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Clinical research advances for pacing in interatrial septum

Bo WANG ; Yinghui WANG ; Hongwei DU ; Ying LUAN

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):667-669. doi:10.3969/j.issn.1008-0074.2015.06.24

Cardiac pacing site has an important impact on the activation sequence and systolic synchrony of heart , which is an important factor determining clinical effect of cardiac pacing .Along with expanding and use of active fixed electrode in clinic ,especially adjustable bending delivery sheath ,it makes right atrial pacing of non -tradition‐al site possible .But whether changing atrial pacing site can reduce atrial fibrillation load after pacemaker implanta‐tion is still controversial .Now the present article made a simple review about research progress of interatrial septum pacing .

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Clinical feature analysis in 120 patients with early or non-early acute coronary syndrome

Juyuan LI ; Quanru BAO

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):651-653. doi:10.3969/j.issn.1008-0074.2015.06.19

Objective:To compare and analyze clinical features between patients with early and non‐early acute coro‐nary syndrome (ACS) .Methods :A total of 120 ACS patients were selected ,including 71 patients with early ACS (early ACS group ,onset time≤12h) and 49 patients with non‐early ACS (non‐early ACS group ,onset time >12h) . Risk factors ,clinical features ,mortality ,incidence rates of myocardial infarction ,rehospitalization and major ad‐verse cardiovascular events (MACE) were compared and analyzed between two groups .Results:There were no sig‐nificant difference in percentage of each ACS risk factor between two groups , P>0.05. Compared with non‐early ACS group ,there was significant reduction in incidence rate of heart failure (73.5% vs .54.9% ) ,significant rise in incidence rates of obvious chest pain (32.7% vs .73.2% ) and shock (46.9% vs .62.0% ) in early ACS group (P<0.05 all) ,but there was no significant difference in incidence rate of arrhythmia between two groups (P>0.05) . After one‐year follow‐up , compared with non‐early ACS group , there were significant reduction in mortality (18.4% vs .4.2% ) ,incidence rates of myocardial infarction (18.4% vs .4.2% ) ,rehospitalization (30.6% vs . 14. 1% ) and MACE (38. 8% vs .16. 9% ) in early ACS group , P<0. 05 all .Conclusion:Initial symptom is more ob‐vious ,but related complications are fewer and the prognosis is better in patients with early acute coronary syndrome .

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Analysis of overweight and obese population distribution in a sanatorium and their relationship with blood glucose level

Xiaoyan XI ; Chunxing LIU

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):630-632. doi:10.3969/j.issn.1008-0074.2015.06.13

Objective:To analyze data of 5604 cases who received health examination in our hospital ,and understand morbidities of overweight and obesity in these people and their relationship with blood glucose level . Methods :Morning venous blood was taken from the 5604 subjects undergoing health examination to measure blood glucose lev‐el ,and their body weight and height were measured at the same time ,then body mass index (BMI) was calculated and analyzed .Results:Among the 5604 subjects , prevalence rates of overweight and obesity were 42.1% and 13. 3% respectively ,and they were 50% and 16. 4% in men ,and 25. 4% and 6. 8% in women respectively .Among different age groups (except ≥71 years group) , prevalence rate of overweight in men was significantly higher than that of women , P<0.01 all;except ≥61 years subjects , prevalence rate of obesity in men was significantly higher than that of women ,P<0.01 .In overweight group ,risk relative (RR) of impaired fasting blood glucose and dia‐betes mellitus to those of subjects with normal body weight was 2.32 (95% CI 1.91~2.82) and 2.92 (95% CI 2.31~3.70) respectively ;in obesity group , RR of impaired fasting blood glucose and diabetes mellitus to those of subjects with normal body weight was 3.2 (95% CI 2.57~3.99) and 5.17 (95% CI 4.53~5.90) respectively , P=0.001 all . Conclusion:Overweight and obesity have become a common problem among our customer groups .Compared with those with normal body weight ,overweight and obesity greatly increase risk ratio of impaired fasting blood glucose .

