Korea Hansen's Disease and Mythology of Settlement Village.
Korean Leprosy Bulletin.2007;40(1):59-79.
Korean Leprosy Bulletin
2002 (v1, n1) to Present ISSN: 1671-8925
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8 Cases of Hansen's Disease(New case & Relapse).
Korean Leprosy Bulletin.2007;40(1):51-58.
In 2006, we find 7 new cases and one relapse case, diagnosis by the clinical finding, skin smear, skin biopsy, lepromin test, ELISA for PGL-I antibody, and DNA-PCR. In new cases, the mean age is 59.3, mean BI is 3.3+, mean O.D. of PGL-I antibody is 0.941, numbers of TTC repeat are 13(3 cases), 11(2 case), 12(1 cases), and 31(1 case), and of GACATC repeats are 4(5 Koreans) and 3(2 foreigners). In relapse case, a 45 years-old male patient is revealed that BI is 5+, O.D. of PGL-I antibody is 1.096, numbers of TTC repeat are 12 and GACATC repeats are 4.
Biopsy ; Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Humans ; Lepromin ; Leprosy ; Male ; Middle Aged ; Recurrence ; Skin
Biopsy ; Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Humans ; Lepromin ; Leprosy ; Male ; Middle Aged ; Recurrence ; Skin
Korean Leprosy Bulletin.2007;40(1):31-49.
The purposes of this study were to investigate the oral health care conditions of patients who have Leprous disease, which is an infectious disease(Dental caries: DMF rate and DMFT rate, and Periodontal conditions: CPITN0, CPITN1 CPITN2 CPITN3 ) and the satisfaction of use of denture fabrication related to general, functional and esthetic factors among dental patients for pre-Prothodontic Oro-maxillofacial minor surgury in National sorokdo hospital. The objects for this study were 754patients(male: 453, female: 301, 60-69ages: 340, 70-79ages: 414)treated in the oral health center among Leprous disease patients with gingivitis and periodontal disease, residents in the Sorokdo from 2003, January to 2005, September. 1. The results of Dental caries investigated that the number of 60-80year-old patients group that DMF rate was 99.2% of them, DMFT rate 59.2% 2. The results of periodontal conditios investigated that the number of 60-69year-old patients group were Community Periodontal treatment need index(CPITN)0: 15, CPITN1: 2, CPITN2: 66, CPITN3: 257, and 70-79year-old patients group were CPITN0: 27, CPITN1: 1, CPITN2: 116, CPITN3: 271 (Community Periodontal treatment need index(CPITN)0 of patients who have Leprous disease means anodontia states) 3. Dental fabrication patients for pre-Prothodontic Oro-maxillofacial minor surgury have operated Lower lip reconstruction, Hypergingivotomy, Flap, Alveoloplasty, Tours ostotomy and Apicoectomny
Alveoloplasty ; Anodontia ; Dental Caries ; Dentures* ; Female ; Gingivitis ; Humans ; Leprosy ; Lip ; Oral Health ; Periodontal Diseases
Alveoloplasty ; Anodontia ; Dental Caries ; Dentures* ; Female ; Gingivitis ; Humans ; Leprosy ; Lip ; Oral Health ; Periodontal Diseases
Spacer graft using deep temporal fascia in the treatment of paralytic ectropion.
Korean Leprosy Bulletin.2007;40(1):25-30.
BACKGROUND: Spacer graft is known to be a very effective surgical method in the treatment of paralytic ectropion. OBJECTIVE: This study was performed to evaluate deep temporal fascia as a spacer instead of Alloderm in spacer graft to correct paralytic ectropion. METHODS: In seven patients with the lower lid ectropion as a sequela of Hansen's disease, a strip of deep temporal fascia, 4.0cm long and 0.5cm wide, was obtained from the scalp. A separation between the tarsal plate and the capsulopalpebral fascia was made and the strip was inserted into the space. Two ends of the strip were fixed to the medial and lateral canthal ligaments respectively like a sling. RESULT: In all patients, immediate postoperative improvement was achieved, which was to the same degree in the patients treated with Alloderm previously reported. And no serious complications were observed in both donor and graft sites. CONCLUSION: As a spacer in spacer graft, patient's own deep temporal fascia shows good cost-effectiveness ratio and can be an alternative to Alloderm. However, further studies are neccessory to find out the long term efficacy, especially recurrence.
Ectropion* ; Fascia* ; Humans ; Leprosy ; Ligaments ; Recurrence ; Scalp ; Tissue Donors ; Transplants*
Ectropion* ; Fascia* ; Humans ; Leprosy ; Ligaments ; Recurrence ; Scalp ; Tissue Donors ; Transplants*
M. leprae typing by genomic diversity of clinical isolates in Korea.
Korean Leprosy Bulletin.2007;40(1):3-24.
