Journal Detail Information

1

Cite

Share

Effect of walking on rehabilitation in aged patients with hypertension complicated anxiety

Mei-Juan CHEN ; Bo DONG ; Li LI ; Li-Hong NING ; Ling-Zhong ZENG ; Dan-Ping SHEN

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):617-619. doi:10.3969/j.issn.1008-0074.2018.06.01

Objective:To explore effect of walking on rehabilitation in aged patients with hypertension complicated anxiety.Methods:A total of 160 aged patients with hypertension complicated anxiety were enrolled,randomly divided into medica-tion group (n＝80,received routine medication ) and exercise group (n＝80,received walking exercise based on routine medication),both groups were treated for four months.Carotid intima-media thickness (IMT) and ZUNG self-rating anxi-ety scale (SAS) score before and after treatment,incidence rate of cardiovascular events after one-year follow-up were compared between two groups.Results:Compared with before treatment,there were significant reductions in IMT and SAS score in two groups after treatment,P＝0.001 all;compared with medication group after treatment,there were significant reductions in IMT [ (1.05 ± 0.26) mm vs.(0.90 ± 0.46) mm] and SAS [ (38.07 ± 0.25) scores vs.(23.02 ± 0.46) scores] in exercise group,P＜0.01 both.During one-year follow-up,total incidence rate of cardiovascular events in exer-cise group was significantly lower than that of medication group (30.67% vs.69.74%,P＝0.001).Conclusion:Walking helps to improve anxiety,reduce incidence of adverse cardiovascular events in aged patients with hypertension complicated anxiety.It’ s safe and reliable,which is worth extending.

2

Cite

Share

Changes of Hcy,vWF and tissue factor procoagulant activity within 48h after onset in CHD patients and relationship between 3 indicators and coronary heart disease onset

De-Kui LI ; Ming-An ZHU ; Duo-Zhi CHENG

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):620-624. doi:10.3969/j.issn.1008-0074.2018.06.02

Objective:To observe and compare differences of levels of homocysteine (Hcy),von Willebrand factor (vWF) and tissue factor procoagulant activity (TF-PCA) between patients with coronary heart disease (CHD) and healthy resi-dents,and analyze relationship between above 3 indicators and coronary heart disease onset.Methods:Clinical data of 95 CHD emergency patients (CHD group),who were treated in our department of cardiology from Apr 2013 to Dec 2015,and 95 healthy residents (healthy control group) were retrospectively analyzed.According to state of an illness,CHD group was further divided into stable angina pectoris (SAP) group (n＝33),unstable angina pectoris (UAP) group (n＝31) and acute myocardial infarction (AMI) group (n＝31).Levels of Hcy,vWF and TF-PCA were measured and compared among all groups and different time after onset in CHD patients.Multifactor Logistic regression analysis was used to analyze influ-encing factors of CHD types.Results:Compared with healthy control group,there were significant rise in levels of Hcy [ (9.22 ± 3.45) μmol/L vs.(17.80 ± 6.94) μmol/L],vWF [(122.40 ± 10.18)% vs.(160.13 ± 10.48)%] and TF-PCA [ (30.12 ± 10.49) s vs.(69.45 ± 8.26) s] in CHD group,P＝0.001 all.Compared with SAP group,there were signifi-cant rise in levels of Hcy [ (14.30 ± 3.15) μmol/L vs.(20.50 ± 4.97) μmol/L vs.(25.77 ± 6.10) μmol/L],vWF [ (141.56 ± 9.45)% vs.(168.23 ± 11.29)% vs.(185.56 ± 11.40)%] and TF-PCA [ (45.13 ± 11.52) s vs.(53.16 ± 18.45) s vs.(64.49 ± 11.59) s] in UAP group and AMI group,and those of AMI group were significantly higher than those of UAP group,P＜0.05 or ＜0.01.As onset time went by,there were significant reductions in levels of Hcy,vWF and TF-PCA in CHD patients,and all of them accorded with 1h＞12h＞24h＞48h,there existed significant difference be- tween any two time points,P＝0.001 all.Multifactor Logistic regression analysis indicated that Hcy,vWF and TF-PCA were independent risk factors for CHD type (OR＝2.586～5.058,P＝0.001 all).Conclusion:Levels of Hcy,vWF and TF-PCA significantly rise in CHD patients,the more severe disease is,the higher levels are.Along with time goes by,their levels significantly reduce.Combined detection of them can be used for predicting CHD type.The Hcy,vWF and TF-PCA are independent risk factors for CHD type.

