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Cerebral Infarction Producing Sudden Isolated Foot Drop.

Journal of Clinical Neurology.2007;3(1):67-69. doi:10.3988/jcn.2007.3.1.67

Foot drop usually results from lesions affecting the peripheral neural pathway related to dorsiflexor muscles, especially the peroneal nerve. Although a central nervous system lesion is suspected when there is a lack of clinical evidence for a lower motor neuron lesion, such cases are extremely rare. We describe a patient with sudden isolated foot drop caused by a small acute cortical infarction in the high convexity of the precentral gyrus. This report indicates that a cortical infarction may have to be considered as a potential cause of foot drop.
Central Nervous System ; Cerebral Infarction* ; Foot* ; Humans ; Infarction ; Motor Neurons ; Muscles ; Neural Pathways ; Peroneal Nerve

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Reversible Verbal and Visual Memory Deficits after Left Retrosplenial Infarction.

Jong Hun KIM ; Kwang Yeol PARK ; Sang Won SEO ; Duk L NA ; Chin Sang CHUNG ; Kwang Ho LEE ; Gyeong Moon KIM

Journal of Clinical Neurology.2007;3(1):62-66. doi:10.3988/jcn.2007.3.1.62

The retrosplenial cortex is a cytoarchitecturally distinct brain structure located in the posterior cingulate gyrus and bordering the splenium, precuneus, and calcarine fissure. Functional imaging suggests that the retrosplenium is involved in memory, visuospatial processing, proprioception, and emotion. We report on a patient who developed reversible verbal and visual memory deficits following a stroke. Neuropsychological testing revealed both anterograde and retrograde memory deficits in verbal and visual modalities. Brain diffusion-weighted and T2-weighted magnetic resonance imaging (MRI) demonstrated an acute infarction of the left retrosplenium.
Brain ; Gyrus Cinguli ; Humans ; Infarction* ; Magnetic Resonance Imaging ; Memory Disorders* ; Memory* ; Neuropsychological Tests ; Proprioception ; Stroke

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Striopallidodentate Calcification and Progressive Supranuclear Palsy-Like Phenotype in a Patient with Idiopathic Hypoparathyroidism.

Tae Won KIM ; In Seok PARK ; Sung Hoon KIM ; Kwang Soo LEE ; Yeong In KIM ; Joong Seok KIM

Journal of Clinical Neurology.2007;3(1):57-61. doi:10.3988/jcn.2007.3.1.57

We present a 77-year-old woman with levodopa-nonresponsive parkinsonism, dementia, and supranuclear gaze palsy on vertical and horizontal gaze. Laboratory findings were consistent with idiopathic hypoparathyroidism, and brain computed tomography showed extensive bilateral calcifications of the basal ganglia, centrum semiovale, dentate nuclei, and cerebellar white matter. These results illustrate that striopallidodentate calcification due to hypoparathyroidism may present with symptoms mimicking progressive supranuclear palsy.
Aged ; Basal Ganglia ; Brain ; Dementia ; Female ; Humans ; Hypoparathyroidism* ; Paralysis ; Parkinsonian Disorders ; Phenotype* ; Supranuclear Palsy, Progressive

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Mild Encephalopathy with Reversible Lesion in the Splenium of the Corpus Callosum and Bilateral Frontal White Matter.

Jeong Seon CHO ; Sang Won HA ; Young Su HAN ; Sang Eun PARK ; Ki Moo HONG ; Jeong Ho HAN ; Eun Kyoung CHO ; Doo Eung KIM ; Jea Geun KIM

Journal of Clinical Neurology.2007;3(1):53-56. doi:10.3988/jcn.2007.3.1.53

A 59-year-old man visited an emergency room due to the sudden onset of severe dysarthria with a drowsy mental status. MRI demonstrated T2 prolongation and restricted diffusion involving the splenium of the corpus callosum and bilateral frontal white matter neurological signs and symptoms were mild, and the recovery was complete within a week. Follow-up MRI performed one month later revealed complete resolution of the lesions. The clinical and radiological courses were consistent with previously reported reversible isolated splenial lesions in mild encephalitis/encephalopathy except for the presence of frontal lesions. This case suggests that such reversible lesions can occur outside the splenium.
Corpus Callosum* ; Diffusion ; Dysarthria ; Emergency Service, Hospital ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Middle Aged

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Polyneuropathy Associated with IgA Paraproteinemia and Amyloidosis: A Case Report and Literature Review.

Yunsook JHANG ; Jung Ju LEE ; Jong Moo PARK ; Ja Seong KOO ; Byung Kun KIM ; Ohyun KWON

Journal of Clinical Neurology.2007;3(2):116-119. doi:10.3988/jcn.2007.3.2.116

Paraproteinemia potentially causes peripheral neuropathy via an unknown underlying pathogenetic mechanism. We report a case of pathologically proven amyloid neuropathy with AL amyloidosis with an IgA kappa light chain, which was initially diagnosed as neuropathy associated with monoclonal gammopathy of undetermined significance. This case indicates that in cases of neuropathy with paraproteinemia, the other potential causes should be excluded by appropriate means, especially pathological evaluations.
Amyloid Neuropathies ; Amyloidosis* ; Immunoglobulin A* ; Monoclonal Gammopathy of Undetermined Significance ; Paraproteinemias* ; Peripheral Nervous System Diseases ; Polyneuropathies*

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Pure Sensory Deficit at the T4 Sensory Level as an Isolated Manifestation of Lateral Medullary Infarction.