Recently, PCR-based typing would be of great value for Epidemiological investigation to identify infectious source of leprosy, understand transmission pattern, and distinguish between relapse & re-infection. Variable TTC DNA repeats in non-coding region and 6bp(GACATC) tandem repeats in rpoT gene revealed PCR products of different size may be useful to investigate the epidemiology of leprosy. Authors have typed clinical isolates of M. leprae in Korea using difference of TTC DNA repeats in non-coding region and 6bp(ACATCG) tandem repeats in rpoT gene. Of the sequence analysis of isolates(M. leprae) of 52 patients(44 Koreans, 8 foreigners; Bangladesh, Indonesia, Philippine, Sri Lanka, Thailand) M. leprae with 12 TTC repeats was showed most common(13 cases, 29.5%) in 44 Korean isolates and 42 Koreans(95.5% of Korean isolates) isolates demonstrated four copies of 6bp(ACATCG) tandem repeats in rpoT gene and the isolates with three copies were found in 2 Koreans and 8 foreigners.
Bangladesh ; DNA ; Emigrants and Immigrants ; Epidemiology ; Humans ; Indonesia ; Korea* ; Leprosy ; Polymerase Chain Reaction ; Recurrence ; Sequence Analysis ; Sri Lanka ; Tandem Repeat Sequences
Bangladesh ; DNA ; Emigrants and Immigrants ; Epidemiology ; Humans ; Indonesia ; Korea* ; Leprosy ; Polymerase Chain Reaction ; Recurrence ; Sequence Analysis ; Sri Lanka ; Tandem Repeat Sequences
Leprosy Control and Information System.
Korean Leprosy Bulletin.2001;34(1):79-96.
Many futurists state that the rate of change that has happened around the world over the past 10 years is greater than at all other period's of time. The leading factor, irrelevant of an individuals knowledge, is the popularization of the Internet. People now can get large amounts of information at a very low cost. Popularization of information technology has changed the economic competitiveness from existing physical production capacity to information collecting and information processing power. . In other words, advanced products that have high added value, generated by collecting and processing technical information, are superior to products that are made physically. With respect to Hansen's disease, after MDT was introduced in 1980's, and WHO started to eliminate leprosy in 1991, Hansen's disease situation has changed in most of the world. However, using only the traditional information systems that were used in the past, it is difficult to cope with this situation. To improve and keep the competitiveness, it is necessary to keep pace with available changes in technology, and it is essential to establish flexible information system about the disease. To do this, we have to create new services. To create a new paradigm for dealing properly with changes in the management of Hansen's disease in the information society, I would like to introduce an information system. As part of the development of this system, I would like to introduce new material resources including an information system, human resources, databases, and network.
Automatic Data Processing ; Humans ; Information Systems* ; Internet ; Leprosy*
Automatic Data Processing ; Humans ; Information Systems* ; Internet ; Leprosy*
Optimization for cell lysate preparation of M. leprae from infected nude mouse.
Korean Leprosy Bulletin.2001;34(1):47-56.
The method of cell lysate preparation of M. leprae is an important technique in the study of leprosy. This report describes the optimization of method for cell lysate preparation of M. leprae obtained from infected nude mouse. After M. leprae isolated from nude mouse foot-pad was disrupted by sonication, it was centrifuged and then whole lysate was prepared. With this method it was possible to isolate 0.3 mg whole cell lysate using 20 mg of M. leprae. By SDS-PAGE and Coomassie blue staining, the number of protein in M. leprae is less than that of other bacteria, for example, E. coli and M. smegmatis. It is likely that this is due to the small genome size. This work will contribute to the analysis of new protein antigen of M. leprae and the basic study for the development of vaccine in leprosy.
Animals ; Bacteria ; Electrophoresis, Polyacrylamide Gel ; Genome Size ; Leprosy ; Mice ; Mice, Nude* ; Sonication
Animals ; Bacteria ; Electrophoresis, Polyacrylamide Gel ; Genome Size ; Leprosy ; Mice ; Mice, Nude* ; Sonication
Korean Leprosy Bulletin.2001;34(1):25-46.
Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae, which is an obligate intracelluar pathogen. It presents broad spectrum of clinical manifestations depending on the host's specific cell-mediated immune response to M. leprae. Especially, type I Th cells and macrophages are important in defense mechanism to M. leprae, and the immune response is regulated by cytokines secreted by immune cells. Recent investigations showed nitric oxide(NO) was the key molecule in the killing activity of macrophages, which was enhanced by IFN-gamma but suppressed by TGF-beta1 and IL-10. Since cytokine is secreted by activated immune cells with antigenic stimulation, decreased antigens by treatment modulates the expression of cytokines in leprosy. In this study, we observed the dynamics of cytokines expression using RT-PCR, such as TGF-beta1 and IL-10, which suppress the activity of macrophages, IFN-gamma, which activates macrophages, and iNOS, which represents the killing activity of macrophages, in the lesions taken from fifteen borderline lepromatous leprosy patients before and after multiple drug therapy for 4 weeks. The results are summarized as follows: 1. Before treatment, cytokines were expressed in order of IL-10, iNOS, TGF-beta1 and IFN-gamma(p>0.05). 2. After 4 weeks treatment, cytokines were expressed in order of iNOS, IL-10, TGF-beta1 and IFN-gamma(p<0.05). 3. Fifty-four percent of patients showed a non-polarized Th 0 pattern, 33% a polarized Th 1 pattern, and 20% Th-negative. Th 2 pattern was not observed. 4. The changes of cytokines expression after 4 weeks treatment were not significant, although mRNA of IL-10, TGF-beta1 and IFN-gamma were somewhat decreased. 5. There was negative correlation between TGF-beta1 and iNOS(gamma(2)=0.499, p<0.05, before treatment), positive correlation between TGF-beta1 and IFN-gamma(gamma(2)= 0.622, p<0.05, before treatment), and positive correlation between IFN-gamma and IL-10(gamma(2)= 0.935, p<0.05, before treatment; gamma(2)= 0.937, p<0.05, after treatment). In conclusion, these results suggest that TGF-beta1 and IL-10 may contribute to immune suppression in multibacterial leprosy patients, and that TGF-beta1 suppresses iNOS expression in macrophages. With 4 weeks treatment, the significant changes in cytokines expression were not observed. Interestingly, the majority of BL patients showed Th 0 pattern of cytokine, and none of Th 2 pattern.
