Journal Detail Information

1

Cite

Share

Korean Journal of Dermatology.1991;29(2):155-158.

Formaldehyde is contained in various everyday products such as shampoos, detergents, leathers and papers, and is thought to be one of the important couses of clothing related contact dermatitis(ACD). The results about the minimum sensitizing concentrations of formaldehyde were different, and the concentration of 30 pg per gram of textiles was the least one. We measured the quantity of formaldehyde in 16 different types of textiles which are widely used in Korea to investigate whether the textiles contain an enough amount of formaldehyde to induce ACD and washing can reduce the amount of it. The results were as follows : 1. The quantity of formaldehyde ranged from 3 to 1246 pg per gram of textiles. 2. Three types textiles contained more than 100pg of formaldehyde per gram of textiles and 6 between 50 pg and 100pg. 3. 1.00% cotton, ramie and rayon contained the highest content of formaldehyde per gram fabric. 4. After washing, the average quantity of formaldehyde decreased to 60% of that, of pre-wash measure.
Boehmeria ; Clothing ; Detergents ; Formaldehyde* ; Korea ; Textiles*

2

Cite

Share

Effect of suction blister fluid and IFN-gamma on HLA-A,B,C and HLA-DR espression in cultures human melanocytes.

Ai Young LEE ; Yoo Shin LEE

Korean Journal of Dermatology.1991;29(2):151-154.

HLA-A, B, C and HLA-DR are very important in the regulation of immune response and of transplant success or failure, but there have been a few reports about F3I A expression in melanocyt.es, a minor population of cpidermal cells. In the treatment of stable or segmental vitiligo, allogeneic melanocytes graft could t)e potentially useful if rejection does not. occur. The aim of this study was to examine the expression of HI.A-A, B, C and HI.A-DR in cultured hurnan melanocytes with and without. stimulation by INF-r and suction blister fliid. All strains of cultured me- lanocytes expressed HLA-A, B, C regardless of stmulation, but HLA-DR was expressed only following stimulation of INI-r. HLA expression in me]anocytes appears to be similar to that in keratinocytes.
Blister* ; HLA-A Antigens ; HLA-DR Antigens* ; Humans* ; Keratinocytes ; Melanocytes* ; Suction* ; Transplants ; Vitiligo

3

Cite

Share

Effects of supernatants of cultured keratinocytes on melanocyte proliforation and melanization.

Woong Suck SUH ; Mu Hyoung LEE ; Jai Kyung PARK ; Choong Rim HAW

Korean Journal of Dermatology.1991;29(2):139-150.

To evaluate the effects of kerationocytes on the growth of melanocytes, keratinocyte conditioned media (K-CM) with different molecular weight obtained by dialysis were added to melanocyte growth medium (M-GM). In addition, K-CM only, and K-CM mixed with each component of M-GM, such as TPA(12-tetradecanoyl- phorbol-13-acetate), IBMX(isobutylmethylxanthine) and CT(cholera toxin), were used for the culture of melanocytes. 1) The proliferation of melanocytes was incresased to 2.86 x 10(5)+/-0.87 x 10(5) cells/ well and 2.87 x 10(5)+/-0.71 x 10(5) cells/well in 25% K-CM with a cut-off molecular weight of 2,000 and 25% K-CM with a cut,-off molecular weight between 6000 8000 respectively, as compared to 1.88 x 10(5)+/-0.45 x 10(5) cells/well in the control group (p < 0.05). 2) The amount of melanin was increased to 0.2987+/-0.0830ng/mlin 25% un- dialyzed K-CM, as compared to 0.2264+/-0.0643ng/ml in the control group, but this differnce was not statistically significant. 3) Maximum proliferation of melanocytes was observed in 35% concentration of K-CM with a cut-off molecular weight of 6000 8000. 4) Maximum of melanin production was observed in 35% concentration of undialyzed K-CM 5) As compared to 7.86 x 10+/-1.74 x 10(5) cells/well in M-GM,proliferation of melanocytes in 35% K-CM with a cut-off molecular weight of 6000 8000 was de- creased to 1.38 X 10(5)+/-0.97 X 10(5) cells/well. 6) There was no difference in melanocyte proliferation between 6.81 x 10(5)+/-2.19 x 10(5) cells/well in 35% 6,000 8,000 M.W. cut-off dialyzed K-CM, with IBMX only, and 7.86 x 10(5)+/-1.74 x 10(5) cells/well in M-GM. 7) Compared to 0.2303+/-0.0700ng/well cell in M-GM, the amount of melanin was increased to 0.3227+/-0.0900ng/cell, 0.3624+/-0.0900ng/cell and 0.2928+/-0.0500ng/cell, respectively, when TPA, IBMX, CT was added to 35% undialyzed K-CM. It also increased to 0.3176+/-0.1100 in 35% undialyzed K-CM(p<0.05). In summary, the results proved that cellular activating substances released from keratinocytes affect the proliferation of melanocyte and the synthesis of melain. It is also expected that methods used in this study can be clinically utilized because melanocyte culture is possible on K-CM without adding tumor promotors.
1-Methyl-3-isobutylxanthine ; Culture Media, Conditioned ; Dialysis ; Keratinocytes* ; Melanins ; Melanocytes* ; Molecular Weight

4

Cite

Share

A case of angiolymphoid hyperplasia with eosinophilia and its treatment with carbon dioxide laser.

