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Studies of three fields lymphadenectomy for patients with thoracic segments squamous cell carcinoma of esophagus

Chengguang HU ; Jianhong LIAN ; Bin REN ; Shuangping ZHANG ; Chunli WANG ; Shiping GUO

Cancer Research and Clinic.2009;21(8):473-475. doi:10.3760/cma.j.issn.1006-9801.2009.08.014

Objective To investigate the difference of complication incidence, death rate, quantity of lymphadeneetomy, lymphatic metastasis rate and long-term survival rate in thoracic squamons cell carcinoma of esophagus between three fields lymphadenectomy (3-FL) and traditional method. Methods Homoehronous 96 esophageal cancer patients were fractionated in two groups, 46 patients for 3-FL, the other 50 patients for traditional method. Results The average quantity of lymphadenectomy was 39.28 pieces per patient in 3-FL, and was significantly higher than 13.30 pieces per patient in traditional method (P <0.01). The rate of metastatic lymphatic nodes was 73.91%(34/46) in 3-FL patients, significantly higher than38.00%(19/50) in traditional method patients. For incidence of postoperative complications, recurrent laryngeal nerve damage and respiratory complication in 3-FL patients was significantly higher than patients in traditional method (P <0.05). The chest fluid obviously inereasod in 3-FL patients than in traditional method patients. There was significant contrast in 3-year survival rate between 3-FL patients and traditional method patients. Conclusion The there fields lymphadenectomy expand scope of lymphdenectomy effectually, accurate the staging of thoracic esophageal carcinoma. At the same time, a lot of evidence was found in raising survival rate for 3-FL. Disadvantage of 3-FL was severe surgical trauma, high incidence of complication, and a long recovery time after operation.

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Application of tumor markers in esophageal squamous cell carcinoma

Lei GONG ; Xiaodong ZHANG

Cancer Research and Clinic.2009;21(8):433-435. doi:10.3760/cma.j.issn.1006-9801.2009.08.001

The determination of tumor markers is of great value for esophageal squamous cell carcinoma. This article reviews the application status of routine tumor markers and the progression on the role of tumor markers in early diagnosis, predicting chemotherapy or radiotherapy response, monitoring disease recurrence and evaluation of prognosis in esophageal squamous cell carcinoma.

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Clinical comparison and analysis of laparoscopic and open operation for colorectal neoplasms

Zuo FU ; Xiaobo LIANG

Cancer Research and Clinic.2009;21(8):476-478. doi:10.3760/cma.j.issn.1006-9801.2009.08.015

Objective To evaluate the feasibility and short-term outcome of laparoscopic operation for colorectal neoplasm in comparison with open operation procedure for colorectal neoplasm, laparoscopic operation for colorectal neoplasm may be critical in the evolving practice of medieine. Methods 234 cases of colorectal neoplasm were divided into two groups and was analyzed. 103 patients with colorectal neoplasm underwent laparoscopic operation (LCS), while 131 cases received open operation (OCS). Results The mean operating time in laparoscopic operation group was significantly longer than in open operation group (P <0.05). The blood loss was less. Time to pass flatus, time to ambulate and return of bowel function were restored earlier in laparoscopic operation group than that in open operation group (P <0.05). Duration of hospital stay were longer in open operation group than that in laparoscopic operation group (P <0.05). There was not significant difference in the length, distal margin, size of tumors and number of removed lymphatic nodes(P > 0.05) between the two groups. Laparoscopic colorectal resection is better in pathologic sample compared with the traditional open operation procedure. Conclusion Laparoscopic colorectal resection is secure and effective for colorectal neoplasm, and it is with lower blood loss during operation,earlier return of bowel function and shorter hospitalization, and provide better short-term outcome compared with the traditional open procedure.

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Preliminary result of modified cylindrical abdominoperineal resection

Zhigang GAO ; Zenghui YANG ; Zhenjun WANG ; Guanghui WEI ; Minzhe LI ; Yanfu DU

Cancer Research and Clinic.2009;21(8):444-446. doi:10.3760/cma.j.issn.1006-9801.2009.08.004

