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Knowledge Discovery on Compatibility Laws of TCM Prescription for Stroke Disease Based on Biclustering Method

Chinese Journal of Information on Traditional Chinese Medicine.2013;(11):16-18,19. doi:10.3969/j.issn.1005-5304.2013.11.007

Objective To explore the key elements in prescription and summarize the law of prescription-herb treatment, to find core herbs/herb group which play a key role in pharmacological effects, then provide new methods and modern techniques for theory of prescription development and TCM clinical research. Methods The text data sources of stroke disease were retrieved from databases of traditonal Chinese prescription. After pre-processing and information extraction, a prescription-herb matrix was constructed, and then biclustering method was used to simultaneous clustering two dimensions of data. Results Totally 648 effective records were gained after preprocessing, and 6913 herbs were extracted, then a 100×648 prescription-herb matrix was generated. Finally 4-way clustering results were output, along with 8 high descriptive prescriptions, then characteristics of prescription laws of diagnosis and treatment according different syndrome and various types of herbs commonly used were summarized. Conclusion This method can be well applied for prescription-herb knowledge discovery in TCM prescription databases. The prescription-herb information can be effectively extracted, and laws of prescription-herb and syndrome-treament can be mined.

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Discovery of Anti-cancer Function of Old Drugs Based on Chinese Herbal Nature Combination

Shan CHEN ; Yun WANG

Chinese Journal of Information on Traditional Chinese Medicine.2013;(8):23-25,26. doi:10.3969/j.issn.1005-5304.2013.08.009

Objective To explore the anti-cancer function of old drugs from the perspective of the concept of Chinese herbal nature combination, and provide method and a new thinking style for the new function discovery from old drugs under the guidance of the theory of traditional Chinese medicine (TCM). Methods Using lung cancer with qi and yin deficiency as the example, the therapeutic principles of TCM anti-lung cancer treatment were analyzed and Chinese herbal nature combination patterns (CHNCP) for cancer treatment were extracted based on the relationship between function and Chinese herbal nature combination. The chemical medicines were re-screened with the cancer CHNCP and the candidates were identified. Results The therapeutic principle of TCM anti-lung cancer treatment is invigorating qi and nourishing yin. Fifteen chemical medicines were identified as the anti-cancer candidates, including 2 anti-cancer drugs being used in clinics and 4 drugs having the anti-cancer activity. Conclusion The method for finding the anti-cancer function of old drugs based on the Chinese herbal nature combination is feasiable, which provide new clues for application of old drugs.

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Studies on Film Coating Technology of Anshen Buxin Pills

Yingming ZHANG ; Qiming ZHUANG

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective Improve sugar coating and finished product stability to be fit for users. Method Adopt new technology of film coating to substitute for sugar coating. Result The finished products which adopt the film coating technology are better to resolve original questions there are some spots on finished products surface and are not fit for some people to use. Reduce dosage of anti-activities and shorten disintegration time, improve products quantity and stability. Conclusion The film coating method is simple and ideal, which is good for application.

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Study on the Preparation of Lingqiao Jiedu Pellets

Qian REN

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective To prepare Lingqiao Jiedu Pellets. Methods Lingqiao Jiedu Pellets was prepared by extrusion-spheronization method. Formulation composition and process factors influencing physical properties, such as spherical shape degree and productivity, were optimized. And it had a film coating by fluidized bed. Results Blend the extraction with MCC, and add adequate water. And squeeze with 30 r/min and roll 6 min with the rate of 48 Hz, drying and screening. Conclusion The pellets had a good appearance and stable quality.

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Optimum Selection of the Extracting Procedure of Rhizoma Corydalis

Shan HUANG ; Feng CHEN ; Liwei GUO

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective To choose the bestway of extracting procedure of Rhizoma corydalis. Methods The optimal extraction process is selected with the orthogonal design. The content of corydalis B and the yield of extracts were used to evaluate the factor levels. Results The ideal extraction process is:extracted with 75% alcohol for 2 times, first 6 times amount, soaked 0.5 h, refluxed 1.5 h, then 4 times amount, refluxed 1.5 h. Conclusions This extractive condition is the best way.

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The Distinction of LI-SU Lotion by TLC and GC

Helin ZHANG ; Guangguo DONG ; Zaili QI

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective To establish the quality distinction methods of LI-SU lotion by TLC and GC. Methods To examine the main chemical compostion by TLC and GC. Results TLC stain is distinct. GC method can discriminate the active ingredient successfully. Conclusions The method of TLC and GC is feasible to quality discrimination of LI-SU lotion.

