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Search for enzyme inhibitors from the ocean

Keyi WANG

Academic Journal of Second Military Medical University.1982;0(01):-.

Some enzyme inhibitors derived from the ocean were described briefly in this review.

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EFFECTS OF ANTI-DENDRITIC CELL MONOCLONAL ANTIBODY ON EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS

Shisong JIANG

Academic Journal of Second Military Medical University.1985;0(06):-.

The experimental autoimmune myasthenia gravis (EAMG) was induced by-inoculating C57BL/6 mice with partially purified acetylcholine receptor (AchR) plus complete Freund's adjuvent. The clinical signs of mice included decrement of striated muscle contraction, proliferative response of splenic lymphocytes to AchR and production of sera anti-AchR antibody. Pretreatment of the mice with anti-dendritic cell monoclonal antibody 33D1 prevented the occurrence of EAMG

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Changes of Plasma Vasopressin Content in Some Physiological States in Men

Lin PING

Academic Journal of Second Military Medical University.1981;0(03):-.

The changes of arginine vasopressin (AVP) levels in plasma in some physiological states in healthy men were studied by RIA. Mean plasma AVP concentration in 30 normal adults after 12 h of overnight water deprivation was 10.6?2.5 pg/ml, and decreased from 11.85?6.0 to 1.8?1.6 pg/ml 1 h after an oral water load (20 ml/kg) administered in 16 dehydrated normal subjects (P

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Differentiated bone marrow-derived multipotent adult progenitor cells in treatment of rabbit cardiac infarction

Xiaohua WANG

Academic Journal of Second Military Medical University.2000;0(08):-.

98%.Thick myofibers were observed by transmission electron microscopy after induction with 5-aza.Four weeks after transplantation,the left ventricle ejection fraction,the movement extent of left ventricle,left ventricle systolic wall thickening and dp/dt of rabbits were all higher than those of the control group and cardiac infarction model group(P

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PREPARATION OF?-ENDORPHIN ANTISERUM AND DEVELOPMENT OF ITS RADIOIMMUNOASSAY

Yuanxiang ZHU

Academic Journal of Second Military Medical University.1985;0(05):-.

A sensitive and specific antiserum for ?-endorphin(?-EP)was raised in male New Zealand white rabbits by primary and 5 booster injections with synthetic ?n-EP which was coupled to thyroglobulin with carbodimide.The antiserum has a high titer(1: 16000)and high avidity(detection limit 5 fmol/tube, IC50260 fmol/tube, Kaff about 6.35 x 109 L/mol).A reliable radioimmunoassay was developed.The results show that the method is suitable for measuring immunoreactive ?-EP contents in pituitary, brain areas and plasma of rats.

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INVESTIGATION ON MEASURING CHINESE SPEECH INTELLIGIBILITY OF EAR PLUGS

Wenyuan GAO

Academic Journal of Second Military Medical University.1981;0(03):-.

This paper reports the method for evaluating the speech intelligibility . of ear protectors.Twenty subjects wearing 3 types of ear plugs ("MT-86", "65", "85-Ⅱ" ear plugs) were presented with stable 50-Chinese-word signals. The results show that the intelligibility was higher with "MT-86" than with "65" and "85-Ⅱ ", and this method was a better measure to evaluate the influence of ear protectors on the intelligibility of speech.

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ULTRAVIOLET ABSORPTION OF BILE ACIDS IN MINIBECK REAGENT

Jianxin LI

Academic Journal of Second Military Medical University.1981;0(04):-.

The characteristic ultraviolet absorption of ten kinds of free and conjugated bile acids in Minibeck reagent is observed. The monohydroxycholanic acids have absorption maximum at 310 nm, dihydroxycholanic acids a strong maximum at 310 nm and a weaker maximum at 390 nm,but trihydroxycholanic acids a strong maximum at 390 nm and a weaker maximum at 310 nm. The molar absorptivities of free and conjugated bile acids in one type are approximately equal under 310 or 390nm. The absorbance is in linear proportion to concentration of bile acids in Minibeck reagent below 5-10 mM, and it is stable at least for 48 hours under cold and dark storage. A trihydroxycholanic acid solution containing mono-or dihydroxy-cholanic acid maintains their original absorption feature, and has apeak value of additive property.Each component of bile acids could be calculated by the absorbance at 310 and 390 nm.

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STUDIES OF THE EFFECTIVE CONSTITUENTS OF RHODODENDREN SIMSII PLANCH (lll):The Isolation and Identification of Ursoiic Acip

Bingxiang XU

Academic Journal of Second Military Medical University.1981;0(04):-.

The previous paper has described the isolation of five effective constituents: quercetin, quercitrin, hyperin, matteucinol and matteucinin from water extract of dried leaves of Rhododendren simsii planch and their structures were also elucidated. This paper reports the separation and identification of triterpenic acid from ethyl alcohol extract of the planto On the basis of spectral analysis,preparation of its derivatives and in comparison with the control, the structure is determined to be Ursolic acid, which is an effective constituent of an expectorant.

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A PRELIMINARY REPORT ON THE CLINICAL APPLICATION OF LXF-ICFBCS( Continuous Flow Blood Cell Separator)

Shanghua QIAN

Academic Journal of Second Military Medical University.1982;0(02):-.

The clinical application of the separator in the treatment of 4 patients suffering from Waldenstrom's macroglobulinemia,acute myelocytic leukemia, chronic lymphocytic leukemia and polycythemia vera was reported. With exception of one case of acute myelocytic leukemia, in which the WBC count in peripheral blood did not show marked decrease, all other 3 cases showed marked improvement in blood picture after separation. The blood sample cultures of 4 cases for bacteria were negative, suggesting the sterilization efficacy of ethylene oxide vapour to the bowl and polyvinyl chloride tubes in the CFBCS system was reliable.Hep-arinization with a dose of 80 u/kg showed safe anticoagulation effect. The causes of chilliness, rigor and fever,and the factors influencing the fluency of blood flow were discussed. The preventive measures were suggested.

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EFFECTS OF METRONSDAZOLE DERIVATIVE ON MEMBRANE PERMEABILITY OF~51Cr LABELLED L_7712 CELLS

Xiangshun MENG

Academic Journal of Second Military Medical University.1985;0(05):-.

This report describes the effects of a new radiosensitizer, metronidazole derivative (CM) synthesized in our laboratory, on membrane permeability of 51Cr labelled L7712 cells.It was found that CM could be incorporated into the cancer cells easily, and resulted in increased membrane permeability.Under aerobic condition, the release rate of 51Cr was increased when the cells were irradiated with more than 40 Gy Y-rays.At a dose of 0-80 Gy, the sensitization effects of CM on membrane permeability of irradiated cells were not found.

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