Objective To report the preliminary result of cylindrical abdominoperineal resection (cylindrical APR) and pelvic reconstruction with human acellular dermal matrix (HADM). Methods Cylindrical APR was performed in 13 consecutive patients with advanced very low rectal cancer between January 2008 and April 2009. The mesorectum was not dissected off the levator muscles at abdominal part of the operation, the perineal part of the operation was done in the prone position. The levator muscles were exposed circumferentiaUy. The coccyx and part of the 5th sacrum were dissected and Waldeyer" s fascia divided. The levator muscles were divided laterally on both sides from posterior to anterior. The remaining pelvic floor muscle fibers were divided just posterior to the transverse perineal muscles and the levator muscles were resected en bloc with the anus and lower rectum. The specimen was cylindrical. The pelvic defects were reconstructed with HADM. Results There was no bowel perforation, and all specimens were proved CMR negative by pathology. Perineal wounds were healed uneventfully. After 8 months" follow-up, no patient developed perineal wound breakdown, bulge or hernia. There was 1 patient developed perineal wound infection; one patient developed seroma and three with perineal pain. Five patients with short-term urinary retention recovered within 10 days. Conclusion Clinical APR and HADM pelvic reconstruction can reduce circumferential margin positive and rectum perforation rate, and made the procedure easier and safer without increasing complications.

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The methylation of PTEN gene in gastric carcinoma

Keping FEI ; Hongjun LIU ; Yulong SHI ; Chensheng LI ; Jingfu SUN ; Yanying CHEN

Cancer Research and Clinic.2009;21(6):374-376. doi:10.3760/cma.j.issn.1006-9801.2009.06.005

Objective To explore the relationship between the abnormal expression of anti-oncogene PTEN in gastric carcinoma and the clinicopathological characteristics. Methods Mythylation specific PCR was applied to detect the expression of PTEN methylation in gastric carcinoma and their normal tissues from 45 patients. Results The methylation took place in 40.0 percent in gastric carcinoma and 2.2 percent in their normal tissues, and the difference was significant(P<0.05). The methylation rate in poorly differentiated adenocarcinoma was 60.0 percent ,while 15.0 percent in highly-moderately differentiated group, the difference was significant (P<0.05). In the 24 cases with lymph node metastasis, mythylation was observed in 13 cases, and the difference was significant (P<0.05). Conclusion The methylation of PTEN gene was associated with gastric carcinoma, it may play an important role in the development of the disease.

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Relationship of P-AKT abnormal expression with angiogenesis in follicular thyroid carcinoma

Peng ZHAO ; Fangfang JI ; Yangang WANG

Cancer Research and Clinic.2009;21(6):377-379. doi:10.3760/cma.j.issn.1006-9801.2009.06.006

Objective To study the abnormal expression of P-AKT in follicular thyroid carcinoma and its relationship with angiogenesis. Methods MVD and expressions of P-AKT, VEGF in 40 specimens of FTC tissues were detected by immunohistochemical PV6000 method. Results The expression rate of P-AKT in FTC was higher than that of non-FTC tissues. The result was of statistical significance (P<0.001). There were correlations between the MVD of FTC tissue and the expression of P-AKT and VEGF (P<0.05). The MVD of P-AKT positive FTC tissue was higher than that of negative tissues (P<0.05). The MVD of VEGF positive FTC tissue was also higher than that of negative tissues(P<0.05). There were correlations between the expression of P-AKT and VEGF(P<0.05). Conclusion The hyperexpression of P-AKT played an important role in the secondary deposits and development of human follicular thyroid carcinoma. AKT/VEGF pathway may exist in FTC, and AKT is the key factor in the pathway which regulated the expression of VEGF.

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Study on the expression change of HIF-1α and VEGF in protein levels and the correlation of them in QBC939 cell line under chemical hypoxia induced by CoCl2

Baohong ZHAO ; Jiansheng LIU

Cancer Research and Clinic.2009;21(6):368-370. doi:10.3760/cma.j.issn.1006-9801.2009.06.003

Objective To examine the expression change of HIF-1α and VEGF in protein levels and the corelation of them in Q8C939 cell line under chemical hypoxia induced by CoCl2 in vitro. Methods ELISA and immunohistochemical technique were used to examine the change of VEGF and HIF-1α protein level in QBC-939 line in different concentrations (200, 150, 100, 50, 0 μmol/L) of COCl2 and different periods (6 h, 12 h, 24 h, 48 h) in hypoxia. Results CoCl2 can up-regulate the expression of HIF-1α and VEGF at least partly in a dose and time dependent pattern. ELISA demonstrated that the level of VEGF protein in different concentrations and different hypoxia periods, the result showed that the VEGF protein was in different concentration groups over contrast group (P<0.05). The VEGF protein also increased continuously with the growing of hypoxia time (P<0.05). Immunohistochemical detection of concentrations of different groups, HIF-1α, VEGF protein in the average gray compared with the control group was different(P<0.05). Different time periods of hypoxia HIF-1α, VEGF protein in the average gray, any two group comparisons have difference (P<0.05). Different concentrations, the normal control group, different time period HIF-1α and VEGF protein expression of relevance were analyzed. The correlation coefficient was 0.830, P <0.01, 0.909, P <0.01. Conclusion In QBC939 cell line of hypoxia, there is up-regulation HIF-1α and VEGF.HIF-1α regulated the expression of VEGF.