3

Cite

Share

Therapeutic effect of rehabilitative exercise on angina pectoris and its impact on cardiac autonomic nervous function,IL-6 and BNP level

Tian-Zhi HUANG

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):624-628. doi:10.3969/j.issn.1008-0074.2018.06.03

Objective:To study therapeutic effect of rehabilitative exercise on angina pectoris and its impact on cardiac au-tonomic nervous function,levels of interleukin (IL)-6 and brain natriuretic peptide (BNP).Methods:A total of 128 pa- tients with angina pectoris,who were treated in our hospital from Jan 2013 to Dec 2016,were enrolled as rehabilitative ex-ercise group (received routine treatment and rehabilitative exercise ) and treated for six months.Another 128 healthy sub-jects were regarded as healthy control group.Blood lipid levels,indexes of heart rate variability (HRV),levels of IL-6 and BNP were observed and compared between two groups before and after treatment.Results:1.Comparison of blood lipids and BNP (table 2,4):(1) Before vs.after treatment in rehabilitative exercise group:after six-month treatment,there were significant reductions in levels of TG,TC,LDL-C,IL-6 and BNP,and significant rise in HDL-C level,P＝0.001 all;(2) Comparison between two groups after treatment:Compared with healthy control group after treatment,there were significant rise in levels of TG [ (1.56 ± 0.17) mmol/L vs.(2.15 ± 0.22) mmol/L],TC [ (1.53 ± 0.20) mmol/L vs.(4.01 ± 0.43) mmol/L],LDL-C [ (2.79 ± 0.29) mmol/L vs.(3.21 ± 0.25) mmol/L],IL-6 [ (12.21 ± 1.34) pg/ml vs.(20.18 ± 2.19) pg/ml] and BNP [ (89.96 ± 9.21) ng/L vs.(410.69 ± 42.76) ng/L],and significant reduction in HDL-C level [ (1.16 ± 0.19) mmol/L vs.(0.98 ± 0.11) mmol/L] in rehabilitative exercise group,P＝0.001 all.2.HRV index comparison (table 3):(1) Healthy control group (resting vs.after exercise):after exercise there were signif-icant reductions in lnVLF,lnLF,lnHF and lnTP,and significant rise in ln (LF/HF),P＝0.001 all;(2) Rehabilitative exercise group before treatment (resting vs.after exercise):after exercise only lnVLF significantly reduced,P＝0.005;(3) Healthy control group vs.rehabilitative exercise group before treatment,no matter resting or after exercise,there were significant reductions in lnVLF,lnLF,lnHF and lnTP,and significant rise in ln (LF/HF) in rehabilitative exercise group,P＝0.001 all;(4) Rehabilitative exercise group after treatment (resting vs.after exercise):after exercise there were significant reductions in lnVLF,lnLF,lnHF,lnTP and ln (LF/HF),P＝ 0.001 all;(5) Rehabilitative exercise group resting (before vs.after treatment):after treatment there were significant rise in lnVLF,lnLF,lnHF and lnTP,P＝0.001 all;(6) Rehabilitative exercise group after exercise (before vs.after treatment):after treatment there were sig-nificant rise in lnLF and lnHF,and significant reduction in ln (LF/HF),P＜0.01 all.Conclusion:Rehabilitation exercise can significantly improve blood lipid levels,relieve inflammation,improve cardiac autonomic nervous function with signifi-cant therapeutic effect in patients with angina pectoris,and it＇s safe and reliable.

