Journal Detail Information

1

Cite

Share

Lung Cancer with Acute Myocardial Infarction.

In Jae OH ; Kyu Sik KIM ; Young Chul KIM

Journal of Lung Cancer.2007;6(2):92-92. doi:10.6058/jlc.2007.6.2.92

A 63-year-old man with recurred squamous cell lung carcinoma was admitted to our facility due to an acute onset of chest and upper back pain. He had undergone a left pneumonectomy in July of 2004, and had been receiving EGFR-TKI (Tarceva(R)) as a 3rd line treatment since he had relapsed. His electrocardiographic findings (Panel A) showed acute lateral wall myocardial infarction, and his cardiac enzymes were slightly elevated. 2D-echocardiography and chest CT (Panel B) disclosed the presence of metastatic cancer invading the myocardium along the left circumflex coronary artery, however, there was no critical stenosis observed during a coronary angiography (Panel C). His pain was relieved gradually by medical treatment that included an angiotensin converting enzyme inhibitor, betablocker and opioids. After this treatment, a 4th line treatment was initiated
Analgesics, Opioid ; Back Pain ; Chest Pain ; Constriction, Pathologic ; Coronary Angiography ; Coronary Vessels ; Electrocardiography ; Humans ; Lung Neoplasms* ; Lung* ; Middle Aged ; Myocardial Infarction* ; Myocardium ; Peptidyl-Dipeptidase A ; Pneumonectomy ; Thorax ; Tomography, X-Ray Computed

2

Cite

Share

Metastases to Skeletal Muscles from Non-Small Cell Lung Cancer Demonstrated by 18F-FDG PET/CT.

Seong Young KWON ; Shin Young JEONG ; Jung Joon MIN ; In Jae OH ; Young Chul KIM ; Hee Seung BOM

Journal of Lung Cancer.2007;6(2):91-91. doi:10.6058/jlc.2007.6.2.91

Hematogenous metastases to skeletal muscles are extremely rare metastases that may present as painful masses in the proximal skeletal muscles. The reasons for the rarity of metastatic tumors in skeletal muscle are not clear. However, the whole body coverage and high sensitivity of 18F-FDG PET/CT make it suitable for evaluating distant metastasis. We report here the findings of 18F-FDG PET/CT in a 66-year-old female with non-small cell lung cancer (adenocarcinoma) and multiple metastases to skeletal muscles
Aged ; Carcinoma, Non-Small-Cell Lung* ; Female ; Fluorodeoxyglucose F18* ; Humans ; Lung Neoplasms ; Muscle, Skeletal* ; Neoplasm Metastasis* ; Positron-Emission Tomography and Computed Tomography*

3

Cite

Share

Efficacy and Safety of Weekly Low Dose Paclitaxel and Cisplatin as First Line Therapy in Advanced NSCLC of Elderly Patients.

Jung Ho LEE ; Mi Hye KWON ; Ji Hyun JEOUNG ; Go Eun LEE ; Eu Gene CHOI ; Moon Jun NA ; Hyun Min CHO ; Young Jin KIM ; Weon Kuu CHUNG ; Young Jun CHO ; Ji Woong SON

