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Study of correlation of serum adiponectin with type 2 diabetes and its macrovascular complications

Chinese Journal of Diabetes.2010;18(3):207-208. doi:10.3969/j.issn.1006-6187.2010.03.014

Objective To explore the correlation of adipnectin with T2DM and its macrovascular complications. Methods The levels of serum adiponectin, plasma glucose, serum lipids, and fasting insulin were measured in normal subjects, type 2 diabetic patients and type 2 diabetic patients with macrovascular complications. Results (1) The serum adiponectin level was significantly lower in type 2 diabetic patients than in normal subjects, and was the lowest in type 2 diabetic patients with macrovascular complications. (2) Serum adiponetin level was negatively correlated with BMI,HOMA-IR, HbA_1c,TG and fasting insulin level. Conclusions The results suggest that lower serum adiponectin level may be related to macrovascular complications in type 2 diabetic patients.

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The clinical meaning of 1h-plasma glucose cutoff value during OGTT in the screening of diabetes and IGR

Le LIU ; Ping FENG

Chinese Journal of Diabetes.2010;18(3):204-206. doi:10.3969/j.issn.1006-6187.2010.03.013

Objective To determine 1 hour plasma glucose cutoff value during OGTT to screen diabetes and IGR and its relationship with islet β cell function and insulin sensitivity. Methods 4731 subjects were recruited to perform an OGTT.The cutoff value of 1h-plasma glucose during OGTT was analyzed by receiver operating characteristic curve (ROC curve).And according to the two cutoff values,we classified all the subjects to three groups,and compared HOMA-IR,HOMA-β,insulinogenic index and shape index among groups,then analyzed its correlation with each parameter. Results According to ROC results, to diagnose type 2 diabetes mellitus,the optimal cutoff value of 1h plasma glucose during OGTT was 12.935mmol/L,with sensitivity of 81.52%,specificity of 86.94%. To diagnose impaired glucose regulation(IGR),the optimal cutoff value of 1h plasma glucose was 9.815mmol/L,with sensitivity of 74.96% and specificity of 77.86%. We classified all the subjects to three groups, and among the three groups the insulinogenic index, shape index, HOMA-IR, HOMA-β showed statistically significant difference (all P＜0.01). There was a negative correlation of OGTT-1hPG with insulinogenic index and HOMA-β(all P＜0.01) and a positive correlation of OGTT-1h PG with shape index and HOMA-IR (all P＜0.01). Conclusions To diagnose type 2 diabetes mellitus,the optimal cutoff value of 1h plasma glucose during OGTT is 12.935mmol/L.To diagnose impaired glucose regulation(IGR),the optimal cutoff value of 1h plasma glucose is 9.815mmol/L.And 1h PG can reflect the islet β-cell function and insulin resistance.

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The effect of rosiglitazone combined with insulin on plasma aldosterone in diabetes patients

Wei WANG ; Xiaohui GUO ; Peihong JIA

Chinese Journal of Diabetes.2010;18(3):201-203. doi:10.3969/j.issn.1006-6187.2010.03.012

Objective To investigate if edema caused by rosiglitazone is associated with the change of aldosterone level. Methods Plasma aldosterone levels in different periods from patients treated with rosiglitazone combined with insulin were measured.Type 2 diabetes patients who have been treated with insulin alone were divided into two groups: patients treated with rosiglitazone(4mg/d) combined with insulin(RSG+insulin group), or treated with insulin alone (insulin group)(n=10). Aldosterone levels, incidence of edema and weight gain were monitored every two months during six months. Results The incidence of edema and weight gain were higher in RSG+insulin group than in insulin group. After two months, aldosterone levels were higher in RSG+insulin group than in insulin group[(77.8±25.9)vs(60.2±27.6)pg/ml,P＞0.05],but it had no statistical difference; after four months, aldosterone levels were higher in RSG+insulin group than in insulin group[(87.2±27.1)vs (61.5±25.6) pg/ml,P＜0.05]. After six months, aldosterone level recovered gradually,it had no statistical difference compared with that of control[(77.0±21.0)vs(69.6±21.7) pg/ml,P＞0.05]. Conclusions The cause of early edema in type 2 diabetic patients treated with rosiglitazone combined with insulin was probably assosiated with elevated aldosterone level.