4

Cite

Share

Relationship among levels of peripheral blood miRNA-21 and TGF-β1,CCL5 in patients with acute myocardial infarction and its significance

Bo-Yi SHAO

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):629-632. doi:10.3969/j.issn.1008-0074.2018.06.04

Objective:To observe levels of peripheral blood miRNA-21,transforming growth factor β1 (TGF-β1) and CC type chemokine ligand 5 (CCL5) in patients with acute myocardial infarction (AMI),and explore their relation-ship and clinical significance.Methods:A total of 57 AMI patients treated in our hospital were selected as AMI group.Another 50 healthy people undergoing physical examination in our hospital simultaneously were selected as healthy control group.Peripheral blood miRNA-21 expression,levels of CCL5,TGF-β1,creatine kinase (CK),CK isoenzyme MB (CK-MB) and cardiac troponin I (cTnI),and coronary Gensini score were measured in all subjects.Relationship among above indexes was analyzed in AMI patients.Results:Compared with healthy control group,there were significant rise in miRNA-21 expression [ (0.67 ± 0.06) vs.(0.89 ± 0.09)],levels of CCL5 [ (17.53 ± 3.75) ng/ml vs.(35.37 ± 5.06) ng/ml],CK [ (85.24 ± 18.33) U/L vs.(173.29 ± 32.56) U/L],CK-MB [ (16.37 ± 2.03) U/L vs.(23.34 ± 2.51) U/L],cTnI [ (11.25 ± 3.23) ng/ml vs.(31.45 ± 8.79) ng/ml] and Gensini score [ (1.65 ± 0.26) scores vs.(43.25 ± 12.13) scores],and significant reduction in TGF-β1 level [ (31.45 ± 8.79) ng/ml vs.(11.25 ± 3.23) ng/ml] in AMI group,P＝0.001 all;in AMI group,peripheral blood miRNA-21 expression was significant positively correlated with levels of CCL5,CK,CK-MB and cTnI (r＝0.476～0.593,P＜0.05 all),and significant inversely correlated with TGF-β1 level and coronary Gensini score (r＝ -0.417,-0.625,P＜0.05 both).Conclusion:Peripheral blood miRNA-21 expression is high,and closely associated with levels of CCL5,TGF-β1 and coronary stenotic degree in AMI patients.It may be used as a potential target for clinical diagnosis and treat-ment of AMI.

5

Cite

Share

Influencing factors of incidence of MACE in AMI patients after PCI

Lai WEI

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):633-637. doi:10.3969/j.issn.1008-0074.2018.06.05

Objective:To explore influencing factors of recent period incidence of major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).Meth-ods:Clin data of 459 patients with acute ST elevation myocardial infarction (STEMI),who received PCI in our hos-pital from Jan 2013 to Mar 2017,were retrospectively analyzed.According to recent period incidence of MACE af-ter PCI or not,patients were divided into MACE group (n＝96) and non-MACE group (n＝363).Influencing fac-tors of recent pertiod MACE were analyzed in these patients.Results:Incidence rate of MACE was 20.92% (96/459) among the 459 patients.Compared with non-MACE group,there were significant rise in percentages of men,hypertension,hyperlipidemia,diabetes mellitus (DM),smoking,radial artery puncture and postoperative poor ST regression,aged,NYHA class,onset-to-reperfusion time,levels of cTnI,NT-proBNP,TG,LDL-C,Hcy and hsCRP,and number of coronary diseased vessels,and significant reductions in LVEF,HDL-C level and percentage of preoperative intensive statin therapy in MACE group (gender P＜0.05,else P＜0.01).Multifactor Logistic re-gression analysis indicated that age ≥68 years,DM,LDL-C≥2.83mmol/L,NT-proBNP≥3874pg/ml,hsCRP≥23.91mg/L and postoperative poor ST regression were independent risk factors for recent period MACE in STEMI patients after PCI (OR＝1.683～6.890,P＜0.01 all),and preoperative intensive statin therapy was its independent protective factor (OR＝0.543,P＝0.001).Conclusion:The incidence of recent period MACE in AMI patients after PCI is affected by many factors.Clinicians should intervene and treat patients according their risk factors in order to reduce incidence rate of MACE after PCI and improve prognosis.

