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Lateral tarsal strip operation for the correction of paralytic and involutional Ectropion in Sorokdo Leprosy Patients.

Korean Leprosy Bulletin.2010;43(1):35-49.

PURPOSE: To evaluate the effect of the lateral tarsal strip for the correction of the paralytic and involutional ectropion in Sorokdo leprosy patients. METHODS: Lateral tarsal strip operations were performed in 23 Sorokdo leprosy patients with recurrent corneal erosion and exposure keratopathy due to ectropion. Preoperative and postoperative sclera show and lagophthalmos were measured with a slit lamp, and anterior segment findings were taken at 1 week, 2 weeks and last follow up after the surgery. Postoperative subjective functional improvements were assessed at the last follow up. RESULTS: There was significant reductions between preoperative and postoperative measurements for scleral show (from 2.19 +/- 0.22 mm to 0.37 +/- 0.11 mm) and lagophthalmos (from 4.51 +/- 0.38 mm to 2.07 +/- 0.24 mm) (p<0.05). Ocular irritation symptoms including pain and tearing, and cosmetic satisfaction significantly improved after the surgery. CONCLUSIONS: Lateral tarsal strip operation is an effective surgical option in the treatment of paralytic and involutional ectropion in leprosy patients.
Cosmetics ; Ectropion ; Follow-Up Studies ; Humans ; Leprosy ; Sclera

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Surgical Correction of Paralytic deformity of the Lips in Hansen's Disease.

Sung Yul AHN ; Hyang Joon PARK ; Jong Pill KIM

Korean Leprosy Bulletin.2010;43(1):27-34.

BACKGROUND: Damage of the facial nerve, especially buccal and marginal mandibular branches, causes facial palsy and paralytic deformity of the lips such as lower lip ectropion, lip drooping, deviation of the mouth, inability of closing mouth, and the loss of the nasolabial folds. OBJECTIVE: To find out the best surgical method to correct paralytic deformity of the lips. METHODS: We reviewed retrospectively the various surgical treatment modalities of the paralytic deformity of the lips performed in The Institute for Leprosy Research for 13 years. RESULTS: One hundred and twenty five surgical procedures were performed in 80 patients with Hansen's disease. Of these, the static method, dermal suspension flap, was done in 15 cases, the dynamic methods were done in 64 cases, and others were done in 46 cases. All patients showed postoperatively clinical improvement above the average. Two patients received reoperation or additional procedures due to relapse of the condition. CONCLUSIONS: The dynamic method using tensor fascia lata was superior to other treatment modalities.
Congenital Abnormalities ; Ectropion ; Facial Nerve ; Facial Paralysis ; Fascia Lata ; Humans ; Leprosy ; Lip ; Mouth ; Recurrence ; Reoperation ; Retrospective Studies

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Subjective oral health perception of Hansen's disease in Sorokdo.

Dong Chan OH ; Young Tag LEE ; Sung Lim LEE ; Jin Ah JUNG ; Hyun Chul SONG ; Young A YOUN ; Kill sam KIM ; Jeong Hee CHOI ; Eun Kyoung GO

Korean Leprosy Bulletin.2010;43(1):15-25.

The purpose of this study was to examine subjective oral health perception of Hansen's disease in Sorokdo. And the relationship of four categories (chewing ability, intraoral pain, intraoral othersysptom, and communication ability and social relationship) with clinical index was tried to clarify. The 460 subjects of Hansen's disease in Sorokdo was selected for oral examination and survey. The results are as follows: 1. 73.1% of Hansen's disease in Sorokdo recognized that their oral health is unwell. 2. 70% of total population recognized that they have limitation about chewing function, Especially, 35.9% of Hansen's disease feels chewing difficulty for standard foodstuffs as rice cake. 3. In intraoral pain, painful tooth was 76.3%, sensitive tooth was 43.2%. and temporomandiblular joint pain was 15.2%. 4. In intraoral other symptoms, tooth mobility was 71.3%, food impaction was 78.9% gingiavl bleeding was 96.8%, xerostomia was 62.8%, and halitosis was 84.2%. 5. 21.5% of Hansen's disease in Sorokdo has communication difficulty by teeth or denture problem, and 39.2% of them avoid relationship with other people.
Aged ; Arthralgia ; Communication ; Dentures ; Diagnosis, Oral ; Halitosis ; Hemorrhage ; Humans ; Leprosy ; Mastication ; Oral Health ; Tooth ; Tooth Mobility ; Xerostomia

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The usefulness of multiple displacement amplification in the molecular studies in Hansen's disease.

