Journal Detail Information

1

Cite

Share

ERRATUM: Expression of Erythropoietin in the Spinal Cord of Lewis Rats with Experimental Autoimmune Encephalomyelitis.

Sa Yoon KANG ; Ji Hoon KANG ; Jay Chol CHOI ; Jung Seok LEE ; Chang Sub LEE ; Taekyun SHIN

Journal of Clinical Neurology.2009;5(2):105-105. doi:10.3988/jcn.2009.5.2.105

The publisher wishes to apologize for incorrectly displaying the corresponding author's academic degree and position. We correct the corresponding author's academic degree from MD to DVM. The correspondig author belongs to the department of veterinary anatomy, college of veterinary medicine. The correct e-mail address is shint@jejunu.ac.kr.

2

Cite

Share

ERRATUM: Citicoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion.

Hyun Joon LEE ; Ji Seung KANG ; Yeong In KIM

Journal of Clinical Neurology.2009;5(2):104-104. doi:10.3988/jcn.2009.5.2.104

The publisher wishes to apologise for incorrectly displaying the second author's academic degree. We correct the second author's academic degree from MS to AD.

3

Cite

Share

Abnormal Vestibular Evoked Myogenic Potentials in Medial Medullary Infarction.

Je Young SHIN ; Hyun Seok SONG ; Ja Won KOO ; Hak Seung LEE ; Ji Soo KIM

Journal of Clinical Neurology.2009;5(2):101-103. doi:10.3988/jcn.2009.5.2.101

BACKGROUND: The medial vestibulospinal tract (MVST), which descends in the medial longitudinal fasciculus (MLF), may mediate the vestibular evoked myogenic potentials (VEMPs) in the contracting sternocleidomastoid muscle. We report herein abnormal VEMPs in a patient with medial medullary infarction (MMI) that appeared to involve the MLF. CASE REPORT: A patient with infarction involving the right medial medulla showed decreased p13-n23 amplitude and increased p13/n23 latencies of the VEMPs on the right side. These abnormal VEMPs recorded in an MMI patient support the theory that VEMPs are mediated by the MVST contained within the MLF. CONCLUSIONS: VEMPs may represent a valuable tool for investigating vestibular dysfunction originating from the saccule, even in patients with central vestibulopathies, which is not readily defined by conventional vestibular function tests.
Contracts ; Humans ; Infarction ; Muscles ; Saccule and Utricle ; Vestibular Evoked Myogenic Potentials ; Vestibular Function Tests

4

Cite

Share

Stroke Mimicking Encephalopathy as an Initial Manifestation of Diffuse Large B-Cell Lymphoma.

Jeong Min KIM ; Keun Hwa JUNG ; Soon Tae LEE ; Hee Kwon PARK ; Kon CHU ; Jae Kyu ROH

Journal of Clinical Neurology.2009;5(2):97-100. doi:10.3988/jcn.2009.5.2.97

BACKGROUND: Systemic lymphoma can be difficult to recognize due to its diverse manifestations. Paraneoplastic leukoencephalopathy has rarely been reported in the context of lymphoma. CASE REPORT: We report a 45-year-old man with systemic lymphoma whose initial manifestation was sudden-onset leukoencephalopathy, mimicking stroke. This patient, who was eventually diagnosed with diffuse large B-cell lymphoma, initially presented with sudden cognitive impairment and gait disturbance. Radiological studies suggested a paraneoplastic leukoencephalopathy. Chemotherapy for lymphoma resulted in clinical and radiological improvement. CONCLUSIONS: The presented case indicates that diffuse large B-cell lymphoma may initially appear as a treatable leukoencephalopathy.
B-Lymphocytes ; Cerebral Infarction ; Gait ; Humans ; Leukoencephalopathies ; Lymphoma ; Lymphoma, B-Cell ; Middle Aged ; Stroke

5

Cite

Share

Acute Subdural Hematoma Following Spinal Cerebrospinal Fluid Drainage in a Patient with Freezing of Gait.

Han Joon KIM ; Yong Jin CHO ; Joong Yang CHO ; Dong Ha LEE ; Keun Sik HONG

Journal of Clinical Neurology.2009;5(2):95-96. doi:10.3988/jcn.2009.5.2.95

BACKGROUND: Headache is a common complication of lumbar puncture (LP). Although in most cases post-LP headaches are not severe and have a benign course, they can also be a manifestation of a potentially life-threatening complication such as subdural hematoma (SDH). CASE REPORT: We describe a patient in whom a massive SDH developed after LP and cerebrospinal fluid (CSF) drainage, which were performed during the diagnostic evaluation of freezing of gait. CONCLUSIONS: SDH should not be excluded from the differential diagnosis of headache following LP, especially when there is a loss of CSF.
Diagnosis, Differential ; Drainage ; Freezing ; Gait ; Headache ; Hematoma, Subdural ; Hematoma, Subdural, Acute ; Humans ; Spinal Puncture

6

Cite

Share

Scoliosis in Patients with Parkinson's Disease.

