Objective: To research the effects of cardiovascular endocrine hormone and insulin-resistance in aged patients with hypertension. Methods: The t-PA of serum (plasma), activity of PAI、 ANP、 ET、 A Ⅰ 、 A Ⅱ and IR were determined in 40 patients with Ⅰ and Ⅱ stage of hypertension and in 30 healthy subjects (control group). Results: The PAI、 ANP 、 ET、 A Ⅱ and total cholesterol and triglyceride levels were apparently higher in patients with hypertension than in healthy control group. The t-PA and IS were obviously lower in hypertensive patients than in healthy control group. Conclusion:The cardiovascular endocrine hormone and insulin-resistance play an important role in genesis and development of hypertension in aged.