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The diagnostic efficiency of 1,5-anhydroglucitol for diabetes mellitus

Jiajian CHEN ; Yuhui YE ; Zhuolian WEN

Chinese Journal of Diabetes.2010;18(3):198-200. doi:10.3969/j.issn.1006-6187.2010.03.011

Objective To explore the value of serum 1,5-AG in the diagnosis of diabetes mellitus by applying the method of pyranose oxidase (PROD). Methods 1,5-AG,FPG、2hPG and HbA_1c were determined in 50 case of DM,100 case of IGT and 30 control subject. ROC curve was applied to evaluate the diagnostic efficiency of 1,5-AG,FPG and HbA_1c for DM. Results Serum 1,5-AG was obviously lower in the diabetes than in IGT and controls(P＜0.01). Compared with controls, IGT patients had lower serum 1,5-AG(P＜0.05).1,5-AG level had significantly negative correlation with FPG,2hPG and HbA_1c respectively. The area under the ROC curve of 1,5-AG,FPG and HbA_1c are 0.948、0.921、0.817,respectively. Conclusions 1,5-AG level shows significantly correlation with glucose tolerance. Serum 1,5-AG measurement could be used as useful indicator in the screening of diabetes mellitus as well as in the monitoring of glycemic control.

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Effect of Ginkgo biloba extracts on hippocampal apoptosis in diabetic encephalopathy rat

Xinlei FAN

Chinese Journal of Diabetes.2010;18(2):143-146. doi:10.3969/j.issn.1006-6187.2010.02.020

Objective To study the relation between diabetic rat encephalopathy and hippocampal apoptosis, and the therapeutic effect and mechanism of Ginkgo biloba extract. Methods Sixty rats were assigned into control group(NC), diabetic encephalopathy group (DM+B) and EGb-treatment group (EGb) randomly, and every group was further divided into two time points of 1 month (NC_1 ,DM+B_1, EGb_1 ) and 3 month(NC_3 ,DM+B_3, EGb_3 ). The behavioral abnormalities were investigated by water maze test and the apoptosis levels of brain tissue by ELISA. Immunohistochemistry and RT-PCR were performed to determine the protein and mRNA expressions of Bcl-2 and Bax. Results (1) Mild dysfunction of learning and memory was detected in DM+B_1 group, and the dysfunction became worse in DM+B_3 group. The matters were greatly improved in EGb-treatment groups. (2) The expressions of Bcl-2 protein and mRNA were increased in DM+B_1 and DM+B_3 groups, and were stronger in EGb_1 and EGb_3 groups. (3) The expressions of Bax protein and mRNA were obviously increased in DM+B_1 and DM+B_3 groups, and were dramatically reduced in EGb_1 and EGb_3 groups. (4) Compared with control group, the apoptosis level of brain tissue was increased in DM+B_1 group, and obviously greater in DM+B_3 group. In the EGb-treatment groups the levels were dramatically reduced. Conclusions Diabetic encephalopathy may be closely related to hippocampal apoptosis. EGb has an protective effect and the mechanism may be attributed to its effects inhibiting apoptosis.

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DGMS-revealed glycemic excursions and hypoglycemic incidence in type 2 diabetes mellitus in the elderly during insulin glargine versus mixed insulin treatment

Ping WANG ; Kaisi ZHU

Chinese Journal of Diabetes.2010;18(2):127-128. doi:10.3969/j.issn.1006-6187.2010.02.015

To compare the degree of glycemic excursions by dynamic glucose monitoring in type 2 diabetes in the elderly when their HbA_1c≤6. 5, The mean blood glucose level and hypoglycemia incidence were observed. The amplitude of glycemic excursions revealed by DGMS was significantly lower in insulin glargine group than in mixed insulin group (P<0.05). The incidence of hypoglycemia were lower in glargine group than in mixed insulin group(P<0.05).

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Analysis of apelin level and related factors in patients with obesity and different glucose tolerances

Xiaohong OU ; Jinkui YANG

Chinese Journal of Diabetes.2010;18(2):109-111. doi:10.3969/j.issn.1006-6187.2010.02.009

Objective To evaluate apelin level in patients with obesity and different glucose tolerances, investigate relevance of apelin with body mass index(BMI), blood lipid and blood glucose. Methods According to different glucose results of oral glucose tolerance test, 120 subjects were divided into three groups: normal glucose tolerance(NGT),impaired glucose tolerance(IGT) and type 2 diabetes(T2DM). All of the subjects were also divided into obese and non-obese subgroups based on their BMI(≥25kg/m~2 or ＜25kg/m~2 ). Plasma apelin levels were compared among groups of NGT, IGT and T2DM. Fasting plasma glucose(FPG)and 2h postprandial plasma glucose (2hPG) after OGTT, lipid profile and BMI were measured. Results Both fasting and 2h postprandial plasma apelin had significant differences in these groups (P<0.05,or P<0.01). The overweight and obese subgroups in the IGT group and diabetes group had higher apelin levels than their counterpart subgroups in the NGT group. BMI, FPO, systolic blood pressure(SBP) were independent influencing factors for apelin (P<0.05 ,or P<0.01). Conclusions Plasma apelin level is related to obesity and type 2 diabetes.

