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The effect of resveratrol combined with arabinosylcytosin in K562 cell Fas/FasL and survivin expression

Journal of Chongqing Medical University.1986;0(03):-.

Objective:This study was aimed to explore the apoptotic effect the K562 cells treated by resveratrol and/or arabinosylcytosin.Methods:Fas/FasL expressian was detected by immunohistochemical method and survivin expression was detected by RT-PCR in K562 cells,48 hours after treatment by resveratrol and arabinosylcytosin respectively.Results: Fas/FasL expression in K562 cells,treated by resveratrol and arabinosylcytosin respectively,was significantly increased compared with the control group(P0.05),contrary to FasL expression(P0.05).Conclusions:In conclusion the resveratrol and/or arabinosylcytosin could upregulate Fas/FasL expression and activate the apoptosis pathway of Fas/FasL to induce the apoptosis of K562 cells.It could downregulate the expression of survivin to promote apoptosis.The two drugs had synergistic effect.

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LITHIUM RATIO IN LITHIUM CARBONATE TREATMENT OF MANIA

Keqin WANG

Journal of Chongqing Medical University.1986;0(03):-.

This paper reports 39 cases of manic patients treated with lithium carbonate or lithium carbonate plus chlorpromazine. Levels of plasma lithium, sodium and potassium, erythrocyte lithium and lithium ratio -were determined when the blood lithium had reached the steady state and continued 4 weeks of treatment respectively. The mean duration of ditcontinuing chlorpromazine at the second time of determination in the combined drug group was 17?8.5 days.We found most lithium treated patients (83%) who got improvement or remission showed elevation of their lithium ratio. On the average, chlorpromazine can increase the erythrocyte lithium by 31 % and lithium ratio by 20%. Plasma lithium, erythrocyte lithium and lithium ratio were in positive correlation. Sex, family history, Plasma sodium and potassium level showed no correlation with their lithium ratio

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THE TRANSFERABLE AND IMMUNOLOGICAL STUDIES ON SHOCK TOXIN

Xuling GONG

Journal of Chongqing Medical University.1986;0(02):-.

For transferable and immunologieal studies on shock toxin (lethal faetor), a hind limbs ischemia tourniquet shock in rats has been examined. The blood of rats subjectd to severe shock transfused into mild shock rats has not significantly increased the mortality of the latter. Both the recruited plasma from shock rats and the plasma from the rats immunized with severe shork plasma had no therapeutic effects on tourniquet shock. It therefore appears that there is no specific and immunogenic shock toxin produced in the tourniquet shock in rats

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STUDYING MATHEMATICAL MODELS OF THE TEMPERATURE CONTROL ON FERTILITY OF THE HAEMAPHYSALIS LONGICORNIS

Zhongqin YANG

Journal of Chongqing Medical University.1986;0(02):-.

By the method of system identification, in this paper the mathematical models of the temperature control on fertility of the hasmaphysalis longicornis is established, and some predictions and estimations are given. The differences' between, the models and other models in the siminlar area are that,the models are coatinuous and differantiable other than segmented and undifferentiable

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EFFECTS OF SODIUM PUMP K~+-pNPPase ACTIVITY IN RAT BRAIN AND KIDNEY BY THE URINE FROM PATIENTS WITH HEPATITIS

Hengjing OUYANG

Journal of Chongqing Medical University.1986;0(02):-.

We find that K+-pNPPase from brain of rats is inhibited by the urine of patients with hepatitis, and of the control, desalted through a sephadex G-23 colum n.the percentage of inhibition showed as I%[I%=(1-Vi/Vo)?100%] was 59.9 ? 8.9 (n= 9) from patients with fulminant hepaticfailure (If), and was 84.1 ? 9.4 (n = 10) from chronic active hepatitic patients (Ic), The control (In) was 70.6?15,2 (n=13).It showed that the inhibition of FHF urine was less marked than that of CAH.P

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THE USE OF ATRACURIUM IN CLINICAL ANAESTHESIA

Su MIN

Journal of Chongqing Medical University.1986;0(04):-.