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Changes and significance of serum levels of vascular endothelial growth factor and placental growth fac-tor in patients with hypertensive disorder complicating pregnancy

Chunbo ZHU ; Bei ZHANG

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):623-626. doi:10.3969/j.issn.1008-0074.2015.06.11

Objective:To observe expressions of vascular endothelial growth factor (VEGF ) and placental growth factor (PLGF) in patients with hypertensive disorder complicating pregnancy (HDCP) during early and mid pregnancy ,and pro‐vide basis for diagnosing HDCP .Methods:A total of 46 normal pregnant women (normal pregnancy group ) and 39 HDCP patients (HDCP group) were enrolled .The HDCP group was further divided into gestational hypertension group (n=26) , mild preeclampsia group (n=8) and severe preeclampsia group (n=5) .Enzyme linked immunosorbent assay (ELISA) was used to measure serum VEGF and PLGF levels during early ,mid and late pregnancy ,and those were compared among a‐bove groups .Results:Compared with normal pregnancy group ,there were significant reductions in serum levels of VEGF [ (187.54 ± 17.36) ng/L vs .(123.35 ± 16.46) ng/L] and PLGF [ (217.49 ± 26.32) ng/L vs .(128.32 ± 21.23) ng/L] in HDCP group during mid period (24th week) , P<0. 01 all ,and serum VEGF and PLGF levels more significantly reduced during late pregnancy (34th week) (P<0.01);in HDCP group ,compared with gestational hypertension group and severe preeclampsia group ,PLGF level [(127.46 ± 16.55) ng/L ,(158.40 ± 26.33) ng/L vs .(99.02 ± 27.26) ng/L] significantly reduced in mild preeclampsia group on 24th week;the serum VEGF and PLGF levels more significantly reduced on 34th week , P<0. 05 or <0. 01 . Conclusion:Reduced serum levels of VEGF and PLGF during mid pregnancy in HDCP patients are help to early diagnosing HDCP .

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Correlation among cardiac function,inflammation factor and plasma testosterone level in aged male patients with chronic heart failure

Wen YIN ; Haiyan LIU ; Haoyu WANG ; Tao LIU ; Shirong CHEN

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):620-622. doi:10.3969/j.issn.1008-0074.2015.06.10

Objective:To observe the correlation among cardiac function ,inflammation factor and plasma testoster‐one level in aged male patients with chronic heart failure (CHF) .Methods :A total of 91 male CHF inpatients were selected from our hospital ,including 31 cases with NYHA cardiac function class Ⅱ ,30 cases with class Ⅲ and 30 ca‐ses with class Ⅳ .Another 40 corresponding male patients without CHF were regarded as non‐CHF control group . Plasma levels of testosterone ,interleukin (IL)‐6 ,tumor necrosis factor (TNF)–α and brain natriuretic peptide (BNP) and cardiac function were compared between two groups .Results:Compared with non‐CHF control group , there were significant reductions in plasma testosterone level , P<0. 05 or 0. 01 ,and they more reduced along with NYHA cardiac function class rose in all CHF subgroups ,P<0.05 or <0.01 .Correlation analysis indicated that tes‐tosterone level was inversely correlated with IL‐6 and TNF‐α levels (r= -0.244 , -0.322 , P<0.05 both) ,and positively correlated with LVEF (r=0.322 ,P=0.01) .Conclusion:In patients with chronic heart failure ,the poo‐rer cardiac function is ,the lower plasma testosterone level is .Testosterone level measurement contributes to judging disease degree and prognosis of patients with chronic heart failure .

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Relationship among carotid artery plaque, C reactive protein level and coronary artery lesion

Xiangqin ZENG

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):614-616. doi:10.3969/j.issn.1008-0074.2015.06.08

Objective:To explore the relationship among carotid intima‐media thickness (IMT) ,plaque score ,plasma level of C reactive protein (CRP) and coronary artery lesion in patients with coronary heart disease (CHD) .Meth‐ods:A total of 83 CHD patients were enrolled as CHD group and 37 patients without CHD were enrolled as non‐CHD group .CHD patients received coronary angiography .According to number of diseased coronary vessels ,CHD patients were divided into single vessel coronary disease group (n=28 ,single vessel group ) ,double‐vessel coronary disease group (n=31 ,double‐vessel group) and triple‐vessel coronary disease group (n= 24 ,triple‐vessel group) . Plasma CRP level and carotid IMT were measured ,and carotid atherosclerotic plaques were classified in all groups . Results :Compared with non‐CHD group ,there were significant rise in CRP level [ (0.89 ± 0.54) mg/L vs . (3.50 ± 3.42) mg/L] and IMT [ (0.65 ± 0.27) mm vs . (1.04 ± 0.31) mm] in CHD group (P<0.05 or <0.01);Com‐pared with single‐vessel group and double‐vessel group ,the CRP level of triple‐vessel group [ (1.44 ± 1.03) mg/L , (3.71 ± 3.52) mg/L vs .5.82 ± 3.98) mg/L] significantly rose ;the percentage of carotid plaque class 3 of triple‐ves‐sel group (0% 、0% vs .25% ) significantly rose (P<0.01 all) .Conclusion:C reactive protein level and carotid intima‐media thickness significantly rise in patients with coronary heart disease ,and there are significant rise in C reactive protein level and percentage of carotid atherosclerotic plaque class 3 in patients with multi‐vessel coronary disease .

