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New developments in gastrointestinal stromal tumor

China Oncology.2000;0(06):-.

Gastrointestinal stromal tumor(GIST) is the most common mesenchymal malignancy of the GI tract. The mainstay of treatment is surgery. For patients in whom complete resection is not possible, or in patients with metastatic or recurrent disease, they are unresponsive to standard chemotherapy and to radiotherapy. There has been no effective systemic treatment for unresectable GIST or metastatic disease. Gain-of-function mutations of the KIT proto-oncogene occur in up to 90% of GIST, allowing constitutive activation of tyrosine kinase (i.e. auto-phosphorylation of tyrosine residues independent of ligand-receptor binding), leading to aberrant cell division and tumour growth. Imatinib selectively inhibits the tyrosine kinase activity associated with KIT, which forms the rationale for evaluating its effects in GIST. Herein, we review recent developments in treatment for GIST and implication for optimal treatment in these patients.

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Nedaplatin combined with radiotherapy in the treatment of advanced nasopharyngeal carcinoma

Fei ZHOU ; Jinhong LUO ; Liwei WANG

China Oncology.2000;0(06):-.

0.05). NDP had lower reaction rate, vomiting (15.62%) occurred in NDP group, compared to that which occurred in DDP group (46.88%), with a significant difference between the two groups (P

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A randomized clinical study of capecitabine plus oxaliplatin compared with fluorouracil/leucovorin plus oxaliplatin in the treatment of advanced gastric cancer

Shaojun CHEN ; Haixin HUANG ; Guisheng LI

China Oncology.2000;0(06):-.

0.05)。The median time to progression (mTTP)was 5.8 months in XELOX group and 5.7 months in FOLFOX4 group. The median survival time (MST) was 10.0 months in XELOX group and 9.8 months in FOLFOX4 group, The toxicities were well tolerated,The incidence of grade Ⅲ+Ⅳ nausea and vomiting was significantly lower in XELOX group than in FOLFOX4 group (P0.05).Conclusions:Both of the two regimens were feasible, well tolerated and effective in treatment of advanced gastric cancer。XELOX regimen may be safer than FOLFOX4 regimen,especially in elderly patients or patients with ECOG PS of 1 to 2.

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Clinical study of video-assisted mini-thoractomy surgery for lung tumor with lymphadenectomy

Jiaming CHE ; Weicheng QIU ; Xiaoqing YANG

China Oncology.2000;0(06):-.

Background and purpose: VATS lobectomy has gained popularity for lung tumor around the world during the recent twenty years.Complete anatomic resections and node dissections are routinely being performed at many centers under VATS, but some thoracic surgeons are concerned regarding the safety, benefit and radical resection of this operative method. Our study was aimed to evaluate the reliability and feasibility of pulmonary resection and lymphadenectomy by video-assisted mini-thoractomy (VAMT) for patients with lung tumor.Methods:From August to September 2006,radical lobectomy or pneumonectomy and systemic lymphadenectomy were performed on 9 patients with lung tumor through video assisted mini-thoracotomy surgery.incidence of complications, total number of dissected lymph nodes,number of metastatic lymph nodes,survival and life quality were evaluated.Results:Totally 100 lymph nodes were removed at average 15.0 minutes, and there was no accident and death happened in the whole operation which only consumed 2.3 hours. Serious postoperative complications and death also did not happen.Conclusions:Video assisted mini-thoracotomy surgery should fulfill the same quality lymphadenectomy and lung tumor definitive resection.

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Loop electrosurgical excision procedure for treatment of CINⅢ and cervical carcinoma stage Ⅰ_(A1)

Zhiling ZHU ; Xin LU

China Oncology.2000;0(06):-.

Background and purpose:High frequency loop electrosurgical excision procedure(LEEP)has been widely used in the treatment of cervical intraepithelial neoplasia. The purpose of this study was to explore the value of loop electrosurgical excision procedure in the diagnosis and management of CINⅢ and stage ⅠAl cervical carcinoma.Methods:A retrospective analysis was carried out in 396 cases of CINⅢ and cervical carcinoma with stage ⅠAl undergoing operation and loop electrosurgical excision procedure between January 2003 and October 2006 at Obstetrics and Gynecology Hospital of Fudan University.Results:The coincidence rate of the multiple biopsies before the procedures compared with the conization ones was 88.6 % (351/395). The incidence of residual disease was 10.2%(6/59) and 7.7 % (6/78), respectively in patients with positive margins and negative margins.Conclusions:Loop electrosurgical excision procedure can improve both the diagnosis and treatment of CINⅢ and cervical carcinoma stage ⅠAl. We should offer further treatment properly to the cases with positive margin because of the persistent lesions.

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Whether the hepatitis B virus envelope as a gene transfer vector has targeting ability for liver cancer

Dejian PAN ; Donglin WANG ; Zhengtang CHEN

China Oncology.2000;0(06):-.