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Association between ApoB/ApoA1 ratio and metabolic syndrome

Rong LUO ; Yuanjuan JIANG ; Dan CHENG ; Zhoujun LIU ; Li ZHONG ; Bangqiong WANG ; Qinghong CHENG ; Yonghong WANG ; Qifu LI

Chinese Journal of Diabetes.2010;18(2):95-97. doi:10.3969/j.issn.1006-6187.2010.02.005

Objective To assess if the ratio of ApoB/ApoA1 is related to the metabolic syndrome and its components. Methods 709 adults living in Chongqing were enrolled. Weight, height, blood pressure, waist circumferences, fasting plasma glucose(FPG) , fasting serum insulin(FIns) and lipids were measured. ApoB/ApoA1 ratio, BMI and insulin resistance index were calculated. Results ApoB/ ApoA1 ratio was increased in subjects with insulin resistance(IR)and MS. Compared with the low ApoB/ ApoA1 ratio group, the high ApoB/ApoA1 ratio group was more likely to get MS(OR=3.5)and IR(OR =2.3) (P<0.001). Conclusions ApoB/ApoA1 ratio is strongly associated with IR, MS and its components, and a high ApoB/ApoA1 ratio is a valuable marker of MS.

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Effects of 3-deoxyglucosone on blood glucose of normal mice

Qian WANG ; Guorong JIANG ; Lurong ZHANG

Chinese Journal of Diabetes.2010;18(3):220-222. doi:10.3969/j.issn.1006-6187.2010.03.019

Objective To study the effect of exogenous 3-deoxyglucosone (3-DG) on blood glucose of normal mice. Methods Kunming male mice were divided into two groups: 3-DG (5mg/kg) treatment and control group.At day 1,week 1 and week 2 after treatment, we compared fasting blood glucose,and did the glucose tolerance test in 3-DG group after 2 weeks' 3-DG administration. Results Blood glucose was increased obviously 2h after administration with 3-DG once versus pre-administration and control (7.78±0.694 vs 6.41±0.408,and 6.43±0.43,all higher than control,but no statistical significance (P＞0.05). There were no differences in 6 hour fasting blood glucose after once administration with 3-DG and in 12 hours fasting blood glucose two weeks after administration with 3-DG between 3-DG and Con groups. After 3-DG administration for two weeks,as compared with Con, the 30 minute blood glucose of 3-DG administration mice during OGTT was obviously increased (19.47±1.541 vs 17.22±1.911,P＜0.05), but glucose levels at 60 minute and 120 minute had no changes (P＞0.05). Conclusions Exogenous 3-DG increases the normal mice's blood glucose immediately after once administration with 3-DG and results in up-moving of glucose physiological curve and leads to a light impairment of glucose tolerance when mice were continuously fed with 3-DG for 2 weeks.

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N-acetylcysteine attenuates myocardial hypertrophy in streptozotocin-induced diabetic rats

Yuhong HE ; Zhongyuan XIA ; Fang WANG

Chinese Journal of Diabetes.2010;18(3):211-213. doi:10.3969/j.issn.1006-6187.2010.03.016

Objective To investigate the protective effect of N-acetylcysteine(NAC) on the development of myocardial hypertrophy in diabetic rats induced by streptozotocin. Methods Male SD rats were randomly divided into normal control (NC), control treatment (NCT), diabetic (DM) and diabetes treatment (DMT) groups. NAC was administered at dose of 1.4～1.5g·kg~(-1)·d~(-1) to NCT and DMT groups in the drinking water for 8 weeks. At termination the rats were surgically prepared for hemodynamic measurement, such as systolic blood pressure, heart rate, the rate of left ventricle relaxation (-dp/dt) and the time to maximum relaxation (T). Subsequently, the hearts were removed to assay relative ratio of left ventricle weight versus body weight (LVW/BW) and cardiomyocyte cross sectional areas.Plasma glucose, insulin, 15-F_(2t)-isoprostane(15-F_(2t)-Isop) concentration and superoxide dismutase (SOD) activity were analyzed. Results The LVW/BW ratio and cardiomyocyte areas were significantly attenuated by NAC treatment as compared to DM group (P＜ 0.05). Increases in -dp/dt and SOD activity and the decreases in glucose, 15-F_(2t)-Isop T (P＜ 0.05) were found at the same time. Conclusions NAC can effectively prevent the development of myocardial hypertrophy and improve diastolic function in diabetic rats, which may be related to its antioxidant capacity.

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