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The effect of periodontal therapy on the gingival thickness in patients with drug-induced gingival enlargement.

Won Kyung KIM ; Jin BAEK ; Young Kyoo LEE

The Journal of the Korean Academy of Periodontology.2005;35(4):1109-1125. doi:10.5051/jkape.2005.35.4.1109

The purpose of this study was to observe the effects of periodontal therapy, including nonsurgical periodontal therapy with azithromycin, surgical therapy, and maintenace therapy on the drug-induced gingival enlargement, by means of measuring gingival thickness. The test group of 18 patients with drug-induced gingival enlargement received scaling, root planing with azithromycin for 5 days, with or without surgical periodontal treatment. The control group of 18 patients who had not taken any medication, received scaling and root planing, with or without surgical periodontal treatment. Both groups received supportive periodontal therapy every 3 months for 2 years. The mean period of total treatment is 32 months in the test group and 31 months in the control group. The thickness of the buccal gingiva was measured using an ultrasonic device of SDM(R)(Krupp Corp., Essen, Germany). The results revealed that the test group(1.21+/-0.51mm) showed statistically thicker buccal gingiva than the control group(1.01+/-0.3mm). In the test group, the buccal gingiva was thickest on 2nd molars and was thinnest on canines of both dental arches. In the control group, the buccal gingiva was thickest on central incisors in the maxilla and 2nd molars in the mandible, while the thinnest areas were on canines in the maxilla and 1st premolars in the mandible. It would be concluded that the periodontal treatment with azithromycin aids in decreasing the degree of the gingival enlargement but cannot prevent the recurrence completely.
Azithromycin ; Bicuspid ; Dental Arch ; Dental Scaling ; Gingiva ; Humans ; Incisor ; Mandible ; Maxilla ; Molar ; Recurrence ; Root Planing ; Ultrasonics

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Osteoblastic differentiation of adult stem cells by Biphasic Calcium Phosphate.

Myoung Ku LEE ; Sung Woo LIM ; Sung Hee PI ; Yun Sang KIM ; Hyung Shik SHIN ; Hyoung Keun YOU

The Journal of the Korean Academy of Periodontology.2005;35(4):1097-1108. doi:10.5051/jkape.2005.35.4.1097

The present study was to determine the influence of micro-macro biphasic calcium phosphate(MBCP) on proliferation and differentiation of human marrow-derived mesenchymal stem cells. Primary stem cells were cultured from bone marrow and 3-4 passaged cells were used. This study tested the proliferative effects by cell counting. Collagen sythensis, alkaline phosphatase activity, expression of osteocalcin and bone sialoprotein by Western blot analysis were evaluated. The cellular proliferation of ASC was not influenced by MBCP. Collagen synthesis of ASC cultured on MBCP significantly increased at 5th and 7th days(p<0.05). The ALP activity in ASC cultured on MBCP significantly increased at 5th and 7th days(p<0.05). The expression of OC and BSP incresaed in ASC cultured on MBCP. These results suggest that MBCP may stimulates the osteoblastic activity of ASC.
Adult Stem Cells* ; Adult* ; Alkaline Phosphatase ; Blotting, Western ; Bone Marrow ; Calcium* ; Cell Count ; Cell Proliferation ; Collagen ; Humans ; Integrin-Binding Sialoprotein ; Mesenchymal Stromal Cells ; Osteoblasts* ; Osteocalcin ; Stem Cells

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Nitric oxide production and inducible nitric oxide synthase expression induced by Porphyromonas gingivalis lipopolysaccharide.

Eun Young PAEK ; Eun Young CHOI ; Jeom Il CHOI ; Ju Yun LEE ; Sung Jo KIM

The Journal of the Korean Academy of Periodontology.2005;35(4):1081-1095. doi:10.5051/jkape.2005.35.4.1081

No abstract available.
Nitric Oxide Synthase Type II* ; Nitric Oxide* ; Porphyromonas gingivalis* ; Porphyromonas*

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The Healing of Exposed Implant Surfaces in A Maxillary Sinus Cavity.

Seoung Ho LEE ; Byung Ho CHOI ; Shi Jiang ZHU ; Jae Hyung JUNG ; Tae Min YOU ; Hyeon Jung LEE ; Jingxu LI ; Jin Young HUH

The Journal of the Korean Academy of Periodontology.2005;35(4):1073-1079. doi:10.5051/jkape.2005.35.4.1073

OBJECTIVE: The aim of this study was to investigate whether dental implant exposure to the maxillary sinus cavity increases the risk of maxillary sinus complications. STUDY DESIGN: An implant was placed bilaterally in the maxillary sinus of eight adult female mongrel dogs in a way that it penetrated the bone and mucous membrane of the maxillary sinus floor to the extent of 2 mm, 4 mm, or 8 mm. The implants were left in place for six months. RESULTS: Radiographic and histologic examinations did not show any signs of pathologic findings in the maxillary sinus of the eight dogs. CONCLUSION: This study indicates that implant protrusion into the maxillary sinus cavity is not related to the development of sinus complications.
Adult ; Animals ; Dental Implants ; Dogs ; Female ; Humans ; Maxillary Sinus* ; Mucous Membrane

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Suppressive effect of Curcuma xanthorrhiza oil on plaque and gingivitis.