Journal of Lung Cancer.2007;6(2):85-90. doi:10.6058/jlc.2007.6.2.85

PURPOSE : Anti-cancer chemotherapeutic agents act by inhibiting tumor cell proliferation through cytotoxic action, therefore the generally tolerated maximum dose is administered to patients. However, this often results in the production of undesirable toxicities, such as bone marrow suppression, and a long interruption of treatment is necessary for recovery to occur before additional cycles of treatment are administered. Paclitaxel and cisplatin are well known effective chemotherapeutic agents used for the treatment of Non-Small Cell Lung Cancer (NCSLC), however, they have substantial toxicities. To evaluate efficacy and safety of a therapy consisting of a weekly low dose of paclitaxel and therapy in elderly patients with advanced NSCLC. MATERIALS AND METHODS : Thirteen treatment-naive, elderly patients over 65 years old who were diagnosed with stage IV NSCLC at Konyang University from April 2005 to October 2006 were enrolled in the present study. Paclitaxel at a dose of 55 mg/m2 in combination with cisplatin at a dose of 20 mg/m2 was administered intravenously on day 1, 8, and 15 with 1 week of interruption for a total of six cycles of chemotherapy. RESULTS : The mean age of the ten patients included in this study was 69.5 years. Following treatment, 50 % of the patients exhibited a partial response to treatment, whereas the disease remained stable in 40% of the patients, and progressed in 10% of the patients. The median survival time (Kaplan-Meier method) was 15 months (4~24 months), and the 6-month, 1-year, and 2-year survival rates were 80%, 50%, and 10%, respectively. The median progression survival time was 8 months (2~14 months) and the 6- and 12-month progression free survival rates were 60% and 10%, respectively. Grade 3 neutropenia occurred in only 1 case (10%). CONCLUSION : The results of this study indicated that chemotherapy consisting of a weekly low dose of paclitaxel and cisplatin could be more effective and have lesser toxicity when administered to elderly patients with advanced NSCLC. In addition, this treatment regimen showed a promising response rate
Aged* ; Bone Marrow ; Carcinoma, Non-Small-Cell Lung ; Cell Proliferation ; Cisplatin* ; Disease-Free Survival ; Drug Therapy ; Humans ; Neutropenia ; Paclitaxel* ; Survival Rate

4

Cite

Share

Compliance with Adjuvant Chemotherapy for Completely Resected Non-small Cell Lung Cancer.

Hyun Sung LEE ; Moon Soo KIM ; Jong Mog LEE ; Heung Tae KIM ; Bo Ryong HWANG ; Dong Seok HAN ; Hyun Kyong AHN ; Jae Ill ZO

Journal of Lung Cancer.2007;6(2):78-84. doi:10.6058/jlc.2007.6.2.78

PURPOSE : To evaluate the compliance of patients who underwent complete resection of non-small cell lung cancer (NSCLC) with adjuvant chemotherapy. MATERIALS AND METHODS : Between January 2004 and May 2006, patients who underwent a complete resection for NSCLC were referred to oncologists for adjuvant chemotherapy. Three or 4 cycles of platinum-based adjuvant chemotherapy was then performed according to the protocol or the preference of the oncologists. RESULTS : Two hundred and thirty-two patients were enrolled in this study. The median age of the study group was 60.9 years and 76.7 % of the patients enrolled were male. 34.9%, 28.8% and 36.2% of the patients were in stage IB, II and III respectively. In addition, 142 of the patients (61.2%) completed all planned cycles, whereas 65 patients (28%) received no therapy. The causes of start failure for adjuvant chemotherapy consisted of decreased postoperative performance status (n=39), refusal (n=13) and distant metastasis at the initial follow-up (n=2). The causes of cessation during adjuvant chemotherapy included the occurrence of severe adverse effects (n=12), aggravation of the disease with newly developed metastasis (n=4) and others (n=6). The mortality related to the adjuvant chemotherapy was 1.3 % (n=3), all of the fatalities were due to pneumonia and sepsis. Univariate analysis showed that age, postoperative complications and pathologic staging were the significant factors that determined whether the adjuvant chemotherapy was completed. Multivariate analysis demonstrated statistically significant differences in compliance when age and pathologic staging were considered. CONCLUSION : Adjuvant chemotherapy for completely resected NSCLC was performed with satisfactory compliance in approximately 60% of the patients included in this study, and age plays an important role in the compliance of adjuvant chemotherapy. Elderly subsets will be examined to help determine the effect of age on compliance and outcome. In addition, the medical oncologist tended to complete the adjuvant chemotherapy for more advanced cases of lung cancer than for stage IB lung cancer
Aged ; Carcinoma, Non-Small-Cell Lung* ; Chemotherapy, Adjuvant* ; Compliance* ; Disulfiram ; Drug Therapy ; Follow-Up Studies ; Humans ; Lung Neoplasms ; Male ; Mortality ; Multivariate Analysis ; Neoplasm Metastasis ; Pneumonia ; Postoperative Complications ; Sepsis

5

Cite

Share

Mutational Analysis of Pro-apoptotic BNIP3 Gene in Non- Small Cell Lung Cancers.

