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Construction of TCM determination of treatment based on syndrome differentiation system of type 2 diabetes:thinking and method

Ximing LIU

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(08):-.

Type 2 Diabetes Mellitus(T2DM) is classified as two types according to somatotype,one is obesity or overweight,the other is normal or emaciation.It can also be classifi ed as two types according to symptoms,one is accompanied with typical syndromes(polyuria,polydipsia,polyphagia and weight loss),the other one is not.Generally speaking,the typical syndrome is not obvious among the patients with obesity or overweight,which is coincident with the theory about stuffy and fully sensation in the middle energizer and interior heat mentioned in emperor’s internal classic.So the therapeutic method is regulating the function of the middle energizer,evacuating full and stagnation,resolving phlegm and removing pathogenic heat.The typical syndrome is obvious among the patients with normal bodily form or emaciation,which is according with the traditional theory about defi ciency of yin and dryness-heat.So the therapeutic method is nourishing yin and clearing heat.The two types above are absolutely different.

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Effects of Warming and Tonifyin Kidney-Yang Drugs on Liver Mitochondria Proteome of Rats with Kidney-Yang Deficiency

Dezhao LU

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(02):-.

Objective: To study the effects of warming and tonifying kidney-Yang drugs on the liver mitochondria proteome of rats with kidney-yang deficiency using two-dimensional difference gel electrophoresis(2-D DIGE).Methods: Every liver mitochondria protein sample from the normal rats,the kidney-yang deficiency rats and the kidney-yang deficiency rats treated with warm and tonify kidney-yang drugs were labeled with Cy3 or Cy5 randomly,Each Cy3-labeled sample and Cy5labeled sample were mixed on the same 2-D gel along with a Cy2-labeled mixture of all samples as an internal standard and run on the same gel.All images were analyzed by DeCyder software DIGE technology with internal standard.16 unique proteins were selected,and in which 10 protein were successfully identified.Results: In the kidney-yang deficiency rats,the expressions of carbamoyl-phosphate synthetase 1,dihydrolipoamide branched chain transacylase,ubiquinol-cytochrome c reductase,isovaleryl coenzyme A dehydrogenase,heat shock protein 60,succinyl-CoA synthetase,hydroxyamino-coenzyme A dehydrogenase/ ketoacyl coenzyme acetyl coenzyme A dehydrogenase ?subunit,ornithine transcarbamylase and glutathione peroxidase all increased.While the expression of ornithine aminotransferase decreased.After the treatment of warming and tonifying kidney-yang drugs,the expressions of above-mentioned proteins all had rectification in different degrees. Conclusion: The metabolism of carbohydrate,lipids and protein had been rectified when the kidney-yang deficiency rats were fed with warming and tonifying kidney-yang drugs,which was likely attributed to the improvement of stability of mitochondria membrane.

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Study on Enhancing of TCM Life Quality in Patients with Type 2 Diabetes Mellitus

Ximing LIU

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(04):-.

QOL(quality of life) is not only one of the most important parts among the four clinical therapeutic evaluations,but also the main measurement tool to evaluate the clinical therapeutic efficiency of type 2 Diabetes Mellitus(T2DM).Based on the theory of traditional Chinese medicine,specific QOL assessment scale of TCM for T2DM should be made to evaluate the therapeutic efficiency.The assessment scale is a necessary to study T2DM of TCM.As far as TCM treating T2DM is concerned,it can also provide evidence of clinical therapeutic evaluation.

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Classification of Etiology Theory in TCM Based on Concept of Unification of Human and Nature

Jianbo HUANG

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(07):-.

This article expounds the formation,connotation and development of the etiology theory in TCM.By analyzing the deficiency of the existent etiology theory in TCM,we proposed that the essence of the etiology theory in TCM should be studied based on the concept of unification of human and nature.With the guidance of the concept of unification of human and nature,the etiology theory in TCM could be formed an integrated theory.The classification of etiology in TCM which includes basic etiology,secondum etiology and developing etiology was proposed,which makes the etiology theory system in TCM more scientific and logical.

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Exporation of medical charicteritics in the early ancient times centering on Yijingbianqi Lun in Suwen

Zhongzheng LI

China Journal of Traditional Chinese Medicine and Pharmacy.2006;0(09):-.

