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The effect of long term low dose roxithromycin on the chest CT imaging and clinical symptoms change of bronchiectasis stable patients

Qi QIU ; Xinhui TANG ; Junjie BAO ; Jie PAN ; Liang ZHU

Chinese Journal of Biochemical Pharmaceutics.2014;(2):79-80,83.

Objective To explore the clinical effect and lung CT change of long-term used of low-dose roxithromycin in treatment for bronchial expansion patients in stable phase. Methods 94 cases collected in the Department of Respiration, The Second Hospital Affiliated to Suzhou University from February 2011 to December 2012 were diagnosed as bronchiectasis, 34 cases in control group were given oral treatment for ambroxol 30 mg, three times one day, 60 cases in treatment group were added roxithromycin 75 mg on basis of control group, two times one day. Patients in two groups were both treated for 6 months. The therapeutic effect and the score of life quality and dyspnea scores in two groups were observed, and the changes of CT data were compared before and after treatment. Results After treatment, the life quality score and dyspnea score of two groups were all improved, but the treatment group was signiifcantly higher than the control group (P<0.05). The effective rate in treatment group was 86.67%, which was signiifcantly higher than 70.59%in the control group (P<0.05). After treatment, chest CT imaging score of patients in treatment group were improved, signiifcantly better than that in the control group (P<0.05). Conclusion Long-term low dose administration of roxithromycin can control and stable bronchiectasis symptoms, and improve signs and symptoms .

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Preparation and pharmacokinetics study of immunoconjugate composed of Adriamycin nanoparticles and VEGFR2 monoclonal antibody

Xiangbao YIN ; Linquan WU ; Mingwen HUANG ; Zhiqiang LUO ; Xin YU ; Jun HUANG ; Hongsong XING

Chinese Journal of Biochemical Pharmaceutics.2014;(2):141-143,147.

Objective To prepare the immunoconjugate composed of Adriamycin nanoparticles and VEGFR 2 monoclonal antibody(conjugate of ADM-NP and VEGFR 2-MAb) and study its pharmacokinetics property. Methods Adriamycin nanoparticles were prepared by using double emulsion method, with PLA and O-CMC as materials. Conjugate of ADM-NP and VEGFR 2-MAb was prepared by using molecule conjugate technology. Immunoreactivity of the conjugate with type IV collagenase and H 22 cell were analyzed by using ELISA. Pharmacokinetics parameters of the immunoconjugate were obtained by using SD rats as study objects. Results The prepared ADM-NP was sphere particles under SEM, which diameters were (160±34) nm. The drug loading rate and entrapment rate were (30.15±3.5)% and (80.56±4.24)% respectively. Conjugate of ADM-NP and VEGFR 2-MAb was successfully prepared, which had immunoreactivity with type IV collagenase and H 22 cell. The immunoconjugate showed good ADM control-release ability and could prolong the retention time of ADM in vivo. Conclusion Conjugate of ADM-NP and VEGFR 2-MAb keeps the immunoreactivity of VEGFR 2-MAb and shows good ADM control-release ability.

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Identification of chemical composition in traditional Chinese medicine by liquid chromatography-mass spectrometry

Hui YU

Chinese Journal of Biochemical Pharmaceutics.2014;(3):172-173,177.

Objective To identify the chemical components of traditional Chinese medicine by liquid chromatography-mass spectrometry.Methods Chemical components of 86 traditional Chinese medicines were identified by two methods,observation group with LC-MS method and control group with traditional LC methods.The identification efficacy,accuracy,and identification time between two methods were compared. Results The excellent rate in observation group was 76.74% (66/86),the excellent and good rate was 90.70%(78/86),which were significantly higher than those in control group (P<0.05 ).83 kinds of traditional Chinese medicine were successfully identified in observation group,the success rate was 96.5 1%,significantly higher than control group(P<0.05).The identification tine,retention time after correction of errors in observation group were significantly less than control group(P<0.05 ).Conclusion LC-MS has high accuracy,short identification time and wide adaptation range in identification of chemical components of traditional Chinese medicine.

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Clinical observation of leflunomide and glucocorticoids in treatment of chronic nephritis

Xianwen LUO

Chinese Journal of Biochemical Pharmaceutics.2014;(3):160-161,164.

