Journal Detail Information

1

Cite

Share

Polymorphisms of monoamine oxidase gene and its correlation with certain psychiatric disorders

Lu ZHANG ; Baojie WANG ; Mei DING ; Hao PANG ; Jinjing ZHANG

Chinese Journal of Forensic Medicine.1988;0(04):-.

Monoamine oxidase(MAO) is a kind of mitochondrial outer membrane enzyme that degrades biogenic amines,such as catecholamine and serotonin.It has a variety of biological functions,and can be found in various human tissues,including nervous system.Two MAO enzymes,MAO-A and MAO-B have been identified.MAO gene has polymorphisms,and some of which have a close relationship with certain psychic diseases,such as major depression,alcoholism,antisocial personality disorder and so on.MAO gene can acts as a new forensic individual identification and parentage testing genetic marker or legal psychiatry testing referential genetic marker.

2

Cite

Share

Applicable Value of the Nocturnal Penile Tumescence Test In the Judgement of Erectile Dysfunction after Trauma

Xianzhou JIANG ; Zhishun/ XU

Chinese Journal of Forensic Medicine.1986;0(01):-.

0.05 ). Conclusion The NPT test is simple and practical, and its diagnostic accuracy is comparable to that of the combined test. The NPT test should be used as an examination of choice for the primary etiological diagnosis in ED after trauma.

3

Cite

Share

Mechanism of proliferation migration and differentiation of neural stem cells

Dongmei JIA ; Yiwu ZHOU ; Guanglong HE

Chinese Journal of Forensic Medicine.1986;0(01):-.

Recent researches have showed that neural stem cells be isolated not only in the embryonic nervous system but also in adult nervous system. Neural stem cells have some capacity for self-renewal, migration and can differentiate into neurons, astrocyte and oligodendrocyte. This provides a basis in therapy of degenerative diseases and functional recovery of the central nervous system injury. Also helps in the study of determining the postmortem interval ( PMI) and postmortem injury. Distribution, biological characteristic, identification and the factors effecting the proliferation, differentiation and migration with reference to therapy of neural stem cells and applications in forensic pathology are reviewed.

4

Cite

Share

Dependence analysis between sudden manhood death syndrome and mutation of SCN5A

Ke HE ; Jianshe XU ; Zhenyuan WANG

Chinese Journal of Forensic Medicine.1986;0(01):-.

In resent years, the accounts about adults' sudden death without specific reason have been increased. The definition of cause of death was a hot potato to legal medical experts. With the deep - going of etiology to molecular level, clinical cardiac diseases' researches have confirmed that the arrhythmia has been resulted from a kind of " idiopathic disorder of cardiac action potential" that is related to cardiac sodium channel diseases by SCN5A mutation confirmed by using the techniques of molecular genetics. The paper reviewed the characteristic of SMDS ( Sudden Manhood Death Syndrome) in forensic science and some kinds of diseases' genotype and phenotype in clinical medicine, and hoped to acquire some revelation for further related research.

5

Cite

Share

A study on the relationship between visual acuity and the latency and spatial fequency of P100 of pattern reversal visual evoked potentials in a view of forensic science

Shengyan LI ; Zhiwei ZHANG ; Xiaorong ZHOU

Chinese Journal of Forensic Medicine.1986;0(01):-.

Objective To investigate the relationship between the parameter of P100 elicited by pattern stimuli, spatial frequency and visual acuity in the posttraumatic eyes. Methods 81 eyes sustained blunt injury in outpatients were enrolled from West China Hospital, Sichuan University. The control group was composed of 199 eyes without disease or trauma. Different P100 wave including amplitude and latency were recorded in each eye stimulated by reversal pattern with 5 - sized checkerboards. The data were processed by SPSS to describe the relationship between the visual acuity and the parameter of P100 wave. A linear and regression analysis was done in the statistic procedure. Results There was a high correlation between spatial frequency ( X) and the log visual acuity ( Y). Regression equations were deduced for evaluating the visual acuity. There was a correlation between the latency of P100 wave (X) and the log visual acuity (Y) in all the examined eyes. Conclusion The established regression equations can be used to evaluate the visual acuity as an accurate and objective method. There is a promising future of its application in the forensic clinical authentication of visual function.

6

Cite

Share

An experimental study on substance P in plasma, laryngopharygeal tissue and the lungs in guinea pigs with anaphylactic shock

Jiwei BAI ; Cairong GAO ; Guangmu REN

Chinese Journal of Forensic Medicine.1986;0(01):-.