6

Cite

Share

Effects of exercise training on rehabilitation in patients after percutaneous coronary intervention

Hong-Mei YU

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):637-641. doi:10.3969/j.issn.1008-0074.2018.06.06

Objective:To explore effects of exercise training on cardiac function,exercise function and quality of life in pa-tients after percutaneous coronary intervention (PCI).Methods:A total of 150 patients after PCI,who were hospitalized in our hospital from Jan 2014 to Dec 2015,were selected.Patients were randomly and equally divided into routine treat-ment group (received routine treatment and health guidance ) and exercise training group (received moderate intensity exer-cise training based on routine treatment group ),both groups were intervened for 12 weeks.Cardiac function indexes,6min walking distance (6MWD),score of Seattle angina questionnaire (SAQ) and incidence rate of major adverse cardiovascular events (MACE) were observed and compared between two groups before and after intervention.Results:Compared with before intervention,there were significant rise in left ventricular ejection fraction (LVEF) and 6MWD,and significant re-ductions in left ventricular end-diastolic dimension (LVEDd) and NYHA class in exercise training group after 12-week in-tervention,P＜0.01 all;there were significant rise in all dimension scores of SAQ in two groups after intervention,P＜ 0.05 or ＜0.01.Compared with routine treatment group after intervention,there were significant rise in LVEF [ (54.19 ± 7.75)% vs.(60.63 ± 9.28)%],6MWD [ (437.49 ± 21.37) m vs.(453.26 ± 31.76) m] and all dimension scores of SAQ,and significant reductions in LVEDd [ (5.24 ± 0.83) cm vs.(4.72 ± 0.78) cm] and NYHA class [ (1.78 ± 0.72) classes vs.(1.43 ± 0.67) classes] in exercise training group,P＜0.05 or ＜0.01.Incidence rate of MACE of exercise training group was significantly lower than that of routine treatment group (6.67% vs.18.67%),P＝0.027.Conclusion:Exercise training can improve cardiac function,exercise function and quality of life,reduce incidence rate of MACE in pa-tients after PCI,which is worth extending.

7

Cite

Share

Correlation among high sensitivity C reactive protein,inflammatory factor levels and cardiac function in patients with dilated cardiomyopathy

Jing LIAN ; Ai-Ju ZHANG ; Yan ZHANG

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):642-645. doi:10.3969/j.issn.1008-0074.2018.06.07

Objective:To explore correlation among high sensitivity C reactive protein (hsCRP),inflammatory factor levels and cardiac function in patients with dilated cardiomyopathy (DCM).Methods:A total of 102 DCM patients were continu-ously collected in our hospital from Mar 2014 to Mar 2016.According to their hsCRP level at hospitalization,patients were divided into low hsCRP group (n＝51,≤3mg/L) and high hsCRP group (n＝51,＞3mg/L).Levels of hsCRP,brain na-triuretic peptide (BNP),interleukin (IL)-6,IL-1 and tumor necrosis factor (TNF)-α,left ventricular end-diastolic di-mension (LVEDd) and left ventricular ejection fraction (LVEF) were measured and compared between two groups.Corre-lation between inflammatory factors and cardiac function indexes were analyzed.Results:Compared with low hsCRP group [ (2.18 ± 0.12) mg/L],there were significant rise in LVEDd [ (58.47 ± 6.16) mm vs.(66.58 ± 9.45) mm],levels of BNP [(232.04 ± 56.07) pg/ml vs.(466.34 ± 105.12) pg/ml],IL-6 [(6.48 ± 2.48) ng/L vs.(9.38 ± 2.41) ng/L],IL-1 [(63.58 ± 6.58) ng/L vs.(67.84 ± 5.75) ng/L] and TNF-α [(74.58 ± 8.39) ng/L vs.(79.58 ± 10.71) ng/L],and significant reduction in LVEF [ (38.67 ± 6.08)% vs.(33.23 ± 5.15)%] in high hsCRP group [ (3.87 ± 1.53) mg/L],P＜0.05 or ＜0.01.Linear correlation analysis indicated that in high hsCRP patients,hsCRP level was significant positive-ly correlated with levels of IL-6,IL-1 and TNF-α ( r＝0.328～0.341,P＜0.05 all);levels of hsCRP,IL-6,IL-1 and TNF-α were significant positively correlated with BNP level,LVEDd and NYHA class (r＝0.241～0.432,P＜0.05 or ＜0.01),and significant inversely correlated with LVEF (r＝ -0.346～ -0.327,P＜0.05 all).Conclusion:High sensitivity C reactive protein level is significantly correlated with cardiac function in DCM patients.Therefore,it can be used as an important index monitoring cardiac function changes in these patients.

