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Effective administration model for gestational diabetes mellitus in the community

Huihua CAI ; Yuanli HE ; Xuefeng WANG ; Shilei PAN

The Journal of Practical Medicine.2014;(4):662-664. doi:10.3969/j.issn.1006-5725.2014.04.058

Objective To investigate the effective administration model for gestational diabetes mellitus (GDM) in the community. Methods In a prospective study, the 75 g oral glucose tolerance test (OGTT) was performed in 4 713 resident pregnant women over 20 years old who received antenatal care in a general hospital or a special hospital from Sep. 2011 to Aug. 2012. Five hundred and thirty-three pregnant women were diagnosed as GDM, 198 patients who labored in a general hospital were enrolled in thegroup A , and the rest who labored in a special hospital were enrolled in the group B. 198 cases with non-GDM were enrolled in the group C. Results The incidence of GDM during this study period was 11.3%. The maternal age , gestationl weeks and OGTT results of patients in the three groups were significantly different (P < 0.05). With the increase of maternal age of pregnant women, the blood glucose increased while the gestationl weeks descreased. No significant differencees were shown in prevalence of polyhydramnios, hypertensive disorder complicating pregnancy, premature labor, macrosomia , fetal growth restriction and neonatal asphyxia among the three groups (P > 0.05). However, significant differences were found in the incidence of postpartum hemorrhage and cesarean section. The incidence of postpartum hemorrhage increased significantly in the patients of group B (χ2= 7.156, v = 2, P = 0.028). The incidence of cesarean section increased significantly in the patients of group A (χ2= 63.592, v = 2, P = 0.000). Conclusion Establishing an effective administration model for gestational diabetes mellitus in the community could control the incidence of GDM associated complications.

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A randomized controlled study of the mixed- or single-application of etomidate and propofol during modified electroconvulsive therapy (MECT)

Hongzu ZHAO ; Erlong CUI ; Hongxing ZHANG

The Journal of Practical Medicine.2014;(4):615-617. doi:10.3969/j.issn.1006-5725.2014.04.039

Objective To explore the feasibility of the mixed- or single-application of etomidate and propofol during modified electroconvulsive therapy (MECT). Methods Ninety hospitalized schizophrenics undergoing MECT were randomly assigned to 3 groups which were respectively anesthetized with mixed liquor application of etomidate and propofol (group E-P), etomidate (E) or propofol (P). Charge delivered (CD), EEG seizure duration (ESD), postictal suppression index (PSI), seizure energy index (SEI) and seizure generalization index (SGI) were recorded. Mental status and memory levels were assessed with the Positive and Negative Syndrome Scale (PANSS) and Wechsler Memory Scale (WMS) before and after treatment. The adverse reactions were recorded. All data were analyzed with the software SPSS12.0. Results The ESD, PSI, SEI, SGI and WMS scores, and the minus score of PANSS were significantly higher (P < 0.05) and CD was lower (P < 0.05) in group E-P than those in group P. No significant alteration between group E-P and group E (P > 0.05). The adverse reactions such as nausea/vomiting and secretion increase in group E-P were lower than those in group E (P < 0.05). The injection pain of group E-P was lower than that of group P (P<0.05). Conclusion The mixed liquor of etomidate and propofol has an advantage over the single-application of the two drugs during MECT.

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Research on sevoflurane combined with remifentanil anesthesia inabdominal surgeries

Dexing LIU ; Honglei ZHANG ; Xue ZHENG ; Chao ZHANG ; Zhaoqiong ZHU

The Journal of Practical Medicine.2014;(4):612-614. doi:10.3969/j.issn.1006-5725.2014.04.038

Objective To observe the anesthesia and recovery results of sevoflrane and remifentanil combined anesthesia in open or laparoscopic surgeries. Methods 60 cases of ordinary surgeries from the department of gynecology and general surgeries were included in this study with 30 cases in each group. (1)recording total sevoflurane inhalation time, muscular relaxant amount, end tidal sevoflurane concentration;(2)recording BP,HR at 10 min after induction,operation staring and ending,ventilation recovery, opening eye and extubation period;also sevoflurane concentration 5 min after stopping medicine and ventilation recovery;recording time period between surgery ending and autonomous respiration recovery , eye opening and extubation. Results No any adverse events happen in each patient.the sevoflurane inhalation time in open surgery group was (157.20 ± 47.28) min, longer than that of laparoscopic surgeries group (73.50 ± 11.23)min(P<0.05), we had seen no statistical significance in all other index observed (P>0.05). Conclusion Sevoflurane combined remifentanil anesthesia can achieve stable intra-operative maintenance and rapid postoperative recovery quality , we suggest the widespread usage of it in clinic.

