The Journal of Practical Medicine 2015;(9):1431-1433

doi:10.3969/j.issn.1006-5725.2015.09.014

Expression and clinical value of serum thymidine kinase 1 in patients with acute exacerbation of chronic obstructive pulmonary disease

Yin LIU ; Mengmeng JIN ; Zhendong QIAN ; Meili CHEN ; Rui HUANG ; Ting DU ; Yanbei ZHANG

Keywords

Acute exacerbation of chronic obstructive pulmonary disease; Serum thymidine kinase 1; Efficacy

Country

China

Language

Chinese

Abstract

Objective To investigate the relations and evaluation value of serum thymidine kinase 1 (sTK1) in the treatment of patients withacute exacerbation of chronic obstructive pulmonarydisease (AECOPD). Methods The retrospective treating studies were performed on 104 patients with AECOPD , sTK1 level was de-tected by chemiluminescence dot-blot assay before and after treatment , and the correlation between the expression of sTK1 and CRP after treatment in the two groups was analyzed. Results The levels of sTK1 and CRP in the ef-fective group significantly lowered after treatment (P < 0.05). The expression of sTK1 in the effective group and in the ineffective group after treatment was significantlycorrelated with CRP (P < 0.05). Conclusion sTK1 can be used as a valuable indicator to evaluate the severity of AECOPD and to estimate the efficacy of AECOPD thera-py.