8

Cite

Share

Relationship between CCL2 CCR2 and platelet aggregation rate in patients with acute myocardial in-farction

Nan QU ; Chun-He ZHENG

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):646-649. doi:10.3969/j.issn.1008-0074.2018.06.08

Objective:To explore relationship among expressions of CC type chemokine ligand 2 (CCL2) and its re-ceptor (CCR2) and platelet aggregation rate in patients with acute myocardial infarction (AMI).Methods:A total of 60 AMI patients treated in our coronary care unit were regarded as AMI group,another 60 healthy subjects un-dergoing physical examination were enrolled as normal control group.Plasma CCL2 level,expressions and location of platelet CCL2 and CCR2 in coronary thrombus tissue were measured in two groups.Changes of activated glyco-protein Ⅱb/Ⅲa compound (PAC-1) and CD62p levels,and influence of different CCL2 level on platelet aggregation rate (PAR) were compared in normal control group before and after CCL2 stimulus.Results:Compared with nor-mal control group,there were significant rise in plasma CCL2 level [ (159.63 ± 54.32) pg/ml vs.(218.79 ± 76.34) pg/ml],expressions of platelet CCL2 [ (0.86 ± 0.38) vs.(2.05 ± 0.59)] and CCR2 protein [ (0.93 ± 0.42) vs.(2.67 ± 0.51)] in AMI group (P＝0.001 all),co-location expression relationship existed between CCL 2/CCR2 and CD62p in AMI patients.Compared with before CCL2 stimulus,there were significant rise in expressions of PAC-1 [ (9.83 ± 3.14)% vs.(18.96 ± 4.25)%] and CD62p [ (5.08 ± 1.16)% vs.(8.33 ± 1.89)%] in normal control group after CCL2 stimulus,P＝0.001 both.When CCL2 ≥100ng/ml,maximum PAR was significantly higher than that of CCL2＝0ng/ml level,P＝0.001 all.Conclusion:Expression of CCL2/CCR2 is closely associated with plate-let aggregation rate in AMI patients.CCL2/CCR2 may be involved in disease progress via affecting platelet aggrega-tion rate.

9

Cite

Share

Correlation among levels of high sensitive C reactive protein,natriuretic peptide,endothelin-1 and nonvalvular atrial fibrillation

Peng ZHANG ; Rui-Ni ZHANG ; Fei LI ; Feng GAO ; Dong-Yan WANG

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):650-653. doi:10.3969/j.issn.1008-0074.2018.06.09