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Randomized study of kezhi Capsules in Treating Nonalconolic Fatty Liver

Yuewu YANG ; Gemin XIAO ; Baiming ZHAO ; Hongzhi YANG ; Min DAI ; Lichun TENG

The Journal of Practical Medicine.2014;(4):638-640. doi:10.3969/j.issn.1006-5725.2014.04.048

Objective To evaluate the effect and side effects of Kezhi capsule in short-term treatment of nonalcoholic fatty liver disease (NAFLD). Methods 60 NAFLD cases of outpatients according to the inclusion criteria of were randomly assigned to two groups: the treated group-30cases with the prescription of Kezhi capsule , and the control group-30cases with the prescription of Xuezhikang. The treatment Course of taking Kezhi capusule (1.25 g, tid, po) and Xuezhikang(0.6 g, bid, po)was 24 weeks. Results After treatment in both groups we saw the significant decrease of the levels of ALT, AST, TC, TG, LDL-C, CREAT, BUN, BMI and TCM Syndromes scores, and the improvement of the ultrasonographic findings of liver steatosis. In the Xuezhikang group we saw higher decrease of TC and TG than the Kezhi capsule group with statistic difference (P < 0.05), while in Kezhi capsule group we saw higher decrease of BMI , TCM Syndromes scores and the improvement of the ultrasonographic findings of liver steatosis than the xuezhikang group with statistic difference (P < 0.05). Conclusions The results show that kezhi capsule is effective for the treatment of NAFLD without obvious side effects.

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Randomized controlled study of flying needle with intradermal needle in shu-acupoint for insomnia

Ying LI ; Xiuhua CHEN ; Quanxin CHEN

The Journal of Practical Medicine.2014;(4):631-634. doi:10.3969/j.issn.1006-5725.2014.04.045

Objective To compare the effective difference of the flying needle with intradermal needle among the shu-acupoint group , the estazolam group and the non- point acupuncture group. Methods Three undred and fifteen patients who met the inclusion criteria were randomly enrolled into three groups for the insomnia severity index (ISI) and rating changes detection. After 2-week treatment,the patients were followed up at 4 weeks later. Results The ISI decreased gradually at 1 week, 2 weeks, and 4 weeks after treatment.The therapeutic effects of the three groups were all better than ever before at 1 week, 2 weeks, and 4 weeks after treatment (P<0.05). The follow-up therapeutic effect of the flying needle acupuncture group was better than that of the estazolam group and of the non-point acupuncture group (P<0.05). The curative effect of flying needle acupuncture is better than that in the other two groups (P < 0.05). Conclusion The subjective sleep quality of insomnia patients received flying needle with intradermal needle in shu-acupoint is beter than that of insomnia patients of the Estazolam group and of the non-point acupuncture group.

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Effects of the administration of erythropoietin-alpha before total knee arthroplasty on patients with mild anemia

Yonggen ZOU ; Jian ZHANG ; Jiexiang YANG

The Journal of Practical Medicine.2014;(4):566-568. doi:10.3969/j.issn.1006-5725.2014.04.021

Objective To observe the effects of erythropoietin-α administered before the total knee arthroplasty (TKA) on the blood transfusion in patients with mild anemia. Methods 60 patients with mild anemia, who were arranged to receive TKA , from 2010-2012 , were assigned to received either 40 000U of erythropoietin-αfor 3 times (once a week) 3 weeks before the surgery (intervention group, n=30) or not (control group, n=30). Then the hemoglobin levels , transfusion ratio , inpatient length of stay and duration of surgery between the 2 groups were analyzed. Results The hemoglobin level was increased from 11.5 g/dL to 14.3 g/dL in intervention group before the surgery (P<0.01). The blood transfusion rate was decreased from 96.6%to 56.6% (P=0.013) during the surgery. And the length of hospital stay was similar between the 2 groups. Conclusion Erythropoietin-αadministered 3 weeks before the TKA surgery could reduce the blood transfusion rate of patients with mild anemia.

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Effects of ginsenoside Rg3-induced P27 expression on proliferation of human erythroleukemia K562 cells

Linna MA ; Yu LIANG ; Ranfeng CHEN

The Journal of Practical Medicine.2014;(7):1066-1069. doi:10.3969/j.issn.1006-5725.2014.07.018

Objective To explore the effects of ginsenoside Rg3 on the expression of P27 in human erythrol-eukemia cell line K562 and cell proliferation. Methods Human erythroleukemia cell line K562 cells were cultured to exponential phase, then K562 cells were treated with different concentrations of Rg3 (6.25, 12.5, 25, 50, and 100 μg/mL) as Rg3 group, and cells treated without Rg3 (0 μg/mL) were take as control group. After 3 days, K562 cells were observed by Wright-Giemsa staining with microscopy , the proliferation of K562 cells were examined by tetrazolium salt (MTT) assay, and the expression of P27 mRNA were detected by fluorescent quantitative RT-PCR assay. Results MTT assay showed that after treatment with Rg3,the inhibition rate (IR) of proliferation of cells in Rg3 groups were increased gradually , and the differences were significant compared with the control group (P < 0.05). The results of fluorescent quantitative RT-PCR showed the levels of P27 mRNA expression in 25,50 and 100 μg/mL Rg3 groups were significant higher than that of control group (P < 0.05). Conclusion The ginsenoside Rg3 can inhibit the proliferation of K562 cells by inducing the expression of P27.