Ji Youn HONG ; Sang Nyun KIM ; Won Ho HA ; Sug Youn CHANG ; In Kwon JANG ; Ji Eun PARK ; Sung Won JUNG ; Yoo Jung UM ; Chong Kwan KIM

The Journal of the Korean Academy of Periodontology.2005;35(4):1053-1071. doi:10.5051/jkape.2005.35.4.1053

To find out the suppressive effect of natural extract Curcuma xanthorrhiza on IL-1beta and MMP-2 derived from periodontal ligament cells through in vitro study and to confirm its effect on plaque and gingivitis through clinical study, Curcuma xanthorrhiza containing toothpaste was used and following results were produced. 1. In vitro study, type IV collagenase MMP-2 production was inhibited dose-dependently in the group treated with Curcuma xanthorrhiza compared to the control group. 2. In vitro study, the production of IL-1beta which is one of the inflammatory mediators associated with periodontitis was inhibited dose-dependently in the group treated with Curcuma xanthorrhiza. 3. On the third week, the plaque index of the groups treated with or without Curcuma xanthorrhiza containing toothpastes were both increased significantly compared to the baseline(p<0.05). 4. On the third week, the gingival index of the group treated with Curcuma xanthorrhiza containing toothpaste was not significantly different from baseline. However, the group treated without Curcuma xanthorrhiza containing toothpaste showed a significant increase of gingival index at shielded area(p<0.05). 5. The gingival index of the group without Curcuma xanthorrhiza containing toothpaste showed a significant increase in the sites without tooth brushing when compared to sites with tooth brushing(p<0.05). However, there was no significant difference for the group with Curcuma xanthorrhiza containing toothpaste in sites either with or without tooth brushing. 6. The Bleeding on probing for the group without Curcuma xanthorrhiza containing toothpaste showed no significant difference even when tooth brushing was done. However, for the group with Curcuma xanthorrhiza containing toothpaste, bleeding on probing was significantly reduced compared to baseline when tooth brushing was done(p<0.05).
Collagenases ; Curcuma* ; Gingivitis* ; Hemorrhage ; Periodontal Index ; Periodontal Ligament ; Periodontitis ; Tooth ; Toothpastes

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Long-term Evaluation of IMZ Implants; Success and Survival Rates.

Ji Eun PARK ; Tae Gyun KIM ; Ui Won JUNG ; Chang Sung KIM ; Seong Ho CHOI ; Kyoo Sung CHO ; Chong Kwan KIM ; Jung Kiu CHAI

The Journal of the Korean Academy of Periodontology.2005;35(4):1039-1052. doi:10.5051/jkape.2005.35.4.1039

No abstract available.
Survival Rate*

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The Bone regenerative effects of tetracycline blended chitosan membranes on the calvarial critical size defect in Sprague dawley rats.

Gyung Joon CHAE ; Tae Gyun KIM ; Ui Won JUNG ; Soo Bok LEE ; Yong Sik JUNG ; Yong Keun LEE ; Chang Sung KIM ; Kyoo Sung CHO ; Jung Kiu CHAE ; Chong Kwan KIM ; Seong Ho CHOI

The Journal of the Korean Academy of Periodontology.2005;35(4):1019-1037. doi:10.5051/jkape.2005.35.4.1019

