Chinese Journal of Biochemical Pharmaceutics 2010;31(2):107-110

Study on gatifloxacin in situ pH-sensitive gel release in vitro

Yajing XU ; Rongfeng HU ; Hui YIN ; Yu GAO

Keywords

gatifloxacin; pH-sensitive; in situ gel; drug release; in vitro

Country

China

Language

Chinese

Abstract

purpose To investigate the release properties of gatifloxacin in situ pH-sensitive gel in vitro.Methods The improved paddle method and the membraneless model were applied in assessing the drug release behavior.Results The gel erosion and drug release were increased with the increase of surface area and shaking frequency.The cumulative quantities of gel erosion were well correlated with the cumulative release of drug loaded in the gel.Conclusion Gatifloxacin was released from in situ pH-sensitive gel with zero-order kinetics characters,and drug release was mainly controlled by gel erosion.