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Acute Phase Retinal Phototoxicity Induced by Blue Fluorescent Light.

Young Hoon PARK ; Soon Cheol CHA ; Duk Kee HAHN

Yeungnam University Journal of Medicine.1995;12(1):75-83. doi:10.12701/yujm.1995.12.1.75

Even though phototherapy is an effective means of treating hyperbilirubinemia, adequate binocular shields are essential to prevent light hazard of retina during phototherapy. The phototherapy to young albino rabbits was performed under various conditions; exposured for 12, 24, and 48 hours, continuity or intermittence of irradiation, and use of shields. Although there was no definite pathologic change in indirect ophthalmoscopic examination, severe damage was seen at electron microscopic level. In all experimental groups, swelling and edema of photoreceptor were seen. at right after phototherapy. Futhermore, more severe damage was seen in case of intermittent irradiated group and prolong exposed group. In mydriatic eyes, severity of damage was similiar to non mydi iatic eyes, but area of retinal damage was more extensive than non-mydriatic eves.. In control group which was protected by binocular shields during phototherapy, no significant abnormality was found.
Dermatitis, Phototoxic* ; Edema ; Hyperbilirubinemia ; Phototherapy ; Rabbits ; Retina ; Retinaldehyde* ; Telescopes

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An Elementary School Children Screen Test for Attention Deficit Hyperactivity Disorder in Taegu City.

Heung Bae PARK ; Jin Sung KIM ; Sang Ruyl JANG ; Sung Chan PARK ; Hye Soo SUH ; Kwang Hun LEE ; Young Uck KIM ; Chang Su KIM

Yeungnam University Journal of Medicine.1995;12(1):56-74. doi:10.12701/yujm.1995.12.1.56

The authors applied ADDES-HV parent evaluation scale for the purpose of screeing test to 538 2nd grade elementary school students from March 1994 to May. The results were as follows: There was no differences in scores of ADHD between schools. In comparing the male and female between three school students, male students showed signifieant high scores (p<0.05) than female students in the score of ADDES-HV subscale and total. There was no significant differences in ADDES-HV scale between male students and female students in both ADHD patients and normal controls. In reliability test for test and retest, the reliability coefficient was higher satisfatorily and that of inattention was 0.80, inpulsivity was 0.69, hyperactivity was 0.63 and the total score was 0.82. In reliability test by internal consistancy, the Cronbach a coefficient of patient group was 0.85(p<0.05) and that of normal control was 0.84(p<0.05). The Concurrent validity between ADDES-HV scale and DSM- III -R scale was 0.57(p<0.05) in ADHD patient group and 0.84(p<0.05) in normal control group. In discriminant validity test between ADHD patient group and normal control, the ADHD patient group showed higher score(p<0.05). The total disciminant capacity of the patient group in ADDES-HV scale was 94.44%. When we regard the cut off point as standard deviation 1.5, the male student was 80 score and the female student was 69 score. In this point of view, ADDES-HV scale was proved to be the useful screening test tool for ADHD research and showed higher reliability and validity in applying to Korean subjects.
Attention Deficit Disorder with Hyperactivity* ; Child* ; Daegu* ; Female ; Humans ; Male ; Mass Screening ; Parents ; Reproducibility of Results

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Diagnostic Efficiency of Lactate Dehydrogenase, Crreatine Kinase and Troponin T in Acute Myocardial Infarction.

Chae Hoon LEE ; Kyung Dong KIM ; Chung Sook KIM

Yeungnam University Journal of Medicine.1995;12(1):48-55. doi:10.12701/yujm.1995.12.1.48

The present study was designed to evaluate the efficiency of total lactate dehydrogenase, total creatine kinase, LD1/LD2 ratio, CK-MB and newly developed troponin T in acute myocardial infarction. The level of troponin T was 0.010.02 pg/L in 34 healthy person, but the peak vaule of acute myocardial infarction ranged in 4.7-24.2 pg/L. Total lactate dehydrogenase was peaked in 1 to 3 days after chest pain and then progressively decreased, but LD1/LD2 ratio was persistently higher than 1.0 for 10 days in most patients. Total creatine kinase and CK-MB were peaked in 1-2 days, and normalized in 3-4 days, so they, were useful in early diagnosis of acute myocardial infarction, but not for the late stages of acute myocardiz l infarction. Troponin T is early elevated and persistently high level for more than 10 days. Comparing with total lactate dehydrogenase, total creatine kinase, LD1/LD2 ratio and CK-MB, troponin-T test improves the efficiency of serodiagnostic method for the detection of ischemic myocardial damage.
Chest Pain ; Creatine Kinase ; Early Diagnosis ; Humans ; Infarction ; L-Lactate Dehydrogenase* ; Lactic Acid* ; Myocardial Infarction* ; Phosphotransferases* ; Troponin T* ; Troponin*

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ene Expression of Enzymes Related to Glutathione Metabolism in Anticancer Drug-resistant L1210 Sublines.

