Objective　To investigate the effect of combining use of methotrexate and mifepristone on treating unruptured tubal pregnancy.Methods　Treatment consisted of 300mg of mifepristone administered orally one time and 20mg of methotrexate injected intravenously consecutively for 5 days.The previous cases who received only 20mg methotrexate injected intravenously were selected as control group.Results　The success rate of the combination group was 87.5% which was significantly higher than that of the control group.The effect of treatment was related to serum β-hcG levels and whether there was embryos with cardiac activity or not.Conclusion　The treatment of unruptured tubal pregnancy with the combination of methotrexate and mifepristone is safe and effective.It is suitable for the unruptured tubal pregnancy with stable vital signs,but without acute abdominal pain or embryonic cardiac activity and β-hCG＜30μg/L.