Auacurium has been used in 107 patients during i. v. procaine balanced anesth- esia. The results show that atracurium facilitates tracheal intubation with only slight cardiovascular affect,it produces satosfactory muscle relaxaction and quick recovery from anesthesia .Its action and recovery from anesthesia are not markedly affected by functional disorder of liver and kidney, cardio-yascular diseases, age of patient and long-standing operation.

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THE USE OF TOTAL PARENTERAL NUTRITON (TPN) IN SURGICAL PATIENTS

Yanqing WANG

Journal of Chongqing Medical University.1986;0(04):-.

A series of 61 patients are presented, among them 38 patients(twenty with cancer of esophagus, two with cancer of cardia, four with cancer of the upper part of st- omach, and radical resection were done in all of them)have been supported by TPN during perioperative and postoperative period, none of leakage at the anastomostic stoma occured; five paients with external fistulas of the alimentary tract supported by TPN healed spontaneously in four, operative closure of fistula was necessary in one, and all were cured. TPN was used in other 18 patients with miscellaneous disease, among them two of the patients with acute haemorrhagic pancreatitis were cured.One patient with major nutritional problem is presented in detail, for whom TPN had been continued for 225 days.

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SERUM SIALYLTRANSFERASE AND FUCOSYL-TRANSFERASE ACTIVITV IN PATIENTS WITH NASOPHARYNGEAL OR LARYNGEAL CARCINOMA

Xianfu WANG ; At EI

Journal of Chongqing Medical University.1986;0(04):-.

Serum sialy transferase(ST) and fucosyltransferase(FT) were determinated in 56 patients with nasopharyngeal or laryngeal carcinoma. 18 healthy were normal control. Serum sialic acid and fucose were also determinated in each sample.Comparison were made statistically among groups of stages of cancer, having metastases or no metastases, before treatment,and recurrence or non-recuurrence after cure Our results suggest that determinations of serum ST, FT, sialic acid and fucose could be used as new-indicators of diagnosis f.or advanced nasopharyngeal or laryngeal cancer and differentiation between recurrence and non-recurrence after treatment. However,the levels of ST in serum could be evaluated for metastases or non-metastases before treatment

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PRELIMINARY STUDY ON THE CULTURE CHARACTERISTICS OF CAMPYLOBACTER PYLORIDIS

Zhibang YANG

Journal of Chongqing Medical University.1986;0(04):-.

In the experiments, various media were used to isolate Campylobacter Pyloridis. Onto every medium serum, blood, vitamin, glucose, charcoal and starch were added separately. The results were compared with direct Gram's stain method and urease test. Better growth was obtained on the brain-heart blood agar; almost no. growth occured on the serum agar, normal blood agar and C. jejuni agar. The positive rate was increased after charcoal and starch were added. The positive rate was significantly increased after vitamin and glucose were added. The colonies were increased significantly. It was similar with the results of the direct Gram's stain method

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ANALGESIC ACTION OF LITHIUM SALT IN RAT CAUDATE-PUTAMEN NUCLEUS

Feng YANG

Journal of Chongqing Medical University.1986;0(03):-.

Effect of lithium salt(Li)administnation to caudate-putamen nucleus (CPN) on pain response in the rat was studied by chronic cannula implantation and direct injection of drugs into the brain structurementioned above. The results were as follows:( 1 ) The injection of Li into anterior part of the head of CPN of rats produced significantly the analgesic effect that could be antagonized by naloxone, atropine,phento-lamine.propranolol, lysergic acid diethylamide and bicuculline, but not by haloperidol.(2) The injection of Li into central part of the head of CPN of rats did not produce analgesic effect.The results above showed that microinjection of Li into different parts of the head of CPN could give rise to different effects on pain response and the analgesic effect of Li could be related to metabolic changes of endogenous opioid peptides, acetylcholine, noradrenaline, gama aminobutyric acid and 5-hydroXytryptamin aad mediated by their receptors respectively

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