Journal of Clinical Neurology  2008;4(3):131-133

doi:10.3988/jcn.2008.4.3.131

Warfarin-Induced Intracerebral Hemorrhage Associated with Microbleeds.

Gha Hyun LEE 1 ; Sun U KWON ; Dong Wha KANG

Affiliations

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Keywords

Anticoagulation; Intracerebral hemorrhage; Magnetic resonance imaging

Country

Republic of Korea

Language

English

Abstract

BACKGROUND: Microbleeds (MBs), proposed as a biomarker for microangiopathy, have been suggested as a predictor of spontaneous or thrombolysis-related intracerebral hemorrhage (ICH) in acute ischemic stroke. However, the relationship between MBs and warfarin-induced ICH is not clear. CASE REPORT: We describe two patients who developed warfarin-induced ICH at the site of MBs documented in previous MRI. CONCLUSIONS: The presence of MBs might increase the risk of ICH after warfarin use in ischemic stroke patients. A large cohort study is required to confirm the relationship of MBs with warfarin-induced ICH.