Objective To evaluate therapeutic effect of Leflunomide combined with glucocorticoids on patients with chronic nephritis.Methods 36 patients with chronic nephritis in Guangyuan Hospital of Traditional Chinese Medicine from January 2012 to October 2013,were randomly divided into two groups:the routine group were treated with conventional therapy;While the theraputic group were treated by leflunomide and glucocorticoid.The tests of urinary protein,serum cretonne and blood urea nitrogen were conducted during treatment in both groups. Results The total effective rate was 88.89 %in the treatment group and 72.2% in the control group.the difference was significant(P<0.05 ).After treatment,measured value of urine protein, serum cretonne and blood urea nitrogen were significantly higher than prior treatment(P<0.05 ).Conclusion The therapeutic effect of leflunomide combined corticosteroid on chronic nephritis is better.

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Efficacy and safety of probiotics combined with kangfuxin solution in treatment of mild and moderate active ulcerative colitis

Ke HAN ; Liqing HU

Chinese Journal of Biochemical Pharmaceutics.2014;37(4):98-99,105.

Objective To explore the efficacy and safety of probiotics combined with kangfuxin solution in treatment of mild and moderate active ulcerative colitis.Methods 80 cases of patients with mild and moderate active ulcerative colitis(UC)in Nanyang Central Hospital were divided into two groups according to order of admission,each group had 40 cases.The study group of patients were treated with probiotics combined with kangfuxin solution,while the control group of patients were given probiotics alone.All patients were treated for eight weeks,to compare comprehensive efficacy and colonoscopy disease activity score between two groups of patients. Results The total effective rate of the study group was 97.5%,significantly higher than 80%of the control group,and the difference was statistically significant(P<0.05 );The colonoscopy disease activity score of the study group after treatment was significantly lower than before treatment and of the control group,the difference was statistically significant(P<0.05 );The two groups of patients had no serious adverse reactions.Conclusion Probiotics combined with kangfuxin solution has a significant efficiency in treatment of active mild and moderate ulcerative colitis.

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The clinical efficacy of iron polysaccharide complex in the treatment of iron deficiency anemia and its effect on content of sTfR and SF

Yuan HE

Chinese Journal of Biochemical Pharmaceutics.2014;37(4):116-117,120.

Objective To investigate the clinical efficacy of iron polysaccharide complex in the treatment of iron deficiency anemia and its effect on content of serum transferrin receptor(sTfR)and serum ferrin(SF).Methods 132 patients with iron deficiency anemia in Guizhou Provincial People’s Hospital were received iron polysaccharide complex for one month,we analysed the clinical efficacy of iron polysaccharide complex in the treatment of iron deficiency anemia.The content of blood indicators,serum iron(SI),sTfR and SF were detected and analyzed before and after treatment. Results Iron polysaccharide complex had a good effect on iron deficiency anemia,the obvious effective rate was 59.09%and total efficiency was 85.61%;blood indicators and SI improved significantly(P<0.05),sTfR decreased significantly(P<0.05),SF increased significantly(P<0.05);SI and sTfR,SF, sTfR/SF has a good linear relationship relatively.Conclusion The mechanism of iron polysaccharide complex on patients with iron deficiency anemia is related with SF levels increased and sTfR levels reduced.

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Clinical efficacy evaluation of mifepristone alone and combined with Gongliuxiao capsule in the treatment of uterine fibroids

Weijing JIA ; Jin JIANG

Chinese Journal of Biochemical Pharmaceutics.2014;37(4):111-112,115.

Objective To investigate and compare the clinical efficacy of mifepristone alone and combined with Gongliuxiao capsule in the treatment of uterine fibroids.Methods 106 patients with uterine fibroids in Harrison International Peace Hospital from December 2012 to December 2013 were selected.The patients were randomly divided into control group and experimental group(n=53).The former were treated with mifepristone alone while the later were treated with the combination of mifepristone and Gongliuxiao capsule.All the patients were given 2 courses of treatment with 12 weeks for a course.The menstrual phase,volume of menstruation,uterus and the volorne of uterine fibroids before and after the treatment,and the clinical efficacy of both groups were evaluated.All the results were recorded and compared. Results The menstrual phase,volume of menstruation,uterus and uterine fibroids of both groups after the treatment were significantly less than those before treatment (P <0.05 ).And the total effective rate of experimental group was 92.45%,which was significantly higher than 73.58% of control group.Both groups had some mild adverse reactions,which didn’t affect the treatment.Conclusion The combination of mifepristone and Gongliuxiao capsule has a great efficacy in the treatment of uterine fibroids.Compared with the use of mifepristone alone,the combination treatment is much more effective.

