Journal of Lung Cancer  2010;9(2):106-109

doi:10.6058/jlc.2010.9.2.106

Tumor Lysis Syndrome Induced by Radiotherapy in Non-Small Cell Lung Cancer.

Dong Hyo NOH 1 ; Ki Eun HWANG ; Jeong Hyun SHIN ; Dong KIM ; Kyung Hwa CHO ; Keum Ha CHOI ; Seong Hoon PARK ; Eun Taik JEONG ; Hak Ryul KIM

Affiliations

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Keywords

Tumor lysis syndrome; Radiotherapy; Non-small cell lung carcinoma

Country

Republic of Korea

Language

English

Abstract

Tumor lysis syndrome (TLS) is an oncologic emergency that is characterized by numerous metabolic abnormalities, including hyperuricemic nephropathy, hyperphosphatemia, hypocalcemia, hyperkalemia and increased serum creatinine. This syndrome is common for tumors with rapid cell turnover and growth rates, and for bulky tumors with high sensitivity to anti-neoplastic treatments. Hence, TLS is a well-recognized clinical problem in hematologic malignancies. TLS is rarely observed to be induced in solid tumors by chemotherapy. Herein we present the second case of TLS that developed during radiotherapy in a patient with non-small cell lung cancer.