Objective:To explore correlation among levels of high sensitive C reactive protein (hsCRP),brain natri-uretic peptide (BNP),endothelin 1 (ET-1) and nonvalvular atrial fibrillation (NVAF).Methods:A total of 124 NVAF patients hospitalized in our department of cardiology were selected.According their heart rhythm character-istics,they were divided into paroxysmal NVAF group (n＝56) and chronic NVAF group (n＝68).Another 48 pa-tients with sinus rhythm,corresponding gender,age,disease condition to NVAF group were simultaneously enrolled as sinus rhythm group.Levels of hsCRP,BNP and ET-1 were measured and compared among all groups.Results:Compared with sinus rhythm group,there were significant rise in levels of hsCRP [ (1.52 ± 0.86) mg/L vs.(2.32 ± 1.38) mg/L vs.(3.35 ± 3.02) mg/L],BNP [ (225.31 ± 70.23) pg/ml vs.(352.42 ± 167.02) pg/ml vs.(403.12 ± 132.05) pg/ml] and ET-1 [ (1.42 ± 0.65) ng/ml vs.(1.96 ± 0.76) ng/ml vs.(2.34 ± 1.15) ng/ml] in paroxys-mal NVAF group and chronic NVAF group,and those of chronic NVAF group were significantly higher than those of paroxysmal NVAF group,P＜0.05 or ＜0.01.Pearson correlation analysis indicated that serum BNP level was significant positively correlated with ET-1 level in NVAF patients (r＝0.325,P＝0.001).Logistic regression analy-sis indicated that levels of BNP,hsCRP and left atrial diameter were independent risk factors for NVAF (OR＝1.42,1.21,1.33,P＜0.05 or ＜0.01).Conclusion:Levels of high sensitive C reactive protein,brain natriuretic peptide and endothelin-1 are closely correlated to nonvalvular atrial fibrillation.

10

Cite

Share

Analysis of hospitalization costs among CHD patients undergoing PCI in a hospital of Anhui province during 2012-2016

Fang-Fang ZHU ; Ping YU ; Guang YAN

Chinese Journal of cardiovascular Rehabilitation Medicine.2018;27(6):654-658. doi:10.3969/j.issn.1008-0074.2018.06.10

Objective:To analyze hospitalization cost of patients with coronary heart disease (CHD) undergoing per-cutaneous coronary intervention (PCI) in recent years and its influencing factors.Methods:Hospitalization cost data of CHD patients undergoing PCI in a hospital of Anhui province from 2012 to 2016 were collected.Changes of hos-pitalization costs and its influencing factors were statistically analyzed.Results:Number of hospitalized CHD pa-tients undergoing PCI gradually rose year by year.From 2012 to 2016,there was significant rise in mean examina-tion fee per time (except 2012 vs.2013),significant reductions in mean medicine fee per time,mean bed fee and other fees (except 2013 vs.2014 ) and mean hospitalization duration per time (except 2012 vs.2013,2014 vs.2015),P＜0.05 or ＜ 0.01.Patients with full public insurance possessed the highest mean hospitalization fee per time.Mean medicine fee per time of male group was significantly higher than that of female group [5368.66 (3831.01,7974.22) RMB vs.5045.16 (3721.97,7308.26) RMB],P＝0.019.Mean treatment fee per time of 50～70 years group was significantly higher than that of ≤50 years group [ (36351.63 (27925.86,47714.41) RMB vs.34622.20 (27296.66,46504.87) RMB],P＝0.024;compared with ≤50 years group and 50～70 years group,there were significant rise in all fees in ＞70 years group,P＜0.05 or ＜0.01.Compared with hospitalization ≤7d group,there were significant rise in all fees in 7～14d group and ＞14d group,and those of ＞14d group were signif-icantly higher than those of 7～14d group,P＝0.001 all.Multifactor linear regression analysis indicated that hospi-talization duration was independent risk factor for hospitalization fee of CHD patients undergoing PCI (β＝0.461,P＝0.001),while insurance way was its independent protective factor (β＝ -0.078,P＝0.001).Conclusion:Eco- nomic burden of CHD inpatients undergoing PCI is still heavy,we must improve theraputic effect,reduce hospital stays,in order to reduce patients′economic burden.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share