Journal Detail Information

1

Cite

Share

Research progress in targeted therapy of non small cell lung cancer

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):441-442,448. doi:10.3969/j.issn.1005-1678.2017.06.168

Objective To investigate the clinical effect of targeted drug therapy for non-small cell lung cancer.MethodsThe study group received gefitinib targeted drug therapy, the control group was given erlotinib treatment, recording two groups of patients with non-small cell lung cancer, survival time, follow-up treatment costs and adverse reaction incidence (drug).ResultsThe total efficiency of treatment (37.50%) and the control group (the total efficiency of treatment 35.42%) no obvious difference;no significant difference between the survival time of patients in group two non-small cell lung cancer, but the study group treatment costs significantly less than the control group (P<0.05);two groups of patients with non-small cell lung cancer were treated with erlotinib and gefitinib poisoning reaction contrast did not significant difference.ConclusionGefinitib targeted therapy of non-small cell lung cancer can be based on protecting the clinical curative effect and prognosis of the patients, reduce the economic pressure, more conducive to the positive reception and treatment.

2

Cite

Share

Investigation and analysis of anti liver disease drugs in our hospital during 2012 to 2016

Lubiao BU ; Qianzhou LV

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):437-440. doi:10.3969/j.issn.1005-1678.2017.06.167

Objective To analyze the application situation of the anti HBV drugs, and provide reference for clinical rational use of drugs and improve the therapeutic effect of liver disease.MethodsBy using the method of hospital management system, the application situation from 2012 to 2016 in our hospital of various types of anti liver disease drugs, including drug name, dosage forms.The specifications, the number of drug, drug cost, drug use quantity, the amount of medication, medication frequency (DDDs), daily drug cost (DDDc) and other indicators were sorted and analyzed.ResultsThe total amount and drug therapy of anti liver disease drug in our hospital showed increasing trend,the annual growth rate of the amount of medication was also showing a rising trend, the 2015 annual growth in the amount of medication for the highest rate, 41.56%.The annual hepatoprotective drugs in various anti proportion are the first in liver disease drug, liver drugs accounted for the largest amount of drugs and the reduced glutathione, the amount of drugs and antiviral drugs in the largest proportion of entecavir.ConclusionThe application of Anti Sense drugs showing a growth trend year by year, the amount of medication of the annual growth rate is higher, suggesting that the incidence rate of liver disease in our province had a rising trend.At the same time, hepatoprotective drugs accounted for relatively large of the existence medicine The phenomenon of substance abuse, clinicians should pay attention to.In the promotion of rational use of anti hepatitis drugs, clinicians and pharmacists should jointly do a good job of drug evaluation, has achieved the effective, reasonable application of drug safety and economic purposes.

3

Cite

Share

Lesch-Nyhan syndrome in a Chinese family with mutation in the HGPRT gene

Jiao HUANG ; Yu CHEN ; Chu ZHANG ; Qinxian GUO ; Xianfeng ZHANG ; Lizhen MA ; Yuhong ZHAN

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):435-436,440. doi:10.3969/j.issn.1005-1678.2017.06.166

Lesch-Nyhan syndrome(LNS) is a congenital X-linked recessive inherited disorder caused by mutations in the hypoxanthine guanine phosphoribosyl transferase (HPRT) gene.A deficiency of the HPRT enzyme is responsible for the disease.The main clinical manifestation includes hyperuricemia, juvenile-onset gouty arthritis and neurological developmental disorders.Studies have reported there are more than 400 HPRT gene mutation sites, but the incidence of LNS in the Chinese population is extremely low.Here we report a 16-year-old male patient who suffered neurological dysfunction at an early age and gouty arthritis in his youth.DNA of patient and his family members were extracted from peripheral blood lymphocytes.The coding region and the intron-exon boundaries of HPRT gene were sequenced by standard methods.We found a mutation in exon 3 of the HPRT gene of the patient and his mother (Exon3:c.143G>A), which resulted in an arginine to histidine (p.R48H) substitution in the encoded protein.No activity of the enzyme HPRT was detected in the erythrocytes.The same mutation was reported in several European families, but was found in Chinese family for the first time.Clinicians in China have poor experience in diagnosing LNS case, due to the low incidence in China.Therefore LNS screening for infants or adolescents with hyperuricemia, gouty arthritis and neurological dysfunction should be performed.

