Korean Leprosy Bulletin  2003;36(1):27-34

Evaluation of an Immunochromatography Assay Kit for the Detection of Antibodies to the Mycobacterium leprae-specific Phenolic Glycolipid-I Antigen.

Jong Pill KIM 1 ; Sang Nae CHO ; Young Hoon KO

Affiliations

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Keywords

leprosy; phenolic glycolipid-I; immunochromatographic assay; serodiagnosis

Country

Republic of Korea

Language

Korean

Abstract

Among the many reported applications of the detection of antibodies to phenolic glycolipid-I (PGL-I) of Mycobacterium leprae, the use of seroprevalence as an indicator of the magnitude of the leprosy problem may turn out to be very useful in leprosy control programs. In order to facilitate the use of PGL-I based serology in leprosy control programs, however, a simple test system for the detection of antibodies to PGL-I has been required. For being searched the meaning of qualitative analysis for PGL-I antibodies, we examined enzyme-linked immunosorbent assay and immunochromatographic assay kit using PGL-I neoglycoconjugate antigens. The sensitivity was 91.7%, and the specificity was 78.1%.