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The efficacy analysis of sodium β-aescin in the treatment of swelling after lower limb fracture operation

Wenge CHEN

Chinese Journal of Biochemical Pharmaceutics.2014;37(4):91-92,94.

Objective To discuss the efficacy and safty of sodium β-aescin in the treatment of swelling after lower limb fracture operation.Methods From February 2011 to February 2014 in Minda Hospital Affiliated to Hubei Minzu University,patients with swelling limb after lower limb fracture operations were selected as research subjects.The patients were divided into experimental group and control group randomly.The experimental group were received sodiumβ-aescin,the control group were received mannitol.After 4 days treatment,limb circumference,swelling score and pain score in two groups were compared. Results Compared with control group,the limb circumference,swelling score and pain score in experimental group significantly reduced after 4 days treatment(P<0.05 );the therapeutic effect in experimental group was significantly better than that in control group(P<0.05).The incidence of adverse reaction in two groups had no significant difference.Conclusion Application of sodiumβ-aescin on lower limb fracture shows good therapeutic effect.

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Clinical study of atorvastatin and sodium ferulic acid on renal interstitial fibrosis of diabetic nephropathy

Huiqing LI ; Haiying YU

Chinese Journal of Biochemical Pharmaceutics.2014;37(4):121-122,125.

Objective To observe the clinical efficacy of atorvastatin combined with sodium ferulic acid on renal interstitial fibrosis of diabetic nephropathy(DN).Methods According to the diagnostic and staging criteria of DN,56 patients of DN(Mogensen stage Ⅲ~Ⅳ)who hadn’t received lipid-lowering treatment in the last 2 months and glycemic control were within the standard were randomly divided into control group (n =28 )and experimental group(n=28).Control group were received basic treatment including diabetes diet,decreasing blood glucose level and adjusting blood pressure.Experimental group were added atorvastatin combined with sodium besides the basic treatment above-mentioned.The course is both 4 weeks in two groups.Changes of fasting plasma glucose(FPG),blood urea nitrogen(BUN),serum creatinine(SCr)and 24-hour urine albumin excretion rate (24hUAER),transforming growth factorβ1 (TGF-β1 )before and after the treatment in two groups were observed. Results The differences of FPG,BUN, SCr,24h UAER and TGF-β1 in two groups before and after treatment were statistically significant(P<0.01).Conclusion Atorvastatin combined with sodium ferulate can function cooperatively in the treatment of diabetic nephropathy and can delay renal interstitial fibrosis.

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Research of the application value of ropivacaine compounding with dezocine on brachial plexus block

Hongmeng QIN ; Dong HAN ; Guozheng LI

Chinese Journal of Biochemical Pharmaceutics.2014;37(4):106-107,110.

Objective To research the anesthetic effect of ropivacaine compounding with dezocine on brachial plexus block.Methods From January 2011 to September 2013,180 cases upper extremity surgery patients were selected and divided into group A,group B and group C in Nanyang Central Hospital.Patients in group A received 25 mL 0.4%ropivacaine injection for brachial plexus block;based on group A,group B was injected 10 mg dezocine to assist anesthesia;group C received a mixture of 25 mL 0.4% ropivacaine and 10mg dezocine injection.The anesthetic effect and adverse reactions of the patients in three groups were recorded and compared. Results The onset of anesthesia of group C was(17.43 ±1.53)min,which was the shortest of three groups,but there were no significant differences.The duration of sensory blockade and duration of analgesia was(8.22 ±1.63)h and (11.33 ±1.90)h,which were all longer than group A and group B,and there was significant differences(P<0.05);the visual analogue scale(VAS) scores of group C at each time before surgery was the shortest,but there were no significant differences.The VAS scores of group C at 1 h,6 h,12 h and 24 h after surgery were all lower than group A and B,and there were no significant differences.Conclusion Ropivacaine compounding with dezocine on brachial plexus block can improve the effect of anesthesia,extend the duration of analgesia.

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