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Two cases of synchronous squamous cell carcinoma and adenocarcinoma of the uterine cervix.

Sang Il PARK ; Hee Jung WOO ; Soo Yeon JO ; Beob Jong KIM ; Moon Hong KIM ; Suck Chul CHOI ; Sang Young RYU ; Eui Don LEE ; Kyung Hee LEE

Korean Journal of Gynecologic Oncology.2005;16(3):273-278.

Cervical cancer is the most common malignancy of the female genital tract in Korea. The most common histologic type of cervical cancer is squamous cell carcinoma. The simultaneous occurrence of histologically distinct squamous cell carcinoma of the cervix and invasive adenocarcinoma of the cervix is extremely unusual. We have experienced two cases of synchronous squamous cell carcinoma and adenocarcinoma of the uterine cervix. We report these cases with a brief review of the literature.
Adenocarcinoma* ; Carcinoma, Squamous Cell* ; Cervix Uteri* ; Female ; Humans ; Korea ; Uterine Cervical Neoplasms

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Neoadjuvant chemotherapy in cervical carcinoma during pregnancy: Case report.

Se Hee MUN ; Hee Sug RYU ; Hye Jin CHANG ; Ho Yeon KIM ; Ki Hong CHANG ; Jung Pil LEE

Korean Journal of Gynecologic Oncology.2005;16(3):268-272.

When the cervical cancer is diagnosed in early stage during pregnancy, the treatment can be postponed for fetal viability. This case presents a patient diagnosed as cervical cancer stage Ib1 during her pregnancy. The patient had 2 cycles of neoadjuvant chemotherapy (Paclitaxel-cisplatin) formerly and cesarean section was done at 33rd weeks of intrauterine pregnancy, then radical abdominal hysterectomy with bilateral pelvic lymph node dissection and paraaortic lymph node biopsy was immediately performed right after the delivery. For the baby born, there was neither complication nor congenital anomaly but mild bilateral ventriculomegaly seen on brain CT taken on 3 days after birth. This case offers a better chance for both mother and fetus while conserving fetal viability and managing the early cervical cancer during pregnancy through close follow up.
Biopsy ; Brain ; Cesarean Section ; Drug Therapy* ; Female ; Fetal Viability ; Fetus ; Follow-Up Studies ; Humans ; Hysterectomy ; Lymph Node Excision ; Lymph Nodes ; Mothers ; Parturition ; Pregnancy* ; Uterine Cervical Neoplasms

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A case of primary leiomyosarcoma of the mesentery with hepatic metastasis.

Ho Ah KIM ; Sang Il PARK ; Heung Seop SONG ; Mung In KIM ; Beob Jong KIM ; Moon Hong KIM ; Suck Chul CHOI ; Sang Young RYU ; Eui Don LEE ; Kyung Hee LEE ; Soo Yung JUNG

Korean Journal of Gynecologic Oncology.2005;16(3):264-267.

Primary tumors of the mesentery are uncommon, and primary leiomyosarcoma of the mesentery is especially rare, and thus an accurate preoperative diagnosis is difficult. We experienced a case of 32-year female with primary leiomyosarcoma of the mesentery. We report this case with a brief review of the literature.
Diagnosis ; Female ; Humans ; Leiomyosarcoma* ; Mesentery* ; Neoplasm Metastasis*

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Cyclin B1 and D1 expression in invasive cervical cancer.

Young Tae KIM ; Min ZHAO ; Hee Yeon KIM ; Moung Hwa KANG ; Jae Wook KIM ; Sung Hoon KIM ; Jae Hoon KIM ; Sang Wun KIM ; Bo Sung YOON

Korean Journal of Gynecologic Oncology.2005;16(3):256-263.