Jong Pill KIM

Korean Leprosy Bulletin.2010;43(1):3-13.

Appreciable amounts of high-quality DNA are frequently required for use in molecular diagnostic and epidemiology studies. The limited availability of DNA can be a critical obstacle to meeting research and clinical needs. And molecular methods have not been routinely applied to the obligate intracellular organism Mycobacterium leprae because of the difficulty of obtaining a genomic DNA template from clinical material. The MDA (multiple displacement amplification) reaction is increasingly the method of choice for many applications because of its extensive coverage of the genome, the generation of extremely long DNA products compared with older whole genome amplification methods and the high DNA yields, even from exceedingly low amounts of starting material. In the study, the author evaluated the usefulness of this method for the molecular studies in Hansen's disease.
Displacement (Psychology) ; DNA ; Genome ; Leprosy ; Mycobacterium leprae ; Pathology, Molecular

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Coloration of the skin on the face due to clofazimine is cleared by Q-switched ND-YAG laser.

Jong han JUN

Korean Leprosy Bulletin.2007;40(2):61-65.

The Clofazimine is a rimino-phenazine dye. The color is a purplish-back. The drug is reported to be weakly bactericidal and also effective in the management of leprosy reactions apparently. The drug produces relatively few side effects in the majority of patients. The most prominent is coloration of the skin. The coloration can range anywhere from a reddish-tan to purplish-black. so, many patients avoid taking clofazimine. The Q-switched ND-YAG laser is a good medical instrument for clearing coloration of the skin. It releases two wavelength of 532nm and 1064nm. The wavelength of 532nm reachs shallow depth of the skin. So, it is effective in the clearance of a red, yellow tatto, freckle and lentigo. The wavelength of 1064nm reachs about 4-6mm depth of the skin. So, it is effective in the clearance of blue-black tatto and ota nevus. The leprosy patients who has purplish-black coloration of the skin in the face due to clofazimine is cleared by Q-switched ND-YAG laser. We operated twice with 3months interval. The wavelength is 532nm, spot size 3mm, energy 1.5J/cm2. The coloration of the skin in the face is almost cleared.
Clofazimine* ; Humans ; Lasers, Solid-State* ; Lentigo ; Leprosy ; Melanosis ; Nevus of Ota ; Skin*

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Phenol peeling for treatment of deep wrinkle in leprosy patient.

Sung yul AHN ; Hyang Joon PARK

Korean Leprosy Bulletin.2007;40(2):51-60.

The untreated leprosy skin takes on a waxy appearance & feel full. Thickening is most marked over the face, which starts to devolp into folds, hanging down to produce the classical lion-like facies. The deep folds in disease state change to the numerous compacted shallow wrinkle with less elasticity of the skin. To correct these wrinkles of the patients healed from the leprosy, we tried the stone-VK formula application to the 14 patients, who are men 10 & women 4 in the age distribution of 55~78 years old. The use of the phenol & croton oil chemical peeling this method is more effective than other chemical & conventional surgical method to remove facial wrinkle. We need more experience of this peeling. In preliminaxy report, our superior results in removing facial wrinkle is presented.
Age Distribution ; Croton Oil ; Elasticity ; Facies ; Female ; Humans ; Leprosy* ; Male ; Phenol* ; Skin

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A Study on the Life Eexpectancy and Years of Potential Life Lost of the Person affected Leprosy in Korean.

Jong Pill KIM

Korean Leprosy Bulletin.2007;40(2):25-50.

A main objective of public health work is to increase life expectancy in the best health conditions possible. Mortality data represent essential elements for the quantification of health problems. Death counts and related rates are among the simplest indicators to analyze mortality. They represent a summary measure of a population's mortality experience that may be used to establish and monitor health priorities or objectives. Years of Potential Life Lost (YPLL) is a measure of the relative impact of several diseases and health problems in a society, The objective of this indicator is to provide a wider view of the relative importance of the most relevant causes of premature mortality and it is used primarily in the planning and definition of health priorities. To proffer the idea for the development of total Hansen service system programme, I present the reviews of the life expectancy and Years of Potential Life Lost in the case under Hansen service and general population in Korea.
Health Priorities ; Humans ; Korea ; Leprosy* ; Life Expectancy* ; Mortality ; Mortality, Premature ; Public Health

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Fracture in Sorokdo National Hospital.

Sung Gun LEE

Korean Leprosy Bulletin.2007;40(2):15-24.

