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Expression of CD44 gene nm23 gene TGFα and TNFα in epithelial ovarian cancer

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(3):155-157.

ObjectiveTo explore the relation of the expression of intron 9 in CD44 gene,nm23 gene and the serum levels of TGFα and TNFα to the development, metastasis and prognosis of epithelial ovarian cancer. Methods The expressions of intron 9 in CD44 gene, nm23 gene, TGFα and TNFα in epithelial ovarian cancer were measured by semi -quantitative RT - PCR, immunohistochemical technique and radioimmunoassay ( RIA ). Results There was positive expression of intron 9 in CD44 gene,nm23 gene,TGFα and TNFα in 36 cases of epithelial ovarian cancer. The higher levels of nm23 gene and TGFa were obvious in early stage of ovarian cancer. ConclusionTo study the ovarian cancers biologic behavior with these multipe factors can provide theoretical basis for early diagnosis, gene therapy and predicting prognosis.

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Relationship between serum CRP CH50 C3 concentration in premature labor and subclinical chorioamnionitis

Xianghua YIN ; Zhenji PIAO ; Yanchun SONG

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(3):152-154.

Objective To determine the early diagnostic value of serum C -reactive protein (CRP)、 total complement( CH50 ) activity and complement 3 (C3) concentration of premature women in the subclinical infection.MethodsSolid phase enzyme linked immunosorbent assay ( ELISA method ) was used for measurements of serum CRP levels. According to modified Mayer simple tubular colorimetric method and simple agar immunodiffusion method, we determined the CH50、C3 concentration respectively.Results Premature women with subclinical chorioamnionitis showed higher serum CRP concentration than that of normal pregnancy women (P<0.01). In the subclinical chorioamnionitis, the more serious the infection, the higher the CRP concentration, while CH50 and C3 concentrations were correspondently decreased. Serum CRP concentration in premature labor was the most sensitive index that suggested subclinical chorioamnionitis. ConclusionsSerum CRP、CH50 and C3 concentrations in premature labor are simple,reliable and accurate indexes for early diagnosis of subclinical infection.

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Clinical study of mifepristone with or without tamoxifen in the treatment of leiomyoma

Lijun YANG ; Jiaxue WEI

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(3):145-146.

ObjectiveTo investigate the efficacy of mifepristone with or without tamoxifen in the treatment of leiomyomas. Methods173 symptomatic patients with leiomyomas were divided into 2 groups randomly. Group A (88cases) received mifepristone 25mg per day;Group B(85 cases) received mifepristone per day combined with tamoxifen l0mg twice a day from the first day of menstrul cycle for three months. Leiomyoma and uterine size were measured by B ultrasound, the changes of endometrium were examined pathologically. Estrogen and progesterone levels, hemoglobin and liver renal function were all measured, meanwhile, adverse effects of drugs were assessed. ResultsAll the patients in the 2 groups were amenorrhea with increased hemoglobin, the level of estrogen and progesterone remained in the early stage of proliferation phase. The uterus and leiomyoma sizes in two groups both reduced, but those in group B reduced less significantly(P＜0.01). Adverse effects showed similarity and needed no special control. ConclusionsBoth mifepristone and mifepristone combined with tamoxifen show good efficacy in the treatment of leiomyoma, but mifepristone combined with tamoxifen is more suitable.

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A pathomorphological analysis of the endometrial stromal tumors of uterus

Donghui GUO

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(2):111-112.

Objective To furthur recognize the pathomorphological features of the endometrial stromal tumors.MethodsThe clinicopathological analysis was made for 19 cases of endometrial stromal tumors of uterus, including 1 of nodule, 15 of low-grade sarcomas and 3 of high-grade sarcomas. ResultsThe location of neoplasm predominated in submucosal in 4 cases, 4 cases of sarcomas recurred after operation. 4 cases showed extrauterine tumors. Sex-cord-like differentiation presented in 6 tumors. Smooth muscle differentiation was found in 7 cases. ConclusionLow-grade endometrial stromal sarcomas is the commonest histopathological pattern in the endometrial stromal tumors. Sex-cord-like differentiation and smooth muscle differentiation are not rare in endometrial stromal tumors.

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Effects of angiogenesis on the development of endometrial carcinoma

Jinquan CUI ; Liju SUN ; Nan MA

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(2):109-110.

ObjectiveTo study the effects of angiogenesis on the development of endometrial carcinoma. Methods Hysterectomy specimens were stained immunohistochemically by the marker of factor Ⅷ-related antigen for endothelium vessels in normal controls, patients with endometrial hyperplasia and with endometrial carcinoma. Results The microvascular density(MVD) in tumour increased gradually from normal endometrium to endometrial hyperplasia and to endometrial carcinoma(P<0.01). MVD correlated with the mvometrial invasion, histologic grades and the stages.ConclusionMYD in endometrial hyperplasia increases. MVD can be used as a prognostic factor.

