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Research Progress of Baishouwu in the Last Decade

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):131-136. doi:10.3969/j.issn.1005-5304.2015.07.041

Baishouwu is a traditional tonic Chinese medicinal herb which is rich in Shandong, Liaoning and Jiangsu Privences. Baishouwu mainly contains steroids, polysaccharose, acetophenone, and essential oil, with the efficacy of nourishing liver and kidney, tonifying essence and blood, blackening the beard and hair, and prolonging life. This article retrieved relevant literature in the last decade about biological study, chemical constituents, and pharmacological activities of Baishouwu, with a purpose to provide a scientific basis for its rational researches and development.

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Research Progress in the Anti-tumor Mechanism of Action of Tanshinone IIA

Jie YANG ; Jie LI ; Shulong JIANG

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):128-130. doi:10.3969/j.issn.1005-5304.2015.07.040

Tanshinone ⅡA has a broad anti-tumor activity and good prospects for clinical application. Its possible mechanism of action involves the regulation of cell cycle, inhibition of cell proliferation, induction of apoptosis, inhibition of tumor invasion, metastasis and inhibition of angiogenesis, and reversal of multidrug resistance. This article reviewed the research progress of anti-tumor effect of tanshinone ⅡA in recent years.

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Research Progress of TCM Medicinal Herbs and Their Active Ingredients in Anti-bacterial Biofilms of Caries

Yumei LIU ; Jingshu XU

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):125-127. doi:10.3969/j.issn.1005-5304.2015.07.039

Caries is one of the most common chronic progressive oral diseases. TCM medicinal herbs have many advantages compared with traditional dental drugs for caries (such as fluoride). In recent years, cariogenic TCM medicinal herbs have attracted the attention of many domestic and foreign scholars. Caries is not caused by a single factor. The development of caries is closely related to bacterial biofilms that are formed by streptococcus mutans, streptococcus sanguis, actinomyces inside, actinomyces and lactobacillus. Therefore, this article took a brief overview of TCM medicinal herbs and their active ingredients that inhibit the bacterial biofilms.

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Analysis of the Utilization of TCM Decoction Pieces for Clearing Damp and Promoting Diuresis in Affiliated Hospital of Nanjing University of TCM During 2009-2013

Yufeng ZHU ; Ying HU ; Qian ZHANG ; Yemei JIN

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):122-124. doi:10.3969/j.issn.1005-5304.2015.07.038

Objective To know the utilization and development trend of TCM decoction pieces for clearing damp and promoting diuresis in our hospital;To provide references for rational medicine use and purchase in clinic. Methods Excel software was used to analyze the utilization of TCM decoction pieces for clearing damp and promoting diuresis in our hospital during 2009-2013 from the aspects of consumption quantity, consumption sum, and annual average growth. Results The consumption quantity of TCM decoction pieces for clearing damp and promoting diuresis in our hospital increased year by year with average growth rate of 10.58%;the consumption sum increased year by year with average growth rate of 20.21%. The consumption quantity of TCM decoction pieces for inducing diuresis to alleviate edema took the lead among all kinds of medicine, followed by medicine for inducing dampness for treating jaundice, and medicine for inducing diuresis for treating stranguria. Conclusion Both the consumption quantity and the consumption sum of TCM decoction pieces for clearing damp and promoting diuresis in our hospital have been increasing year by year. The proportion of which in total quantity and the consumption sum of TCM decoction pieces and the medicine utilization structure have kept stable, and its usages is rational on the whole.

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Clinical Application Analysis on Panlongqi Pieces in Liangxiang Hospital of Fangshan District from January to March in 2014

Xiaohong ZHANG

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):120-121. doi:10.3969/j.issn.1005-5304.2015.07.037

Objective To analyze the prescriptions containing Panlongqi Pieces for clinical application;To guide reasonable usage of medicine in clinic. Methods Adopted retrospective investigation method by selecting 1178 prescriptions of Chinese patent medicine containing Panlongqi Pieces from January to March in 2014. The unreasonable elements in these prescriptions were analyzed. Results Among the 1178 prescriptions, there were 585 unreasonable prescriptions, occupying 49.66%. Problems in the application of Panlongqi Pieces in clinic lie in differentiation of syndromes, combination of medication, incompatibility of medicine in prescription, and usage and dosage. Conclusion Doctors should attach importance to differentiation and reasonable usage in clinical application, which can achieve expected therapeutic effect.