Seong Yong KIM ; Jae Ryong KIM ; Jung Hye KIM

Yeungnam University Journal of Medicine.1995;12(1):32-47. doi:10.12701/yujm.1995.12.1.32

Glutathione(GSH) has a very important role in detoxification of cells and is closely related to antitumor drug-resistance of cancer cells. In order to evaluate the importance of glutathione metabolism in the drug-resistant cancer cells, the concentration of celluar GSH and activities of y-glutamylcysteine synthetase(GCS), y-glutamyl transpeptidase (GGT) and glutathione S-transferases(GST) in the adriamycin, vincristine, or cisplatin resistant L1210 (L1210AdR; L1210VcR, or L12100s) sublines were measured. Expression and amplification of GCS, GGT, and GST-i7 genes were also observed in the parent L1210 and the drug-resistant L1210 sublines. The concentration of GSH was increased 5.34 fold in L12100s, 2.83 fold in L1210VcR, and 1.78 fo-d in L1210AdR, compared to L1210. The activities of GCS and GGT were -increased in drug-resistant L1210 sublines. The GST activity was increased in L1210VcR and L1210Cis but decreased in L1210AdR compared to L1210. Expression of GCS, GGT, and GST-rr genes were increased in the resistant L1210 sublines compare to the parent L1210 in northern blot analyses. Overexpression of GCS, GGT, and GST-77 were observed in the resistant sublines, and the increases of the concentration of glutathione and the activities of GCS and GGT in the resistant sublines may be involved in a part of the drug-resistance in the resistant sublines.
Blotting, Northern ; Cisplatin ; Doxorubicin ; Drug Resistance ; Glutathione* ; Humans ; Metabolism* ; Parents ; Vincristine

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Biological Monitoring.

Chang Yoon KIM

Yeungnam University Journal of Medicine.1995;12(1):21-31. doi:10.12701/yujm.1995.12.1.21

No abstract available.
Environmental Monitoring*

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Serum AST.ALT Activities in the Diagnosis of Liver Diseases.

Heon Ju LEE

Yeungnam University Journal of Medicine.1995;12(1):10-20. doi:10.12701/yujm.1995.12.1.10

No abstract available.
Diagnosis* ; Liver Diseases* ; Liver*

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A study of PCNA Expression in Gastric Adenoma and Adenocarcinoma.

Mi Jin KIM ; Won Hee CHOI ; Tae Sook LEE

Yeungnam University Journal of Medicine.1995;12(1):1-9. doi:10.12701/yujm.1995.12.1.1

A monoclonal antibody to PCNA, which can be used on routinely processed tissue, was applied to 25 cases of gastric adenomas and 64 cases of gastric adenocarcinomas in order to diffentiate adenoma and adenocarcinoma and also to evaluate the prognostic value in adenocarcinoma. The results were summerized as follows: The PCNA labelling index was 29.14+/-12.77% in control, 44.09+/-17.11% in adenoma and 80.15+/-10. 69 in adenocarcinoma, resulting in significant increase in adenocarcinoma compared to adenoma. In adenocarcinoma, no significant correlation was observed between PCNA labelling index and histologic grade, and there -was increased tendency of PCNA labelling index in proportion to depth of invasion without statistical significance. The PCNA index was significantly increased in advanced adenocarcinoma compared to early gastric carcinoma, and also in positive nodal metastasis group than in negative group. From above results, the PCNA stain will be able to provide a helpful method for the differential diagnosis between gastric adenoma and adenocarcinoma, and could be a useful prognostic factor in adenocarcinoma if other factors are considered together.
Adenocarcinoma* ; Adenoma* ; Diagnosis, Differential ; Neoplasm Metastasis ; Proliferating Cell Nuclear Antigen* ; Stomach

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Dermatophytes Isolated From Korea.

Ki Hong KIM

Yeungnam University Journal of Medicine.1990;7(2):13-26. doi:10.12701/yujm.1990.7.2.13

No abstract available.
Arthrodermataceae* ; Korea*

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The development of organ transplantation.

Bo Yang SUH

Yeungnam University Journal of Medicine.1990;7(2):1-11. doi:10.12701/yujm.1990.7.2.1

No abstract available.
Organ Transplantation* ; Transplants*

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A Case of the Inverted Papilloma with Verrucous Carcinoma of the Nose and Paranasal Sinuses.

Myeong Soo JANG ; Mun Heum PARK ; Jang Su SUH

Yeungnam University Journal of Medicine.1989;6(2):279-285. doi:10.12701/yujm.1989.6.2.279

Inverted Papilloma arising from mucous membrane of the nasal cavity and paranasal sinuses is rare benign neoplasm, and usually unilateral arise from lateral wall of nasal cavity. This tumor is histologically benign neoplasm but clinically malignant, because of frequent recurrence and extensive bone destruction. And occasionally, this tumor can be transformed to squamous cell carcinoma or verrucous carcinoma. Recently, we have experienced a case of the inverted papilloma with verrucous carcinoma of the nose and paranasal sinuses and patient expired due to extension of intracranial cavity. We report out case with review of current literatures.
Carcinoma, Squamous Cell ; Carcinoma, Verrucous* ; Humans ; Mucous Membrane ; Nasal Cavity ; Nose* ; Papilloma, Inverted* ; Paranasal Sinuses* ; Recurrence

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