Objective: To discuss the effects of nursing intervention in the rebleed rate of the cirrhosis patients after endoscopic esophageal varix ligation.Methods:60 cirrhosis patients with endoscopic esophageal varix ligation were randomly divided into intervention(n=30)and control group(n=30).Both groups received usual care and the intervention group did additional nursing intervention as psychological nursing health education relaxation training,effective coping strategy,familial and social support system.Resets:The rebleed rate was significantly lower.the time of hospital stay shorter and the hospital expense less in the intervention than in the control group(P<0.05). Conclusion:The nursing intervention in the patients with endoscopic esophageal varix ligation can obviously decrease the rebleed rate, abate reduce their economic burden and improve their quality of life.