Jong Sam BAIK ; Jeong Yeon KIM ; Joong Hyun PARK ; Sang Won HAN ; Jae Hyeon PARK ; Myung Sik LEE

Journal of Clinical Neurology.2009;5(2):91-94. doi:10.3988/jcn.2009.5.2.91

BACKGROUND AND PURPOSE: Scoliosis is more common in patients with Parkinson's disease (PD) than in the general elderly population. We compared clinical characteristics between PD patients with and without scoliosis, to identify the relationship between the direction of scoliosis and the laterality of the dominant symptoms of PD. We also studied the associations between dopaminergic pharmacotherapy and scoliosis (defined by a spinal curvature deviation of 10 degrees or larger). METHODS: The study population comprised 97 patients (42 men and 55 women) with idiopathic PD. All of the patients submitted to a whole-spine scanograph to allow measurement of the degree of scoliosis by Cobb's method. RESULTS: True scoliosis was found in 32 of the 97 PD patients, and was observed more frequently in women than in men (28 vs. 4, respectively; p=0.006). The age of patients without scoliosis was significantly lower than that of those with scoliosis (66.5+/-9.2 years vs. 72.8+/-7.3 years, respectively, mean+/-SD, p<0.001). There was no correlation between PD symptom laterality and scoliosis. The rate of occurrence of scoliosis did not differ between de novo and levodopa (L-dopa)-treated patients. CONCLUSIONS: We suggest that neither L-dopa treatment nor the laterality of the initial symptoms of PD is related to the appearance of scoliosis.
Aged ; Female ; Humans ; Levodopa ; Male ; Parkinson Disease ; Scoliosis ; Spinal Curvatures

7

Cite

Share

Plasma Total Homocysteine Levels are not Associated with Medial Temporal Lobe Atrophy, but with White Matter Changes in Alzheimer's Disease.

Sung Rae KIM ; Seong Hye CHOI ; Choong Kun HA ; Shin Goo PARK ; Hae Wook PYUN ; Dae Hyun YOON

Journal of Clinical Neurology.2009;5(2):85-90. doi:10.3988/jcn.2009.5.2.85

BACKGROUND AND PURPOSE: Elevated plasma total homocysteine (tHcy) levels are reported to be associated with an increased risk of Alzheimer's disease (AD). However, the mechanism by which homocysteine contributes to the pathogenesis of AD is as yet unknown. The aim of this study was to elucidate the relationship between white matter changes (WMC) and medial temporal lobe atrophy (MTA) on brain magnetic resonance imaging (MRI), and plasma levels of tHcy in AD patients. METHODS: Seventy-two patients with a clinical diagnosis of probable AD were recruited to the study. Plasma tHcy levels, vascular risk factors, and WMC and MTA on brain MRI were evaluated in all patients. The AD patients were classified into two groups: those with no or minimal WMC (69.2+/-8.8 years, mean+/-SD, n=36) and those with moderate-to-severe WMC (74.6+/-4.6 years, n=36) on brain MRI. RESULTS: In a univariate logistic regression analysis, the risk of moderate-to-severe WMC in AD was significantly associated with increasing age, female gender, lower education level, hypertension, high plasma tHcy levels, and lower Mini-Mental State Examination (MMSE) score. Multivariate logistic regression analysis revealed only high plasma tHcy as the independent and significant risk factor for moderate-to-severe WMC [odds ratio (OR; adjusted for age, gender, education level, MMSE score, and hypertension comparing the top tertile - tHcy levels > or =12.9 micromol/L - with the bottom tertile - tHcy levels < or =9.4 micromol/L)=7.35; 95% confidence interval, confidence interval=1.36-39.84; p=0.02], and age as a borderline significant risk factor (OR=1.08, 95% CI=0.99-1.19, p=0.09) in AD patients. Plasma tHcy levels were not correlated significantly with either right or left MTA. CONCLUSIONS: Our results suggest that the vascular pathway mediates the association between elevated plasma tHcy levels and AD.
Alzheimer Disease ; Atrophy ; Brain ; Female ; Glutamates ; Guanine ; Homocysteine ; Humans ; Hypertension ; Leukoaraiosis ; Logistic Models ; Magnetic Resonance Imaging ; Plasma ; Risk Factors ; Temporal Lobe ; Pemetrexed

8

Cite

Share

Cognitive Impairment in Essential Tremor without Dementia.