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Relationship among plasma levels of adiponectin, Lp-PLA2 and carotid atherosclerotic plaque stability in patients with acute cerebral infarction

Guixian Lü

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):597-599. doi:10.3969/j.issn.1008-0074.2015.06.03

Objective:To explore the relationship among plasma levels of adiponectin (APN) ,lipoprotein‐associated phospholipase A2 (Lp‐PLA2) and carotid atherosclerotic plaque stability in patients with acute cerebral infarction (ACI) .Methods:A total of 149 ACI patients ,who hospitalized in our hospital within 24h after onset ,were en‐rolled as ACI group .Another 90 subjects without cerebral infarction from our physical examination center were re‐garded as non‐ACI control group .According to carotid ultrasound results ,ACI patients were divided into normal ca‐rotid group (n=36) ,stable plaque group (n=47) and unstable plaque group (n=66) .Enzyme linked immunosor‐bent assay (ELISA) was used to measure plasma levels of APN and Lp‐PLA2 in all groups ,and the results were com‐pared then .Results: (1) Compared with non‐ACI control group ,there was significant reduction in plasma APN level [ (20.02 ± 4.01) ng/ml vs .(8.95 ± 3.07) ng/ml] and significant rise in Lp‐PLA2 [ (40.31 ± 8.27)μg/L vs . (58.21 ± 9.21)μg/L] in ACI group ,P<0.01 both ;(2) From normal carotid group ,stable plaque group to unsta‐ble plaque group ,APN level gradually reduced [(18.21 ± 2.98) ng/ml vs .(10.31 ± 2.12) ng/ml vs .(6.58 ± 1.96) ng/ml] ,while Lp‐PLA2 level gradually rose [ (42.25 ± 6.91)μg/L vs .(50.11 ± 5.78)μg/L vs .(69.01 ± 11.90)μg/L] ,there was significant difference in pairwise comparisons ,P<0.05 or <0.01;(3) Linear correlation analysis indicated that plasma APN level was inversely correlated with Lp‐PLA2 level in ACI group (r= -0.782 ,P=0.036) .Con‐clusion:Plasma levels of adiponectin and lipoprotein‐associated phospholipase A2 are closely associated with carotid athero‐sclerotic plaque instability ,their combine detecting is help to diagnosis and judging patient′s condition .

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Research progress on the relationship among high sensitive C reactive protein, neutrophil-lymphocyte ratio and heart failure

Xiaoqin SHEN ; Min GUO

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):676-678. doi:10.3969/j.issn.1008-0074.2015.06.27

In recent years ,researches suggested that inflammation is closely related to occurrence and development of heart failure .Some studies have indicated that high sensitive C reactive protein (hsCRP) and neutrophil -lym‐phocyte ratio (NLR) were independent predictors for prognosis of heart failure ,so it is new targets for heart failure treatment .The present article made a review for new progress of related research .

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Influence of IL-35 on occurrence and development of heart failure

Zhang BO ; Sun YONG ; Wu JIAN

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):673-676. doi:10.3969/j.issn.1008-0074.2015.06.26

Heart failure is a syndrom of heart disease with high morbidity and mortality .There are more and more evidence indicating immune activation developing important role in the occurrence and development of heart failure . Interleukin (IL)‐35 ,known as a negative regulatory factor of one of the members of IL‐12 family ,participates pathogenetic process of heart failure .The present article made a review for influence of IL‐35 on heart failure .

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Diagnostic significance of serum cTnI level raise in patients without acute myocardial infarction

Lezhi SHENG ; Zhenrong CAI

Chinese Journal of cardiovascular Rehabilitation Medicine.2015;24(6):669-672. doi:10.3969/j.issn.1008-0074.2015.06.25

In clinical work of emergency visit and department of cardiology ,some cases are usually encountered , their cardiac troponin levels rise ,but there is no corresponding cardiac ischemic manifestations on ECG ,even no chest tightness and chest pain etc .The present article collected some related data for those patients without acute myocardial infarction but their troponin levels rose abnormally .They were reviewed as follow .

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