OBJECTIVE: Cyclin is a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases (CDKs), have been reported in malignant tumors. This study was undertaken to quantitatively detect cyclin B1 and D1 in cervical cancer. METHODS: A quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis were used to analyze the expression of cyclin B1, D1 mRNA and proteins, respectively, in fresh invasive cervical cancer (n=41) and normal cervix tissue (n=10). RESULTS: There was significantly greater cyclin B1 expression in invasive cervical cancer than in normal cervix tissue (p=0.019). However, cyclin D1 expression was not significantly different (p=0.967). A Western blot analysis yielded similar results. CONCLUSION: Our results were consistent with the concept that up-regulation of cyclin B1 expression occurred in cervical cancer and an aberrant expression of cyclin B1 might play an important role in cervical carcinogenesis.
Blotting, Western ; Carcinogenesis ; Cell Cycle ; Cervix Uteri ; Cyclin B1* ; Cyclin D1 ; Cyclin I ; Cyclin-Dependent Kinases ; Cyclins* ; Female ; Humans ; RNA, Messenger ; Up-Regulation ; Uterine Cervical Neoplasms*

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Transcutaneous DNA vaccination increase the CTL response: Preliminary results for the therapeutic HPV DNA vaccination.

Chan Joo KIM ; Eun Kyoung YIM ; Hae Nam LEE ; Keun Ho LEE ; Tae Chul PARK ; Sung Eun NAMKOONG ; Jong Sup PARK

Korean Journal of Gynecologic Oncology.2005;16(3):242-255.

OBJECTIVE: Transcutaneous immunization (TCI) is a novel vaccination based on the application onto bare skin. We compared the immune response after TCI with the model DNA (OVALBUMIN) to HPV E7 and various adjuvant with intramuscular injection. We investigated the efficacy of immunization with new construct driven by K6hf promoter and compared with CMV promoter. METHODS: First, we make new construct ligated with OVA to Hair-follicle Specific pK6hf Promoter and evaluated the expression. Mouse skin was transfected with pCMV-OVA, pK6hf-OVA, pCMV-beta gal and pK6hf-beta gal and expression was determined by RT-PCR and X-Gal staining. OVA protein expression was analyzed by Western blot. Second, we immunized C57/ BL6 mice with pCMV-OVA or pK6hf-OVA DNA and cholera toxin (CT) and/or CpG. CTL was measured by ELISPOT assay of the splenocytes from the mmunized mice with the DNA vaccine. RESULTS: The beta-Galactosidase activity by X-Gal staining was detected in the epithelium of the mice skin after pK6hf-beta gal application. The mRNA and protein expression from pK6hf-OVA were evident following transcutaneous methods. Those were weaker than pCMV-OVA. TCI with pCMV-OVA and LipofectAMINE 2000 trigered an speicific CTL and Th2 response. CpG was the adjuvant for CTL after pCMV-OVA. CT and CpG did increase the CTL after pK6hf-OVA. CONCLUSION: Our data demonstrate that TCI of DNA is possible methods of CTL. CpG and CT were useful in the adjuvant for CTL. The pK6hf-OVA can induce specific CTL. This result is of potential relevance for the development of therapeutic HPV- specific DNA vaccines with TCI and pK6hf promoter can be used safely.
Animals ; beta-Galactosidase ; Blotting, Western ; Cholera Toxin ; DNA* ; Enzyme-Linked Immunospot Assay ; Epithelium ; Immunization ; Injections, Intramuscular ; Mice ; Ovum ; RNA, Messenger ; Skin ; Vaccination* ; Vaccines, DNA

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Identification of TACC3 (Transforming Acidic Coiled-Coil 3) as a novel target of paclitaxel-mediated tumor therapy in cervical cancer cells.

Eun Kyoung YIM ; Keun Ho LEE ; Hee Jung LEE ; Chan Joo KIM ; Tae Chul PARK ; Soo Jong UM ; Jong Sup PARK

Korean Journal of Gynecologic Oncology.2005;16(3):229-241.