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Antiproliferative Effect of Ligustilide on Human Lung Adenocarcinoma A549 Cells

Lihong WANG ; Xingbin WU ; Li WANG

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):55-59. doi:10.3969/j.issn.1005-5304.2015.07.016

Objective To investigate the effects of ligustilide on the proliferation of human lung adenocarcinoma A549 cells and its mechanism. Methods CCK-8 method was used to detect the effects of ligustilide on activity of A549 cells. Apoptosis rate was measured by TUNEL. Nuclear morphological changes of A549 cells were observed by fluorescence microscope after staining by Hoechst 33258. ELISA was used to detect the VEGF levels after incubation with ligustilide. Western blot was used to detect the expression of NF-κB, Bcl-2, Bax and the protein expression of phosphorylation of JNK. Results A549 cell activity was significantly inhibited after incubated with 15, 30, 60, 120, 180μmol/L ligustilide for 12, 24, 48 h (P<0.05, P<0.01, P<0.001) in a dose and time-dependent manner (P<0.05, P<0.01);Apoptosis rate increased by 30, 60, 120 μmol/L ligustilide for 12, 24, 48 h in a dose and time-dependent manner;A549 cells treated with ligustilide for 48 h appeared the apoptosis forms, including nuclear shrinkage, beating, strong blue fluorescence staining, and the chromatin divided producing apoptotic body;30, 60, 120μmol/L ligustilide increased the expression of p65 subunit of NF-κB protein in the nuclei and the phosphorylation levels of JNK protein, reduce the expression of suppression apoptosis protein Bcl-2, and raised the expression of pro-apoptotic protein Bax (P<0.05, P<0.01, P<0.001). Conclusion By inhibiting the expression of VEGF, ligustilide can inhibit the formation of tumor angiogenesis. By regulating the expression of NF-κB and the phosphorylation levels of JNK protein and reducing the ratio of Bcl-2/Bax, ligustilide can promote tumor cell apoptosis.

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Effects of Celastrol on HepG2 Cells Migration

Na DU ; Jianhua FU ; Jian LI ; Fusheng LIU ; Yin ZHANG ; Ting LIU ; Zeqi SU ; Xia DING

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):51-54. doi:10.3969/j.issn.1005-5304.2015.07.015

Objectives To explore a better inhibitory effect of concentration and time of Celastrol on migration of HepG2 cells. Methods HepG2 cells were planted and cultured in 6-well plates. When the adherent cell density reached 70%-80%, cell migration was manufactured by scratch experiment model. Then, cell morphology and cell migration were observed under microscope with different concentrations of Celastrol 5, 1, 0.5, 0.1, 0.01μmol/L and DMSO at 0, 6, 12, 24 h. They were pictured and rates of cell migration and inhibition ratios of all groups were calculated. Results Celastrol inhibited HepG2 cell migration, and its inhibitory effect on the migration velocity was concentration-dependent in a certain range. The higher the concentration of Celastrol, the stronger effect is. Celastrol of the same concentration at different times had different inhibitory effect on cell migrationof HepG2 cells (P<0.05). Celastrol of different concentrations at the same time had different inhibitory effects on cell migration of HepG2 cells (P<0.05);Celastrol of high concentration cause dsevere changes in the cell morphology. Conclusion Celastrol of high concentration causes changes in the cell morphology and cell apoptosis of HepG2 cells. Celastrol inhibits HepG2 cell migration, which is dependent on the concentration and action time. The inhibitory effect of Celastrol on HepG2 cell migration is most obvious under final concentration of 5μmol/L at 6 h.