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MYC suppresses ovarian cancer cell adhesion and invasion ability through downregulation of human integrinβ1

Zongyuan YANG ; Xiaoshui ZHOU ; Xiao WEI ; Yi LIU ; Chen GONG ; Gang CHEN ; Danhui WENG

The Journal of Practical Medicine.2014;(7):1048-1052. doi:10.3969/j.issn.1006-5725.2014.07.013

Objective To explore the influence of MYC expression level on ovarian cancer cells adhesion and invasion ability,and the involvement of the integrinβ1 in the adhesion and invasion control. Methods Comparative study was done to analyze the relationship between the mRNA level of MYC and ITGB1 among sixty cell lines from the NCI-60 cells bank; Western blot was performed to demonstrate the correlation of MYC and ITGB1 protein level in ovarian cancer cell lines;Immunohistochemistry was adopted to compare the expression level of MYC and ITGB1 in paired primary and metastatic ovarian cancer tissue. Furthermore ,we employed in vitro adhesion test to detect the alteration of ovarian cancer cell adhesion ability to ECM molecular like fibronectin ,collagen I and laminin after fluctuation of MYC and ITGB1 expression; Transwell assay was applied to check the invasion ability variation with the disturbance of MYC and ITGB1 level. Results The mRNA levels of MYC and ITGB1 were dramatically inverse-correlated in NCI-60 cells bank(P<0.01);The protein levels of MYC and ITGB1 in ovarian cancer cell lines were also negative correlated; The primary ovarian cancer tissue showed lower expression of ITGB1 and higher expression of MYC,while the matched metastasis displayed the opposite outcome;Ovarian cancer cells reduced adhesive and invasive capacity in case of ITGB1 being down-regulated ,however, the adhesive and metastatic ability improved tremendously with elevation of ITGB1;Promoted adhesion and invasion ability and rise of ITGB1 expression were observed after downregulation of MYC,meanwhile,and inhibition of ITGB1 reversed the increasement of adhesion and invasion ability. Conclusions MYC,inversely-correlated with ITGB1 in ovarian cancer cells,inhibited ovarian cancer cells adhesion and invasion. Inhibition of MYC could lead to enhanced adhesion and invasion ability of ovarian cancer cells.

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Application of MRI cranial surface locating device in localization of small intracranial space-occupying lesions

Youpei WEI ; Xiguang LIU ; Fang LI

The Journal of Practical Medicine.2014;(7):1027-1029. doi:10.3969/j.issn.1006-5725.2014.07.006

Objective To explore the feasibility of applying MRI cranial surface locating device in localization of small intracranial space-occupying lesions before the surgeries. Methods Thirty patients with small intracranial space-occupying lesion were localized by MRI cranial surface locating device before the surgeries. The clinical accuracy was verified during the surgeries and the results were compared with cases without using the device. Results According to the verifications during the surgeries , 30 cases which used MRI cranial surface locating device showed much higher accuracy than that using the traditional method. Conclusions MRI cranial surface locating device can precisely delineate the surgical target area. The device is easy to operate and also can help to design the rational surgical approach with minimum injuries , significantly improve accuracy of locating small intracranial space-occupying lesions and it is safe , effective and worthy of widely used clinically.

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Application of three-dimensional digital subtraction angiography in the evaluation of ruptured intracranial aneurysm after clipping

Hui SHI ; Bing ZHAO ; Ming ZHONG ; Yi ZHANG ; Kuang ZHENG ; Zequn LI ; Xianxi TAN

The Journal of Practical Medicine.2014;(7):1024-1027. doi:10.3969/j.issn.1006-5725.2014.07.005

Objective To assess the application of three-dimensional digital subtraction angiography (3D-DSA) in evaluation of ruptured intracranial aneurysm after clipping and to discuss the different variable use of vol-ume rendering(VR), gradient rendering (GR) and maximum intensity projection (MIP). Methods From January 2011 to December 2012 , 88 patients with 92 ruptured intracranial aneurysms were treated with clipping using titani-um clips in our hospital and followed up by both 2D-DSA and 3D-DSA. Residual aneurysms , Clips place, clips and parent arteries and stenosis of parent arteries were evaluated by volume rendering (VR), gradient rendering (GR) and maximum intensity projection (MIP). Results Among 92 clipped aneurysms, 23 residual aneurysms were found by 3D-DSA. Residual aneurysms were recorded according to the Sindou grade: 15 of gradeⅠ, 3 of gradeⅡ, 4 of grade Ⅲand 1 of grade Ⅳ. Three patients of grade Ⅲand 1 of grade Ⅳwith residual aneurysms were retreated by clipping or coiling, and 1 patient of grade Ⅲ was dead with rupture of residual aneurysm. The clips and number of clips were clearly visualized , and relationship between the clips and the aneurysms was well demonstrated by VR, GR and MIP images. VR, GR images showed the remnants clearly. Three-dimensional digital subtraction angiography did not showed accurate details of the stenosis of parent arties which required an analysis of 2D-DSA. Conclusion Three-dimensional digital subtraction angiography can be used for definite evaluation of resid-ual aneurysms after clipping, especially by VR, GR images. It is helpful to manage the residual ruptured aneurysms.

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