OBJECTIVE: Paclitaxel is currently used in the treatment of ovarian, breast, gastric, colorectal, lung and recurrent cervical cancer. Initial studies on the mechanism of action of paclitaxel have demonstrated that this drug alters microtubule assembly, by inhibiting microtubule depolymerization and changing microtubule dynamics. Although treatment of various tumor cells with paclitaxel induces apoptosis, but early paclitaxel-targeted proteins is not yet known. We tried to search paclitaxel-targeted proteins and to investigate its functions. METHODS: The effects of paclitaxel on HeLa cervical cancer cell growth were evaluated by cell proliferation assay, DAPI stain, and FACS analysis. We performed proteome analysis including 2-DE and MALDI-TOF-MS in nontreated-and paclitaxel-treated HeLa cells, as a result, we identified TACC3 protein that is down-regulated with paclitaxel treatment. We tried to characterize TACC3 functions through in vitro treatment of paclitaxel or RNAi technique. RESULTS: Paclitaxel- and TACC3 siRNA-treated cells are unable to proceed normally through the cell cycle and are arrested in G2/M phase and reveal apoptotic morphology. TACC3 levels after paclitaxel treatment decreased as a time- and dose- dependent manner both mRNA and protein levels. We confirmed that the role of TACC3 down-regulation for microtubule stabilization was similar to that of paclitaxel. Also, TACC3 is expressed at high levels in various cancer cells and tumor tissues. CONCLUSION: This study is proposed that the TACC3 protein may be participated in microtubule formation as an oncoprotein during mitosis and be regulated by paclitaxel as a novel target.
Apoptosis ; Breast ; Cell Cycle ; Cell Proliferation ; Down-Regulation ; HeLa Cells ; Humans ; Lung ; Microtubules ; Mitosis ; Paclitaxel ; Proteome ; RNA, Messenger ; Uterine Cervical Neoplasms*

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The accuracy and cost-effectiveness of triple screening tests in cervical neoplasia.

Yong Tark JEON ; Yong Beom KIM ; Jae Weon KIM ; Noh Hyun PARK ; Yong Sang SONG ; Soon Beom KANG ; Hyo Pyo LEE

Korean Journal of Gynecologic Oncology.2005;16(3):221-228.

OBJECTIVE: Ideal cancer screening program should be not only accurate but also cost-effective. However, in Korea, the two aspect of cervix cancer screening program was not yet evaluated. Thus we conducted this study to evaluate the cost-effectiveness and accuracy of various screening methods for detecting uterine cervical neoplasia. METHODS: We used various methods (conventional Pap smear, cervicography and HPV test) to detect cervical neoplasia on 255 women who visited the Seoul National University Hospital from Dec. 1996 to Jul. 1997 and analyzed the accuracy and cost-effectiveness of each method along with various combinations of methods using Bayesian theorem. The accuracy was judged by the final histopathologic diagnosis. RESULTS: Sensitivity (SE) and specificity (SP) of each method to detect cervical intraepithelial neoplasia (CIN) 1 or above were 83.0% and 69.4% in Pap smear, 53.7% and 85.2% in cervicography, and 57.8% and 80.6% in HPV test, respectively. The combination of Pap smear with cervicography or with HPV test for detecting CIN 1 or above had same SE and SP of 89.1% and 62.0% respectively. The combination of cervicography and HPV test had SE of 78.9% and SP of 70.4%. Three methods combination showed 93.9% SE and 54.6% SP. The estimated cost per method was highest in three methods combination (117,000 won) and lowest in Pap smear alone (12,000 won). The cost for detection of one case of cervical neoplasia was highest in combination of cervicography and HPV test (241,907 won) and lowest in Pap smear alone (25,385 won). CONCLUSION: The combinations of each method showed increased SE. These combinations, however, had low SP and high cost than individual method. Cervicography or HPV test alone should not be considered as an alternative to Pap smear for cervical cancer screening because its cost-effectiveness is not significantly better than that of Pap smear.
Cervical Intraepithelial Neoplasia ; Diagnosis ; Early Detection of Cancer ; Female ; Humans ; Korea ; Mass Screening* ; Sensitivity and Specificity ; Seoul ; Uterine Cervical Neoplasms

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A case of Gliomatosis Peritonei after 10 years following Operation of Immature Teratoma of the Ovary.

Moo Sung JO ; Sung Chol KIM ; Ki Hyung KIM ; Man Soo YOON

Korean Journal of Gynecologic Oncology.2005;16(1):82-86.

Gliomatosis peritonei, the implantation of neuroglial tissue upon the peritoneal surface, is a rare event most often associated with solid or immature teratoma of the ovary in young girls. The majority of cases occur in association with teratomas containing immature element. However malignant transformation of the glial tissue has been reported. Here we experienced a case of mature glial implants presenting in an 27-year-old female, 10 years after initial diagnosis and removal of an ovarian immature teratoma, and report this case with brief review of literatures.
Adult ; Diagnosis ; Female ; Humans ; Ovary* ; Teratoma*

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An analysis of articles published in Korean Journal of Gynecologic Oncology and Colposcopy.

