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Dynamic Comparison of Total Flavones Content in Various Parts of Mosla Dianthera Harvested in Different Seasons

China Pharmacist.2014;(4):615-616,617.

Objective:To study the content of total flavones in different parts of Mosla dianthera harvested in different seasons to pro-vide reference for the determination of optimal medicinal part and harvesting time of the plant. Methods:The total flavones content of M. dianthera was determined by TLC-UV. Results:The content of total flavones extracted from the plant in September was highest, and that in the leaves was much higher than that in the stems or the roots. Conclusion:It is advisable to harvest the aerial parts of M. dianthera in September.

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Influence and Curative Effect Observation of Carvedilol on Serum Matrix Metalloproteinase -2, 9 and 10 (MMP-2, 9 and 10) in Patients with Chronic Congestive Heart Failure

Jinjin ZHU ; Zhikui SUN

China Pharmacist.2014;(5):816-817,818.

Objective: To study the influence and curative effect of carvedilol on serum matrix metalloproteinase -2, 9 and 10 (MMP-2, 9 and 10) in the patients with chronic congestive heart failure (CHF). Methods:Totally 76 patients with CHF were select-ed and randomly divided into the observation group and the control group. All the patients were given routine medical treatment, inclu-ding cardiotonic treatment ( digoxin) , diuresis ( thiadiazide) , vascular dilation ( nitrate ester) and so on. The patients in the observa-tion group were additionally given carvedilol for 6 months. The changes of serum MMP-2, 9 and 10 levels in the patients before the treatment and 6 months after the medical treatment were observed, and the curative effect and safety were studied as well. Results:Af-ter the 6-month medical treatment, the serum MMP-2, 9 and 10 levels in all the patients were obviously declined(P<0. 05), and the declining rates in the observation group were much higher than those in the control group(P<0. 05). Meanwhile, the total clinical effi-ciency of the observation group was 94. 74%, which was higher than that of the control group (78. 95%) (P<0. 05). Conclusion:Carvedilol has favorable curative effect and safety in the treatment of CIF, and the underlying mechanism may be relative to the de-crease of serum MMP-2, 9 and 10 levels.

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Clinical Effect of Titanoreine Suppositories and Hypertonic Magnesium Sulfate Solutions in the Treatment of Postpartum Hemorrhoids Acute Attack

Qingkang CHEN ; Youda WANG

China Pharmacist.2014;(5):814-815,816.

Objective:To investigate the clinical curative effect of Titanoreine suppositories combined with hypertonic magnesium sulfate solutions in the treatment of postpartum hemorrhoids acute attack. Methods:Totally 58 patients with postpartum hemorrhoids a-cute attack in our hospital from August 2012 to August 2013 were randomly divided into the observation group and the control group, 29 cases in each. The control group was treated with Titanoreine suppositories combined with hemorrhoids suppositories, and the observa-tion group was treated with Titanorein suppositories combined with hot compress using 50% sulfur acid magnesium liquids on the basis of sitz bath with potassium permanganate liquids. After the 7-day treatment, the clinical curative effect and adverse reactions were com-pared between the two groups. Results:The total effective rate in the observation group was 89. 7%(26/29), which was significantly higher than that in the control group 58. 6%(17/29). The pain relief rate on the first day was 93. 1% (27/29) in the observation group, which was also significantly higher than that in the control group 58. 6%(17/29) with statistically significant difference ( P<0. 01). Conclusion: Titanoreine suppositories combined with hypertonic magnesium sulfate solutions in the treatment of postpartum hemorrhoids acute attack is with rapid onset of action and obvious curative effect.

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Improvement of Mobile Phase in Determination Method for Penicillin V Potassium Tablets in Chinese Phar-macopoeia

Guoping YANG

China Pharmacist.2014;(5):878-879,880.

Objective:To improve the determination method for penicillin V potassium tablets. Methods:An Inertis ODS-SP C18 column (150 mm × 4. 6 mm, 5 μm) was used. The mobile phase consisted of A and B(60∶40) [ A: pH 3. 5 phosphate buffer(0. 5 mol·L-1 potassium dihydrogen phosphate solution, adjusting pH to 3. 5 with phosphoric acid)-acetonitrile-water (10∶30∶60);B:pH 3. 5 phosphate buffer-acetonitrile-water (10∶55∶35)]. The flow rate was 1. 0 ml·min-1, the detection wavelength was 268nm, the column temperature was room temperature and the injection volume was 10 μl. Results:The linear range of penicillin V potassium was 0. 032 9-0. 821 6 mg·ml-1(r=0. 999 9, and the average recovery was 99. 9%( RSD=0. 6%, n=9). Conclusion:The method is reproducible and accurate, and can be used in the content determination of penicillin V potassium tablets and capsules.

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The clinical effect of Misoprostol promoting cervical mature for before abortion

Jun ZHAO ; Heye LV

China Pharmacist.2014;(5):859-860,870.

Objective:Objective To investigate the clinical effect of Misoprostol promoting cervical mature for before abortion . Method:8 patients of induced abortion operation were enrolled in our hospital from January 2013 to January 2012 , and were randomly divided into observation group and control group, each group had 124 cases, the observation group was given misoprostol which placed in cvaginal fornix preoperative , and control group without prompting cervical ripening drug. Observation of cervical dilatation, degree of pain, operation time and bleeding volume in two groups of patients. Result: The efficiency rate of observation group was 96. 8%, significantly higher than 82. 3% in the control group, the difference was statistically significant (P<0. 05);there were 100 cases of painless in the observation group , and 51 cases in control group, the degree of pain in the observation group were obviously improved than the control group , the difference was statistically significant (P<0. 05);,operation time of treatment group was shorter than the control group, the amount of bleeding surgery was significantly lower than the control group, the differences were statistically significant (P<0. 05). Conclusion:Misoprostol is given before induced abortion , can relax cervical effectively, shorten operation time, reduce the patients' pain, reduce the difficulty of operation, increase the safety of operation , is worth the clinical promotion.

