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Research for induced pluripotent stem cells in cardiovascular area

Chinese Journal of cardiovascular Rehabilitation Medicine.2014;23(2):215-217,218. doi:10.3969/j.issn.1008-0074.2014.02.30

Induced pluripotent stem cells (iPSCs)are pluripotent stem cells obtained through transduction of specific transcription factors and reprogramming of human and animal somatic cells,Which are similar to embryonic stem cells.The iPSCs possesses characteristics of unlimited proliferation,self-reneWal and multi-differentiation.This arti-cle mainly summarized current research condition,application value and prospects of iPSCs in cardiovascular area, and its defect in application of current stage.

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Exploration of the rehabilitation education in aged patients with cardiovascular disease

Saizhu XU ; Aihua REN

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(2):125-126.

Objective:To study the practical methods and the results of the rehabilitation education.Methods: One hundred cardiovascular patients over 65 years old who are receiving the com prehensive rehabilitation treatment are selected for rehabilitation education,an d comparisons were conducted between pre-and post-education.Results: After receiving the rehabilitation education,the cognition on disease (51%→89%)、rehabilitation therapy(47%→93%),confidence of to win a victory on d i sease(53%→90%)、attendance rate(71%→98%) increase obviously,and irrationality living habit decrease obviously(36%→13%). Conclusion: The rehabilitation education plays an important role in the rehabilitation of t he aged cardiovascular patients,and it is very practical and feasible.

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Detection of serum D-dimer and its clinical significance

Chuanyou XIA

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(2):121-123.

Objective:Dynamically observe the serum D-dimer level of patients wit h thrombus, for instructing drug therapy and judging prognosis.Methods: Detect serum D-dimer level by latex agglutination in 113 cases, among these 20 cases were normal(control group), and 93 cases were patients with thrombus(patient g roup).Results:Detecting results of control group were all negative, positive rate of patient group were 67%～100% according type of disease.Conclusion:Level of serum D-dim er is obviously increase in patient with thrombus. It's ideal detecting index of patient with thrombus.

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The significance of QTc and QTcd in predicting cardiac events of CHF patients

Qingtan ZHANG ; Dianfeng SUN ; Shanglang CAI

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(2):118-120.

Objective:To investigate the predictive value of QT interval dispersion (QTd),cor rected QT interval dispersion (QTcd) and corrected QT interval(QTc) of car diac events in patients with congestive heart failure (CHF).Methods: QTd、QTcd、QTc and QTcd/QTc of 106 CHF patients were reviewed. Results:QTd、QTcd、QTc and QTcd/QTc of patients with and without cardiac events had significant difference respectively(P<0.05、<0.01、<0.05、<0.001 respectively).Conclusion: QTd、QTcd、QTc and QTcd/QTc are independent factors in predictin g cardiac events of CHF patients. In which,QTcd/QTc is the most accurate factor.

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Correlation between carotid atrery atherosclerosis and coronary heart disease

Lianmei LIU ; Kening SONG ; Li LI

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(1):26-28.

Objective: To study the correation between carotid artery atherosclerosis and coronary heart disease (CHD). Methods: Color Doppler flow imaging was employed to evaluate carotid artery atherosclerosis in 90 patients with CHD, carotid artery ultrasonography and coronary angiography were performed simultaneously in 20 cases. Results: The thickness of internus-middle membrane and the index number of atheroma both increased remarkably in all cases, and the group with MI had obvious abnomal parameter of blood stream in internal carotid artery. The conformed rate of coronary angiography with ultrasonography in carotid is 75 % in 20 cases,and the moreserious the pathological change of coronary is, the higher the happening rate of carotid artery atherosclerosis is. Conclusion: The degrees of carotid artery atherosclerosis can reflect the degree of pathological changes of coronary indirectly.

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Analysis of the patient's death cause in hospital after cardiac valve replacement

Xiaohong ZHENG ; Qiying GAO ; Dongwu SHI

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(1):20-22.