The major goals of periodontal therapy are the functional regeneration of periodontal supporting structures already destructed by periodontal disease as well as the reduction of signs and symptoms of progressive periodontal disease. There have been many efforts to develop materials and therapeutic methods to promote periodontal wound healing. There have been increasing interest on the chitosan made by chtin. Chitosan is a derivative of chitin made by deacetylation of side chains. Chitosan has been widely studied as bone substitution and membrane material in periodontology. Many experiments using chitosan in various animal models have proven its beneficial effects. Tetracycline has been considered for use in the treatment of chronic periodontal disease and gingivitis. The aim of this study is to evlauate the osteogenesis of tetracycline blended chitosan membranes on the calvarial critical size defect in Sprague Dawley rats. An 8mm surgical defect was produced with a trephine bur in the area of the midsagittal suture. The rats were divided into five groups: Untreated control group versus four experimental group. Four types of membranes were made and comparative study was been done. Two types of non-woven membranes were made by immersing non-woven chitosan into either the tetracycline solution or chitosan-tetracycline solution. Other two types of sponge membranes were fabricated by immersing chitosan sponge into the tetracycline solution, and subsequent freeze-drying. The animals were sacrificed at 2 and 8 weeks after surgical procedure. The specimens were examined by histologic analyses. The results are as follows: 1. Clinically the use of tetracycline blended chitosan membrane showed great healing capacity. 2. The new bone formations of all the experimental group, non-woven and sponge type membranes were greater than those of control group. But, there was no significant difference between the experimental groups. 3. Resorption of chitosan membranes were not shown in any groups at 2 weeks and 8 weeks. These results suggest that the use of tetracycline blended chitosan membrane on the calvarial defects in rats has significant effect on the regeneration of bone tissue in itself. And it implicate that tetracycline blended chitosan membrane might be useful for guided tissue regeneration.
Animals ; Bone and Bones ; Chitin ; Chitosan* ; Gingivitis ; Guided Tissue Regeneration ; Membranes* ; Models, Animal ; Osteogenesis ; Periodontal Diseases ; Porifera ; Rats ; Rats, Sprague-Dawley* ; Regeneration ; Sutures ; Tetracycline* ; Wound Healing

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The Effect of single Low-Power CO2 Laser irradiation on human PDL fibroblast Proliferation & Differentiation.

In Kwon JANG ; Tae Gyun KIM ; Ui Won JUNG ; Chang Sung KIM ; Seong Ho CHOI ; Kyoo Sung CHO ; Jung Kiu CHAI ; Chong Kwan KIM

The Journal of the Korean Academy of Periodontology.2005;35(4):1003-1017. doi:10.5051/jkape.2005.35.4.1003

No abstract available.
Fibroblasts* ; Humans* ; Lasers, Gas*

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A clinical effect of desensitizing agents applied on the root surface after periodontal treatment.

Sung Il PARK ; Chin Hyung CHUNG ; Sung Bin LIM ; Ki Seok HONG

The Journal of the Korean Academy of Periodontology.2005;35(4):991-1002. doi:10.5051/jkape.2005.35.4.991

The purpose of this study was to compare the effect of desensitizing agents applied on hypersensitive root surface following periodontal treatment. This study included 21 subjects(168 vital teeth). To evaluate dentin sensitivity, three clinical tests(tactile, air stream, cold water) were tried and three different densensitizing agents(MS coat, Elmex gel, Superseal) were individually applied. After application, reassessment was done at 1 minute, 1 week, 1 month and 3 months. The results were as follows: 1. The degree of dentin sensitivity was measured highly in the sequence of cold water, air stream and tactile and significantly decreased in all four groups with lapse of time(p<0.05). 2. There was no significant difference between all four groups in the tactile test with lapse of time. 3. There was no significant difference between three experimental groups in the air stream test with lapse of time. however, one minute later, it was measured highly in the sequence of Superseal, MS coat and Elmex 4. There was no significant difference between three experimental groups in the cold water test with lapse of time. As a result of this study, all of three agents were significantly effective in reducing dentin hypersensitivity and these agents could be positively employed to patients complaining of dentin hypersensitivity following periodontal treatment.
Dentin Sensitivity ; Humans ; Rivers ; Water

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A comparative study for the efficacy of plaque removal of two powered toothbrushes and a manual toothbrush.

Dae Ho JUN ; Chin Hyung CHUNG ; Sung Bin LIM ; Ki Seok HONG

The Journal of the Korean Academy of Periodontology.2005;35(4):975-989. doi:10.5051/jkape.2005.35.4.975

Periodontal disease is caused by accumulation of bacterial plaque. For the reason, plaque control is essential to control and prevent periodontal disease. Among the plaque control methods, mechanical plaque removal, tooth brushing is common and reliable. But it depends on individual habituation and their manner. To catch up the gap of effectiveness, lots of oral hygiene appliances have been developing. Powered toothbrush is the most interesting field and is showing on the market with various motion type. This study was performed to compare clinical effects of plaque removal between powered toothbrush and manual toothbrush. The results were as follows: 1. Plaque index was decreased statistically after the brushing than before the brushing in every group.(p<0.05) 2. Comparing plaque index among the three groups before and after brushing, there were no statistically significant differences. 3. Interproximal plaque index was decreased statistically after the brushing than before the brushing in every group.(p<0.05) 4. Comparing interproximal plaque index among the three groups before and after brushing, there were no statistically significant differences.
Oral Hygiene ; Periodontal Diseases ; Tooth

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