Sang Eun LEE ; Woong JU ; Hwa Jung KIM ; Jae Weon KIM ; Noh Hyun PARK ; Yong Sang SONG ; Soon Beom KANG ; Hyo Pyo LEE

Korean Journal of Gynecologic Oncology.2005;16(1):77-81.

OBJECTIVE: We aimed to assess the distribution of research design, type, field and classification for the articles published in Korean Journal of Gynecologic Oncology and Colposcopy during recent 15 years. METHODS: A total of 473 papers published in Korean Journal of Gynecologic Oncology and Colposcopy from 1990 to 2004 were reviewed for retrospective descriptive analysis. First, all papers were analyzed according to the design, type, field of study. Then they were classified again depending on specific topics under the criteria used in science citation index journal, "Gynecologic Oncology". Articles presented at symposia were excluded from this analysis. RESULTS: We observed that distribution in study design showed the inclination toward case series study (71.7%) and case report (26.8%). To the contrary, the numbers of cohort study and randomized controlled trial were five and one, respectively. The distributions of articles were 321 in survey, 6 in experiment, 7 in clinical trial. There were 12 articles belonging to overview of secondary research. Secondary classification based on study field revealed 108 articles in causation, 82 in diagnosis, 73 in therapy as descending order. There were 80 articles of molecular biology including immunology and tumor suppressor genes, 66 articles of cervical cancer, and 36 articles of epithelical ovarian cancer. CONCLUSION: These results suggest that the reports on Korean Journal of Gynecologic Oncology and Colposcopy are mainly converged to case series studies in the design of study and survey in the type of study.
Allergy and Immunology ; Classification ; Cohort Studies ; Colposcopy* ; Diagnosis ; Genes, Tumor Suppressor ; Molecular Biology ; Ovarian Neoplasms ; Research Design ; Retrospective Studies ; Uterine Cervical Neoplasms

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Comparison of the solution of ThinPrep(TM) Pap test with the Cervical Sampler(TM) of Hybrid Capture (HC) II for detecting Human papillomavirus (HPV) DNA.

So Jin YEO ; Mi Kyeong KANG ; Kei Hyun NAM ; Jeong Sig KIM ; Tae Hee KIM ; Kwon Hae LEE

Korean Journal of Gynecologic Oncology.2005;16(1):70-76.

OBJECTIVE: Our purpose was to compare the difference and the positivity rate between Preserv Cyt(TM) solution of Thin-Prep(TM) Pap test and Cervical Sampler(TM) of Hybrid Capture II for detecting HPV DNA. METHODS: We collected samples of the cervix by using Preserv Cyt(TM) solution of Thin-Prep(TM) Pap test and a Cervical Sampler(TM) of Hybrid Capture II from ninety one women who screened for cervical carcinoma and precancerous cervical lesions between January 2003 and March 2003. At the same time, we tested the sample using the Preserv Cyt(TM) solution left over with a sample conversion kit. The cut off value for positive test result was above 1 pg/mL. RESULTS: The results of comparing the test using the Preserv Cyt(TM) solution of Thin-Prep(TM) Pap test with the one using Cervical Sampler(TM) showed negative results and 34 patients showed positive results with a significant high kappa coefficient of 0.674. The HPV titer of <1 were considered negative, while the HPV titer of 1 were considered positive. The positive HPV titer results were then subdivided into values of 1-10 and >10. Agreement rates of Preserv Cyt(TM) solution according to the HPV titer of Cervical Sampler(TM) were as follows: 97.7% in values below 1, 96.8% in values above 10, but 17.6% in values 1 to 10. So, the agreement rate was low between Cervical Sampler(TM) and Preserv Cyt(TM) solution in low value of HPV of Cervical Sampler(TM). CONCLUSION: Comparing the test using Preserv Cyt(TM) solution with Cervical Sampler(TM), there was a high correspondence and the Preserv Cyt(TM) solution was facilitated to detection for HPV at a time.
Cervix Uteri ; DNA* ; Female ; Humans*

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