Background and purpose:The reason for hepatitis B virus (HBV) with hepatocyte specificity is PreS1 enchased on the hepatitis B virus envelope (HBVE). So HBVE may have a potential application in liver targeting gene transfer. In this study, we investigated whether HBVE has the ability to target liver cancer cells. Methods:HBVE was obtained from the supernatant of Hep G 2.2.15 cells through PEG8000 system and ?-propiolactone method. The pIRS2-EGFP was packed with HBVE and resulted in the product HBVE-GFP. HBVE-GFP was transfected into HepG2, A549, HeLa and FB cells. The green fluorescent protein (GFP) expression was observed under a fluorescent microscope. The rate of GFP positive cells was determined by flow cytometer.Results:The GFP could be observed in the four groups, but the HepG2 group had a higher fluorescent intensity than the other 3 groups. The transfected rate of HepG2 group was (71.35?0.03)% , much higher than other groups(P

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Comparison of intensity-modulated and three-dimensional conformal techniques for radiotherapy of esophageal carcinoma

Zhiqin JIANG ; Guoliang JIANG

China Oncology.2006;0(07):-.

Three-dimensional conformal radiation therapy(3D-CRT) and intensity-modulated radiation therapy(IMRT) are becoming important parts for research of treatment in esophageal carcinoma patients.The advances of dosimetric study in 3D-CRT,IMRT of esophageal carcinoma and the evaluation indices are reviewed.

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Modified three-weeks' docetaxel/cisplatin as first line chemotherapy for advanced non-small cell lung cancer

Shaowei ZHOU ; Haiping ZHANG ; Li WANG

China Oncology.2006;0(07):-.

Background and purpose: Docetaxel/cisplatin are widely used in chemo-naive patients with advanced non-small cell lung cancer(NSCLC),but the standard 3-weeks'project of docetaxel caused significant toxicity.We performed this study to compare the effect and toxicity of modified and standard 3-weeks'docetaxel/cisplatin as first line chemotherapy for advanced NSCLC.Methods:68 patients with stage ⅢB or Ⅳ NSCLC(proven by histology or cytology) were randomly divided into two groups,modified(A) and standard(B) chemotherapy.Group A: docetaxel 75 mg/m2,divided into 2 days,ivgtt d1 and d 8,cisplatin 25 mg/(m2?d),ivgtt d 1-d 3,q3w;Group B: docetaxel 75 mg/m2,ivgtt d 1,cisplatin was administered as Group A,q3w.The effect and toxicity were assessed after two cycles and one-year survival was followed up.Results:There was no CR in both groups.10 PR,20 SD,4 PD were found in group A,the overall response rate is 29%;whereas 11 PR,20 SD,3 PD were found in group B,the overall response rate is 32%.The one-year survival rate were 38% and 35% in group A and B,respectively.There were no significant difference about the overall response rate(P=0.793) and one-year survival rate(P=0.801) between group A and B.The rates of grade Ⅲ/Ⅳ neutropenia were 18% and 47% in group A and B respectively.The difference was statistically significant(P=0.010).Conclusions:In comparison with the standard 3-weeks'docetaxel/ cisplatin chemotherapy,the modified one has similar response rate but lower hematologic toxicity,and thus it was well tolerated.

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Influence of MRI on the staging system of 78 patients with nasopharyngeal carcinoma (NPC)

Yucheng LIN

China Oncology.2006;0(07):-.

Background and purpose: The patients with nasopharyngeal carcinoma(NPC) are staged according to Chinese 1992 staging system that is mainly based on clinical symptoms and CT image.Since MRI has been widely used in the clinic,the results were reported to be more accurate than the CT scan.The purpose of this study was to compare the diversity in tumor extension of NPC by computerized tomography(CT) versus magnetic resonance imaging(MRI) and to evaluate if the difference has any impacts on the '92 staging system.Methods:The MRI and CT were taken and compared prior to radiotherapy for 78 cases with histologically proved NPC from Aug.2005 to Aug.2006.Clinical staging was estimated according to '92 staging system based on both of CT or MRI data and clinical information.Results:MRI was significantly superior to CT in the detection of invasion in anterior-styloid space(82.0% vs 65.4%),oropharynx(34.6% vs 20.5%),retropharyngeal lymphatic metastasis(74.4% vs 55.1%),base of skull(51.3% vs 30.8%),cavernous sinus(19.2% vs 5.1%),nasal sinuses(33.3% vs 19.2%) and pterygopalatine fossa(16.7% vs 6.4%.),all the difference showed statistical significance.There were no statistical differences between CT and MRI in the evaluation of involvement of nasal cavity(28.2% vs 21.8%),post-styloid space(65.4% vs 67.9%),pharynx cavity(2.6% vs 1.3%) and cervical lymph node metastasis.According to MRI data,42.3% of T classification,25.6% of N classification,and 28.2% of clinical stages were changed compared to CT scan.Conclusions:There is remarkable advantage of MRI in the detection of infiltration of NPC,especially in the base of skull,cavernous sinus,and retropharyngeal lymphatic metastasis.The '92 stage system should be changed to adapt MRI information into clinical stage and it might impact on the prognosis of NPC.

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Prognostic factor analysis of 603 cases with gastric cancer undergoing radical resection

Gang ZHAO ; Jiangfeng QIU ; Zhiyong WU

China Oncology.2006;0(07):-.

0.05).Histological type,gross type,tumor site,lymph node metastasis and depth infiltration were related to the prognosis of gastric cancer(P

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