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Effects of Jianpi Yangxue Qufeng Formula on Aquaporin-3 in Model Mice Skin Tissue with Chronic Eczema

Jing TIAN ; Xinhong LI ; Huiwen ZHU ; Xiande MA ; Changqing FENG ; Min WANG

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):47-50. doi:10.3969/j.issn.1005-5304.2015.07.014

Objective To observe the effects of Jianpi Yangxue Qufeng Formula (JPYXQF) on the AQP3 in mice with chronic eczema, and explore mechanism of action. Methods Fifty healthy male mice were randomly divided into 5 groups, namely normal group, model group, positive medicine group and JPYXQF high and low dose groups. Low-dose DNCB and Sennae Fominm were used to establish mice models of chronic eczema with spleen deficiency. JPYXQF groups were treated by JPYXQF for gavage, while the positive medicine group was treated by levocetirizine hydrochloride for gavage. The expression of AQP3 in mice skin tissue was detected by immunohistochemical method. At the same time, the pathological changes of skin were observed. Results The pathology of mice skin lesion showed that JPYXQF has certain recovery effects on the inflammation injury of skin lesion. Compared with the normal group, expression of AQP3 over expressed in model group. Compared with the model group, the expression of AQP3 in all treatment groups significantly decreased, and the staining intensity decreased. In the model group, the average optical density of AQP3 was significantly higher than that in the normal group (P<0.01). Compared with the model group, the treatment groups can reduce the expression of AQP3 in mice skin tissues (P<0.05). Conclusion JPYXQF can reduce the over expression of AQP3 in skin lesion, which is probably its mechanism for the treatment of chronic eczema.

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Term Selecting Research on Traditional Chinese Medicine and Related Disciplines for the Revision of Chinese Traditional Medicine and Materia Medica Subject Headings

Yana DONG ; Jing LIU ; Ling ZHU ; Lihong LIU ; Haiyan LI

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):40-42. doi:10.3969/j.issn.1005-5304.2015.07.012

Objective To confirm subject headings which are prepared to be added, deleted and modified in the class of traditional Chinese medicine and related disciplines (TG class) for the new edition of Chinese Traditional Medicine and Materia Medica Subject Headings (CTMMeSH). Methods Compiling principle, word frequency statistics and database retrieval results were considered. Other references, such as MeSH, were also used to help choose subject headings of TG class. Results In TG class, 35 subject headings were planned to be added, such as “medicine, traditional Korean”and“TCM constitution”;35 subject headings were planned to be deleted, such as“medicine, eastern tradition”and“meridians”;19 subject headings were planned to be modified, such as “four-constitution medicine” and “Minority Medicine”. The subject headings of “Minority Medicine”were unified to harmonize the problems of“TCM pharmacy”with other classes of subject terms. Conclusion Subject headings of TG class are chosen based on word frequency statistics. The word form are unified refer to regulation, teaching materials and documents, and should coordinate with subject headings of other classes.

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Effects of Modified Jianpi Yishen Decoction on Urinary Osteopontin of Calcium Oxalate Nephrolithiasis Patients After Operation

Yan WANG ; Feng LIN ; Xueyun WENG ; Xumin XU ; Shaolong YU ; Zhifeng CHEN ; Zhipeng WEN

Chinese Journal of Information on Traditional Chinese Medicine.2015;(7):36-39. doi:10.3969/j.issn.1005-5304.2015.07.011

Objective To observe the effects of modified Jianpi Yishen Decoction on urinary osteopontin (OPN) in calcium oxalate nephrolithiasis patients after percutaneous nephrolithotomy (PCNL) or ureteroscope lithotomy (URL);To clarify the mechanism of modified Jianpi Yishen Decoction on the prevention of calcium oxalate kidney stones. Methods Totally 116 calcium oxalate nephrolithiasis patients were randomly divided into trial group (62 cases) and control group (54 cases). The trial group took modified Jianpi Yishen Decoction every other day, while the control group took potassium sodium hydrogen citrate granules three times a day. The concentrations of OPN, urinary calcium and urinary oxalic acid of the patients in the two groups were observed before treatment and 2 weeks and 4 weeks of treatment. Results The concentration of urinary OPN of 2 weeks and 4 weeks of the treatment in the trial group was significantly increased compared with before treatment (P<0.05), and the difference was statistically significant compared with the control group (P<0.05). The concentration of urinary OPN in the control group had no significant change after treatment (P>0.05). The differences in the concentrations of urinary calcium and urinary oxalic acid of the two groups between before and after treatment were not significant (P>0.05). Conclusion Modified Jianpi Yishen Decoction can effectively restrain the formation of the calcium oxalate stones by increasing the level of urinary OPN, which demonstrates effective prevention in the calcium oxalate nephrolithiasis patients after PCNL or URL.

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