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Effects of optional cesarean section on the level of plasma motilin and serum gastrin in neonatal umbilical blood

Zhijun XIA ; Shulan ZHANG ; Zhuo ZHOU

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(2):107-108.

ObjectiveTo explore the effects of optional cesarean section on the level of plasma motilin and serum gastrin in umbilical blood and their relationship with gastroenteric symptoms of neonates. MethodsWe measured the concentrations of plasma motilin and serum gastrin in umbilical blood from neonates undergoing optional cesarean operation, emergency cesarean section and vaginal delivery by radioimmunoassay(RIA). ResultsFull-term deliveries undergoing optional cesarean section were with significant gastrointestinal symptoms. Plasma motilin and serum gastrin were significantly lower in neonates undergoing cesarean operation without birth initiate group(optional cesarean section)than that in cesarean section with birth initiate group and vaginal delivery group (P<0.05). ConclusionCesarean operation without birth initiate influences neonatal gastroenteric symptoms.Breast feeding which begins as early as possible will help to relieve those symptoms.

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Relationship between range of operative and postoperative ovary function in 55 endometriosis

Jun PAN ; Wen DI ; Defu CHEN

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(2):102-104.

ObjectiveTo study the relationship between the range of operations and the incidence of climacteric syndrom,the time of episode, degree and estrogen level in endometriosis after operations. MethodsThesexual hormone level was measured and climacteric syndrome was followed up after operation in 55 endometriosis. ResultsThe incidence of climacteric syndrom in oophorectomy was more frequent and earlier than partial oophorectomy. Meanwhile, the syndrome was much severe and the level of E2 was lower in the former group than those in the later one. ConclusionSo we should retain the ovary tissue and blood supply as much as possible. 6 months postoperation is suggested to be suitable to begin hormone replacement therapy. The dosage should be adviced to remain the blood hormone level just like one ovary does.

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Clinical study of influence of Doula delivery on cesarean section morbidity

Ping WANG ; Jianhua LIU

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(2):99-101.

Objective To discuss the influence of Doula delivery and non -Doula delivery on cesarean section(CS)morbidity. Methods796 cases with Doula delivery and 800 cases with non-Doula delivery were compared in CS morbidity, CS causes, dystocia morbidity in vaginal delivery and neonatal distress. ResultsThe main causes of CS in both groups were fetal distress, fetal malposition and cephalopelvic disproportion and uterine inertia (problems of"power"), The CS morbidity in Doula delivery group(24.37%) was significantly lower than that in non-Doula group(38.25%) (P<0.01). In Doula delivery, CS due to uterine inertia was significantly less than that in non-Doula delivery (P<0.05). However, CS rate due to fetal distress was higher in the former group (P<0.05). In the vaginal delivery cases of the two groups, dystocia morbidity in Doula delivery group(6.00%) was statistically lower than that in non-Doula delivery group(9.72%) (P<0.05). The rates of neonatal distress in the two groups were not significantly different (P>0.05). ConclusionDoula delivery can decrease the CS morbidity without increasing the rate of neonatal distress. Therefore, Doula delivery is worth administering in clinical practice.

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Discussion of interrupted circular suture dming caesarean section with placenta previa

Miao ZHANG ; Yanzhi JIN ; Zijie ZHOU

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(2):93-94.

ObjectiveTo discuss the value of interrupted circular suture in hemostasis of placenta previa during cesarean section. Methods We summarized 54 caesarean section patients with placenta previa. Results The hemostasis was succeeded in all of the 9 patients and uterus was retained without postpartum complications. The duration of operation was obviously shorter than that of hysterectomy( P＜0.05). Bleeding and blood transfusion were less than that of hysterectomy, but without statistical difference (P＞0.05). ConclusionInterrupted circular suture is one of the efficient methods in controlling postpartum bleeding during caesarean section with placenta previa.

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Retrospective analysis of clinical outcomes in 89 gravidas with placenta praevia

Yajun XIA ; Xiangmei YUAN ; Li TENG

Chinese Journal of Practical Gynecology and Obstetrics.2001;17(2):90-92.

ObjectiveTo investigate relationship between the degree of placenta praevia, vaginal bleeding and clinical outcomes. MethodsRecords of 89 patients with placenta praevia(mild praevia group 43; severe praevia group 46) were reviewed retrospectively, and outcomes were compared. ResultsThe gestational age at the first bleeding and diagnosis was significantly smaller in severe group than that in mild one (P<0.05). The incidence of antepartum haemorrhage, the times of bleeding and the episodes of heavy bleeding in two groups showed no significant differences(P>0.05). The gestational age at diagnosis and delivery and birthweight were significantly smaller in women with antepartum bleeding than in those without( P<0.01 ). The number of deliveries by emergency caesarean section in women with antepartum bleeding was significantly higher than that in those without (P<0.01). ConclusionThe clinical outcomes of placenta praevia are highly variable. There are no obvious clinical features that are typical in predicting the clinical outcomes. The number of bleeding episodes and the degree of praevia are not associated with outcomes, so they can't be the proof to determine the treatment plan ahead of time.

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