Cytokines ; Drug Therapy ; Granulomatous Disease, Chronic ; Homicide ; Humans ; Interleukin-10* ; Leprosy* ; Leprosy, Multibacillary* ; Macrophages ; Mycobacterium leprae ; RNA, Messenger* ; Transforming Growth Factor beta1*
Cytokines ; Drug Therapy ; Granulomatous Disease, Chronic ; Homicide ; Humans ; Interleukin-10* ; Leprosy* ; Leprosy, Multibacillary* ; Macrophages ; Mycobacterium leprae ; RNA, Messenger* ; Transforming Growth Factor beta1*
Korean Leprosy Bulletin.2001;34(1):13-24.
Leprosy is chronic infectious disease caused by Mycobacterium leprae, a microorganism to which only a small portion of any given population is susceptible. Although M. leprae can be found nearly anywhere in the body outside the central nervous system, even in the more severe types of leprosy it produces significant damage only in the superficial nerves, the skin, the anterior third of eye, the upper respiratory tract, and testis. Bacillary invasion of peripheral nerve commonly occur in leprosy patients and lepromatous neuropathy is treatable neuropathy in the world. So early detection of lepromatous neuropathy is important for social adaptation and prevention of life threatening complications. For differential diagnosis with other peripheral neuropathies, general overviews of peripheral neuropathies about anatomical, clinical, laboratory and diagnostic aspects of peripheral nervous system.
Central Nervous System ; Communicable Diseases ; Diagnosis, Differential ; Humans ; Leprosy ; Mycobacterium leprae ; Peripheral Nerves ; Peripheral Nervous System ; Peripheral Nervous System Diseases ; Respiratory System ; Skin ; Testis
Central Nervous System ; Communicable Diseases ; Diagnosis, Differential ; Humans ; Leprosy ; Mycobacterium leprae ; Peripheral Nerves ; Peripheral Nervous System ; Peripheral Nervous System Diseases ; Respiratory System ; Skin ; Testis
Changes of Leprosy Research in the Post Genomic Era.
Korean Leprosy Bulletin.2001;34(1):3-12.
Leprosy has turned out to be a minor health problem in Korea due to implementation of multidrug therapy, intensive case detection and mobile works for the villages for last 20 years. Even we have 20 new cases a year and national registry of 18,000, elimination of leprosy in Korea will require more decades in comparison with Japan, which seems to be an advanced country in leprosy work but still has new cases not more than 10 a year. As genome of M. leprae has unravelled to public in 2001, molecular biologic and genetic research work in leprosy area will progress rapidly near future. Range of leprosy research depends on the state of personal and grant resources in the nation. As Korea has only limited scientist, clinicians and financial support for research work to solve problems in leprosy. To maintain research capabilities and man powers in leprosy, it is reasonable to adjust our research works for priorities of the problems in leprosy work in Korea. Diagnosis, follow up and detection of drug resistance in new cases using molecular epidemiologic and genetic tools are one of high priorities in Korea. Management of neuritis and prevention of deformities on eyes, hands and foot of post-period of multidrug therapy appear to be an important area to improve the quality of life of the treated patients. Collaboration with researchers in tuberculosis, adoption of methods from them can expand research capacity and keep leprosy research alive in Korea.
Congenital Abnormalities ; Cooperative Behavior ; Diagnosis ; Drug Resistance ; Financial Support ; Financing, Organized ; Foot ; Genetic Research ; Genome ; Hand ; Humans ; Japan ; Korea ; Leprosy* ; Neuritis ; Quality of Life ; Tuberculosis
Congenital Abnormalities ; Cooperative Behavior ; Diagnosis ; Drug Resistance ; Financial Support ; Financing, Organized ; Foot ; Genetic Research ; Genome ; Hand ; Humans ; Japan ; Korea ; Leprosy* ; Neuritis ; Quality of Life ; Tuberculosis
Country
Republic of Korea
Publisher
Society of Korean Leprologists
ElectronicLinks
http://www.leprosy.or.krEditor-in-chief
Abbreviation
Korean Lepr Bull
Vernacular Journal Title
나학회지
ISSN
1229-1536
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
1960
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