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The level of souble interleukin 7receptor in serum from lupus nephritis patients and clinical implication

Peifeng KE ; Anping PENG ; Lixin WANG ; Xinyi LU ; Peijian HUANG

The Journal of Practical Medicine.2015;(9):1428-1430. doi:10.3969/j.issn.1006-5725.2015.09.013

Objective To investigate the level of soluble interleukin 7 receptor (sIL-7R) in serum of lupus nephritis(LN)patients and evaluate its clinical significance. Methods sIL-7R level in serum of LN patients and healthy controls were measured by ELISA , while total 24 hours urinary protein and complement C3 of LN patients were measured by BN ProSpec. The level of sIL-7R correlation with SLEDAI, total 24 hours urinary protein and complement C3 were analyzed respectively. Results The levelof sIL-7R was higher in serum of LN patients than healthy controls (P < 0.01). Moreover, its expression in serum was increased in LN patients in active stage than in LN patients in stable stage (P < 0.05). The level of sIL-7R was positively assosicated with SLEDAI, total 24 hours urinary protein(P < 0.01, P < 0.05) and negatively with complement C3 (P < 0.05). Conclusion The level of sIL-7R is upregulated in serum in LN patients and correlated with disease activity and progression, so it may be expected to become a potential marker of disease in prediction.

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Resistance to cyclic fatigue andfracture of structurally compromised root restored with three different postand core systems

Xichao HONG ; Jing WEN ; Shide YU ; Yanru LI

The Journal of Practical Medicine.2015;(9):1425-1427. doi:10.3969/j.issn.1006-5725.2015.09.012

Objective To compare the fracture resistances of teeth restored with 3 different posts-core and failure modes. Methods 54lower premolarsendodontically treated teeth were selected for thisstudy and divided into three groups randomly (without ferrule, 1 mm ferrule and 2 mm ferrule). Each group was then divided into 3 sub-groups (6 teeth in each group) and restored with cast post-core, glass fiberpost-core, andceramic post-core respectively. After thermocycling specimens , the fracture resistance was measured using a cyclic fatigue testing machine. Data were analyzed with 2-way ANOVA (α = 0.05). Results Fiber post-core group exhibited significantly higher resistance to fracture compared with groups of cast post-core and ceramic post-core (P<0.05). Preparing dentin ferrules increased significantly fatigue resistance (P < 0.05). Conclusions Glassfiber posts were able to preserve and reinforce the remaining tooth structures. Dentin ferrule preparation is necessary to enhancefractureresistance.

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The clinical effects of Banxia Xiexin Decoction cured by gastric syndromes

Lili ZHU ; Xiaofeng ZHAO ; Hai GUO ; Shunian LI

The Journal of Practical Medicine.2015;(9):1546-1547. doi:10.3969/j.issn.1006-5725.2015.09.054

Objective To study the clinical effect of BanxiaXiexinDecoction on gastric symdrome. Methods 82 patients withgastric syndrome hospitalized in our hospital from April 2012 to April 2014 were randomized evenly into the control group and the observation group In the control group , the patients were treated with thebasic treatment using Western medicine while the observation group was treated with BanxiaXiexin decoction based on the basic treatment. Then , the two group were compared in terms curative effects. Results The total effective rate in the observation group was significantly higher than that of the control group (92.68%vs. 70.73%, P < 0.05), while the rate of complications in the treatment group was significantly lower than that in the control group (12.20 vs. 29.27%, P < 0.05). Conclusion Western medicine plus BanxiaXiexin Decoctionis effective in the treatment of gastric syndrome. It may be fast at improving the symptoms and good at preventing the relapse of disease.

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Effects of heroin use on serum levels of homocysteine

Weihua HUANG ; Xiaoshan XIAO

The Journal of Practical Medicine.2015;(9):1519-1521. doi:10.3969/j.issn.1006-5725.2015.09.044

Objective To determine whether concentrations of plasma homocysteine and status of folate and vitamin B12 were altered in patients with heroin dependence compared with control subjects. Methods We recruited 20 patients with heroin addiction. Twenty age-and sex-matched healthy volunteers as the control group were enrolled. Blood concentrations of homocysteine, folate and vitamin B12 were measured in a fasted status. Results Mean homocysteine level was higher in the heroindependence group than in the control group [18.3 ± 4.5 (Q1 = 14.7, Q2 = 17.6, Q3 = 19.2) vs. 8.4 ± 2.7 (Q1 = 5.9, Q2 = 8.5, Q3 = 10.5) μmol/L, P < 0.001]. Patients in heroinaddictiongroup had signi cantly lower folate levels compared with the control group [6.6 ± 2.6 (Q1=4.6, Q2=6.4, Q3=8.1) vs. 12.7 ± 2.5 (Q1 = 11.1, Q2 = 13.0, Q3 = 17.5) ng/mL, P < 0.001]. There was significant difference on plasma B12 concentrations between heroin users and controls [384.1 ± 228.8 (Q1=312.0, Q2=348.5, Q3=374.5) vs. 399.4 ± 45.1 (Q1=358.0, Q2=394.5, Q3=428.3) Pg/mL, P < 0.001]. Heroin users group demonstrated a negative correlation of homocysteine with folate , which was statistically significant in heroin users groups (r = - 0.614; P = 0.004), there was a trend towards a negative correlation of homocysteine with B12 in heroin users (r = -0.605; P = 0.005), respectively. Conclusions We conclude that patients with heroin dependence are prone to high concentration of plasma homocysteine.