Joong Seok KIM ; In Uk SONG ; Yong Soo SHIM ; Jeong Wook PARK ; Ji Yeon YOO ; Yeong In KIM ; Kwang Soo LEE

Journal of Clinical Neurology.2009;5(2):81-84. doi:10.3988/jcn.2009.5.2.81

BACKGROUND AND PURPOSE: Several clinical studies have demonstrated that patients with essential tremor (ET) may have cognitive deficits; however, there are no published data regarding detailed neuropsychological assessments of ET without dementia. We therefore conducted a case-control study of cognitive function in patients with ET. METHODS: The cohort for this study comprised 34 consecutive patients with ET without dementia and 33 age-matched controls, all of who completed a dementia-screening questionnaire and underwent a detailed neuropsychological investigation. RESULTS: Severe impairments were observed in most domains for the ET group compared to the controls, including attention, part of language function, verbal memory, and frontal executive functions. CONCLUSIONS: Our results support the finding that the subclinical cognitive deficits characterized by attention, verbal memory impairments, and executive dysfunction are a clinical feature of ET. In addition, our results also support the finding that age at examination and educational status are the most important risk factors associated with cognitive deficits in patients with ET.
Case-Control Studies ; Cognition ; Cohort Studies ; Dementia ; Educational Status ; Essential Tremor ; Executive Function ; Humans ; Memory ; Risk Factors ; Surveys and Questionnaires

9

Cite

Share

Cerebellar Hypoperfusion during Transient Global Amnesia: An MRI and Oculographic Study.

Young Soon YANG ; Ji Soo KIM ; Sang Yun KIM ; Yu Kyeong KIM ; Yong Tae KWAK ; Il Woo HAN

Journal of Clinical Neurology.2009;5(2):74-80. doi:10.3988/jcn.2009.5.2.74

BACKGROUND AND PURPOSE: Transient global amnesia (TGA) is characterized by sudden anterograde and retrograde amnesia lasting for up to 24 hours. Diffusion-weighted magnetic resonance imaging (DWI) in cases of TGA and ischemia demonstrates a high frequency of high signal intensities restricted to the hippocampus, and this has been proposed as an etiology of TGA. The aims of this study were to characterize the DWI and single-photon-emission computed tomography (SPECT) findings during the acute and recovered phases of TGA and to correlate the findings with oculomotor abnormalities. METHODS: Five consecutive patients with a clinical diagnosis of TGA underwent DWI and SPECT of the brain within 24 hours after symptom onset and again 3 days later. Eye movements were also recorded using three-dimensional video-oculography. RESULTS: In all patients, DWI disclosed small punctuate (1-3 mm), high-signal lesions in the lateral portion of the hippocampus. The initial SPECT also revealed hypoperfusion in the cerebellar vermis, which had recovered by the follow-up examination. Three patients showed saccadic hypermetria or impaired smooth pursuit only during the acute phase. CONCLUSIONS: Our patients with TGA showed cerebellar vermian hypoperfusion in addition to ischemic insults to the lateral hippocampus. The oculomotor abnormalities observed in our patients support the occurrence of cerebellar dysfunction during the TGA attack.
Amnesia, Retrograde ; Amnesia, Transient Global ; Brain ; Cerebellar Ataxia ; Cerebellar Diseases ; Cerebellum ; Eye Movements ; Follow-Up Studies ; Hippocampus ; Humans ; Ischemia ; Magnetic Resonance Imaging ; Pursuit, Smooth ; Saccades ; Tomography, Emission-Computed, Single-Photon

10

Cite

Share

Recurrent Cerebral Venous Thrombosis Associated with Elevated Factor VIII.

Mi Jung KIM ; A Hyun CHO ; Young Joo NO ; Hee Young KIM ; Jong S. KIM

Journal of Clinical Neurology.2006;2(4):286-289. doi:10.3988/jcn.2006.2.4.286

Cerebral venous thrombosis (CVT) rarely recurs, and the factors associated with a recurrence remain unclear. Recently, however, elevated plasma coagulation factor VIII has been considered a factor related to recurrent venous thromboembolism. Here we report a patient who had recurrent CVT associated with significantly elevated levels of factor VIII despite the chronic use of an antiplatelet agent. Factor IX was also elevated in this patient. These findings suggest that elevated factor VIII is a factor underlying the recurrence of CVT, and that prolonged anticoagulation therapy may have to be considered in patients with elevated coagulation factor levels.
Blood Coagulation Factors ; Factor IX ; Factor VIII* ; Humans ; Plasma ; Recurrence ; Venous Thromboembolism ; Venous Thrombosis*

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share