Sung Hak LEE ; Sug Hyung LEE

Journal of Lung Cancer.2007;6(2):74-77. doi:10.6058/jlc.2007.6.2.74

PURPOSE : Cell death deregulation is a hallmark of human cancers. BNIP3, which was initially identified as a pro-apoptotic member of the Bcl-2 family, plays an important role in apoptosis, necrosis and autophagy. This study was conducted to explore whether mutation of the BNIP3 gene is a characteristic of human non-small cell lung cancers (NSCLC). MATERIALS AND METHODS : In the current study, we used polymerase chain reaction (PCR), single-strand conformation polymorphism (SSCP), and DNA sequencing to detect somatic mutations in the DNA sequences encoding the BH3 (Bcl-2 homology3) and TM (transmembrane) domains that are important to the cell death function of BNIP3 in 48 NSCLCs. RESULTS : SSCP analysis revealed no evidence of somatic mutation in the DNA sequences encoding the BH3 and TM domains of the human BNIP3 gene in the 48 NSCLCs evaluated in this study. CONCLUSION : The data presented here indicate that the pro-apoptotic BNIP3 gene may not be somatically mutated in human NSCLCs, which suggests that mutational events of the BNIP3 gene may not be involved in the mechanisms by which NSCLCs evade cell death
Apoptosis ; Autophagy ; Base Sequence ; Carcinoma, Non-Small-Cell Lung ; Cell Death ; Humans ; Lung Neoplasms* ; Lung* ; Necrosis ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational ; Sequence Analysis, DNA

6

Cite

Share

National Survey of Lung Cancer in Korea, 2005.

Young Chul KIM ; Yong Soo KWON ; In Jae OH ; Kyu Sik KIM ; Sun Young KIM ; Jeong Seon RYU ; Ho Kee YUM ; Suk Joong YONG ; Kwan Ho LEE ; Chang Geol LEE ; Sang Yeub LEE ; Sung Yong LEE ; Maan Hong JUNG ; Eun Taik JEONG ; Kwang Ho IN

Journal of Lung Cancer.2007;6(2):67-73. doi:10.6058/jlc.2007.6.2.67

PURPOSE : Lung Cancer has been the leading cause of cancer deaths in South Korea since the year 2000, and its incidence continues to rise. Here we report the result of national survey of lung cancer conducted by Korean association for the study of lung cancer (KASLC). MATERIALS AND METHODS : A total of 8,788 lung cancer patients diagnosed in 2005 were registered using a web based case report form issued to hospitals equipped with more than 400 beds. RESULTS : The age distribution ranged from 11 to 105 years (64.7+/-0.7 years), 75.8% (6,664) of the patients were male and 28.9% of patients were never smokers. Subjective symptoms at the time of diagnosis included coughing (3,350 patients), dyspnea (2,105), chest pain (1,067), hemoptysis (805), weight loss (789), general weakness (498) and hoarseness (190), while 12% (1,015) of patients had no subjective symptoms. Of the carcinomas grouped into non-small cell lung carcinoma (NSCLC), adenocarcinoma including bronchoalveolar cell carcinoma (1.3%) was the most frequent (36.1%) histopathologic type, followed by squamous cell lung carcinoma (32.1%), large cell carcinoma (1.5%), unclassified non-small cell carcinoma (13.2%) and others (3.7%). In addition, 13.5% of all of the patients were afflicted with small cell lung carcinoma (SCLC). The stage at diagnosis was IA (7.3%), IB (10.2%), IIA (1.3%), IIB (6.1%), IIIA (12.8%), IIIB (21.6%), and IV (40.6%) in the NSCLC group. In SCLC group, 44.6% of the patients were in the limited stage, while 55.4% of the patients were in the extensive stage. The initial treatments included surgery (22.1%), radiation therapy (7.8%), chemo-radiation therapy (5.4%) and chemotherapy (38%), however, 26.6% of the patients were transferred or recorded to have supportive care only. Therefore we compared the outcomes of the Treatment Group (TG, 73.4%) and the Supportive Group (SG, 26.6%). The median survival time (MST) in months (m) was 28 (95% confidence interval 26.5~29.5 m). Multivariate analysis indicated that the independent prognostic factors for NSCLC were age, gender, ECOG PS score, stage, histopathologic type, and treatment or supportive care. In the SCLC group, age, PS score, stage, treatment or supportive care were significant prognostic factors. The TG group showed significantly superior survival when compared to the SG group, even in patients with stage IV disease and in patients that were >75 years old. CONCLUSION : Adenocarcinoma was found to be the most frequent histopathologic type, and active treatments were found to improve the survival of patients with lung cancer, even when they were in advanced stages or elderly
Adenocarcinoma ; Age Distribution ; Aged ; Carcinoma, Large Cell ; Chest Pain ; Cough ; Diagnosis ; Drug Therapy ; Dyspnea ; Hemoptysis ; Hoarseness ; Humans ; Incidence ; Korea* ; Lung Neoplasms* ; Lung* ; Male ; Multivariate Analysis ; Small Cell Lung Carcinoma ; Weight Loss