In Uk SONG ; Joong Seok KIM ; Dong Geun LEE ; Jae Young AN ; Seon Young RYU ; Sang Bong LEE ; Yeong In KIM ; Kwang Soo LEE

Journal of Clinical Neurology.2007;3(2):112-115. doi:10.3988/jcn.2007.3.2.112

In rare cases restricted sensory deficits along the somatotopic topography of the spinothalamic tract can develop from a lateral medullary infarction. To our knowledge, isolated dermatomal sensory deficit as a single manifestation of a lateral medullary infarction has not been reported previously. A 58-year-old man presenting with sudden left-sided paresthesia complained of sensory deficit of pain and temperature below the left T4 sensory level without other neurologic deficits. Diffuse- and T2-weighted magnetic resonance imaging (MRI) of the brain showed high signal intensities in the right lower medulla oblongata, whereas thoracic-spine MRI and somatosensory evoked potentials produced normal findings.
Brain ; Evoked Potentials, Somatosensory ; Humans ; Infarction* ; Magnetic Resonance Imaging ; Medulla Oblongata ; Middle Aged ; Neurologic Manifestations ; Paresthesia ; Spinothalamic Tracts

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Central Nervous System Lymphomatoid Granulomatosis Presenting with Parkinsonism.

Eun Hee SOHN ; Chang Joon SONG ; Hyo Jin LEE ; Samyong KIM ; Jae Moon KIM ; Ae Young LEE

Journal of Clinical Neurology.2007;3(2):108-111. doi:10.3988/jcn.2007.3.2.108

Lymphomatoid granulomatosis (LG) is a potentially malignant lymphoproliferative disorder. The lung is the most common involved site, followed by the skin and nervous system. However, LG of the central nervous system presenting with Parkinsonism is very rare. We report a patient with LG who presented with parkinsonian features such as bilateral rigidity, bradykinesia, and agitation. Brain magnetic resonance imaging showed multifocal punctuate enhanced lesions in both supra- and infratentorial areas. Steroid pulse therapy resulted in a dramatical improvement in the symptoms and MRI abnormalities.
Brain ; Central Nervous System* ; Dihydroergotamine ; Humans ; Hypokinesia ; Lung ; Lymphomatoid Granulomatosis* ; Lymphoproliferative Disorders ; Magnetic Resonance Imaging ; Nervous System ; Parkinsonian Disorders* ; Skin

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Fulminant Guillain-Barre Syndrome Mimicking Cerebral Death Following Acute Viral Hepatitis A.

Bong Hui KANG ; Kwang Kuk KIM

Journal of Clinical Neurology.2007;3(2):105-107. doi:10.3988/jcn.2007.3.2.105

A 32-year-old man was transferred to an intensive care unit due to respiratory difficulties with a 4-day history of progressive areflexic quadriparesis following acute hepatitis A. A nerve-conduction study revealed inexcitability of most nerves. The cerebrospinal fluid showed albuminocytologic dissociation, suggesting Guillain-Barre syndrome (GBS). The patient appeared brain dead on day 4, showing absent brainstem reflexes, respiratory failure, and fully dilated and fixed pupils. This case is an example of how GBS can evolve and simulate a brain-dead state from fulminant deafferentation following acute hepatitis A.
Adult ; Brain Death ; Brain Stem ; Cerebrospinal Fluid ; Guillain-Barre Syndrome* ; Hepatitis A* ; Hepatitis* ; Humans ; Intensive Care Units ; Pupil Disorders ; Quadriplegia ; Reflex ; Respiratory Insufficiency

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A Family Harboring CMT1A Duplication and HNPP Deletion.

Jung Hwa LEE ; Hee Jin KANG ; Hyunseok SONG ; Su Jin HWANG ; Sun Young CHO ; Sang Beom KIM ; Joonki KIM ; Ki Wha CHUNG ; Byung Ok CHOI

Journal of Clinical Neurology.2007;3(2):101-104. doi:10.3988/jcn.2007.3.2.101

Charcot-Marie-Tooth disease type 1A (CMT1A) is associated with duplication of chromosome 17p11.2-p12, whereas hereditary neuropathy with liability to pressure palsies (HNPP), which is an autosomal dominant neuropathy showing characteristics of recurrent pressure palsies, is associated with 17p11.2-p12 deletion. An altered gene dosage of PMP22 is believed to the main cause underlying the CMT1A and HNPP phenotypes. Although CMT1A and HNPP are associated with the same locus, there has been no report of these two mutations within a single family. We report a rare family harboring CMT1A duplication and HNPP deletion.
Charcot-Marie-Tooth Disease ; Gene Dosage ; Humans ; Paralysis ; Phenotype

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A Case of Disseminated Polycystic Dilated Perivascular Spaces Presenting with Dementia and Parkinsonism.

Dong Gun KIM ; Seung Hun OH ; Ok Joon KIM

Journal of Clinical Neurology.2007;3(2):96-100. doi:10.3988/jcn.2007.3.2.96

The perivascular spaces (PVSs) of the brain are lined with pia and contain interstitial fluid. In general, PVSs are small, asymptomatic, and identifiable at all ages. When PVSs are significantly enlarged, they can produce various clinical manifestations such as headache and dizziness. A 67-year-old man was admitted with cognitive impairment and gait disturbance with a 5-month history. Brain MRI showed multiple cystic PVSs in periventricular and subcortical white matter of both hemispheres. Medication with dopaminergic agents produced a moderate clinical improvement, while anticholinesterase was not effective. This case suggests that disseminated polycystic dilated PVSs may present with dementia and Parkinsonism.
Aged ; Brain ; Dementia* ; Dizziness ; Dopamine Agents ; Extracellular Fluid ; Gait ; Headache ; Humans ; Magnetic Resonance Imaging ; Parkinsonian Disorders*

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