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The bronchoscopic features of endobronchial tuberculosis induced by lymphatic fistula and the efficacy of interventional treatment

Qiong FANG ; Yingwen LI ; Yikai XIE ; Hongying LIU ; Manlin WEI

The Journal of Practical Medicine.2015;(9):1482-1485. doi:10.3969/j.issn.1006-5725.2015.09.031

Objective To explore the bronchoscopic features of endobronchial tuberculosis induced by lymphatic fistula and the efficacy of interventional treatment. Methods The data on 31 patients with endobronchial tuberculosis induced by lymphatic fistula who had received bronchoscopic diagnosis and treatment in our hospital during the period of January 2010 to June 2013 were reviewed. The bronchoscopic features , along with the frequency of interventional therapies and duration of the therapies , were retrospectively analyzed; and the efficacy of the therapies and the related complications were assessed. Rusults The endoscopic appearance showed: granuloma (19.4%), necrosis (51.6%), granuloma with necrosis (25.8%), and fistulous opening (3.2%). Dark gray matter or carbon deposition inside the lesions was the characteristics of endobronchial tuberculosis induced by lymphatic fistula. There were 76 orificium fistulae in 31 patients , mostly in the right side. The median frequency of treatment was five in patients with single orificium fistulae and the median treatment duration was 65 days; whereas the median frequency of treatment was nine in patients with multiple fistulae and the median treatment duration was 108 days. There were significant differences between the two groups (P < 0.05 for both comparisons). The effectiveness rate of treatment was 98.7%. The therapy-related complication was of a small amount of bleeding, with a rate of 2.1%. Conlusions Endobronchial tuberculosis induced by lymphatic fistula shows certain characteristics under bronchoscopic examination. Bronchoscopic clamping combined with infusions with antituberculosis agents is a safe, simple, effective therapeutic method.

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The analysis of alveolar bone condition around mandibular incisors in adults with skeletal Class Ⅲmalocclusion by CT

Hua YANG ; Ying JIA ; Yong WANG

The Journal of Practical Medicine.2015;(9):1478-1481. doi:10.3969/j.issn.1006-5725.2015.09.030

Objective To study the mandibular anterior alveolar morphological characteristics of skeletal ClassⅢmalocclusion patients by CT quantitative research , which can provide guidances and indications for clinical skeletal Class Ⅲmalocclusion treatment and prevent iatrogenic complications , such as rootabsorption. Method 25 skeletal Class Ⅲ malocclusion patients during thepostpubertal were selected , three-dimensionalspiralCTscanning was applied to measure cortical and cancellousbonethickness around 6 mandibular incisors for analyzing the relationship between the bone mass and its anatomyaround the mandibular incisors roots. Results (1) The bone thickness around the lower anterior homonym teeth was basically symmetric in the skeletal Class III malocclusion. The labial thickness is a little less than the lingual side , gradually thickening along the root apical direction; (2) The area of mandibular incisors was inhomogeneous , and the 1/2 regional cancellous bone thickness of mandibular incisors was often lacked. Conclusion (1) The synchronous compensation of the teeth and alveolar bone is the significant feature of the skeletal Class Ⅲ malocclusion. (2) The responding regions ofthe alveolar bone in the 1/3 labial-cervical and root-tip may be the sensitive areas during the orthodontic treatment.

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A comparative analysis of the efficacy of HAART with TDF and with AZT

Zhenzhen LU ; Qijian SU ; Xuan LI ; Linchun FU

The Journal of Practical Medicine.2015;(9):1475-1478. doi:10.3969/j.issn.1006-5725.2015.09.029

Objective To compare the efficacy of highly active anti-retroviral treatment (HAART) with and with AZT. Methods Data of 235 HIV patients accepted from Oct. 2010 to Nov. 2013 who took AZT (133) or TDF (102) containing regimen as first-line HAART are analyzed retrospectively. CD4+ T cell counts acted as the base line after 12 months of HAART. Increase in CD4+ T cell count number after the HAART, virological failures and drug resistance were compared between the two groups. Results The two groups had comparable baseline CD4+T cell count, gender ratio, and HIV transmision mode; after 12 months of HARRT, no statistically differences were found between the two groups with regard to CD4 + T cell count and increase in CD4+ T cell count after the 12-month HAART (P > 0.05); AZT-containing group had more virological failure (3/0). Meanwhile AZT-containing group had one thymidine analog mutation (TAMs) which confers resistance to AZT (P > 0.05 for both). Conculsion The two HAARTs have same immunological effects; AZT-containing group exhibits 2.2% viralogial failure, but its direct relationship with AZT has not been confirmed.