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Determination of Triptolide in Compound Tripterygium Wilfordil Syrups by HPLC

Xixia CHENG ; Yunxia LI

China Pharmacist.2014;(2):316-318.

Objective:To establish a method for the content determination of triptolide in compound tripterygium wilfordil syrups by HPLC. Methods:The samples were analyzed on a Diamonsil C18 column(150 mm × 4. 6 mm,5μm), the mobile phase consisted of methanol and water (46∶54), the flow rate was 1. 0 ml·min-1, the detection wavelength was 224 nm, and the column temperature was kept at 30℃, and the injection volume was 10 μl. Results: The linear range of triptolide was 5. 66-33. 96 μg · ml-1 ( r =0. 999 8), and the average recovery was 99. 35% with RSD of 1. 02%(n=9). Conclusion:The method is simple and sensitive with good repeatability, and can be used to control the quality of triptolide in compound tripterygium wilfordil syrups.

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Determination of Norisoboldine in Suoquan Capsules by HPLC

Qing WEN ; Ping NIE ; Ye DING ; Jinfeng ZHENG ; Wenli LI

China Pharmacist.2014;(2):308-309.

Objective:To establish an HPLC method for the determination of norisoboldine in Suoquan capsules. Methods: The chromatographic procedure with acetonitrile-water containing 0. 5% folic acid and 0. 1% triethylamine (10∶90) as the mobile phase was carried out on an Ecosil C18 HPLC(150 mm ×4.6 mm,5 μm). The flow rate was at 1.0 ml·min-1, the detection wavelength was 280nm and the column temperature was 30 ℃. Results: The linear range of norisoboldine was within 38. 56-578. 40 ng ( r =0. 999 2), the average recovery of norisoboldine was 99. 9%(RSD=1. 7%, n=6). Conclusion:The method is highly sensitive, re-liable and accurate, and can be applied in the determination of Suoquan capsules.

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Determination of Pantoprazole Sodium for Injection by High Performance Capillary Electrophoresis

Ziyu SONG ; Dazhong DING ; Chengzhang LUAN

China Pharmacist.2014;(2):240-242.

Objective:To establish a method for the content determination of pantoprazole sodium for injection by high performance capillary electrophoresis. Methods:The determination was performed on an uncoated elastic quartz capillary column, the running buff-er was 0. 01 mol·L-1 potassium dihydrogen phosphate buffer, the running voltage was 25kV,the column temperature was 25℃ and the detection wavelength was 289 nm. Results:The linear range was good within the concentration range of 20. 05-200. 51 μg·ml-1(r=0. 999 6). The average recovery was 99. 03%(RSD=0. 86%, n=9). Conclusion:The method is simple, sensitive and reproduci-ble, and can be used in the determination of pantoprazole sodium for injection.

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Pharmacognostical Identification of Selaginellae Uncinatae Herba

Yimei LIU ; Jia LIU ; Keli CHEN

China Pharmacist.2014;(2):232-234.

Objective:To pharmacognostically identify Selaginellae uncinatae Herba to provide reference for the identification and utilization of Selaginellae uncinatae Herba. Methods:On the basis of observing the characters, structure and microscopic characteris-tics of the powder, Selaginella uncinata Herba was identified by a TLC method using amentoflavone as the reference substance. The contents of total ash, acid insoluble ash and alcohol-soluble extracts in Selaginellae uncinatae Herba were detected as well. Results:The morphological identification, microscopic identification and TLC identification of the herb was respectively established. The content limits of the total ash, acid insoluble ash and alcohol soluble extract were preliminarily determined. Conclusion:The studies provide reference for the identification and quality evaluation of Selaginellae uncinatae Herba.

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Determination of Related Substances in Norfloxacin Glutamate and Sodium Chloride Injections

Jing ZHANG ; Qingquan WANG ; Xuping LIU ; Liangfa WU

China Pharmacist.2014;(2):229-231.

Objective:To detect the related substances in norfloxacin glutamate and sodium chloride injections on the basis of nor-floxacin related substances analysis method described in Chinese Pharmacopoeia 2010 edition to establish a more scientific and feasible method. Methods:HPLC was performed under the following conditions:a Diamonsil C18(2)(250 mm ×4.6 mm,5μm) column, mo-bile phase A of 0. 025 mol·L-1 phosphoric acid-acetonitrile(87∶13), phase B of acetonitrile, with gradient elution at a flow rate of 1. 0 ml·min-1 , the detection wavelength of 278nm and 262nm, the injection volume of 20 μl, and the column temperature of 25℃. Results:Under the HPLC conditions, the samples had good stability and separation. An excellent linear relationship was achieved within the range of 0. 032-3. 179μg·ml-1(r=1. 000 0),the detection limit of impurity A was 0. 159 ng,and the average recovery was 98. 3% with RSD of 0. 64%(n=9). Conclusion:Compared with the existing methods, the gradient elution method is accurate, sen-sitive, specific and reproducible, and can be used in the determination of related substances in norfloxacin glutamate and sodium chlo-ride injections.

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