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The Method for Determination of Chlorogenic Acid in Eucommia ulmodies Oliv by HPLC

Shengjin LIU ; Liuqing DI ; Dekang WU

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective The methods for determination of Chlorogenic Acid(CA) in Eucommia ulmodies Oliv were established and determinated the content of CA. Extract solvent, method, time and times were studied and HPLC method for determination was used. Methods The HPLC system consisted of the column of Lichrospher C18 (4.6 mm?250 mm, 5 ?m) and acetonitrtle-water-phosphoric acid (13∶86.5∶ 0.5) as the mobile phase. The temperature was 25℃. The detective wavelength was 327nm. The flow rate was 0.8 mL/min. External standard method was used. Results The powder of eucommia was extracted twice with 60%methanol-water solution at 100 ℃, the first time for 1.5 h,the second for 0.5 h was the optimum one. The method was linear within the range of 2.22?10-2～55.40?10-2 ?g, the average recovery was 99.55%, and the RSD was 1.98% (n =6). Conclusion The method is simple, sensitive and highly reproductive, and it is suitable for ananlysis of CA in Eucommia ulmodies Oliv.

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Studies on Quality of Anzhongtongbian Capsules

Mei MENG ; Fei HUANG

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective To establish the quality control standard for Anzhongtongbian capsules. Methods Radix Et Rhizoma Rhei, Radix Paeoniae Alba and Cortex magnoliae officinalis in Anzhongtongbian capsules were identified by TLC method. The content of emodin was determined by HPLC. Results The Radix Et Rhizoma Rhei, Radix Paeoniae Alba and Cortex magnoliae officinalis in Anzhongtongbian capsules could be identified by TLC. The linear range of emodin was 0.08～0.24 mg (r =0.9999). The average recovery was 98.86% and RSD=1.11% (n =5). Conclusion This text method is simple and dependable, the exclusive is strong, good in reappearance, and available for the quality control of the preparation.

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Effects of Kanglaite Injection on the Pain Behaviors and Tumor Growth in a Rat Model of Cancer-induced Bone Pain

Huangying TAN ; Fuyun GAO ; Jian CUI

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective To study and evaluate the effects of Kanglaite Injection (KLT) in rat model of cancer pain. Methods According to Medhurst' method, a rat model of cancer-induced bone pain wasestablished by intra-tibial injection of 3?103 MRMT-1 rat mammary gland carcinomal cells in Sprague-Dawley rats. KLT group were treated with 10 mL/kg of KLT, ip, twice daily from day 8 to day 17 after injection of MRMT-1 cells. In celecoxib group, 30 mg/kg, ig, twice daily for 10 days. NS group and sham group were given with 10 mL/kg of NS, ip, twice daily for 10 days. On day 17, rats in morphine group received a single administration of 3 mg/kg morphine. Pain-related behaviors including allodynia (the hind paw withdrawal response to 2 g von Frey filament stimulation) and the difference of weight bearing between hind paws were measured in all 5 groups on day 17. In addition, the left hind limbs were removed and X-rays were obtained for assessing of tumor-induced bone destruction. Results On day 17 after injection of MRMT-1 cells or NS, the paw withdrawal response frequency to 2 g von Frey filament stimulation on the left paw in KLT group, celecoxib group, morphine group and NS group were 53.3%?20.7%, 46.7%?20.7%, 13.3%?16.3% and 90% ?16.7%, respectively. The paw withdrawal response frequency in KLT group was significantly decreased compared with that in NS group (P

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The Effects of DLXNP on Hemorrheology and Bulbar Conjunctiva Microcirculation of Blood Stagnant Syndrome in Rabbits Models

Xiaoqing ZHOU ; Wanghua LIU ; Hua LI

Chinese Journal of Information on Traditional Chinese Medicine.2006;0(01):-.

Objective To investigate the effects of DLXNP on hemorrheology and bulbar conjunctiva microcirculation (BCM) in rabbit and to explore its effects of activating the blood and eliminating the stagnant. Methods The blood stagnant syndrome model was reproduced by injecting dextran 500 into the marginal ear vein. The BCM and the hemorrheology properties were detected and compared. Results Compared with the normal group, the model group's indexes of whole blood relative and whole blood reducing viscosity improved (P

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