluar matrix formation ,decrease bone nodule formation. Ongoing studies are necessary in order to determine effect of DFPR on periodontal regeneration.
Acceleration ; Animals ; Collagen ; Dexamethasone ; Methylene Chloride* ; Mice* ; Osteocalcin ; Osteopontin ; Rats ; Regeneration ; RNA, Messenger

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Transforming growth factor (TGF)-beta1 conjugated chitosan film for enhanced osteoblastic activity.

Yoon Jeong PARK ; Jue Yeon LEE ; Kyung Hwa KIM ; Tae Il KIM ; Myung Hee LEE ; Seung Yoon SHIN ; Yang Jo SEOL ; Yong Moo LEE ; In Chul RHYU ; Young KU ; Soo Boo HAN ; Byung Moo MIN ; Seung Jin LEE ; Chong Pyoung CHUNG

The Journal of the Korean Academy of Periodontology.2004;34(4):781-790. doi:10.5051/jkape.2004.34.4.781

No abstract available.
Chitosan* ; Osteoblasts* ; Transforming Growth Factor beta1 ; Transforming Growth Factors*

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Effects of the MnCl2 on bone formation in fetal rat calvarial cell.

Woong Taek HAN ; De Zhe CIU ; Young Joon KIM ; Hyun Ju CHUNG ; Ok Su KIM

The Journal of the Korean Academy of Periodontology.2004;34(4):771-780. doi:10.5051/jkape.2004.34.4.771

Chronic exposure to high levels of manganese (Mn) leads a pronounced and debilitating disorder known as manganism. Research on the toxic manifestation of manganese have focused primarily on its neurological effects because exposure to high levels of the metal produces a distinct and irreversible extrapyramidal dysfunction resembling the dystonic movements associated with Parkinson's physiological and biochemical systems in the body. The purpose of this study is to determine the effects of Mn on mineralization in primary rat calvarial cells. The experimental groups were in concentration of 0, 10, 30 and 60 micrometer. The results were as follows: 1. ALP activity was decreased in concentration of 30 and 60 micrometer (p<0.01). 2. Bone nodule formation was depressed in concentration of 30 and 60 micrometer at day 14 and 21 (p<0.01). 3. RT-PCR results showed an altered expression of bone matrix proteins. These result suggested that manganese might decrease or alter the expression of the osteoblast phenotype.
Animals ; Bone Matrix ; Manganese ; Osteoblasts ; Osteogenesis* ; Phenotype ; Rats*

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CTG and restoration in treatment of gingival recession associated with a cervical lesion: report of three cases.

Eun Suk KIM ; Jin Woo PARK ; Jo Young SUH ; Jae Mok LEE

The Journal of the Korean Academy of Periodontology.2009;39(4):437-441. doi:10.5051/jkape.2009.39.4.437

PURPOSE: The purpose of this report is to show three cases treated by an intergrated periodontal and restorative dentistry approach. METHODS: Three patients with Miller Class I gingiva recessions associated with cervical lesions were enrolled for treatment. Two patients received a connective tissue graft and resin modified glass ionomer, and one patient was treated with a connective tissue graft, resin restoration. Keratinized gingiva and relative gingival recession were measured. RESULTS: The mean reduction of relative gingival recession was 3.7 mm, and the mean keratinized gingiva increase was 2.5 mm. The percentage of root coverage was 80% in average. No signs of gingival inflammation or bleeding on probing were seen. The patients were satisfied with the final esthetics and had no more dentin hypersensitivity. CONCLUSIONS: This report indicates that teeth with Miller Class I gingival recession associated with cervical lesions can be successfully treated by a connective tissue graft combined with restorative dentistry. However, longitudinal randomized controlled clinical trials must be performed to support this approach.
Acrylic Resins ; Connective Tissue ; Dentin Sensitivity ; Dentistry ; Esthetics ; Gingiva ; Gingival Recession ; Glass ; Glass Ionomer Cements ; Hemorrhage ; Humans ; Inflammation ; Keratins ; Silicon Dioxide ; Tooth ; Tooth Abrasion ; Transplants

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Long-term evaluation of autotransplanted third molars.

Dong Seok SHIN ; Jin Woo PARK ; Jo Young SUH ; Jae Mok LEE

The Journal of the Korean Academy of Periodontology.2009;39(4):431-435. doi:10.5051/jkape.2009.39.4.431

PURPOSE: The purpose of this study is to evaluate the long term clinical and radiographic outcome and stability after transplantation of third molar with complete root formation. METHODS: The subjects were 31 teeth (male 17, female 14, aged 22-55, average 39.9 yr old) of 31 patients who visited the department of periodontics and passed more than two years after autotransplantation procedure and still under regular check up. Modified success criteria of Chamberlin and Goerig was applied to determine the success of autotransplantation. RESULTS: Three out of 31 teeth failed and resulted 90.3% of success rate. When compared according to sex, 15 out of 17 teeth had succeeded in male, 13 out of 14 succeeded in female. When compared the success rate according to cause of extraction, tooth loss due to caries and root fracture had all succeeded but 3 out of 24 had failed in tooth loss due to periodontal disease. When compared according to donor teeth, 12 out of 14 maxillary third molars and 16 out of 17 mandibular third molars had succeeded. CONCLUSIONS: In long term evaluation over two years, if appropriate surgical procedure and proper case selection is made, autotransplantation of the third molar with complete root formation can be the alternative choice that substitutes prosthetic or implant treatment and it is a functionally acceptable procedure.
Aged ; Female ; Humans ; Male ; Molar, Third ; Periodontal Diseases ; Periodontics ; Tissue Donors ; Tooth ; Tooth Extraction ; Tooth Loss ; Transplants

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Treatment of periodontal lesion caused by palatogingival groove in maxillary lateral incisor: case reports.

Sun Ha KIM ; Jin Woo PARK ; Jo Young SUH ; Jae Mok LEE

The Journal of the Korean Academy of Periodontology.2009;39(4):425-429. doi:10.5051/jkape.2009.39.4.425

PURPOSE: The palatogingival groove is a developmental anomaly of the incisor teeth, which often presents severe localized periodontal disease. The purpose of this study was to evaluate the clinical outcome of palatogingival groove-associated periodontal lesion following flap operation with glass ionomer filling. METHODS: Four patients with periodontal lesion associated with the palatogingival groove were chosen for this case study. Clinical indices were taken and radiographic exam was performed at the baseline of the study and four patients were treated by flap operation with GI filling. Post-surgical visits were scheduled at regular intervals to check clinical and radiographic changes. RESULTS: Symptoms and signs of periodontal lesion were almost completely resolved with improvement of periodontal indices CONCLUSIONS: Flap operation with direct glass ionomer restoration is thought to be an acceptable method which can produce favorable results in the treatment of periodontal lesion caused by palatogingival groove on the maxillary lateral incisor.
Acrylic Resins ; Glass ; Glass Ionomer Cements ; Humans ; Incisor ; Periodontal Diseases ; Periodontal Index ; Silicon Dioxide ; Tooth ; Tooth Abnormalities

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