7

Cite

Share

Low-dose, Whole-lung Radiotherapy for Pulmonary Extramedullary Hematompoiesis : A case report.

Si Yeol SONG ; Eun Kyung CHOI ; Jong Hoon KIM ; Seung Do AHN ; Seong Soo SHIN ; Sang Wook LEE

Journal of Lung Cancer.2005;4(1):48-50.

A seventy-seven year old female was consulted for radiation therapy due to the infiltration of lung and pleural effusion from myelofibrosis. She was diagnosed clinically as extramedullary hematopoiesis (EMH), and had severe dyspnea and cardiac dysfunction originated from pulmonary hypertension. She underwent low-dose (2 Gy) whole-lung radiation therapy in 4fractions of 50 cGy each. Clinical symptom, especially dyspnea, and chest X-ray imaging was markedly improved after radiation therapy. We experienced that the low-dose whole-lung radiation therapy to EMH in lung might be effective for the palliation of pulmonary hypertension
Dyspnea ; Female ; Hematopoiesis, Extramedullary ; Humans ; Hypertension, Pulmonary ; Lung ; Pleural Effusion ; Primary Myelofibrosis ; Radiotherapy* ; Thorax

8

Cite

Share

Effectiveness of Breath Hold with a ABC for SRS of Lung Cancer.

Young Eun KO ; Seung Do AHN ; Byong Yong YI ; Sang Wook LEE ; Seong Soo SHIN ; Jong Hoon KIM ; Young Jo NOH ; Eun Kyung CHOI

Journal of Lung Cancer.2005;4(1):42-47.

PURPOSE: It is very important to remove or to reduce the effect of organ motion due to respiration in stereotatic radiosurgery of lung. This study reports the effectiveness of the breath hold technique with a ABC for reducing the breathing effect. MATERIALS AND METHODS: Whole body stereotactic frame (Elekta, Sweden) was used for lung SRS. Patients who have tumor motion range larger than 10 mm from fluoroscopic observation were selected to apply a ABC. Seventeen patients were enrolled in this study. Passive breath hold is possible with our ABC. Automatic breath hold was set at 80% of deep inspiration. Breath hold time was 25~30 seconds depending on the patients. Three consecutive CT scans were performed as indicated in Asan Medical Center SRS procedure for each patients. Lung volume and PTV differences between with breath hold and free breath were examined for 5 patients. RESULTS: The breath hold technique with ABC could be applied for 15 patients. Inter-, intra-treatment organ motion with ABC showed 1.5 mm, while it was 2.3 mm with abdomen compress. When with breath hold technique, PTV and CTV was reduced 33.7% and 45.4%, respectively, and lung volume was increased 32.3 % compared to conventional SRS method. CONCLUSION: Better target localization could be achieved with breath hold technique in lung SRS. Tumor motion could be minimized and relative lung volume irradiation could be reduced
Abdomen ; Chungcheongnam-do ; Humans ; Lung Neoplasms* ; Lung* ; Radiosurgery ; Respiration ; Tomography, X-Ray Computed

9

Cite

Share

Mutational Analysis of Caspase-7 and 8 Genes in Non-small Cell Lung Cancer.