Objective: The aim of our study was to analyse the death cause and related factors of death in hospital of patients after cardiac valve replacement (CVR). Methods: Regression analysis of 34 patients' data was executed. Results: Death rate was 9.9 %, death cause: (1) L.ow cardiac output syndrome is the first complication and death cause (2.6 % ), which was closely related to cardiac function (grade Ⅳ ) before operation, LVEDD＞8.0 cm, LVEF＜0. 40, GR ＞80%, emergency operation, long time of arterial block, etc; (2) Ventricular tachycardia、 ventricular fibrillation is the second cause of death (2. 1%); (3) Respiratory failure (4) Post-operation hemorrhage inducing pericardial tamponade and shock; (5) Postoperation infection of replaced valve and brain complications. Conclusion: The success rate of operation can be increased by selecting patients strictly, improving operation methods, enhancing periopertive monitor.

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Alteration of erythrocyte deformability and adenosine triphosphatase activity of cell membrana in essential hypertensive patients complicated with cerebral infarction

Ruiying SHL ; Hongyan ZHOU ; Ming SUN

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(1):17-19.

Objective: To investigate the alteration of red cell deformability (RCD) and adenosine triphosphatase (ATPase) activity of cell membrane in essential hypertensive (EH) patients and essential hypertension patients complicated with cerebral infarction (HCI). Methods: Twenty healthy individuals, 30 EH patients and 30 HCI patients were selected as subjects. The erythrocyte deformability indexes (DI)、 Na+, K+-ATPase and Ca2+ATPase activities were examined. Results: (1) EH patients had significantly higher DI, lower ATPase activity as compared to healthy individuals. There were significantly negative correlation between DI and ATPase activity, and a significantly positive correalation between DI and diastolic blood pressure in EH patients; (2) There was significantly higher DI, lower ATPase activity in HCI patients than those in EH patients. There was significantly negative correlation between DIand ATPase activity in HCI patients. Conclusion: (1) RCD decreases in EH patients, and RCD is correlated to the decreased ATPase of cell membrane and elevated blood pressure; (2) The decreased RCD level may be related to the occurrence of HCI.

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Examination and analysis of spectrum ECG and ECG 、vectorcardiogram in patients with coronary heart discase

Dongsheng ZENG ; Xiuying CHEN ; Meikui WANG

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(1):11-12.

Objective: To explore the significance of examination of spectrum ECG in patients with coronary heart disease (CHD). Methods: Spectrum ECG and ECG、 vectorcardiogram examination were meanwhile executed in 254 patients with coronary heart disease. Results: Diagnose coincidence rate of CHD was 66.9% by spectrum ECG and ECG、 vectorcardiogram examination. Conclusion: Spectrum ECG is a new detect method for electrocardiogram information.

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Effects of type 2 diabetes mellitus patients with hypertension on lipid metabolism and insulin sensitivity

Fenglian LIU ; Weiwei CUI

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(1):9-10.

Objective: To observe the effects of type 2 diabetes mellitus patients with hypertension on lipid metabolism and insulin sensitivity. Methods: A case-matched study of fasting plasma glucose (FBG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HIDL), low density lipoprotein cholesterol (LDL), insulin (FIN), C-peptide (FCP) and insulin sensitivity index (ISI) were detected in type 2 diabetes mellitus patients with and without hypertensiorn. Results: Twenty patients with type 2 diabetes mellitus complicated hypertension had higher TG、 FINS and FCP, lower HDL and ISI levels than 20 patients with type 2 diabetes mellitus without hypertension. Conclusion: Type 2 diabetes mellitus with hypertension had more remarkable lipid metabolic disorder and insulin resistance than type 2 diabetes mellitus without hypertension.

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Effects of cardiovascular endocrine hormone and insulin-resistance in aged hypertension

Zuosheng SHI

Chinese Journal of cardiovascular Rehabilitation Medicine.2001;10(1):7-9.

Objective: To research the effects of cardiovascular endocrine hormone and insulin-resistance in aged patients with hypertension. Methods: The t-PA of serum (plasma), activity of PAI、 ANP、 ET、 A Ⅰ 、 A Ⅱ and IR were determined in 40 patients with Ⅰ and Ⅱ stage of hypertension and in 30 healthy subjects (control group). Results: The PAI、 ANP 、 ET、 A Ⅱ and total cholesterol and triglyceride levels were apparently higher in patients with hypertension than in healthy control group. The t-PA and IS were obviously lower in hypertensive patients than in healthy control group. Conclusion:The cardiovascular endocrine hormone and insulin-resistance play an important role in genesis and development of hypertension in aged.

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