Korean Journal of Gynecologic Oncology  2007;18(4):284-288

Expression of c-Met in ovarian epithelial tumor.

Bo Seop KIM 1 ; Il Soo PARK ; Yoon Soon LEE ; Tae Bon KOO ; Tae In PARK

Affiliations

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Keywords

c-Met; Epithelial ovarian cancer; Prognosis

Country

Republic of Korea

Language

Korean

Abstract

OBJECTIVE: This study was performed to evaluate the expression of c-Met in epithelial ovarian carcinoma. METHODS: Paraffin-embedded tissues from 50 epithelial ovarian adenocarcinomas were stained immunohistochemically for c-Met expression. The expression of c-Met was correlated with clinicopathologic parameters including, histologic type, tumor size, and tumor stage. RESULTS: c-Met expression was found in 29 cases (58%) among 50 ovarian cancers. In clinicopathologic study, c-Met expression of epithelial ovarian carcinomas did not show the correlation with clinicopathologic parameters such as histologic type, tumor size and stage. CONCLUSION: c-Met expression might be a potential prognostic marker for patients with advanced stage epithelial ovarian cancers. However, larger population-based studies should be performed to determine the prognostic potential of c-Met expression in advanced ovarian carcinoma.