Young Hwa SOUNG ; Jong Woo LEE ; Seok Whan MOON ; Keon Hyon JO ; Young Pil WANG ; Su Young KIM ; Suk Woo NAM ; Won Sang PARK ; Jung Young LEE ; Nam Jin YOO ; Sug Hyung LEE

Journal of Lung Cancer.2005;4(1):38-41.

PURPOSE : Several lines of evidence have indicated that deregulation of apoptosis is involved in the mechanism of cancer development. Caspase-8 activation plays a central role in the initiation phase of apoptosis, while caspase-7 is one of the main execution phase caspases of apoptosis. The aim of this study was to explore the possibility that genetic alterations of the caspase-8 and caspase-7 genes are involved in the development of human non-small cell lung cancer (NSCLC). MATERIALS AND METHODS : We have analyzed the entire coding region of both the caspase-7 and caspase-8 genes to detect the somatic mutations in 100 NSCLCs by using polymerase chain reaction (PCR)- single strand conformation polymorphism (SSCP). RESULTS : The PCR-SSCP analysis detected no mutations in the entire coding regions of both the caspase-7 and caspase-8 genes in the NSCLCs. CONCLUSION : The data presented here suggests that both the caspase-7 and caspase-8 genes may not be somatically mutated in human NSCLCs
Apoptosis ; Carcinoma, Non-Small-Cell Lung* ; Caspase 7* ; Caspase 8 ; Caspases ; Clinical Coding ; Humans ; Polymerase Chain Reaction

10

Cite

Share

Radiotherapy of Brain Metastases from Lung Cancer.

Eun Ji CHUNG ; Sun Min LEE ; Chong Ju KIM ; Yong Tai KIM

Journal of Lung Cancer.2005;4(1):34-37.

PURPOSE : Brain metastasis is estimated to occur in 10~45% of solid cancer patients, and is the most common intracranial tumor in adults. Several neurologic symptom palliations are made with steroid therapy and whole brain irradiation. MATERIALS AND METHODS : We evaluated respectively the clinical characteristics and treatment outcome for 44 patients with metastatic brain tumor from lung cancer during the period from April 2000 to December 2003. RESULTS : Median age of the patients was 61 years. The male : female ratio was 2.7 : 1. Synchronous and metachronous brain metastasis was seen in 18 (40.9%) and 26 patients (59.1%), respectively and median duration between the diagnosis of lung cancer and brain metastases was 6 months (range 1~18 months) in metachronous cases. Pathologic types of lung cancer were as follows : small cell lung cancer in 11 patients and non-small cell lung cancer in 33 patients (squamous cell carcinoma-13, adenocarcinoma-11, large cell carcinoma- 3, others-6). The most common symptom of brain metastasis was headache, which was in 27 patients (61.4%). Seven patients (15.9%) had a single brain metastasis while 37 patients (84.1%) had multiple brain metastases. The total radiation dose to whole brain ranged from 30 to 40 Gy (median 30 Gy). In 29 patients (65.9%) neurological symptoms were resolved after whole brain irradiation. Median survival was 18 weeks for patients with steroid therapy and whole brain radiotherapy. CONCLUSION : In present study, we confirmed that whole brain irradiation is an effective palliative treatment for patients with metastatic brain tumors from lung cancer
Adult ; Brain Neoplasms ; Brain* ; Carcinoma, Non-Small-Cell Lung ; Diagnosis ; Female ; Headache ; Humans ; Lung Neoplasms* ; Lung* ; Male ; Neoplasm Metastasis* ; Neurologic Manifestations ; Palliative Care ; Radiotherapy* ; Small Cell Lung Carcinoma ; Treatment Outcome

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share