Soo Gyoung HUR ; Chun Sang KIM ; Seung Churl LEE ; Inn Ki CHUN ; Young Pio KIM

Korean Journal of Dermatology.1991;29(2):130-135.

A 45-year-old female noticed a pruritic erythematous firm pea sized nodule on the left earlobe about 18 years prior to uisiting our clinic. The lesion has increased in size gradually and involved the whole earlobe. On March 1988, the earlobe became enlarged with extreme pruritus, and showed a tendency of easy bleeding by scratch. The skin lesions consisted of multiple pea to bean sized, shiny dusky red colored, moderate firm nodules or tumors with edema on the left. ear helix, antehelix, external auditoy meatus, and retroauricular fold. The histopathologic studies revealed vascular proliferation, presence of histiocyt.oid endothelial cells, and prominent inflammatory infiltration including large numtaer of eosinophils with fibrosis in the dermis. Hematological studies revealed eosinophilia(9%). Excision of several nodules and intralesional injection of trinmcinolon acetonide did not show complete favorable effect and treatment with carbon dioxide laser was attempted. With the patient under local anesthesia with 2% lidocaine, the lesion were treated with three t,o four passes at 25,100 second intervals with ieradiance 5W(cm. The pro- cedure was repeated until no abnormal findings could be seen in the treatment zone. Treatment with carbon dioxide Iaser on the patient obtained a satisfactory result.
Anesthesia, Local ; Angiolymphoid Hyperplasia with Eosinophilia* ; Bezafibrate ; Carbon Dioxide* ; Carbon* ; Dermis ; Ear ; Edema ; Endothelial Cells ; Eosinophils ; Female ; Fibrosis ; Hemorrhage ; Humans ; Injections, Intralesional ; Lasers, Gas* ; Lidocaine ; Middle Aged ; Peas ; Pruritus ; Skin

5

Cite

Share

Granuloma Annulare Induced by Adalimumab.

Young Jae OH ; Won Jun CHOI ; Joo Yeon KO ; Young Suck RO

Korean Journal of Dermatology.2011;49(7):656-659.

Adalimumab is the first fully humanized monoclonal anti-tumor necrosis factor alpha (TNF-alpha) antibody. This drug has been shown to be of benefit in patients with inflammatory diseases in which TNF-alpha is involved, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and Crohn's disease. As the use of adalimumab is becoming more widespread, cutaneous side effects are being increasingly reported. Various dermatologic adverse events have been reported in the literature, including injection site reactions, psoriasis-like eruption and pityriasis rosea. Herein, we describe a case of GA associated with adalimumab treatment for adult-onset Still's disease, which has not been reported in Korea.
Antibodies, Monoclonal, Humanized ; Arthritis, Psoriatic ; Arthritis, Rheumatoid ; Crohn Disease ; Granuloma ; Granuloma Annulare ; Humans ; Korea ; Necrosis ; Pityriasis Rosea ; Spondylitis, Ankylosing ; Still's Disease, Adult-Onset ; Tumor Necrosis Factor-alpha ; Adalimumab

6

Cite

Share

Aberrant Breast Tissue Associated with Acanthosis Nigricans.

Na Young YOON ; Jae Hong JI ; Seung Phil HONG ; Soo Young JEON ; Sung Ku AHN

Korean Journal of Dermatology.2011;49(1):93-95.

Aberrant breast tissue is a subset of accessory breast tissue, and it exhibits similar consistency to that of the adjacent normal breast tissue, but it lacks an associated nipple complex. It is a developmental anomaly defined as the persistence of breast tissue along the embryonic mammary line. Aberrant breast tissue is most commonly located in the axilla, though it may be present anywhere along the embryonic mammary line. We report here on an 11-year-old girl with aberrant breast tissue and acanthosis nigricans. She had tender masses that became noticeable with the onset of menarche and mottled hyperpigmentation on both axillae. The histopathologic finding of the lesion revealed the typical features of aberrant breast tissue with acanthosis nigricans.
Acanthosis Nigricans ; Axilla ; Breast ; Child ; Female ; Humans ; Hyperpigmentation ; Menarche ; Nipples

7

Cite

Share

A Case of Adenoid Cystic Carcinoma on the Nipple with Axillary Lymph Node Metastasis.