INTRODUCTION: There are insufficient researches about the causes and the actual condition of fracture in Hansen's disease. Hence, I would like to indicate the problem by analysing the actual condition of fractures in Sorocdo Hansen's disease and a link between electromotion scooter and fracture. MATERIAL AND METHODS: Object is 75 patients who were admitted at Sorocdo National Hospital due to fracture from 2003, January to 2006, December. The medical record was analysed by retrospectively. Patient's general feature and the feature related to accident were analysed. Moreover, use of electromotion scooter and the relation between them were researched. RESULTS: The proportion of males to females is 1.41:1. Average age is 73.6 and over 65 years old shows 78.7%(59 persons) which means fracture happens frequently at old age. Predominant percentage of fracture is occurred at summer(34.7%) and autumn(33.4%). In addiction, the number of fracture patients is increased surprisingly since electromotion wheelchair and scooter were introduced in 2005. Hip joint fracture(34.7%) and distal radius fracture (16.0%) are the main region. The major reasonsof fracture are falls(52.2%) and accidents related to electromotion scooter(17.9%). The mortality of patients who were treated surgically(4.9%) is meaningfully lower than that who received conservated treatment(23.5%). CONCLUSION: The aged population and the number of electromotion scooter are been increasing in Sorocdo. Therefore, We need to find the fundamental and specific measure to prevent fracture caused by falls and electromotion scooter accident. Furthermore, surgical treatment is required actively.
Female ; Hip Joint ; Humans ; Leprosy ; Male ; Medical Records ; Mortality ; Radius Fractures ; Retrospective Studies ; Wheelchairs

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Mutation of rpoB gene in M leprae isolates from Korea.

Jong Pill KIM ; Yeon sil KIM

Korean Leprosy Bulletin.2007;40(2):3-14.

Global efforts to control leprosy by intensive chemotherapy, including rifampin, have led to a significant decrease in the number of registered patients. But emergence of rifampin-resistant strains of pathogenic mycobacteria has threatened the usefulness of this drug in treating mycobacterial diseases. Mutations in the rpoB gene, encoding the betasubunit of RNA polymerase, were reported to result in resistance to rifampin in several mycobacterial species, including M leprae. To prevent the emergence and transmission of drug-resistant leprosy and to identify and treat existing cases, it is necessary to establish rapid methods for detection of drug resistance in M leprae. However, M. leprae has not been cultivated on artificial media; therefore, to identify drug susceptibility patterns, bacteria must be tested using Shepard's mouse footpad assay. This in vivo method requires at least 6 months and relatively large numbers of bacteria. Recently, there have been advances in the elucidation of molecular events responsible for drug resistance in mycobacteria Sequences of the rpoB, genes were analyzed for 43 isolates of Mycobacterium leprae from leprosy patients in Korea. Three isolates(6.98%) showed representative mutations in the rpoB, genes, suggesting the emergence of rifampin-resistant M. leprae.
Animals ; Bacteria ; DNA-Directed RNA Polymerases ; Drug Resistance ; Drug Therapy ; Humans ; Korea* ; Leprosy ; Mice ; Mycobacterium leprae ; Rifampin

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Rare atypical feature of type II lepra reaction with ulcerative skin lesion in a lepromatous leprosy patient.

Young Ho WON ; Hyun Woo KIM

Korean Leprosy Bulletin.2016;49(1):49-54.

Lepra reaction is an acute exacervational status occurring in the chronic course of leprosy. Type 2 lepra reaction occur from multibacillus leprosy (such as BL or LL), which mediated by antigen-antibody immune complex deposited vasculitis, involving multiple organs, and usually associated with constitutional symptoms such as fever, malaise, joint pains. The skin lesions is characterized by painful and tender red papules or nodules on the skin, which also refers to erythema nodosum leprosum (ENL). Different rare atypical skin lesions of ENL have been reported such as bullous, ulcerative, necrotic, pustular, sweet syndrome like lesions in literature. The 74 years old male patient with lepromatous leprosy presented as multiple crusted ulcers on the trunk and red edematous nodule on extremities and face. The histopathologic feature was typical for type 2 lepra lesion. Fite stain revealed large histiocytes containing well defined dense granular bacillus. This case was very rare and interesting because of unusual crusted ulcerative skin lesions combined with conventional ENL lesions and leprosy itself is rare in Korea these days.
Antigen-Antibody Complex ; Arthralgia ; Bacillus ; Erythema Nodosum ; Extremities ; Fever ; Histiocytes ; Humans ; Korea ; Leprosy ; Leprosy, Lepromatous* ; Male ; Skin* ; Sweet Syndrome ; Ulcer* ; Vasculitis

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