Objective To explore the pathognomonic findings of anaphylactic shock in forensic medicine. Methods Animal model of anaphylactic shock was developed in guinea pigs. Substance P level in plasma was determined radioimmunoassay, and detected in laryngopharyneal tissue and the lungs by immunohistochemical SABC method followed by image analysis using BI - 2000 image analyzing system. Positive index (PI) was calculated. Results There was a statistically significant difference for substance P concentration in plasma between the guinea pigs with anaphylactic shock (131.01? 18.93pg/?l)and the control animals (87.70 ?7. 60pg/?l) (P

7

Cite

Share

Study on blood drug level of 8 Lidocaine anaphylactic deaths

Yingqiang LU ; Zhaoyan XUAN ; Baijun CUI

Chinese Journal of Forensic Medicine.1986;0(01):-.

Objective To study the relationship between Lidocaine blood drug level and the cause of death from Lidocaine anaphylactic shock. Method Comparing and analyzing the blood drug levels by HPLC between two groups of people whose various indexes are normal before the surgery. Group 1 included 8 cases who accepted Lidocaine as anesthetic and died from Lidocaine anaphylactic shock. Group 2 included 11 cases who also took Lidocaine as anesthetic and passed the surgery smoothly. Results Lidocaine blood level of Group 1 (1.61?0. 45mg/L) is lower than that of Group 2 (2. 44 ?0. 47mg/L). Conclusion Lidocaine blood drug level has nothing to do with the cause of Lidocaine anaphylactic shock.

8

Cite

Share

Study on the correlative factors for mental disorder in patients with head injury

Jinxiang ZHANG ; Ailing ZHAI ; Min CHEN

Chinese Journal of Forensic Medicine.1986;0(01):-.

Objective To explore the correlative factors of mental disorder in patients with head injury. Methods 255 subjects sustained with head injury and survived from traffic accident in Chengdu were assessed with Structured Clinical Interview for DSM-Ⅳ axis Ⅰ disorders (SCID-I/P) , Personality Disorder Questionaire for CCMD-2-R(PDQC), Structured Clinical Interview for CCMD-2-R(SCICP), WAIS-RC, WMS, brain electric activity mapping (BEAM) after completion of clinical management. Based on the diagnostic criteria of organic mental disorder in CCMD-3, mental disorders in 255 subjects were diagnosed. Results The incidence of mental disorders in the patients with head injury was 72.5% (185/255). Mental disorders in patients with head injury were correlated with educational level, type and severity of the head injury, or injuries involving the left frontal lobe injury, the left temporal lobe or multiple lobes and BEAM abnormality. Conclusion The incidence of mental disorder is high in the patients with head injury. Educational level, type and severity of the head injury, the location of the injured brain, injury involving multiple lobes of the brain may affect morbidity of mental disorders in patients with head injury.

9

Cite

Share

Estimation of Age and Radiographic Changes in Chinese Girls at the Age of 11-16 Years with the Characteristic of X-ray Image of Articulations of Bone

Xiaojie XUE ; Xuemei TIAN ; Jizong ZHANG

Chinese Journal of Forensic Medicine.1986;0(01):-.

Objective To set up the method of estimation of age for Chinese girls at the age of 11-16 years according to their characteristic of radiographic changes in articulations of bone. Methods The samples of the X-ray photograph were come out of 6 articulations of humeri, cubiti, manus, coaxe, genus and ankle from 150 girls, ranging in age from 11-16 years old, in Henan province, North of China. The radiographic characteristics of osteoepiphysis at these joints were observed carefully and classified. The data were analyzed with the SPSS package. Result Regression equation was made for radiographic determine of age for Chinese girls at the age of 11-16 years. Conclusion The equation can be used for forensic practice about the determine of age.

10

Cite

Share

Y-STRs Multiplex Amplification and Validation for Forensic Scieuce

Meisen SHI ; Yingbi LI ; Xiaojue YU

Chinese Journal of Forensic Medicine.1986;0(01):-.

Objective In order to increase significantly the discriminatory potential of Y-STR systems available to the forensic community , We have developed and validated a four-color fluorescence multiplex PCR system consisting of 7 male-specific and polymorphic Y-STRs. Methods We designed three sets of constant primers chimerited into three groups of 7 Y-STR's specific primers and utilized fluorescence- labeled these three sets of constant primers to amplified simultaneously 7 Y-STRs in a reaction tube. Allele and haplotype frequencies at these Y-STRs were screened by ABI PRISM310 Genetic Analyzer and analyzed by Genotyper software. Results Following optimization of the polymerase chain reaction , DYS434, Y-GATA-A10,DYS531, DYS557 , DYS456 , DYS444 and DYS448 in a sample of 120 unrelated males , showed4, 5, 5, 8, 8, 6,7 alleles respectively. A total of 101 different haplotypes was identified,of which 89 (88. 11% ) were found in single individuals. The overall haplotypes diversity reached 0.9958. To the one case of mixture stains, our multiplex system drawn conforming conclusion comparing to the result of Y-STR genotypes in suspect's blood sample. Conclusion Our results show that the multiplex system of 7 Y-STR will be very powerful for establishing Y-STR database, the paternity testing and mixture stains identifying.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share