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Follow-up results of heart conduct block after transcatheter closure of ventricular septal defect surgery

Qinghua ZHONG ; Zhiwei ZHANG ; Shengxian FANG ; Mingyang QIAN ; Yumei XIE ; Shushui WANG

The Journal of Practical Medicine.2015;(9):1472-1474. doi:10.3969/j.issn.1006-5725.2015.09.028

Objective To study the prevalence and risk factors of heart conduct block after transcatheter closure of ventricular septal defect (VSD)surgery. Methods A total of 1 069 cases underwent transcatheter closure VSD were retrospectively analyzed. The risk factors were assessed by multivariable logistical analysis. Results The median follow-up time was 2.2 (1 to 4.16) years. The early post-procedure heart conduct block was 20.5 %(219 cases), and 35 cases underwent severe conduct block (3.3%). During the follow-up, there were 43 late onset heart conduct block (4.0%), including 4 (0.4%) complete atrioventricular block. Multivariable logistic analysis showed that implanted of asymmetrical occluder from foreign company was the risks factors for early onset severe conduct block, with longer procedure time. Placement of thin-waist-big-side occluder were risk factor for the late onset conduct block. Conclusions Heart conduct block after transcatheter closure VSD is common , light and recovery. The late onset severe conduct block is minor. Symmetrical occluder should be chosen in transcatheter closure VSD if possible.

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Expression and clinical value of serum thymidine kinase 1 in patients with acute exacerbation of chronic obstructive pulmonary disease

Yin LIU ; Mengmeng JIN ; Zhendong QIAN ; Meili CHEN ; Rui HUANG ; Ting DU ; Yanbei ZHANG

The Journal of Practical Medicine.2015;(9):1431-1433. doi:10.3969/j.issn.1006-5725.2015.09.014

Objective To investigate the relations and evaluation value of serum thymidine kinase 1 (sTK1) in the treatment of patients withacute exacerbation of chronic obstructive pulmonarydisease (AECOPD). Methods The retrospective treating studies were performed on 104 patients with AECOPD , sTK1 level was de-tected by chemiluminescence dot-blot assay before and after treatment , and the correlation between the expression of sTK1 and CRP after treatment in the two groups was analyzed. Results The levels of sTK1 and CRP in the ef-fective group significantly lowered after treatment (P < 0.05). The expression of sTK1 in the effective group and in the ineffective group after treatment was significantlycorrelated with CRP (P < 0.05). Conclusion sTK1 can be used as a valuable indicator to evaluate the severity of AECOPD and to estimate the efficacy of AECOPD thera-py.

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Association between Adiponectin polymorphisms and nonalcoholic fatty liver disease in Han Chinese popu-lation in Qingdao

Yuting CHENG ; Man JIANG ; Yongning XIN ; Baiquan AN ; Shiying XUAN

The Journal of Practical Medicine.2015;(9):1421-1424. doi:10.3969/j.issn.1006-5725.2015.09.011

Objective To investigate the association between the Adiponectin rs266729 and rs2241766 gene polymorphisms and nonalcoholic fatty liver disease in the Han Chinese population residing in Qingdao. Methods Adiponectin rs266729 and rs2241766 gene polymorphisms were genotyped in patients with NAFLD (n = 336) and healthy controls (n = 280) using polymerase chain reaction (PCR). Serum lipid profiles and adiponectin levels were determined using biochemical methods. Statistical analyses were performed using Pearson Chi square test, logistic regression analysis, t test, linear regression analysis. Results We found a significant association between the Adiponectin rs266729 genotype frequencies and allele frequencies between NAFLD pa-tients and controls (χ2= 9.929, P = 0.007; χ2= 9.809, P = 0.002). After adjustment of confounding factor, the rs266729 G allele was associated with an increased risk of NAFLD compared to the C allele (OR = 1.410, 95%CI: 1.082-1.831, P = 0.008) No significant differences were found in the rs2241766 genotype frequencies and allele frequencies between NAFLD population and the controls (OR = 1.410, 95%CI: 1.082-1.831, P = 0.008). Conclusion The Han Chinese in Qingdao carrying the rs266729 G allele are at increased risk of NAFLD.

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