4

Cite

Share

The role of drug combined with B-ultrasonography in obstetrics and gynecology surgery in the diagnosis and treatment of postoperative cesarean section

Xiaojun ZHONG

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):433-434. doi:10.3969/j.issn.1005-1678.2017.06.165

Objective To improve the level of diagnosis and treatment of uterine scar pregnancy after cesarean section,and has a very important relationship with the quality of life of the patients.At present,the purpose of reducing the rate of cesarean section and improving the level of diagnosis and treatment is to improve the quality of life of patients.Methodsthe drug contact ultrasound,analysis of surgical instrument for gynaecology and obstetrics usage of cesarean section to the hospital,and the diagnosis and treatment of uterine incision scar pregnancy patients were selected from 12 patients were investigated.Drugs containing methotrexate combined with mifepristone and mifepristone combined with trichosanthin etc.The diagnosis and treatment process,given daily doses of methotrexate intramuscular injection depth,mifepristone 50mg,two times a day,and then a B-knowledge,in the monitoring,found after a drug combined with gynaecology and obstetric operation type-B ultrasonic monitoring instrument in diagnosis and treatment of cesarean scar pregnancy after mass occurred in the bain line,and the surrounding the blood supply appeared to reduce and disappear.Blood B-HCG levels decreased.The operation of the instrument and the monitoring of the Qing Dynasty under ultrasound monitoring,after abdominal and vaginal B ultrasound monitoring,to avoid the abortion operation of obstetric and gynecological surgical guide device complications,reduce the occurrence of medical disputes.It also realizes the real-time digital recording and storage of the image during the diagnosis and treatment process.Resultsthe drug treatment and application,strengthen the guidance and application of ultrasound in obstetrics and gynecology surgical instrument,reduce the bleeding of uterine scar after cesarean section pregnancy,reduced complications.Conclusionthrough the follow-up of patient records,and proved that this method to reduce the risk,improve the patients quality of life etc.on the safe and effective.

5

Cite

Share

Predictive value of P wave dispersion on atrial arrhythmias

Yong ZHANG ; Xuhang HUA ; Jin LIU

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):421-422. doi:10.3969/j.issn.1005-1678.2017.06.160

Objective To explore the predictive value of P wave dispersion (Pd) and maximum P wave duration (Pmax) of 12 lead ECG in patients with atrial arrhythmia.Methods51 cases of atrial arrhythmia group from October 2013 to April 2015 in Jiashan County First People's Hospital, patients with frequent atrial premature atrial tachycardia, were examined for the determination of P wave dispersion by 12 lead electrocardiograms (Pd) and maximum P wave duration (Pmax), and 53 healthy persons (control group) were compared.ResultsAtrial arrhythmia group Pd and Pmax were significantly higher than the control group, the rate is Pmax=100ms with Pd=40ms high prediction of atrial arrhythmia sensitivity, specificity and diagnostic, Pd=40ms=100ms combined with Pmax diagnosis, the sensitivity increased, but the specificity and diagnostic rate of decline.ConclusionPd is an effective index to predict atrial arrhythmias, and the combined detection of Pd and Pmax can improve the diagnostic sensitivity.

6

Cite

Share

Investigate the changes of BNP and IL-33 levels and their clinical diagnostic values in different heart function classification of patients with heart failure.

Jianxing YAN ; Qinyan LIN ; Jingwan XIANG

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):403-406,409. doi:10.3969/j.issn.1005-1678.2017.06.154

Objective To investigate the changes of B type natriuretic peptide(BNP) and interleukin(IL)-33 levels and their clinical diagnostic values in different heart function classification of patients with heart failure.MethodsFrom January 2016 to January 2017,286 patients with heart failure in our hospital were selected as the heart failure group,while 106 healthy people were selected as the control group.The heart failure group was divided into New York Heart Association(NYHA)Ⅰ(n=76), NYHA Ⅱ(n=129), NYHA Ⅲ(n=61) and NYHA Ⅳ(n=20) according to the NYHA heart function classification criteria.The BNP and IL-33 levels were compared between heart failure group and control group,as so as the different heart function classification groups.And analyzed the factors related to heart failure by single factor and multivariate logistic regression.The diagnostic value of BNP and IL-33 in heart failure were analyzed by receiver operating characteristic(ROC) curve.ResultsThe level of BNP in heart failure group was significantly higher than that in control group(P<0.05),while IL-33 level was significantly lower than that in control group (P<0.05).The BNP levels in heart function classification groups had significant difference(P<0.05),but there was no significant difference in IL-33 level among them.Univariate analysis showed that both BNP and IL-33 were associated factors of heart failure, but multivariate logistic analysis showed that only BNP was an independent factor of heart failure.ROC curve showed that the area under the curve(AUC) of heart failure diagnosed of BNP was bigger than that of IL-33,the difference was statistically significant (P<0.05).ConclusionBNP and IL-33 can both effectively diagnose heart failure, but BNP is more diagnostic value.Besides, BNP can effectively reflect the cardiac function, the degree of disease and prognosis, witch can more scientifically guide the clinical treatment.