Sang Hoon PARK ; Tae Woo NOH ; Kwang Cheol HONG ; Yoo Seok KANG ; Un Ha LEE ; Hyun Su PARK ; Sang Jai JANG

Korean Journal of Dermatology.2011;49(1):90-92.

Adenoid cystic carcinoma of the breast is an uncommon type of breast cancer, and it accounts for 0.1% of all breast cancer. In contrast to the aggressive nature of extramammary adenoid cystic carcinoma, adenoid cystic carcinoma of the breast has a more favorable prognosis. A 55-year-old female patient presented with a 6-month history of a tender mass confined to the nipple of the left breast. A skin biopsy showed a linear and tubular pattern of atypical cells, which was consistent with adenoid cystic carcinoma. Left breast conserving surgery with axillary lymph node dissection was performed. The histopathology of the specimen showed a 1.5 cm sized mass localized to the nipple, and the axillary lymph nodes were positive for tumor metastasis.
Adenoids ; Biopsy ; Breast ; Breast Neoplasms ; Carcinoma, Adenoid Cystic ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Metastasis ; Nipples ; Prognosis ; Skin

8

Cite

Share

Neutrophilic Dermatosis of the Dorsal Hands.

Se Rim CHOI ; Woo Joong KIM ; Hee Jung LEE ; Dong Hyun KIM ; Moon Soo YOON

Korean Journal of Dermatology.2011;49(1):86-89.

Neutrophilic dermatosis of the dorsal hands (NDDH) is a rare, localized variant of Sweet syndrome, and it was first described by Galaria et al. in 2000. It usually occurs in middle-aged women and it is characterized by erythematous papules, plaques, pustules and hemorrhagic bullae that are generally located on the dorsal hands. The histopathological findings show prominent papillary dermal edema and a dense dermal neutrophilic infiltration. A neutrophilic infiltrate can also cause a variable degree of vascular damage: endothelial cell swelling, RBC extravasation, leukocytoclasia and fibrin deposition within the walls of vessels. We report here on a case of NDDH in a 50-year-old man who was treated with oral corticosteroid and the NDDH recurred after 9 months.
Blister ; Edema ; Endothelial Cells ; Female ; Fibrin ; Hand ; Humans ; Middle Aged ; Neutrophils ; Skin Diseases ; Sweet Syndrome

9

Cite

Share

Hypertrophic Lichen Planus That Occurred in an Elderly Woman.

Ho Song KANG ; Jun Oh PAEK ; Kyung Tae PARK ; Joung Soo KIM ; Hee Joon YU

Korean Journal of Dermatology.2011;49(1):82-85.

Lichen planus is a chronic papulosquamous disease that affects the skin and mucous membranes. It is characterized by pruritic violaceous papules that are most commonly seen on the extremities of middle aged adults, but the elderly are rarely affected. Hypertrophic lichen planus usually occurs on the extremities and especially on the shins, and it tends to be the most pruritic variant. An 82-year-old female presented with severe pruritic multiple papules and plaques on the both the upper and lower extremities for 1 year. At first, the lesions began as small, polygonal papules that formed verrucous plaques over several months. Histopathologic examination showed marked hyperkeratosis, irregular acanthosis and wedge-shaped hypergranulosis. The vacuolar alteration and the lymphocytic inflammatory infiltrate were accentuated at the base of the rete ridge. From these findings, we diagnosed these lesions as hypertrophic lichen planus. The lesions were treated with topical steroid and intralesional injection of steroid, and they were slightly improved after 2 months of therapy.
Adult ; Aged ; Aged, 80 and over ; Extremities ; Female ; Humans ; Injections, Intralesional ; Lichen Planus ; Lichens ; Lower Extremity ; Middle Aged ; Mucous Membrane ; Skin

10

Cite

Share

Acantholytic Acanthoma with an Atypical Presentation.

Ji Hye YANG ; Jeong Eun KIM ; Chong Hyun WON ; Sung Eun CHANG ; Mi Woo LEE ; Jee Ho CHOI ; Kee Chan MOON

Korean Journal of Dermatology.2011;49(1):79-81.

Acantholytic acanthoma is a rare benign neoplasm of epidermal keratinocytes and this commonly displays as a solitary, asymptomatic keratotic papule on the trunk. The histologic features are hyperkeratosis, acanthosis, papillomatosis and prominent acantholysis. Dyskeratotic cells are occasionally present, but prominent dyskeratosis is not a characteristic feature of acantholytic acanthoma. Herein, we report on a case of acantholytic acanthoma with several dyskeratoses, and this occurred in a 54-year-old woman who presented with a keratotic plaque that repeatedly pealed on the umbilicus.
Acantholysis ; Acanthoma ; Female ; Humans ; Keratinocytes ; Middle Aged ; Papilloma ; Umbilicus

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share