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Study on the efficacy of neoadjuvant chemotherapy with TTC and FTC regimens for the treatment of breast cancer

Chengzheng WANG ; Shuming MAO ; Shude CUI

Cancer Research and Clinic.2009;21(7):472-474. doi:10.3760/cma.j.issn.1006-9801.2009.07.014

Objective To investigate the efficacy of TTC and FTC regimens as neoadjuvant chemotherapy in breast cancer. Methods Collecting clinical data of 325 patients received neoadjuvant chemotherapy with TIC and FTC regimens from June 2004 to April 2008, among them 138 patients received neoadjuvant chemotherapy with TTC regimen in one group, and 187 patients received neoadjuvant chemotherapy with CTF regimen in the other group. The expression of Topo Ⅱ a in specimen of 325 patients before neoadjuvant chemotherapy were detected by immunohistochemical method. Results Among the 325 cases of neoadjuvant chemotherapy, the overall response rate (RR) was 87.7 % in TIC arm and 67.4 % in FTC arm (P=0.000), but in the group of Topo Ⅱ a(+) Her-2(-), the overall response rate (RR) was 87.8 % in TTC arm and 79.4 % in FTC arm (P=0.266), and in the groups of Topo Ⅱ a(-), there was statistical significance; the pathologic complete response rate (pCR) was 13.7 % in TIC ann and 11.2 % in CTF ann (P=0.491). Conclusion TIC regimen is superior to FTC regimen in the response rate of neoadjuvant chemotherapy, but patients with negative expression of Topo Ⅱ a may get more benefits from 9eoadjuvant taxane and anthracycline chemotherapy.

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Investigation and its clinical significance of the relative activity of multidrug resistance P-glycoprotein in the plasma of breast cancer patients

Xuezhi TIAN ; Aizhi GUO ; Lijuan QIAO ; Huijuan XU

Cancer Research and Clinic.2009;21(7):463-465. doi:10.3760/cma.j.issn.1006-9801.2009.07.011

Objective To investigate the relative activity of multidrug resistance P-glycoprotein in the plasma of breast cancer patients, analyze the expression of P-glycoprotein before and after chemotherapy and evaluate its clinical value. Methods The plasma of patients and chemical reagents were mixed and distributed into the 96-well plate. The plate was read at 340 nm absorbaace before and after reaction. The variation of absorbance for each well was calculated, and then relative activity of each sample was compared to the referent compound activity. The relative activity of over 30 % was taken as positive expression of the P-gp for each sample. Results The frequency of P-glycoprotein expression was significantly increased from 16.2 % before chemotherapy to 43.2 % after chemotherapy (P<0.05). The positive expression of P-glycoprotein before and after chemotherapy were 5/6 and 9/16, respectively, in patients with positive lymph node metastasis, and 1/6 and 7/16, respectively, in patients with negative lymph node metastasis. Conclusion The results of this preliminary study suggest in P-glycoprotein expression in plasma of patients play an important role in the selection of drugs, which may be useful to evaluate the prognosis for treatment of breast cancer patients.

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Docetaxel for 15 patients with paclitaxel-resistant advanced non-small cell lung cancer

Yifei ZHANG ; Yunhua XU ; Xiangyun YE ; Ziming LI ; Linping GU ; Shun LU

Cancer Research and Clinic.2009;21(7):458-460. doi:10.3760/cma.j.issn.1006-9801.2009.07.009

Objective To determine the efficacy and toxicity of docetaxel in patients with paclitaxel-resistant advanced non-small cell lung cancer (NSCLC). Methods The clinical data from 15 patients with NSCLC who were admitted in the Shanghai Chest Hospital from January 2005 to May 2008 were retrospectively analyzed. The effects and toxicities of the second-line treatment were assessed. The progression-free survival time(PFS) and overall survival time(OS) were analyzed. Results The disease control rate was 66.7 %, with a progression-free survival time of 6 months, and a overall survival time of 17.3 months. The 1-year survival rate was 63.3 %. The toxic effects were as expected. Conclusion The doeetaxel-based agent is active in patients with paelitaxel-resistant advanced NSCLC.

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