Some medical charicteritics in the early ancient times are discussed centering on Yijingbianqi Lun in Suwen in order to expound the far-reaching impact of introspection-characterized Chinese culture on early traditional Chinese medicine.At the same time,the article also discussed Stability and Wisdom in the embodiment of Inner Canon of Huangdi.

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The application of the f ive phases-ancient ten months'calendar in the theory of Inner Canon of Huangdi

Juan HE

China Journal of Traditional Chinese Medicine and Pharmacy.2006;0(09):-.

The corresponding season of the ve zang-viscera is the important content of the correspondence between man and universe theory in the Inner Canon of Huangdi,and the corresponding season of the ve zang-viscera related to several modes of calendar.With the exception of the way that combine the ve zang-viscera with calendar which make use of criss and cross or divide into ve parts on 12 months of a year,the authors believe that the newly discovered ancient ten months' calendar had been showed clearly in the Inner Canon of Huangdi.The text of the Inner Canon of Huangdi that cannot be explained well in accordance with twelve months' calendar can be explained by ancient ten months' calendar,and the ancient ten months' calendar is the basis that the ve phases theory is derived from the concept of the ve seasons.

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Deficient Pathogenesis of Five Zang Viscera on Essence qi-yin-yang and Its Correlative Questions

Guangren SUN

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(07):-.

This article elucidates the deficient pathogenesis of the essence-qi-yin-yang of five zang viscera and its related questions.It is pointed that essence deficiency,qi deficiency,yin deficiency and yang deficiency of five zang viscera can explain their different diseases and syndromes,and belong to series-syndrome(类证) pathogenesis.Yin deficiency and yang deficiency of five zang viscera can not happen together with qi deficiency.However they can happen at the same time with the essence deficiency,blood deficiency and body fluid deficiency.The essence deficiency,qi deficiency,yin deficiency and yang deficiency of Kidney are very important to the deficient pathogenesis of the essence-qiyin-yang of five zang viscera.

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Investigating into Relationship between Meridian and Pulse Examination from the Ancient Methods of Pulse-Reading

Cenhan HUANG

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(10):-.

The ancient methods of pulse-reading represented by Bian Que and Nei Jing are the initiation and formation stages of pulse examination in TCM.Allround,rich and colorful methods of meridian examination are foundation and condition of pulse examination.The development of pulse examination is a distinct course,from complicated to simple,mixed to exclusive.The purpose of this article is,from the point of view in the origin of pulse examination,to explore the relationship between meridian and the formation of pulse examination.

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A brief talk on identification of possible disease of WEI Pin-kang

Ying ZHAO

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(10):-.

The academic thought of preventing possoble disease is one of the important part of the theoretical system of Chinese medicine. In Pro. WEI Pin-kang's opinion, we must identify the possible diseases prior to preventing it. The article discusses how to identify the possible disease from three aspects, such as indentifying constitution, comprehensive analysis by the four examination methods, drawing assistance from micro-indexex, which to cultivate young physicians' clinical thinking of indentifying possible disease.

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Preparation and purity determination of sinapine from seeds of Brassica alba

Shulei NAN ; Shengxi WU ; Guoxin WU ; Luqiang HUANG ; Qingqiang LIN

China Journal of Traditional Chinese Medicine and Pharmacy.2005;0(10):-.

Objective:Preparated from seeds of Brassica alba, Sinapine was determinated by RP-HPLC. Methods: Seeds of Brassica alba were shattered, defatted by ether, extracted by alcohol, and crystallized by potassium thiocyanate, then ethanol and water were used to recrystallize for several times. The determination was performed by reversed-phase high performance liquid chromatography(RP-HPLC), using ZORBAX SB-Aq column 4.6 mm?250 mm, 5 ?m. The mobile phase consisted of acetonitrile-0.08 mol/L KH2P04 (20:80) at a flow rate of 1.0 ml/min, and the detection wavelength was 326 nm. Results: Pale yellow needle-like sinapine crystal was obtained, and the yield rate was 0.82%. The purity of sinapine thiocyanate crystal was over 95%. Conclusion: Preparation sinapine by this solvent extraction method was simple, high-purity, high yield, and could be used for industrial production.

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