7

Cite

Share

Investigation and analysis of anti diabetic drugs in our hospital during 2012 to 2016

Lubiao BU ; Qianzhou LV

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):400-402. doi:10.3969/j.issn.1005-1678.2017.06.153

Objective To use in our hospital during 2012 to 2016 anti diabetic drugs were investigated in the analysis, and provide the basis for clinical treatment.MethodsThe drug collected in our hospital during 2012 to 2016 anti diabetic drug name, manufacturer, specifications, quantity, amount, amount, using Excel 2007 for data processing, calculation of DDDs (DDDs) and daily cost (DDC).ResultsFrom 2012 to 2016, the antidiabetic drugs in our hospital the total expenses increased from 12 million 311 thousand and 500 yuan to 19 million 467 thousand and 800 yuan, up 58.13% The amount of consumption.The top three anti diabetic drugs for insulin, sulfonylurea, biguanides;DDDs three for insulin, sulfonylureas, alpha glucosidase inhibitors;DDC three drugs was the highest in Epalrestat Tablets, Insulin Glargine Injection, Insulin Aspart 30 Injection.ConclusionThe treatment of diabetes in our hospital during 2012 to 2016 drug use is more reasonable, the insulin dosage, some new oral proportion is increasing.

8

Cite

Share

Effects of different anti thrombotic strategies on bleeding risk, cardiac events and quality of life in elderly patients with acute non ST segment elevation myocardial infarction complicated with atrial fibrillation

Haiyan CHEN ; Kefeng SUN

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):397-399. doi:10.3969/j.issn.1005-1678.2017.06.152

Objective To investigate the effects of different anti thrombotic strategies on the risk of bleeding, cardiac events and quality of life in elderly patients with acute non ST segment elevation myocardial infarction.MethodsElderly patients with acute non ST elevation myocardial infarction 200 cases of complication in patients with atrial fibrillation, are in our hospital from May 2013 to December 2015 were cardiovascular department, after discharge according to different antithrombotic strategy, according to the 5 groups, including 40 cases of A group, 75mg/d+ 100mg/d treatment with clopidogrel and aspirin;B group 40 cases.Using warfarin therapy;40 cases in group C, 75mg/d or 100mg/d+ with clopidogrel aspirin warfarin therapy;40 cases in group D, using 75mg/d+ 100mg/d+clopidogrel aspirin warfarin therapy, group E received 75mg/d+ clopidogrel aspirin 100mg/d plus warfarin therapy, based on the use of psychological intervention.The risk of bleeding, cardiac events and quality of life scores were compared.ResultsStatistical analysis showed that the incidence of major cardiac events in E group (2.5%) and the quality of life were optimal (the data are statistically significant compared to P<0.05, A, B);C, D, E groups, the risk of major bleeding rate compared with no significant difference.ConclusionThe application of drugs and psychological intervention in the treatment of elderly patients with acute non ST segment elevation myocardial infarction patients can be more effective.

9

Cite

Share

Study on the association of hypersensitivity troponin T level with coronary flow in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Mengping LIU ; Baoqi LIU

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):395-396,399. doi:10.3969/j.issn.1005-1678.2017.06.151

Objective To study the the association of Hs-cTNT level with coronary flow in patients with ST-segment elevation myocardial infarction(STEMI) undergoing percutaneous coronary intervention(PCI).Methods130 cases with STEMI in hospital from January 2014 to December 2014 were divided into the positive group and the negative group according the level of Hs-cTNT.Multivariate analysis were used to examine the association of Hs-cTNT with coronary flow in patients with ST-Segment elevation myocardial infarction undergoing primary PCI.ResultsThe incidence of no reflow in the positive group was significantly higher than that in the negative group (P<0.05) The left ventricular ejection fraction in the positive group was significantly lower than that in the negative group (P<0.05).Multivariate analysis showed that Hs-cTNT was independently associated with coronary flow no-reflow in patients with acute STEMI post-PCI and TIMI flow fractionation events(P<0.05).ConclusionHypersensitivity troponin T is an effective marker for predicting coronary artery flow damage in patients with STEMI after PCI and evaluating risk stratification in patients with STEMI.

10

Cite

Share

Clinical significance of S-100B protein in children with different degrees of amniotic fluid meconium contamination

Lina QI ; Haiying SUN ; Mingqiang SI ; Chang SU

Chinese Journal of Biochemical Pharmaceutics.2017;37(6):393-394. doi:10.3969/j.issn.1005-1678.2017.06.150

Objective Detection of S-100B protein in different degree meconium pollution level in serum of children with value.MethodsIn 2012 June to 2013 December in our department were simple meconium stained amniotic fluid in term newborns in 73 cases, and set up for the observation group, and according to the amniotic fluid pollution degree is divided into 47 cases of amniotic fluid of Ⅰ-Ⅱdegree pollution group and 26 cases in grade Ⅲmeconium group during the same period, selected 20 cases without amniotic fluid contamination in term healthy newborns for the control group, the groups were compared in S-100B protein content difference.ResultsⅢmeconium stained amniotic fluid were within 6h serum S-100B was significantly higher than that in control group(P<0.01), and the degree of contamination of amniotic fluidⅠ-Ⅱgroup compared with the control group, no significant difference(P>0.05).Ⅲ meconium stained amniotic fluid in children with 72h also increased.ConclusionThird degree meconium stained amniotic fluid but normal Apgar score of newborns may still exist in clinical brain injury, so pay close attention to.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share